메뉴 건너뛰기




Volumn 11, Issue 10, 2012, Pages 1219-1225

Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; FARNESOL; FUNGAL PROTEIN; REPRESSOR PROTEIN;

EID: 84867184973     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00144-12     Document Type: Article
Times cited : (88)

References (46)
  • 1
    • 0142030056 scopus 로고    scopus 로고
    • Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP, limits hypha production and promotes virulence of Candida albicans
    • Bahn YS, Staab J, Sundstrom P. 2003. Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP, limits hypha production and promotes virulence of Candida albicans. Mol. Microbiol. 50:391-409.
    • (2003) Mol. Microbiol , vol.50 , pp. 391-409
    • Bahn, Y.S.1    Staab, J.2    Sundstrom, P.3
  • 2
    • 0035033538 scopus 로고    scopus 로고
    • CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans
    • Bahn YS, Sundstrom P. 2001. CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans. J. Bacteriol. 183:3211-3223.
    • (2001) J. Bacteriol , vol.183 , pp. 3211-3223
    • Bahn, Y.S.1    Sundstrom, P.2
  • 3
    • 80855150846 scopus 로고    scopus 로고
    • Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans
    • Bai C, et al. 2011. Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans. Mol. Microbiol. 82:879-893.
    • (2011) Mol. Microbiol , vol.82 , pp. 879-893
    • Bai, C.1
  • 4
    • 44949243150 scopus 로고    scopus 로고
    • UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence
    • Banerjee M, et al. 2008. UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence. Mol. Biol. Cell 19:1354-1365.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 1354-1365
    • Banerjee, M.1
  • 5
    • 34250759780 scopus 로고    scopus 로고
    • Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans
    • Biswas S, Van Dijck P, Datta A. 2007. Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans. Microbiol. Mol. Biol. Rev. 71:348-376.
    • (2007) Microbiol. Mol. Biol. Rev , vol.71 , pp. 348-376
    • Biswas, S.1    van Dijck, P.2    Datta, A.3
  • 6
    • 0035724309 scopus 로고    scopus 로고
    • Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans
    • Bockmuhl DP, Krishnamurthy S, Gerads M, Sonneborn A, Ernst JF. 2001. Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans. Mol. Microbiol. 42:1243-1257.
    • (2001) Mol. Microbiol , vol.42 , pp. 1243-1257
    • Bockmuhl, D.P.1    Krishnamurthy, S.2    Gerads, M.3    Sonneborn, A.4    Ernst, J.F.5
  • 7
    • 0030824249 scopus 로고    scopus 로고
    • Control of filament formation in Candida albicans by the transcriptional repressor TUP1
    • Braun BR, Johnson AD. 1997. Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 277:105-109.
    • (1997) Science , vol.277 , pp. 105-109
    • Braun, B.R.1    Johnson, A.D.2
  • 8
    • 0035801610 scopus 로고    scopus 로고
    • NRG1, a repressor of filamentous growth in C. albicans, is down-regulated during filament induction
    • Braun BR, Kadosh D, Johnson AD. 2001. NRG1, a repressor of filamentous growth in C. albicans, is down-regulated during filament induction. EMBO J. 20:4753-4761.
    • (2001) EMBO J , vol.20 , pp. 4753-4761
    • Braun, B.R.1    Kadosh, D.2    Johnson, A.D.3
  • 9
    • 0032746554 scopus 로고    scopus 로고
    • Filamentous growth of Candida albicans in response to physical environmental cues and its regulation by the unique CZF1 gene
    • Brown DH, Jr, Giusani AD, Chen X, Kumamoto CA. 1999. Filamentous growth of Candida albicans in response to physical environmental cues and its regulation by the unique CZF1 gene. Mol. Microbiol. 34:651-662.
    • (1999) Mol. Microbiol , vol.34 , pp. 651-662
    • Brown Jr., D.H.1    Giusani, A.D.2    Chen, X.3    Kumamoto, C.A.4
  • 10
    • 30044432810 scopus 로고    scopus 로고
    • The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans
    • Cao F, et al. 2006. The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans. Mol. Biol. Cell 17:295-307.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 295-307
    • Cao, F.1
  • 11
    • 36849075751 scopus 로고    scopus 로고
    • Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signaling pathway and the regulation of morphogenesis
    • Davis-Hanna A, Piispanen AE, Stateva LI, Hogan DA. 2008. Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signaling pathway and the regulation of morphogenesis. Mol. Microbiol. 67:47-62.
