-
1
-
-
0034727833
-
Genomic aberrations and survival in chronic lymphocytic leukemia
-
DOI 10.1056/NEJM200012283432602
-
Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000;343:1910-1916. (Pubitemid 32064784)
-
(2000)
New England Journal of Medicine
, vol.343
, Issue.26
, pp. 1910-1916
-
-
Dohner, H.1
Stilgenbauer, S.2
Benner, A.3
Leupolt, E.4
Krober, A.5
Bullinger, L.6
Dohner, K.7
Bentz, M.8
Lichter, P.9
-
2
-
-
70349231440
-
De novo deletion 17p13.1 chronic lymphocytic leukemia shows signif cant clinical heterogeneity: The M. D. Anderson and Mayo Clinic experience
-
Tam CS, Shanafelt TD, Wierda WG, et al. De novo deletion 17p13.1 chronic lymphocytic leukemia shows signif cant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience. Blood 2009;114:957-964.
-
(2009)
Blood
, vol.114
, pp. 957-964
-
-
Tam, C.S.1
Shanafelt, T.D.2
Wierda, W.G.3
-
3
-
-
79951869041
-
TP53 mutations and outcome after f udarabine and cyclophosphamide (FC) or FC plus rituximab (FCR) in the CLL8 trial of the GCLLSG
-
Abstract 1267
-
Zenz T, Hoth P, Busch R, et al. TP53 mutations and outcome after f udarabine and cyclophosphamide (FC) or FC plus rituximab (FCR) in the CLL8 trial of the GCLLSG. Blood 2009;114(Suppl. 1): Abstract 1267.
-
(2009)
Blood
, vol.114
, Issue.SUPPL. 1
-
-
Zenz, T.1
Hoth, P.2
Busch, R.3
-
4
-
-
77957809872
-
Prognostic factors identif ed three risk groups in the LRF CLL4 trial independent of treatment allocation
-
Oscier D, Wade R, Davis Z, et al. Prognostic factors identif ed three risk groups in the LRF CLL4 trial, independent of treatment allocation. Haematologica 2010;95:1705-1712.
-
(2010)
Haematologica
, vol.95
, pp. 1705-1712
-
-
Oscier, D.1
Wade, R.2
Davis, Z.3
-
5
-
-
70449497016
-
Genomic aberrations, VH mutation status and outcome after f udarabine and cyclo-phosphamide (FC) or FC plus rituximab (FCR) in the CLL8 trial
-
Abstract 781
-
Stilgenbauer S, Zenz T, Winkler D, et al. Genomic aberrations, VH mutation status and outcome after f udarabine and cyclo-phosphamide (FC) or FC plus rituximab (FCR) in the CLL8 trial. Blood 2008;112(Suppl. 1): Abstract 781.
-
(2008)
Blood
, vol.112
, Issue.SUPPL. 1
-
-
Stilgenbauer, S.1
Zenz, T.2
Winkler, D.3
-
7
-
-
84860329005
-
Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies
-
Xu-Monette ZY, Medeiros LJ, Li Y, et al. Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies. Blood 2012;119:3668-3683.
-
(2012)
Blood
, vol.119
, pp. 3668-3683
-
-
Xu-Monette, Z.Y.1
Medeiros, L.J.2
Li, Y.3
-
8
-
-
79957949229
-
Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: Results from the LRF CLL4 trial
-
Gonzalez D, Martinez P, Wade R, et al. Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial. J Clin Oncol 2011;29:2223-2229.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2223-2229
-
-
Gonzalez, D.1
Martinez, P.2
Wade, R.3
-
9
-
-
54049141334
-
Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: Results from a detailed genetic characterization with long-term follow-up
-
Zenz T, Krober A, Scherer K, et al. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood 2008;112:3322-3329.
-
(2008)
Blood
, vol.112
, pp. 3322-3329
-
-
Zenz, T.1
Krober, A.2
Scherer, K.3
-
10
-
-
69849107362
-
Subcutaneous alemtuzumab in f udarabine-refractory chronic lymphocytic leukemia: Clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
-
Stilgenbauer S, Zenz T, Winkler D, et al. Subcutaneous alemtuzumab in f udarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 2009;27:3994-4001.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3994-4001
-
-
Stilgenbauer, S.1
Zenz, T.2
Winkler, D.3
-
11
-
-
84863778287
-
ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia
-
Feb 2. [Epub ahead of print]
-
Pospisilova S, Gonzalez D, Malcikova J, et al. ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia 2012 Feb 2. [Epub ahead of print]
-
(2012)
Leukemia
-
-
Pospisilova, S.1
Gonzalez, D.2
Malcikova, J.3
-
12
-
-
27644450586
-
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
-
DOI 10.1182/blood-2004-11-4516
-
Austen B, Powell JE, Alvi A, et al. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. Blood 2005;106:3175-3182. (Pubitemid 41565916)
-
(2005)
Blood
, vol.106
, Issue.9
, pp. 3175-3182
-
-
Austen, B.1
Powell, J.E.2
Alvi, A.3
Edwards, I.4
Hooper, L.5
Starczynski, J.6
Taylor, A.M.R.7
Fegan, C.8
Moss, P.9
Stankovic, T.10
-
13
-
-
0028081261
-
The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin
-
Watanabe T, Hotta T, Ichikawa A, et al. The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood 1994;84:3158-3165.
