Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation

Oncotarget

Volumn 3, Issue 4, 2012, Pages 399-413

  Mathieu, Véronique ^a   Pirker, Christine ^b,c   Schmidt, Wolfgang M ^c   Spiegl Kreinecker, Sabine ^d   Lötsch, Daniela ^b,c   Heffeter, Petra ^b,c   Hegedus, Balazs ^c,e   Grusch, Michael ^b,c   Kiss, Robert ^a   Berger, Walter ^b,c  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d KEPLER UNIVERSITY HOSPITAL   (Austria)

^e SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Aneuploidy; Integrative genomics; Local aggressiveness; Malignant melanoma; Xenograft

Indexed keywords

B RAF KINASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; BRAF PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; NUCLEAR PROTEIN; SIPA1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AURKA GENE; BRAF GENE; CANCER CELL CULTURE; CANCER GROWTH; CANCER LOCALIZATION; CONTROLLED STUDY; FEMALE; GENE CLUSTER; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE LOSS; GENE REPRESSION; GENETIC GAIN; GENETIC VARIABILITY; GENOME ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; MELANOMA SKIN CANCER; METASTASIS; MOLECULAR PATHOLOGY; MOUSE; MUTATOR GENE; NONHUMAN; ONCOGENE N RAS; PHENOTYPE; PRIMARY TUMOR; PTEN GENE; SIGNAL TRANSDUCTION; SIPA1 GENE; TUMOR XENOGRAFT; ANIMAL; DRUG SCREENING; GENETICS; MELANOMA; METABOLISM; MUTATION; NUDE MOUSE; ONCOGENE RAS; PATHOLOGY; PHYSIOLOGY; SKIN TUMOR; TUMOR CELL LINE; TUMOR VOLUME;

ANEUPLOIDY; ANIMALS; CELL LINE, TUMOR; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; GTPASE-ACTIVATING PROTEINS; HUMANS; MELANOMA; MICE; MICE, NUDE; MUTATION; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84867184099     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.473     Document Type: Article

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