    • (2008) Mol. Microbiol , vol.67 , pp. 47-62
    • Davis-Hanna, A.1    Piispanen, A.E.2    Stateva, L.I.3    Hogan, D.A.4
  • 12
    • 77950531344 scopus 로고    scopus 로고
    • Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway
    • Deveau A, Piispanen AE, Jackson AA, Hogan DA. 2010. Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. Eukaryot. Cell 9:569-577.
    • (2010) Eukaryot. Cell , vol.9 , pp. 569-577
    • Deveau, A.1    Piispanen, A.E.2    Jackson, A.A.3    Hogan, D.A.4
  • 13
    • 0033808667 scopus 로고    scopus 로고
    • A single-transformation gene function test in diploid Candida albicans
    • Enloe B, Diamond A, Mitchell AP. 2000. A single-transformation gene function test in diploid Candida albicans. J. Bacteriol. 182:5730-5736.
    • (2000) J. Bacteriol , vol.182 , pp. 5730-5736
    • Enloe, B.1    Diamond, A.2    Mitchell, A.P.3
  • 14
    • 33748491502 scopus 로고    scopus 로고
    • RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development
    • Fang HM, Wang Y. 2006. RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development. Mol. Microbiol. 61:484-496.
    • (2006) Mol. Microbiol , vol.61 , pp. 484-496
    • Fang, H.M.1    Wang, Y.2
  • 15
    • 0032692954 scopus 로고    scopus 로고
    • Ras signaling is required for serum-induced hyphal differentiation in Candida albicans
    • Feng Q, Summers E, Guo B, Fink G. 1999. Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J. Bacteriol. 181:6339-6346.
    • (1999) J. Bacteriol , vol.181 , pp. 6339-6346
    • Feng, Q.1    Summers, E.2    Guo, B.3    Fink, G.4
  • 16
    • 0036224725 scopus 로고    scopus 로고
    • Candida albicans Als1p: An adhesin that is a downstream effector of the EFG1 filamentation pathway
    • Fu Y, et al. 2002. Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway. Mol. Microbiol. 44:61-72.
    • (2002) Mol. Microbiol , vol.44 , pp. 61-72
    • Fu, Y.1
  • 18
    • 79251475563 scopus 로고    scopus 로고
    • 2 acts as a signaling molecule in populations of the fungal pathogen Candida albicans
    • doi:10.1371/journal.ppat.1001193
    • Hall RA, et al. 2010. CO2 acts as a signaling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog. 6:e1001193. doi:10.1371/journal.ppat.1001193.
    • (2010) PLoS Pathog , vol.6
    • Hall, R.A.1
  • 19
    • 79961066995 scopus 로고    scopus 로고
    • The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans
    • Hall RA, et al. 2011. The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryot. Cell 10:1034-1042.
    • (2011) Eukaryot. Cell , vol.10 , pp. 1034-1042
    • Hall, R.A.1
  • 20
    • 4644309973 scopus 로고    scopus 로고
    • Transcription profiling of cyclic AMP signaling in Candida albicans
    • Harcus D, Nantel A, Marcil A, Rigby T, Whiteway M. 2004. Transcription profiling of cyclic AMP signaling in Candida albicans. Mol. Biol. Cell 15:4490-4499.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 4490-4499
    • Harcus, D.1    Nantel, A.2    Marcil, A.3    Rigby, T.4    Whiteway, M.5
  • 21
    • 9644264336 scopus 로고    scopus 로고
    • A Pseudomonas aeruginosa quorumsensing molecule influences Candida albicans morphology
    • Hogan DA, Vik A, Kolter R. 2004. A Pseudomonas aeruginosa quorumsensing molecule influences Candida albicans morphology. Mol. Microbiol. 54:1212-1223.
    • (2004) Mol. Microbiol , vol.54 , pp. 1212-1223
    • Hogan, D.A.1    Vik, A.2    Kolter, R.3
  • 22
    • 0035406382 scopus 로고    scopus 로고
    • Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol
    • Hornby JM, et al. 2001. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl. Environ. Microbiol. 67:2982-2992.
    • (2001) Appl. Environ. Microbiol , vol.67 , pp. 2982-2992
    • Hornby, J.M.1
  • 23
    • 33745140101 scopus 로고    scopus 로고
    • Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens
    • Jensen EC, et al. 2006. Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens. Genome 49:346-353.