-
(1994)
Blood
, vol.84
, pp. 3158-3165
-
-
Watanabe, T.1
Hotta, T.2
Ichikawa, A.3
-
14
-
-
78650861867
-
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia
-
Fabbri M, Bottoni A, Shimizu M, et al. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA 2011;305:59-67.
-
(2011)
JAMA
, vol.305
, pp. 59-67
-
-
Fabbri, M.1
Bottoni, A.2
Shimizu, M.3
-
15
-
-
58249108075
-
A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease
-
Best OG, Gardiner AC, Davis ZA, et al. A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease. Leukemia 2009;23:212-214.
-
(2009)
Leukemia
, vol.23
, pp. 212-214
-
-
Best, O.G.1
Gardiner, A.C.2
Davis, Z.A.3
-
16
-
-
0025112785
-
Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities
-
Juliusson G, Oscier DG, Fitchett M, et al. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med 1990;323:720-724. (Pubitemid 20288941)
-
(1990)
New England Journal of Medicine
, vol.323
, Issue.11
, pp. 720-724
-
-
Juliusson, G.1
Oscier, D.G.2
Fitchett, M.3
Ross, F.M.4
Stockdill, G.5
Mackie, M.J.6
Parker, A.C.7
Castoldi, G.L.8
Cuneo, A.9
Knuutila, S.10
Elonen, E.11
Gahrton, G.12
-
17
-
-
30444451801
-
Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia
-
DOI 10.1182/blood-2005-05-2093
-
Mayr C, Speicher MR, Kof er DM, et al. Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. Blood 2006;107:742-751. (Pubitemid 43076401)
-
(2006)
Blood
, vol.107
, Issue.2
, pp. 742-751
-
-
Mayr, C.1
Speicher, M.R.2
Kofler, D.M.3
Buhmann, R.4
Strehl, J.5
Busch, R.6
Hallek, M.7
Wendtner, C.-M.8
-
18
-
-
60849118132
-
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA)
-
Grubor V, Krasnitz A, Troge JE, et al. Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). Blood 2009;113:1294-1303.
-
(2009)
Blood
, vol.113
, pp. 1294-1303
-
-
Grubor, V.1
Krasnitz, A.2
Troge, J.E.3
-
19
-
-
34447530283
-
Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
-
DOI 10.1016/S0140-6736(07)61125-8, PII S0140673607611258
-
Catovsky D, Richards S, Matutes E, et al. Assessment of f udarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet 2007;370:230-239. (Pubitemid 47069536)
-
(2007)
Lancet
, vol.370
, Issue.9583
, pp. 230-239
-
-
Catovsky, D.1
Richards, S.2
Matutes, E.3
Oscier, D.4
Dyer, M.5
Bezares, R.6
Pettitt, A.7
Hamblin, T.8
Milligan, D.9
Child, J.10
Hamilton, M.11
Dearden, C.12
Smith, A.13
Bosanquet, A.14
Davis, Z.15
Brito-Babapulle, V.16
Else, M.17
Wade, R.18
Hillmen, P.19
-
20
-
-
77957664665
-
Addition of rituximab to f udarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised open-label phase 3 trial
-
Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to f udarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376:1164-1174.
-
(2010)
Lancet
, vol.376
, pp. 1164-1174
-
-
Hallek, M.1
Fischer, K.2
Fingerle-Rowson, G.3
-
21
-
-
45149100665
-
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer Institute-Working Group (NCI-WG) 1996 guidelines
-
Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer Institute-Working Group (NCI-WG) 1996 guidelines. Blood 2008;111:5446-5456.
-
(2008)
Blood
, vol.111
, pp. 5446-5456
-
-
Hallek, M.1
Cheson, B.D.2
Catovsky, D.3
-
22
-
-
36348953152
-
H status and immunophenotyping
-
DOI 10.1038/sj.leu.2404935, PII 2404935
-
Haferlach C, Dicker F, Schnittger S, et al. Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping. Leukemia 2007;21:2442-2451. (Pubitemid 350148886)
-
(2007)
Leukemia
, vol.21
, Issue.12
, pp. 2442-2451
-
-
Haferlach, C.1
Dicker, F.2
Schnittger, S.3
Kern, W.4
Haferlach, T.5
-
23
-
-
33846883741
-
Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays
-
DOI 10.1182/blood-2006-07-034256
-
Pfeifer D, Pantic M, Skatulla I, et al. Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood 2007;109:1202-1210. (Pubitemid 46220669)
-
(2007)
Blood
, vol.109
, Issue.3
, pp. 1202-1210
-
-
Pfeifer, D.1
Pantic, M.2
Skatulla, I.3
Rawluk, J.4
Kreutz, C.5
Martens, U.M.6
Fisch, P.7
Timmer, J.8
Veelken, H.9
-
24
-
-
78650010643
-
Progressive but previously untreated CLL patients with greater array CGH complexity exhibit a less durable response to chemoimmunotherapy
-
Kay NE, Eckel-Passow JE, Braggio E, et al. Progressive but previously untreated CLL patients with greater array CGH complexity exhibit a less durable response to chemoimmunotherapy. Cancer Genet Cytogenet 2010;203:161-168.
