Hindbrain effects of PACAP on gastric motor function in the rat

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 5 35-5, 1997, Pages

  Krowicki, Zbigniew K ^a   Arimura, Akira ^b   Nathan, Nicole A ^a   Hornby, Pamela J ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b TULANE UNIVERSITY   (United States)

Author keywords

Dorsal vegal complex; Intragastric pressure; L glutamate; Nucleus ambiguus; Nucleus raphe obscurus; Pituitary adenylate cyclase activating polypeptide

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE;

AMBIGUUS NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; RHOMBENCEPHALON; SMOOTH MUSCLE CONTRACTILITY; STOMACH MOTILITY; STOMACH PRESSURE; VAGUS NERVE STIMULATION;

EID: 0030919407     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.5.g1221     Document Type: Article

References (34)

1. Akarca, U. S., A. Hammer, A. Takaki, and A. Arimura. Sympathoadrenomedullary system mediates the central inhibitory effect of PACAP-27 on gastric acid secretion in chronic gastric fistula rats (Abstract). Am. J. Gastroenterol. 88: 1502, 1993.
2. Arimura, A. Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regul. Pept. 37: 287-303, 1992.
3. 1-38 across the blood-brain barrier. J. Pharmacol. Exp. Ther. 267: 690-696, 1993.
4. Contreras, R. J., R. M. Beckstead, and R. Norgren. The central projections of the trigeminal, facial, glossopharyngeal and vagus nerves: an autoradiographic study in the rat. J. Auton. Nerv. Syst. 6: 303-322, 1982.
5. Garrick, T., M. Prince, H. Yang, G. Ohning, and Y. Taché. Raphe pallidus stimulation increases gastric contractility via TRH projections to the dorsal vagal complex in rats. Brain Res. 636: 343-347, 1994.
6. Hornby, P. J., C. Rossiter, R. L. White, W. P. Norman, and R. A. Gillis. Medullary raphe: a new site for vagally mediated stimulation of gastric motility in cats. Am. J. Physiol. 258 (Gastrointest. Liver Physiol. 21): G637-G647, 1990.
7. Ishikawa, T., H. Yang, and Y. Taché. Medullary sites of action of the TRH analogue, RX 77368, for stimulation of gastric acid secretion in the rat. Gastroenterology 95: 1470-1476, 1988.
8. Katsoulis, S., A. Clemens, H. Schworer, W. Creutzfeldt, and W. E. Schmidt. PACAP is a stimulator of neurogenic contraction in guinea pig ileum. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28): G295-G302, 1993.
9. Komatsubara, J. Effects of trigeminal stimulation on the vagal ambiguus neurons. Kanagawa Shigaku 23: 598-609, 1989.
10. Hondo, T., T. Tominaga, M. Ichikawa, and T. Iijima. Differential effects of PACAP on synaptic transmission of rat hippocampal slice (Abstract). Soc. Neurosci. Abstr. 21: 1320, 1995.
11. Koves, K. A., A. Arimura, T. G. Gores, and A. Somogyvari-Vigh. Comparative distribution of immunoreactive pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide in rat forebrain. Neuroendocrinology 54: 159-169, 1991.
12. Krowicki, Z. K., A. Arimura, and P. J. Hornby. Opposite gastric motor effects of PACAP38 and VIP when microinjected into the nucleus raphe obscurus of rats. Ann. NY Acad. Sci. USA. 805: 655-660, 1996.
13. Krowicki, Z. K., and P. J. Hornby. Serotonin microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally-mediated pathway. J. Pharmacol. Exp. Ther. 265: 468-476, 1993.
14. Krowicki, Z. K., N. A. Nathan, and P. J. Hornby. Opposing effects of vasoactive intestinal polypeptide on gastric motor function in the dorsal vagal complex and the nucleus raphe obscurus of the rat. J. Pharmacol. Exp. Ther. In press.
15. Legradi, G., S. Shioda, and A. Arimura. Pituitary adenylate cyclase activating polypeptide-like immunoreactivity in autonomic regulatory areas of rat medulla oblongata. Neurosci. Lett. 176: 193-196, 1994.
