Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome

Diabetes, Obesity and Metabolism

Volumn 9, Issue 5, 2007, Pages 679-687

  Trenell, Michael I ^a   Ward, J A ^b   Yee, B J ^a   Phillips, C L ^a   Kemp, G J ^c   Grunstein, R R ^a   Thompson, C H ^d  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d FLINDERS UNIVERSITY   (Australia)

Author keywords

Constant positive airway pressure; Hypoxia; Insulin resistance; Magnetic resonance spectroscopy; Obesity

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CREATINE PHOSPHATE; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOSE; INSULIN; LEPTIN; LIPID;

ADULT; ARTERIAL BLOOD; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE SEVERITY; GLUCOSE HOMEOSTASIS; GLYCEMIC CONTROL; HUMAN; HYPERTENSION; INSULIN RESPONSE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPID STORAGE; MALE; MITOCHONDRIAL RESPIRATION; MUSCLE LEVEL; MUSCLE METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PH; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POSITIVE END EXPIRATORY PRESSURE; PROTEIN BLOOD LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; SKELETAL MUSCLE; SLEEP APNEA SYNDROME; THERAPY EFFECT; TREATMENT DURATION; VENOUS BLOOD;

EID: 34547904628     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2006.00649.x     Document Type: Article

References (49)

1. Grunstein R, Wilcox I, Yang TS, Gould Y, Hedner J. Snoring and sleep apnoea in men: Association with central obesity and hypertension. Int J Obes Relat Metab Disord 1993; 17: 533-540.
2. Ip M, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS. Obstructive sleep apnea is independently associated with insulin resistance. AJRCCM 2002; 165: 670-676.
3. Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol 2004; 160(6): 521-30.
4. Punjabi NM, Sorkin JD, Katzel LI, Goldberg AP, Schwartz AR, Smith PL. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. AJRCCM 2002; 165(5): 677-82.
5. Punjabi NM, Polotsky VY. Disorders of glucose metabolism in sleep apnea. J Appl Physiol 2005; 99: 1998-2007.
6. Gan SK, Kriketos AD, Poynten AM et al. Insulin action, regional fat, and myocyte lipid: Altered relationships with increased adiposity. Obes Res 2003; 11: 1295-1305.
7. Morino K, Petersen KF, Dufour S, et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 2005; 115: 3587-3593.
8. Dyck DJ, Heigenhauser GJF, Bruce CR. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol Scand 2006; 186: 5-16.
9. Kelley DE. Skeletal muscle fat oxidation: Timing and flexibility are everything. J Clin Invest 2005; 115: 1699-1702.
10. Kelley DE, Williams KV, Price JC, McKolanis TM, Goodpaster BH, Thaete FL. Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus. J Clin Endo Metab 2001; 86: 5412-5419.
11. Petersen KF, Dufour S, Befroy D, Garcia BA, Shulman MD. Impaired mitochondrial activity in the insulin resistant offspring of patients with type 2 diabetes. NEJM 2004; 350: 664-671.
12. Petersen KF, Shulman GI. Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am J Cardiol 2002; 90: 11G-18G.
13. Petersen KF, Shulman GI. Cellular mechanism of insulin resistance in skeletal muscle. J Royal Soc Med 2002; 95: 8-13.
14. Kelley DE, Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: A reexamination. Diabetes 2000; 49: 677-683.
15. Chin K, Shimizu K, Nakamura T et al. Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 1999; 100: 706-712.
16. Pastoris O, Dossena M, Foppa P et al. Modifications by chronic intermittent hypoxia and drug treatment on skeletal muscle metabolism. Neurochem Res 1995; 20: 143-150.
17. Bonanni E, Pasquali L, Manca ML et al. Lactate production and catecholamine profile during aerobic exercise in normotensive OSAS patients. Sleep Med 2004; 5: 137-145.
18. Edward Shifflett D, Walker EW, Gregg JM, Zedalis D, Herbert WG. Effects of short-term PAP treatment on endurance exercise performance in obstructive sleep apnea patients. Sleep Med 2001; 2: 145-151.
19. Harsch IA, Pour Schahin S, Radespiel-Tröger M et al. Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2004: 156-162.
20. Makino S, Handa H, Suzukawa K et al. Obstructive sleep apnoea syndrome, plasma adiponectin levels, and insulin resistance. Clin Endocrinol 2006; 64: 12-19.
21. Harsch IA, Schahin SP, Bruckner K et al. The effect of continuous positive airway pressure treatment on insulin sensitivity in patients with obstructive sleep apnoea syndrome and type 2 diabetes. Respiration 2004; 71: 252-259.