    • (2006) Genome , vol.49 , pp. 346-353
    • Jensen, E.C.1
  • 24
    • 46949083912 scopus 로고    scopus 로고
    • Candida albicans Tup1 is involved in farnesolmediated inhibition of filamentous-growth induction
    • Kebaara BW, et al. 2008. Candida albicans Tup1 is involved in farnesolmediated inhibition of filamentous-growth induction. Eukaryot. Cell 7:980-987.
    • (2008) Eukaryot. Cell , vol.7 , pp. 980-987
    • Kebaara, B.W.1
  • 25
    • 79955716397 scopus 로고    scopus 로고
    • Candida albicans, a major human fungal pathogen
    • Kim J, Sudbery P. 2011. Candida albicans, a major human fungal pathogen. J. Microbiol. 49:171-177.
    • (2011) J. Microbiol , vol.49 , pp. 171-177
    • Kim, J.1    Sudbery, P.2
  • 26
    • 75749097655 scopus 로고    scopus 로고
    • Activity and toxicity of farnesol toward Candida albicans are dependent on growth conditions
    • Langford ML, Hasim S, Nickerson KW, Atkin AL. 2010. Activity and toxicity of farnesol toward Candida albicans are dependent on growth conditions. Antimicrob. Agents Chemother. 54:940-942.
    • (2010) Antimicrob. Agents Chemother , vol.54 , pp. 940-942
    • Langford, M.L.1    Hasim, S.2    Nickerson, K.W.3    Atkin, A.L.4
  • 27
    • 0035159043 scopus 로고    scopus 로고
    • Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signaling pathways in the pathogenic fungus Candida albicans
    • Leberer E, et al. 2001. Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signaling pathways in the pathogenic fungus Candida albicans. Mol. Microbiol. 42:673-687.
    • (2001) Mol. Microbiol , vol.42 , pp. 673-687
    • Leberer, E.1
  • 28
    • 6344285788 scopus 로고    scopus 로고
    • Transcriptional response of Candida albicans upon internalization by macrophages
    • Lorenz MC, Bender JA, Fink GR. 2004. Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot. Cell 3:1076-1087.
    • (2004) Eukaryot. Cell , vol.3 , pp. 1076-1087
    • Lorenz, M.C.1    Bender, J.A.2    Fink, G.R.3
  • 29
    • 79960921059 scopus 로고    scopus 로고
    • Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance
    • doi:10.1371/, journal.pbio.1001105
    • Lu Y, Su C, Wang A, Liu H. 2011. Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance. PLoS Biol. 9:e1001105. doi:10.1371/journal.pbio.1001105.
    • (2011) PLoS Biol , vol.9
    • Lu, Y.1    Su, C.2    Wang, A.3    Liu, H.4
  • 30
    • 16344394213 scopus 로고    scopus 로고
    • The G protein-coupled receptor Gpr1 and the G protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans
    • Maidan MM, et al. 2005. The G protein-coupled receptor Gpr1 and the G protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans. Mol. Biol. Cell 16:1971-1986.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1971-1986
    • Maidan, M.M.1
  • 31
    • 79954556424 scopus 로고    scopus 로고
    • The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension
    • doi:10.1371/, journal.pone.0018394
    • Martin R, et al. 2011. The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLoS One 6:e18394. doi:10.1371/journal.pone.0018394.
    • (2011) PLoS One , vol.6
    • Martin, R.1
  • 32
    • 23744445246 scopus 로고    scopus 로고
    • Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum
    • Mosel DD, Dumitru R, Hornby JM, Atkin AL, Nickerson KW. 2005. Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. Appl. Environ. Microbiol. 71:4938-4940.
    • (2005) Appl. Environ. Microbiol , vol.71 , pp. 4938-4940
    • Mosel, D.D.1    Dumitru, R.2    Hornby, J.M.3    Atkin, A.L.4    Nickerson, K.W.5
  • 33
    • 17944370004 scopus 로고    scopus 로고
    • NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans
    • Murad AM, et al. 2001. NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J. 20:4742-4752.
    • (2001) EMBO J , vol.20 , pp. 4742-4752
    • Murad, A.M.1
  • 34
    • 34147176061 scopus 로고    scopus 로고
    • Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans
    • Navarathna DH, et al. 2007. Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. Infect. Immun. 75:1609-1618.
    • (2007) Infect. Immun , vol.75 , pp. 1609-1618
    • Navarathna, D.H.1
  • 35
    • 47049107522 scopus 로고    scopus 로고
    • Complementary adhesin function in C. albicans biofilm formation
    • Nobile CJ, et al. 2008. Complementary adhesin function in C. albicans biofilm formation. Curr. Biol. 18:1017-1024.