16. Lynn, R. B., M. S. Kreider, and R. R. Miselis. Thyrotropin-releasing hormone-immunoreactive projections to the dorsal motor nucleus and the nucleus of the solitary tract of the rat. J. Comp. Neurol. 311: 271-288, 1991.
17. 125I)iodo-TyrP10P,MetO17] vasoactive intestinal peptide binding sites in the rat brain. Neuroscience 23: 539-565, 1987.
18. Masuo, Y., N. Suzuki, H. Matsumoto, F. Tokito, Y. Matsumoto, M. Tsuda, and M. Fujino. Regional distribution of pituitary adenylate cyclase activating polypeptide (PACAP) in the rat central nervous system as determined by sandwich-enzyme immunoassay. Brain Res. 602: 57-63, 1993.
19. McCann, M. J., G. E. Hermann, and R. C. Rogers. Nucleus raphe obscurus (nRO) influences vagal control of gastric motility in rats. Brain Res. 486: 181-184, 1989.
20. Miselis, R. R., L. Rinaman, S. M. Altschuler, X. Bao, and R. B. Lynn. Medullary viscerotopic representation of the alimentary canal innervation in rat. In: Brain-Gut Interactions, edited by Y. Taché and D. Wingate. Boca Raton, FL: CRC, 1991, p. 3-17.
21. Miyata, A., A. Arimura, R. R. Dahl, M. Minamino, A. Uehara, L. Jiang, M. D. Culler, and D. H. Coy. Isolation of a novel 38 residue hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem. Biophys. Res. Commun. 164: 567-574, 1989.
22. Moller, K., Y. Z. Zhang, R. Hakanson, A. Luts, B. Sjolund, R. Uddman, and F. Sundler. Pituitary adenylate cyclase activating peptide is a sensory neuropeptide: immunocytochemical and immunochemical evidence. Neuroscience 57: 725-732, 1993.
23. Ormsbee, H. S., III, and P. Bass. Gastroduodenal gradients in the dog after pyloroplasty. Am. J. Physiol. 230: 389-397, 1976.
24. Paxinos, G., and C. Watson. The Rat Brain in Stereotaxic Coordinates. New York: Academic, 1986.
25. Rogers, R. C., H. Kita, L. L. Butcher, and D. Novin. Afferent projections to the dorsal motor nucleus of the vagus, a horseradish peroxidase histochemical study. Brain Res. Bull. 5: 365-373, 1980.
26. Schworer, H., A. Clemens, S. Katsoulis, H. Kohler, W. Creutzfeldt, and W. E. Schmidt. Pituitary adenylate cyclase-activating peptide is a potent modulator of human colonic motility. Scand. J. Gastroenterol. 28: 625-632, 1993.
27. Seki, Y., M. K. Susuki, K. Baskaya, K. Saito, M. Takayasu, M. Shibya, and K. Suguta. Central cardiovascular effects induced by intracisternal PACAP in dogs. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H135-H139, 1995.
28. Shaffer, M. M., and T. W. Moody. Autoradiographic visualization of CNS receptors for vasoactive intestinal peptide. Peptides 7: 283-288, 1986.
29. Shioda, S., Y. Shuto, A. Somogyvari-Vigh, G. Legradi, H. Onda, and A. Arimura. Distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) receptor in rat brain (Abstract). Soc. Neurosci. Abstr. 20: 516, 1994.
30. Sivarao, D. V., Z. K. Krowicki, T. P. Abrahams, and P. J. Hornby. Intracisternal antisense oligonucleotides to thyrotropin releasing hormone (TRH) receptor mRNA abolish hindbrain TRH-evoked gastric motor excitation. Am. J. Physiol. In press.
31. Spencer, S. E., and W. T. Talman. Modulation of gastric and arterial pressure by nucleus tractus solitarius in rat. Am. J. Physiol. 250 (Regulatory Integrative Comp. Physiol. 19): R996-R1002, 1986.
32. Wild, J. M., B. M. Johnston, and P. D. Gluckman. Central projections of the nodose ganglion and the origin of vagal efferents in the lamb. J. Anat. 175: 105-129, 1991.
33. Wood, J. D., and F. L. Christofi. Effects of PACAP on morphologically identified myenteric neurons in guinea pig small bowel. Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27): G414-G421, 1993.
34. Zhang, X., R. Fogel, and W. E. Renehan. Direct evidence that neurons in the dorsal motor nucleus of the vagus (DMV) are inhibited by neurons in the nucleus of the solitary tract (NTS) (Abstract). Soc. Neurosci. Abstr. 22: 395, 1996.