-
(2010)
Cancer Genet Cytogenet
, vol.203
, pp. 161-168
-
-
Kay, N.E.1
Eckel-Passow, J.E.2
Braggio, E.3
-
25
-
-
33947544426
-
Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: Results from the US intergroup phase III trial E2997
-
DOI 10.1200/JCO.2006.08.3089
-
Grever MR, Lucas DM, Dewald GW, et al. Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: results from the US Intergroup Phase III Trial E2997. J Clin Oncol 2007;25:799-804. (Pubitemid 350010635)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.7
, pp. 799-804
-
-
Grever, M.R.1
Lucas, D.M.2
Dewald, G.W.3
Neuberg, D.S.4
Reed, J.C.5
Kitada, S.6
Flinn, I.W.7
Tallman, M.S.8
Appelbaum, F.R.9
Larson, R.A.10
Paietta, E.11
Jelinek, D.F.12
Gribben, J.G.13
Byrd, J.C.14
-
26
-
-
78650307334
-
TP53 mutation prof le in chronic lymphocytic leukemia: Evidence for a disease specif c prof le from a comprehensive analysis of 268 mutations
-
Zenz T, Vollmer D, Trbusek M, et al. TP53 mutation prof le in chronic lymphocytic leukemia: evidence for a disease specif c prof le from a comprehensive analysis of 268 mutations. Leukemia 2010;24:2072-2079.
-
(2010)
Leukemia
, vol.24
, pp. 2072-2079
-
-
Zenz, T.1
Vollmer, D.2
Trbusek, M.3
-
27
-
-
58249117812
-
The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
-
Dicker F, Herholz H, Schnittger S, et al. The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype. Leukemia 2009;23:117-124.
-
(2009)
Leukemia
, vol.23
, pp. 117-124
-
-
Dicker, F.1
Herholz, H.2
Schnittger, S.3
-
28
-
-
0027436745
-
P53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
-
el Rouby S, Thomas A, Costin D, et al. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression Blood 1993;82:3452-3459. (Pubitemid 23356719)
-
(1993)
Blood
, vol.82
, Issue.11
, pp. 3452-3459
-
-
El Rouby, S.1
Thomas, A.2
Costin, D.3
Rosenberg, C.R.4
Potmesil, M.5
Silber, R.6
Newcomb, E.W.7
-
29
-
-
79958750215
-
A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples
-
Pekova S, Mazal O, Cmejla R, et al. A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: analysis of 1287 diagnostic and 1148 follow-up CLL samples. Leuk Res 2011;35:889-898.
-
(2011)
Leuk Res
, vol.35
, pp. 889-898
-
-
Pekova, S.1
Mazal, O.2
Cmejla, R.3
-
30
-
-
79851477833
-
Evaluation of TP53 mutations with the AmpliChip p53 research test in chronic lymphocytic leukemia: Correlation with clinical outcome and gene expression prof ling
-
Chiaretti S, Tavolaro S, Marinelli M, et al. Evaluation of TP53 mutations with the AmpliChip p53 research test in chronic lymphocytic leukemia: correlation with clinical outcome and gene expression prof ling. Genes Chromosomes Cancer 2011;50:263-274.
-
(2011)
Genes Chromosomes Cancer
, vol.50
, pp. 263-274
-
-
Chiaretti, S.1
Tavolaro, S.2
Marinelli, M.3
-
31
-
-
79960116871
-
Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia
-
Trbusek M, Smardova J, Malcikova J, et al. Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia. J Clin Oncol 2011;29:2703-2708.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2703-2708
-
-
Trbusek, M.1
Smardova, J.2
Malcikova, J.3
-
32
-
-
0027210981
-
Gain of function mutations in p53
-
DOI 10.1038/ng0593-42
-
Dittmer D, Pati S, Zambetti G, et al. Gain of function mutations in p53. Nat Genet 1993;4:42-46. (Pubitemid 23165910)
-
(1993)
Nature Genetics
, vol.4
, Issue.1
, pp. 42-46
-
-
Dittmer, D.1
Pati, S.2
Zambetti, G.3
Chu, S.4
Teresky, A.K.5
Moore, M.6
Finlay, C.7
Levine, A.J.8
-
33
-
-
43749116660
-
Spectrum of p53 mutations in low-grade B-cell malignancies
-
DOI 10.1038/sj.leu.2405002, PII 2405002
-
Bromidge T, Johnson S, Howe D. Spectrum of p53 mutations in low-grade B-cell malignancies. Leukemia 2008;22:1071-1073. (Pubitemid 351689894)
-
(2008)
Leukemia
, vol.22
, Issue.5
, pp. 1071-1073
-
-
Bromidge, T.1
Johnson, S.2
Howe, D.3
-
34
-
-
78751702338
-
TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukemia
-
Zainuddin N, Murray F, Kanduri M, et al. TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukemia. Leuk Res 2011;35:272-274.