22. Trenell MI, Sue CM, Sachinwalla T, Kemp GJ, Thompson CH. Aerobic exercise and muscle metabolism in patients with mitochondrial myopathy. Muscle Nerve 2006; 33: 524-531.
23. EEG arousals: Scoring rules and examples. A preliminary report of the Atlas Task Force of the American Sleep Disorders Association. Sleep 1992; 15: 173-184.
24. Force AAoSMT. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999; 1999: 667-689.
25. Johns MW. A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep 1991; 14: 540-545.
26. Naressi A, Couturier C, Castang I, de Beer R, Graveron-Demilly D. Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals. Comp Biol Med 2001; 31: 269-286.
27. Vanhamme L, Van Huffel S, Van Hecke P, van Ormondt D. Time-domain quantification of series of biomedical magnetic resonance spectroscopy signals. J Magn Reson 1999; 140: 120-130.
28. Kemp GJ, Radda GK. Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: an analytical review. Magn Reson Q 1994; 10: 43-63.
29. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539-553.
30. Li J, Grigoryev DN, Ye SQ et al. Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice. J Appl Physiol 2005; 99: 1643-1648.
31. Ahn CW, Kim CS, Nam JH et al. Effects of growth hormone on insulin resistance and atherosclerotic risk factors in obese type 2 diabetic patients with poor glycaemic control. Clin Endocrinol 2006; 64: 444-449.
32. Saini J, Krieger J, Brandenberger G, Wittersheim G, Simon C, Follenius M. Continuous positive airway pressure treatment. Effects on growth hormone, insulin and glucose profiles in obstructive sleep apnea patients. Horm Metab Res 1993; 25: 375-381.
33. Slentz CA, Aiken LB, Houmard JA et al. Inactivity, exercise, and visceral fat. STRRIDE: A randomized, controlled study of exercise intensity and amount. J Appl Physiol 2005; 99: 1613-1618.
34. Wajchenberg BL, Giannella-Neto D, da Silva ME, Santos RF. Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome. Horm Metab Res 2002; 34: 616-621.
35. Ambrosini G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia inducible factor 1. J Biol Chem 2002; 277: 34601-34609.
36. Polotsky VY, Li J, Punjabi NM et al. Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol (Lond) 2003; 552: 253-264.
37. Spiegel K, Leproult R, L'Hermite-Baleriaux M, Copinschi G, Penev PD, Van Cauter E. Leptin levels are dependent on sleep duration: Relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab 2004; 89: 5762-5771.
38. Grunfeld C, Zhao C, Fuller J et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. A role for leptin in the anorexia of infection. J Clin Invest 1996; 97: 2152-2157.
39. Bogdanis G, Nevill ME, Boobis. LH, Lakomy HKA. Contribution of phosphocreatine and aerobic metabolism to energy supply during repeated spring exercise. J App Physiol 1996; 80: 876-884.
40. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochem J 1992; 281: 21-40.
41. O'Gorman E, Fuchs KH, Tittmann P, Gross H, Wallimann T. Crystalline mitochondrial inclusion bodies isolated from creatine depleted rat soleus muscle. J Cell Sci 1997; 110: 1403-1411.
42. Steeghs K, Benders A, Oerlemans F et al. Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell 1997; 89: 93-103.
43. Ju JS, Smith JL, Oppelt PJ, Fisher JS. Creatine feeding increases GLUT4 expression in rat skeletal muscle. Am J Physiol Endocrinol Metab 2005; 288: E347-E352.
44. Boehm E, Chan S, Monfared M, Walliman T, Clarke K, Neubauer S. Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine. Am J Physiol 2003; 284: E399-E406.
45. Odoom J, Kemp G, Radda G. The regulation of total creatine content in a myoblast cell line. Mol Cell Biochem 1996; 158: 179-188.
46. Lentini S, Manka R, Scholtyssek S, Stoffel-Wagner B, Luderitz B, Tasci S. Creatine phosphokinase elevation in obstructive sleep apnea syndrome: an unknown association? Chest 2006; 129: 88-94.
47. Vanuxem D, Badier M, Guillot C, Delpierre S, Jahjah F, Vanuxem P. Impairment of muscle energy metabolism in patients with sleep apnoea syndrome. Resp Med 1997; 91: 551-557.
48. Kardos A, Taylor DJ, Thompson C et al. Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics. Circulation 2000; 101: 2716-2720.
49. Dudley CR, Taylor DJ, Ng LL et al. Evidence for abnormal Na+/H+ antiport activity detected by phosphorus nuclear magnetic resonance spectroscopy in exercising skeletal muscle of patients with essential hypertension. Clin Sci 1990; 79: 491-497.