Maxadilan, a PAC1 receptor agonist from sand flies

Peptides

Volumn 28, Issue 9, 2007, Pages 1651-1654

  Lerner, Ethan A ^a   Iuga, Aurel O ^a   Reddy, Vemuri B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Leishmaniasis; Maxadilan; PAC1; PACAP; Receptor

Indexed keywords

AMINO ACID; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; INSECT PROTEIN; MAXADILAN; PAC1 RECEPTOR; UNCLASSIFIED DRUG; VASODILATOR AGENT;

AMINO ACID COMPOSITION; ARTICLE; HUMAN; INSECT BITE; LEISHMANIASIS; MAMMAL; NONHUMAN; PARASITE VECTOR; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN STRUCTURE; PSYCHODIDAE; RECEPTOR UPREGULATION; SALIVARY GLAND;

ANIMALS; DIPTERA; INSECT PROTEINS; INSECT VECTORS; LEISHMANIASIS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE, TYPE I;

MAMMALIA; PHLEBOTOMINAE;

EID: 34548426009     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2007.06.021     Document Type: Article

References (21)

1. Gower Jr. W.R., Dietz J.R., McCuen R.W., Fabri P.J., Lerner E.A., and Schubert M.L. Regulation of atrial natriuretic peptide secretion by cholinergic and PACAP neurons of the gastric antrum. Am J Physiol Gastrointest Liver Physiol 284 January (1) (2003) G68-G74
2. Grevelink S.A., Osborne J., Loscalzo J., and Lerner E.A. Vasorelaxant and second messenger effects of maxadilan. J Pharmacol Exp Ther 272 January (1) (1995) 33-37
3. Lanzaro G.C., Lopes A.H., Ribeiro J.M., Shoemaker C.B., Warburg A., Soares M., et al. Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex. Insect Mol Biol 8 May (2) (1999) 267-275
4. Lerner E.A., Ribeiro J.M., Nelson R.J., and Lerner M.R. Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis. J Biol Chem 266 June (17) (1991) 11234-11236
5. Lerner E.A., and Shoemaker C.B. Maxadilan. Cloning and functional expression of the gene encoding this potent vasodilator peptide. J Biol Chem 267 January (2) (1992) 1062-1066
6. Mercer A., Ronnholm H., Holmberg J., Lundh H., Heidrich J., Zachrisson O., et al. PACAP promotes neural stem cell proliferation in adult mouse brain. J Neurosci Res 76 April (2) (2004) 205-215
7. Milleron R.S., Mutebi J.P., Valle S., Montoya A., Yin H., Soong L., et al. Antigenic diversity in maxadilan, a salivary protein from the sand fly vector of American visceral leishmaniasis. Am J Trop Med Hyg 70 March (3) (2004) 286-293
8. Morris R.V., Shoemaker C.B., David J.R., Lanzaro G.C., and Titus R.G. Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection. J Immunol 167 November (9) (2001) 5226-5230
9. Moro O., Tsomides T.J., Tajima M., and Lerner E.A. Maxadilan binds to membrane fractions of brain tissue. Biochem Biophys Res Commun 216 November (1) (1995) 234-241
10. Moro O., Tajima M., and Lerner E.A. Receptors for the vasodilator maxadilan are expressed on selected neural crest and smooth muscle-derived cells. Insect Biochem Mol Biol 26 December (10) (1996) 1019-1025
11. Moro O., and Lerner E.A. Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist. J Biol Chem 272 January (2) (1997) 966-970
12. Moro O., Wakita K., Ohnuma M., Denda S., Lerner E.A., and Tajima M. Functional characterization of structural alterations in the sequence of the vasodilatory peptide maxadilan yields a pituitary adenylate cyclase-activating peptide type 1 receptor-specific antagonist. J Biol Chem 274 August (33) (1999) 23103-23110
13. Nokihara K., Yasuhara T., Nakata Y., Lerner E.A., and Wray V. Chemical synthesis of maxadilan, a non-mammalian potent vasodilatory peptide consisting of 61 amino acids with two disulfide bridges, and its related peptides. Int J Peptide Res Ther 13 June (1-2) (2007) 377-386
14. Pereira P., Reddy V.B., Kounga K., Bello Y., and Lerner E. Maxadilan activates PAC1 receptors expressed in Xenopus laevis melanophores. Pigment Cell Res 15 December (6) (2002) 461-466
15. Qureshi A.A., Asahina A., Ohnuma M., Tajima M., Granstein R.D., and Lerner E.A. Immunomodulatory properties of maxadilan, the vasodilator peptide from sand fly salivary gland extracts. Am J Trop Med Hyg 54 June (6) (1996) 665-671
16. Reddy V.B., Iuga A.O., Kounga K., and Lerner E.A. Functional analysis of recombinant mutants of maxadilan with a PAC1 receptor-expressing melanophore cell line. J Biol Chem 281 June (24) (2006) 16197-16201
17. Soares M.B., Titus R.G., Shoemaker C.B., David J.R., and Bozza M. The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-alpha and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor. J Immunol 160 February (4) (1998) 1811-1816
18. Theodos C.M., Ribeiro J.M., and Titus R.G. Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice. Infect Immun 59 May (5) (1991) 1592-1598
19. Titus R.G., and Ribeiro J.M. Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity. Science 239 March (4845) (1988) 1306-1308
20. Warburg A., Saraiva E., Lanzaro G.C., Titus R.G., and Neva F. Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis. Philos Trans R Soc Lond B Biol Sci 345 July (1312) (1994) 223-230
21. Yamada H., Watanabe M., and Yada T. Cytosolic Ca2+ responses to sub-picomolar and nanomolar PACAP in pancreatic beta-cells are mediated by VPAC2 and PAC1 receptors. Regul Pept 123 December (1-3) (2004) 147-153