-
(2011)
Leuk Res
, vol.35
, pp. 272-274
-
-
Zainuddin, N.1
Murray, F.2
Kanduri, M.3
-
35
-
-
79956071061
-
The prognostic signif cance of TP53 mutations in Chinese patients with chronic lymphocytic leukemia is independent of del(17p13)
-
Dong HJ, Zhou LT, Zhu DX, et al. The prognostic signif cance of TP53 mutations in Chinese patients with chronic lymphocytic leukemia is independent of del(17p13). Ann Hematol 2011;90:709-717.
-
(2011)
Ann Hematol
, vol.90
, pp. 709-717
-
-
Dong, H.J.1
Zhou, L.T.2
Zhu, D.X.3
-
36
-
-
79551640576
-
DNA damage-induced transcriptional program in CLL: Biological and diagnostic implications for functional p53 testing
-
Mohr J, Helfrich H, Fuge M, et al. DNA damage-induced transcriptional program in CLL: biological and diagnostic implications for functional p53 testing. Blood 2011;117:1622-1632.
-
(2011)
Blood
, vol.117
, pp. 1622-1632
-
-
Mohr, J.1
Helfrich, H.2
Fuge, M.3
-
37
-
-
70350511471
-
Detailed analysis of p53 pathway defects in f udarabine-refractory chronic lymphocytic leukemia (CLL): Dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
-
Zenz T, Habe S, Denzel T, et al. Detailed analysis of p53 pathway defects in f udarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial. Blood 2009;114:2589-2597.
-
(2009)
Blood
, vol.114
, pp. 2589-2597
-
-
Zenz, T.1
Habe, S.2
Denzel, T.3
-
38
-
-
0035437138
-
P53 dysfunction in B-cell chronic lymphocytic leukemia: Inactivation of ATM as an alternative to TP53 mutation
-
Pettitt AR, Sherrington PD, Stewart G, et al. p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. Blood 2001;98:814-822.
-
(2001)
Blood
, vol.98
, pp. 814-822
-
-
Pettitt, A.R.1
Sherrington, P.D.2
Stewart, G.3
-
39
-
-
67449149945
-
A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene
-
Johnson GG, Sherrington PD, Carter A, et al. A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene. Cancer Res 2009;69:5210-5217.
-
(2009)
Cancer Res
, vol.69
, pp. 5210-5217
-
-
Johnson, G.G.1
Sherrington, P.D.2
Carter, A.3
-
40
-
-
47549091008
-
A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL
-
DOI 10.1038/sj.leu.2405092, PII 2405092
-
Best OG, Gardiner AC, Majid A, et al. A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL. Leukemia 2008;22:1456-1459. (Pubitemid 352006096)
-
(2008)
Leukemia
, vol.22
, Issue.7
, pp. 1456-1459
-
-
Best, O.G.1
Gardiner, A.C.2
Majid, A.3
Walewska, R.4
Austen, B.5
Skowronska, A.6
Ibbotson, R.7
Stankovic, T.8
Dyer, M.J.S.9
Oscier, D.G.10
-
41
-
-
67650895047
-
Detection of p53 dysfunction in chronic lymphocytic leukaemia cells through multiplex quantif cation of p53 target gene induction
-
Mous R, Jaspers A, Luijks DM, et al. Detection of p53 dysfunction in chronic lymphocytic leukaemia cells through multiplex quantif cation of p53 target gene induction. Leukemia 2009;23:1352-1355.
-
(2009)
Leukemia
, vol.23
, pp. 1352-1355
-
-
Mous, R.1
Jaspers, A.2
Luijks, D.M.3
-
42
-
-
33744503387
-
Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment [2]
-
DOI 10.1038/sj.leu.2404195, PII 2404195
-
Trbusek M, Malcikova J, Smardova J, et al. Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment. Leukemia 2006;20:1159-1161. (Pubitemid 43797312)
-
(2006)
Leukemia
, vol.20
, Issue.6
, pp. 1159-1161
-
-
Trbusek, M.1
Malcikova, J.2
Smardova, J.3
Kuhrova, V.4
Mentzlova, D.5
Francova, H.6
Bukovska, S.7
Svitakova, M.8
Kuglik, P.9
Linkova, V.10
Doubek, M.11
Brychtova, Y.12
Zacal, J.13
Kujickova, J.14
Pospisilova, S.15
Dvorakova, D.16
Vorlicek, J.17
Mayer, J.18
-
43
-
-
59449110380
-
Chemoimmunotherapy may overcome the adverse prognostic signif cance of 11q deletion in previously untreated patients with chronic lymphocytic leukemia
-
Tsimberidou AM, Tam C, Abruzzo LV, et al. Chemoimmunotherapy may overcome the adverse prognostic signif cance of 11q deletion in previously untreated patients with chronic lymphocytic leukemia. Cancer 2009;115:373-380.
-
(2009)
Cancer
, vol.115
, pp. 373-380
-
-
Tsimberidou, A.M.1
Tam, C.2
Abruzzo, L.V.3
-
44
-
-
70350784064
-
P53 expression by immunohistochemistry is an important determinant of survival in patients with chronic lymphocytic leukemia receiving frontline chemo-immunotherapy
-
Schlette EJ, Admirand J, Wierda W, et al. p53 expression by immunohistochemistry is an important determinant of survival in patients with chronic lymphocytic leukemia receiving frontline chemo-immunotherapy. Leuk Lymphoma 2009;50:1597-1605.