    • (2008) Curr. Biol , vol.18 , pp. 1017-1024
    • Nobile, C.J.1
  • 36
    • 77954095162 scopus 로고    scopus 로고
    • Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    • Noble SM, French S, Kohn LA, Chen V, Johnson AD. 2010. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat. Genet. 42:590-598.
    • (2010) Nat. Genet , vol.42 , pp. 590-598
    • Noble, S.M.1    French, S.2    Kohn, L.A.3    Chen, V.4    Johnson, A.D.5
  • 37
    • 80055102810 scopus 로고    scopus 로고
    • Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response
    • Piispanen AE, et al. 2011. Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response. Eukaryot. Cell 10:1473-1484.
    • (2011) Eukaryot. Cell , vol.10 , pp. 1473-1484
    • Piispanen, A.E.1
  • 38
    • 0036840116 scopus 로고    scopus 로고
    • Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule
    • Ramage G, Saville SP, Wickes BL, Lopez-Ribot JL. 2002. Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. Appl. Environ. Microbiol. 68:5459-5463.
    • (2002) Appl. Environ. Microbiol , vol.68 , pp. 5459-5463
    • Ramage, G.1    Saville, S.P.2    Wickes, B.L.3    Lopez-Ribot, J.L.4
  • 39
    • 0035200240 scopus 로고    scopus 로고
    • Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans
    • Rocha CR, et al. 2001. Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol. Biol. Cell 12:3631-3643.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 3631-3643
    • Rocha, C.R.1
  • 40
    • 0142216110 scopus 로고    scopus 로고
    • Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection
    • Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL. 2003. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot. Cell 2:1053-1060.
    • (2003) Eukaryot. Cell , vol.2 , pp. 1053-1060
    • Saville, S.P.1    Lazzell, A.L.2    Monteagudo, C.3    Lopez-Ribot, J.L.4
  • 41
    • 65049086509 scopus 로고    scopus 로고
    • Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
    • Shapiro RS, et al. 2009. Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. Curr. Biol. 19:621-629.
    • (2009) Curr. Biol , vol.19 , pp. 621-629
    • Shapiro, R.S.1
  • 42
    • 58549085192 scopus 로고    scopus 로고
    • The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation
    • Shen J, Cowen LE, Griffin AM, Chan L, Kohler JR. 2008. The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation. Proc. Natl. Acad. Sci. U. S. A. 105: 20918-20923.
    • (2008) Proc. Natl. Acad. Sci. U. S. A , vol.105 , pp. 20918-20923
    • Shen, J.1    Cowen, L.E.2    Griffin, A.M.3    Chan, L.4    Kohler, J.R.5
  • 43
    • 0033979093 scopus 로고    scopus 로고
    • Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans
    • Sonneborn A, et al. 2000. Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans. Mol. Microbiol. 35:386-396.
    • (2000) Mol. Microbiol , vol.35 , pp. 386-396
    • Sonneborn, A.1
  • 44
    • 0037083242 scopus 로고    scopus 로고
    • Essential role of the Candida albicans transglutaminase substrate, hyphal wall protein 1, in lethal oroesophageal candidiasis in immunodeficient mice
    • Sundstrom P, Balish E, Allen CM. 2002. Essential role of the Candida albicans transglutaminase substrate, hyphal wall protein 1, in lethal oroesophageal candidiasis in immunodeficient mice. J. Infect. Dis. 185: 521-530.
    • (2002) J. Infect. Dis , vol.185 , pp. 521-530
    • Sundstrom, P.1    Balish, E.2    Allen, C.M.3
  • 45
    • 77950392425 scopus 로고    scopus 로고
    • Dispersion as an important step in the Candida albicans biofilm developmental cycle
    • Uppuluri P, et al. 2010. Dispersion as an important step in the Candida albicans biofilm developmental cycle. PLoS Pathog. 6:e1000828.
    • (2010) PLoS Pathog , vol.6
    • Uppuluri, P.1
  • 46
    • 58149339808 scopus 로고    scopus 로고
    • UME6 is a crucial downstream target of other transcriptional regulators of true hyphal development in Candida albicans
    • Zeidler U, et al. 2009. UME6 is a crucial downstream target of other transcriptional regulators of true hyphal development in Candida albicans. FEMS Yeast Res. 9:126-142.
    • (2009) FEMS Yeast Res , vol.9 , pp. 126-142
    • Zeidler, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.