SPA-1 controls the invasion and metastasis of human prostate cancer

Cancer Science

Volumn 102, Issue 4, 2011, Pages 828-836

  Shimizu, Yosuke ^a   Hamazaki, Yoko ^a   Hattori, Masakazu ^a,d   Doi, Keiko ^a   Terada, Naoki ^a   Kobayashi, Takashi ^a   Toda, Yoshinobu ^a   Yamasaki, Toshinari ^a   Inoue, Takahiro ^a   Kajita, Yoichiro ^a   Maeno, Atsushi ^a   Kamba, Tomomi ^a   Mikami, Yoshiki ^a   Kamoto, Toshiyuki ^a   Yamada, Tomomi ^b   Kanno, Toru ^a   Yoshikawa, Kiyotsugu ^c   Ogawa, Osamu ^a   Minato, Nagahiro ^a   Nakamura, Eijiro ^c  

^a KYOTO UNIVERSITY   (Japan)

^b MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; FIBRONECTIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN SIPA1; PROTEIN SPA 1; RAP1 PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE SILENCING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCID MOUSE; TUMOR VOLUME;

ANIMALS; BLOTTING, WESTERN; CELL ADHESION; DISEASE PROGRESSION; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; GTPASE-ACTIVATING PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHATIC METASTASIS; MALE; MICE; MICE, SCID; NEOPLASM INVASIVENESS; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 79952767397     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.01876.x     Document Type: Article

References (35)

1. Gronberg H. Prostate cancer epidemiology. Lancet 2003; 361: 859-64.
2. Shen MM, Abate-Shen C. Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev 2010; 24: 1967-2000.
3. Haigis KM, Dove WF. A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nat Genet 2003; 33: 33-9.
4. Threadgill DW. Metastatic potential as a heritable trait. Nat Genet 2005; 37: 1026-7.
5. Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003; 3: 362-74.
6. Vasiliev JM. Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells. Int J Dev Biol 2004; 48: 425-39.
7. van't Veer LJ, Dai H, van de Vijver MJ et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002; 415: 530-6.
8. van de Vijver MJ, He YD, van't Veer LJ et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347: 1999-2009.
9. Crawford NP, Walker RC, Lukes L, Officewala JS, Williams RW, Hunter KW. The Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival. Clin Exp Metastasis 2008; 25: 357-69.
10. Bos JL. Linking Rap to cell adhesion. Curr Opin Cell Biol 2005; 17: 123-8.
11. Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL. Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors. Biochim Biophys Acta 2009; 1788: 790-6.
12. Hattori M, Minato N. Rap1 GTPase: functions, regulation, and malignancy. J Biochem 2003; 134: 479-84.
13. Yajnik V, Paulding C, Sordella R et al. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell 2003; 112: 673-84.
14. Kurachi H, Wada Y, Tsukamoto N et al. Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product. J Biol Chem. 1997; 272: 28081-8.
15. Park YG, Zhao X, Lesueur F et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nat Genet 2005; 37: 1055-62.
16. Crawford NP, Ziogas A, Peel DJ, Hess J, Anton-Culver H, Hunter KW. Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res 2006; 8: R16.
17. Crawford NP, Qian X, Ziogas A et al. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. PLoS Genet. 2007; 3: e214.
18. Crawford NP, Alsarraj J, Lukes L et al. Bromodomain 4 activation predicts breast cancer survival. Proc Natl Acad Sci U S A 2008; 105: 6380-5.
19. Ishida D, Kometani K, Yang H et al. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell 2003; 4: 55-65.
20. Minato N, Kometani K, Hattori M. Regulation of immune responses and hematopoiesis by the Rap1 signal. Adv Immunol 2007; 93: 229-64.
21. Toda Y, Kono K, Abiru H et al. Application of tyramide signal amplification system to immunohistochemistry: a potent method to localize antigens that are not detectable by ordinary method. Pathol Int 1999; 49: 479-83.
22. Hamazaki Y, Fujita H, Kobayashi T et al. Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol 2007; 8: 304-11.
23. Kawanishi H, Matsui Y, Ito M et al. Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer. Clin Cancer Res 2008; 14: 2579-87.
24. Farina A, Hattori M, Qin J, Nakatani Y, Minato N, Ozato K. Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. Mol Cell Biol 2004; 24: 9059-69.
25. Tsukamoto N, Hattori M, Yang H, Bos JL, Minato N. Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J Biol Chem. 1999; 274: 18463-9.
26. York RD, Yao H, Dillon T et al. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 1998; 392: 622-6.
27. Katagiri K, Hattori M, Minato N, Irie S, Takatsu K, Kinashi T. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol Cell Biol 2000; 20: 1956-69.
28. Su L, Hattori M, Moriyama M et al. AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem. 2003; 278: 15232-8.
29. Noda Y, Horikawa S, Furukawa T et al. Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. FEBS Lett 2004; 568: 139-45.
30. Hegerfeldt Y, Tusch M, Brocker EB, Friedl P. Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res 2002; 62: 2125-30.
31. Omelchenko T, Vasiliev JM, Gelfand IM, Feder HH, Bonder EM. Rho-dependent formation of epithelial "leader" cells during wound healing. Proc Natl Acad Sci U S A 2003; 100: 10788-93.
32. Bailey CL, Kelly P, Casey PJ. Activation of Rap1 promotes prostate cancer metastasis. Cancer Res 2009; 69: 4962-8.
33. Singh L, Gao Q, Kumar A et al. The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins. J Virol 2003; 77: 1614-20.
34. Dhanasekaran SM, Barrette TR, Ghosh D et al. Delineation of prognostic biomarkers in prostate cancer. Nature 2001; 412: 822-6.
35. Lapointe J, Li C, Higgins JP et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc Natl Acad Sci U S A 2004; 101: 811-6.