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 1597-1605
-
-
Schlette, E.J.1
Admirand, J.2
Wierda, W.3
-
45
-
-
4444228658
-
Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response
-
DOI 10.1182/blood-2003-09-3236
-
Rosenwald A, Chuang EY, Davis RE, et al. Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response. Blood 2004;104:1428-1434. (Pubitemid 39166521)
-
(2004)
Blood
, vol.104
, Issue.5
, pp. 1428-1434
-
-
Rosenwald, A.1
Chuang, E.Y.2
Davis, R.E.3
Wiestner, A.4
Alizadeh, A.A.5
Arthur, D.C.6
Mitchell, J.B.7
Marti, G.E.8
Fowler, D.H.9
Wilson, W.H.10
Staudt, L.M.11
-
46
-
-
79551504914
-
TP53 mutation and survival in chronic lymphocytic leukemia
-
Zenz T, Eichhorst B, Busch R, et al. TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol 2010;28:4473-4479.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4473-4479
-
-
Zenz, T.1
Eichhorst, B.2
Busch, R.3
-
47
-
-
0037092951
-
Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
-
DOI 10.1182/blood.V99.10.3554
-
Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed f udarabine: results of a large international study. Blood 2002;99:3554-3561. (Pubitemid 34534522)
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3554-3561
-
-
Keating, M.J.1
Flinn, I.2
Jain, V.3
Binet, J.-L.4
Hillmen, P.5
Byrd, J.6
Albitar, M.7
Brettman, L.8
Santabarbara, P.9
Wacker, B.10
Rai, K.R.11
-
48
-
-
55549097826
-
Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: A retrospective European Group for Blood and Marrow Transplantation analysis
-
Schetelig J, van Biezen A, Brand R, et al. Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective European Group for Blood and Marrow Transplantation analysis. J Clin Oncol 2008;26:5094-5100.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5094-5100
-
-
Schetelig, J.1
Van Biezen, A.2
Brand, R.3
-
49
-
-
0033567907
-
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
-
Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848-1854. (Pubitemid 29430400)
-
(1999)
Blood
, vol.94
, Issue.6
, pp. 1848-1854
-
-
Hamblin, T.J.1
Davis, Z.2
Gardiner, A.3
Oscier, D.G.4
Stevenson, F.K.5
-
50
-
-
0033567968
-
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
-
Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999;94:1840-1847. (Pubitemid 29430399)
-
(1999)
Blood
, vol.94
, Issue.6
, pp. 1840-1847
-
-
Damle, R.N.1
Wasil, T.2
Fais, F.3
Ghiotto, F.4
Valetto, A.5
Allen, S.L.6
Buchbinder, A.7
Budman, D.8
Dittmar, K.9
Kolitz, J.10
Lichtman, S.M.11
Schulman, P.12
Vinciguerra, V.P.13
Rai, K.R.14
Ferrarini, M.15
Chiorazzi, N.16
-
51
-
-
31544434508
-
Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
-
DOI 10.1182/blood-2005-06-2395
-
Eichhorst BF, Busch R, Hopf nger G, et al. Fludarabine plus cyclophosphamide versus f udarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood 2006; 107:885-891. (Pubitemid 43156283)
-
(2006)
Blood
, vol.107
, Issue.3
, pp. 885-891
-
-
Eichhorst, B.F.1
Busch, R.2
Hopfinger, G.3
Pasold, R.4
Hensel, M.5
Steinbrecher, C.6
Siehl, S.7
Jager, U.8
Bergmann, M.9
Stilgenbauer, S.10
Schweighofer, C.11
Wendtner, C.M.12
Dohner, H.13
Brittinger, G.14
Emmerich, B.15
Hallek, M.16
-
52
-
-
33947541773
-
Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US intergroup trial E2997
-
DOI 10.1200/JCO.2006.08.0762
-
Flinn IW, Neuberg DS, Grever MR, et al. Phase III trial of f udarabine plus cyclophosphamide compared with f udarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol 2007;25:793-798. (Pubitemid 350002879)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.7
, pp. 793-798
-
-
Flinn, I.W.1
Neuberg, D.S.2
Grever, M.R.3
Dewald, G.W.4
Bennett, J.M.5
Paietta, E.M.6
Hussein, M.A.7
Appelbaum, F.R.8
Larson, R.A.9
Moore Jr., D.F.10
Tallman, M.S.11
-
53
-
-
51649093353
-
Long-term results of the f udarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
-
Tam CS, O'Brien S, Wierda W, et al. Long-term results of the f udarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood 2008;112:975-980.
-
(2008)
Blood
, vol.112
, pp. 975-980
-
-
Tam, C.S.1
O'Brien, S.2
Wierda, W.3
-
54
-
-
74549145611
-
Rituximab, f udarabine, cyclophosphamide, and mitoxantrone: A new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia
-
Bosch F, Abrisqueta P, Villamor N, et al. Rituximab, f udarabine, cyclophosphamide, and mitoxantrone: a new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia. J Clin Oncol 2009;27:4578-4584.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4578-4584
-
-
Bosch, F.1
Abrisqueta, P.2
Villamor, N.3
-
55
-
-
80052180048
-
Frontline chemo-immunotherapy with f udarabine cyclophosphamide alemtuzumab and rituximab for high-risk chronic lymphocytic leukemia
-
Parikh SA, Keating MJ, O'Brien S, et al. Frontline chemo-immunotherapy with f udarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia. Blood 2011;118:2062-2068.
