The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans

Acta Histochemica

Volumn 114, Issue 8, 2012, Pages 827-835

  Gochman, Einat ^a,b   Mahajna, Jamal ^b,c   Shenzer, Pessia ^a   Dahan, Aviva ^d   Blatt, Alexandra ^d   Elyakim, Rami ^d   Reznick, Abraham Z ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^c TEL HAI COLLEGE   (Israel)

^d RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Colitis; Colon cancer; Nitration; Peroxynitrite

Indexed keywords

3 NITROTYROSINE; GELATINASE A; INDUCIBLE NITRIC OXIDE SYNTHASE; PEROXYNITRITE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CANCER CELL CULTURE; COLITIS; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; METASTASIS; PROTEIN EXPRESSION; ZYMOGRAPHY;

COLITIS; COLONIC NEOPLASMS; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PEROXYNITROUS ACID; REAL-TIME POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED; TYROSINE;

EID: 84867143334     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2012.02.004     Document Type: Article

References (24)

1. Aslan M., Cort A., Yucel I. Oxidative and nitrative stress markers in glaucoma. Free Radic Biol Med 2008, 45:367-376.
2. Cooke C.L., Davidge S.T. Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Am J Physiol Cell Physiol 2002, 282:C395-C402.
3. Dedon P.C., Tannenbaum S.R. Reactive nitrogen species in the chemical biology of inflammation. Arch Biochem Biophys 2004, 423:12-22.
4. Feagins L.A., Souza R.F., Spechler S.J. Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer. Nat Rev Gastroenterol Hepatol 2009, 6:297-305.
5. Garg P., Vijay-Kumar M., Wang L., Gewirtz A.T., Merlin D., Sitaraman S.V. Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. Am J Physiol Gastrointest Liver Physiol 2009, 296:G175-G184.
6. Grivennikov S.I., Karin M. Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev 2010, 20:65-71.
7. Jin X.Y., Lee S.H., Kim J.Y., Zhao Y.Z., Park E.J., Lee B.S., et al. Polyozellin inhibits nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and SAPK/JNK in RAW 264.7 cells. Planta Med 2006, 72:857-859.
8. Jung C.H., Jung H., Shin Y.C., Park J.H., Jun C.Y., Kim H.M., et al. Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage. J Ethnopharmacol 2007, 113:183-187.
9. Karin M., Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005, 5:749-759.
10. Kimura H., Hokari R., Miura S., Shigematsu T., Hirokawa M., Akiba Y., et al. Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis. Gut 1998, 42:180-187.
11. Kroncke K.D., Suschek C.V., Kolb-Bachofen V. Implications of inducible nitric oxide synthase expression and enzyme activity. Antioxid Redox Signal 2000, 2:585-605.
12. Naugler W.E., Karin M. NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev 2008, 18:19-26.
13. Nemoto T., Kubota S., Ishida H., Murata N., Hashimoto D. Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors. World J Gastroenterol 2005, 11:3065-3069.
14. Ohshima H., Tazawa H., Sylla B.S., Sawa T. Prevention of human cancer by modulation of chronic inflammatory processes. Mutat Res 2005, 591:110-122.
15. Petrova R.D., Mahajna J., Reznick A.Z., Wasser S.P., Denchev C.M., Nevo E. Fungal substances as modulators of NF-kappaB activation pathway. Mol Biol Rep 2007, 34:145-154.
16. Ren J., Chung S.H. Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways. J Agric Food Chem 2007, 55:5073-5080.
17. Rogler G., Brand K., Vogl D., Page S., Hofmeister R., Andus T., et al. Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 1998, 115:357-369.
18. Terzic J., Grivennikov S., Karin E., Karin M. Inflammation and colon cancer. Gastroenterology 2010, 138:2101-2114.
19. van der Woude C.J., Kleibeuker J.H., Jansen P.L., Moshage H. Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract. Apoptosis 2004, 9:123-130.
20. Wang S., Liu Z., Wang L., Zhang X. NF-kappaB signaling pathway, inflammation and colorectal cancer. Cell Mol Immunol 2009, 6:327-334.
21. Watanabe K., Kawamori T., Nakatsugi S., Wakabayashi K. COX-2 and iNOS, good targets for chemoprevention of colon cancer. Biofactors 2000, 12:129-133.
22. Wong C.K., Zhang J.P., Ip W.K., Lam C.W. Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils. Clin Exp Immunol 2002, 128:483-489.
23. Wu J., Akaike T., Hayashida K., Okamoto T., Okuyama A., Maeda H. Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases. Jpn J Cancer Res 2001, 92:439-451.
24. Zucker S., Vacirca J. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev 2004, 23:101-117.