-
(2011)
Blood
, vol.118
, pp. 2062-2068
-
-
Parikh, S.A.1
Keating, M.J.2
O'Brien, S.3
-
56
-
-
0023009274
-
Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation
-
Heit W, Bunjes D, Wiesneth M, et al. Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement ef ectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation. Br J Haematol 1986;64:479-486. (Pubitemid 17184257)
-
(1986)
British Journal of Haematology
, vol.64
, Issue.3
, pp. 479-486
-
-
Heit, W.1
Bunjes, D.2
Wiesneth, M.3
-
57
-
-
0024566393
-
Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype
-
Dyer MJ, Hale G, Hayhoe FG, et al. Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: inf uence of antibody isotype. Blood 1989;73:1431-1439. (Pubitemid 19131883)
-
(1989)
Blood
, vol.73
, Issue.6
, pp. 1431-1439
-
-
Dyer, M.J.S.1
Hale, G.2
Hayhoe, F.G.J.3
Waldmann, H.4
-
58
-
-
0027456571
-
Structural motifs involved in human IgG antibody effector functions
-
Greenwood J, Clark M, Waldmann H. Structural motifs involved in human IgG antibody ef ector functions. Eur J Immunol 1993;23:1098-1104. (Pubitemid 23120172)
-
(1993)
European Journal of Immunology
, vol.23
, Issue.5
, pp. 1098-1104
-
-
Greenwood, J.1
Clark, M.2
Waldmann, H.3
-
59
-
-
0031790767
-
Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52- deficient cells
-
DOI 10.1046/j.1365-2567.1998.00615.x
-
Rowan W, Tite J, Topley P, et al. Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B-and T-lymphoma cell lines, and subsequent emergence of CD52-def cient cells. Immunology 1998;95:427-436. (Pubitemid 28505700)
-
(1998)
Immunology
, vol.95
, Issue.3
, pp. 427-436
-
-
Rowan, W.1
Tite, J.2
Topley, P.3
Brett, S.J.4
-
60
-
-
0037043653
-
Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy [8]
-
DOI 10.1056/NEJM200208083470619
-
Stilgenbauer S, Dohner H. Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy. N Engl J Med 2002;347:452-453. (Pubitemid 34851846)
-
(2002)
New England Journal of Medicine
, vol.347
, Issue.6
, pp. 452-453
-
-
Stilgenbauer, S.1
Dohner, H.2
-
61
-
-
11144357657
-
Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
-
DOI 10.1182/blood-2003-10-3729
-
Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an ef ective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood 2004;103:3278-3281. (Pubitemid 38525651)
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3278-3281
-
-
Lozanski, G.1
Heerema, N.A.2
Flinn, I.W.3
Smith, L.4
Harbison, J.5
Webb, J.6
Moran, M.7
Lucas, M.8
Lin, T.9
Hackbarth, M.L.10
Proffitt, J.H.11
Lucas, D.12
Grever, M.R.13
Byrd, J.C.14
-
62
-
-
70450267533
-
Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): Results of a prospective, single-arm multicentre study
-
Cortelezzi A, Pasquini MC, Gardellini A, et al. Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): results of a prospective, single-arm multicentre study. Leukemia 2009;23:2027-2033.
-
(2009)
Leukemia
, vol.23
, pp. 2027-2033
-
-
Cortelezzi, A.1
Pasquini, M.C.2
Gardellini, A.3
-
63
-
-
78649471912
-
Clinical outcome of pretreated B-cell chronic lymphocytic leukemia following alemtuzumab therapy: A retrospective study on various cytogenetic risk categories
-
Fiegl M, Erdel M, Tinhofer I, et al. Clinical outcome of pretreated B-cell chronic lymphocytic leukemia following alemtuzumab therapy: a retrospective study on various cytogenetic risk categories. Ann Oncol 2010;21:2410-2419.
-
(2010)
Ann Oncol
, vol.21
, pp. 2410-2419
-
-
Fiegl, M.1
Erdel, M.2
Tinhofer, I.3
-
64
-
-
37649004407
-
Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
-
Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 2007;25:5616-5623.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5616-5623
-
-
Hillmen, P.1
Skotnicki, A.B.2
Robak, T.3
-
65
-
-
33746137366
-
Alemtuzumab in combination with high-dose methylprednisolone is a logical, feasible and highly active therapeutic regimen in chronic lymphocytic leukaemia patients with p53 defects [4]
-
DOI 10.1038/sj.leu.2404265, PII 2404265
-
Pettitt AR, Matutes E, Oscier D. Alemtuzumab in combination with high-dose methylprednisolone is a logical, feasible and highly active therapeutic regimen in chronic lymphocytic leukaemia patients with p53 defects. Leukemia 2006;20:1441-1445. (Pubitemid 44084061)
-
(2006)
Leukemia
, vol.20
, Issue.8
, pp. 1441-1445
-
-
Pettitt, A.R.1
Matutes, E.2
Oscier, D.3
-
66
-
-
84861343178
-
Alemtuzumab plus oral dexamethasone, followed by alemtuzumab maintenance or allogeneic transplantation in ultra high-risk CLL: Interim analysis of a phase II study of the GCLLSG and FCGCLL/MW
-
Abstract 2854
-
Stilgenbauer S, Cymbalista F, Leblond V, et al. Alemtuzumab plus oral dexamethasone, followed by alemtuzumab maintenance or allogeneic transplantation in ultra high-risk CLL: interim analysis of a phase II study of the GCLLSG and FCGCLL/MW. Blood 2011; 118(Suppl. 1): Abstract 2854.
-
(2011)
Blood
, vol.118
, Issue.SUPPL. 1
-
-
Stilgenbauer, S.1
Cymbalista, F.2
Leblond, V.3
-
67
-
-
34247252527
-
Graft-versus-leukemia in chronic lymphocytic leukemia
-
DOI 10.1038/sj.bmt.1705619, PII 1705619
-
Ben-Bassat I, Raanani P, Gale RP. Graft-versus-leukemia in chronic lymphocytic leukemia. Bone Marrow Transplant 2007;39:441-446. (Pubitemid 46605201)
-
(2007)
Bone Marrow Transplantation
, vol.39
, Issue.8
, pp. 441-446
-
-
Ben-Bassat, I.1
Raanani, P.2
Gale, R.P.3
-
68
-
-
0042130360
-
Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: The Cooperative German Transplant Study Group
-
DOI 10.1200/JCO.2003.12.011
-
Schetelig J, T iede C, Bornhauser M, et al. Evidence of a graft-versus-leukemia ef ect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group. J Clin Oncol 2003;21:2747-2753. (Pubitemid 46606321)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.14
, pp. 2747-2753
-
-
Schetelig, J.1
Thiede, C.2
Bornhauser, M.3
Schwerdtfeger, R.4
Kiehl, M.5
Beyer, J.6
Sayer, H.G.7
Kroger, N.8
Hensel, M.9
Scheffold, C.10
Held, T.K.11
Hoffken, K.12
Ho, A.D.13
Kienast, J.14
Neubauer, A.15
Zander, A.R.16
Fauser, A.A.17
Ehninger, G.18
Siegert, W.19
-
69
-
-
34247509369
-
Graft-versus-leukaemia effect after non-myeloablative haematopoietic transplantation can overcome the unfavourable expression of ZAP-70 in refractory chronic lymphocytic leukaemia
-
DOI 10.1111/j.1365-2141.2007.06591.x
-
Khouri IF, Saliba RM, Admirand J, et al. Graft-versus-leukaemia ef ect after non-myeloablative haematopoietic transplantation can overcome the unfavourable expression of ZAP-70 in refractory chronic lymphocytic leukaemia. Br J Haematol 2007; 137:355-363. (Pubitemid 46650260)
-
(2007)
British Journal of Haematology
, vol.137
, Issue.4
, pp. 355-363
-
-
Khouri, I.F.1
Saliba, R.M.2
Admirand, J.3
O'Brien, S.4
Lee, M.-S.5
Korbling, M.6
Samuels, B.I.7
Giralt, S.8
Lima, D.M.9
Keating, M.J.10
Champlin, R.E.11
Bueso-Ramos, C.12
-
70
-
-
20644447584
-
Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia
-
Moreno C, Villamor N, Colomer D, et al. Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia. J Clin Oncol 2005;23:3433-3438.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3433-3438
-
-
Moreno, C.1
Villamor, N.2
Colomer, D.3
-
71
-
-
33845543049
-
Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus
-
DOI 10.1038/sj.leu.2404441, PII 2404441
-
Dreger P, Corradini P, Kimby E, et al. Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia 2007;21:12-17. (Pubitemid 44921829)
-
(2007)
Leukemia
, vol.21
, Issue.1
, pp. 12-17
-
-
Dreger, P.1
Corradini, P.2
Kimby, E.3
Michallet, M.4
Milligan, D.5
Schetelig, J.6
Wiktor-Jedrzejczak, W.7
Niederwieser, D.8
Hallek, M.9
Montserrat, E.10
-
72
-
-
77957743452
-
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: Long-term clinical and MRD results of the German CLL Study Group CLL3X trial
-
Dreger P, Dohner H, Ritgen M, et al. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood 2010; 116:2438-2447.
-
(2010)
Blood
, vol.116
, pp. 2438-2447
-
-
Dreger, P.1
Dohner, H.2
Ritgen, M.3
-
73
-
-
33745324686
-
The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
-
Teeling JL, Mackus WJ, Wiegman LJ, et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol 2006;177:362-371. (Pubitemid 43939148)
-
(2006)
Journal of Immunology
, vol.177
, Issue.1
, pp. 362-371
-
-
Teeling, J.L.1
Mackus, W.J.M.2
Wiegman, L.J.J.M.3
Van Den Brakel, J.H.N.4
Beers, S.A.5
French, R.R.6
Van Meerten, T.7
Ebeling, S.8
Vink, T.9
Slootstra, J.W.10
Parren, P.W.H.I.11
Glennie, M.J.12
Van De Winkel, J.G.J.13
-
74
-
-
77950502126
-
Ofatumumab as single-agent CD20 immunotherapy in f udarabine-refractory chronic lymphocytic leukemia
-
Wierda WG, Kipps TJ, Mayer J, et al. Ofatumumab as single-agent CD20 immunotherapy in f udarabine-refractory chronic lymphocytic leukemia. J Clin Oncol 2010;28:1749-1755.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1749-1755
-
-
Wierda, W.G.1
Kipps, T.J.2
Mayer, J.3
-
75
-
-
73349096649
-
Phase II study of f avopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease
-
Lin TS, Ruppert AS, Johnson AJ, et al. Phase II study of f avopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol 2009;27:6012-6018.
-
(2009)
J Clin Oncol
, vol.27
, pp. 6012-6018
-
-
Lin, T.S.1
Ruppert, A.S.2
Johnson, A.J.3
-
76
-
-
80052566316
-
Interim analysis of EFC6663, a multicenter phase 2 study of alvocidib (f avopiridol), demonstrates clinical responses among patients with f udarabine refractory CLL
-
Abstract 58
-
Lanasa MC, Andritsos L, Brown JR, et al. Interim analysis of EFC6663, a multicenter phase 2 study of alvocidib (f avopiridol), demonstrates clinical responses among patients with f udarabine refractory CLL. Blood 2010;116(Suppl. 1): Abstract 58.
-
(2010)
Blood
, vol.116
, Issue.SUPPL. 1
-
-
Lanasa, M.C.1
Andritsos, L.2
Brown, J.R.3
-
77
-
-
33947243663
-
Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study
-
DOI 10.1200/JCO.2005.05.0401
-
Chanan-Khan A, Miller KC, Musial L, et al. Clinical effcacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol 2006; 24:5343-5349. (Pubitemid 46623164)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.34
, pp. 5343-5349
-
-
Chanan-Khan, A.1
Miller, K.C.2
Musial, L.3
Lawrence, D.4
Padmanabhan, S.5
Takeshita, K.6
Porter, C.W.7
Goodrich, D.W.8
Bernstein, Z.P.9
Wallace, P.10
Spaner, D.11
Mohr, A.12
Byrne, C.13
Hernandez-Ilizaliturri, F.14
Chrystal, C.15
Starostik, P.16
Czuczman, M.S.17
-
78
-
-
45949100928
-
Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
-
Ferrajoli A, Lee BN, Schlette EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2008;111:5291-5297.
-
(2008)
Blood
, vol.111
, pp. 5291-5297
-
-
Ferrajoli, A.1
Lee, B.N.2
Schlette, E.J.3
-
79
-
-
51349123420
-
Lenalidomide is active in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) carrying unfavorable chromosomal abnormalities
-
Abstreact 754
-
Ferrajoli A, Keating MJ, Wierda WG, et al. Lenalidomide is active in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) carrying unfavorable chromosomal abnormalities. Blood 2007; 110(Suppl. 1): Abstreact 754.
-
(2007)
Blood
, vol.110
, Issue.SUPPL. 1
-
-
Ferrajoli, A.1
Keating, M.J.2
Wierda, W.G.3
-
80
-
-
78649630259
-
Navitoclax a targeted high-af nity inhibitor of BCL-2 in lymphoid malignancies: A phase 1 dose-escalation study of safety pharmacokinetics pharmacodynamics and antitumour activity
-
Wilson WH, O'Connor OA, Czuczman MS, et al. Navitoclax, a targeted high-af nity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol 2010;11:1149-1159.
-
(2010)
Lancet Oncol
, vol.11
, pp. 1149-1159
-
-
Wilson, W.H.1
O'Connor, O.A.2
Czuczman, M.S.3
-
81
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase i study of navitoclax in patients with relapsed or refractory disease
-
Roberts AW, Seymour JF, Brown JR, et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol 2012;30:488-496.
-
(2012)
J Clin Oncol
, vol.30
, pp. 488-496
-
-
Roberts, A.W.1
Seymour, J.F.2
Brown, J.R.3
-
82
-
-
80054853285
-
B-cell receptor signaling in chronic lymphocytic leukemia
-
Stevenson FK, Krysov S, Davies AJ, et al. B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2011;118:4313-4320.
-
(2011)
Blood
, vol.118
, pp. 4313-4320
-
-
Stevenson, F.K.1
Krysov, S.2
Davies, A.J.3
-
83
-
-
79953655788
-
CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110{delta}, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia
-
Abstract 55
-
Furman RR, Byrd JC, Brown JR, et al. CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110{delta}, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia. Blood 2010;116(Suppl. 1): Abstract 55.
-
(2010)
Blood
, vol.116
, Issue.SUPPL. 1
-
-
Furman, R.R.1
Byrd, J.C.2
Brown, J.R.3
-
84
-
-
84861345119
-
The Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (R/R) chronic Lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): Follow-up of a phase Ib/II study
-
Abstract 983
-
O'Brien S, Burger JA, Blum KA, et al. The Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (R/R) chronic Lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): follow-up of a phase Ib/II study. Blood 2011; 118(Suppl. 1): Abstract 983.
-
(2011)
Blood
, vol.118
, Issue.SUPPL. 1
-
-
O'Brien, S.1
Burger, J.A.2
Blum, K.A.3
|