Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells

Food and Chemical Toxicology

Volumn 50, Issue 12, 2012, Pages 4382-4388

  Lu, Yue ^a   Li, Ying ^a   Seo, Chang Seob ^b   Murakami, Makoto ^c   Son, Jong Keun ^a   Wook Chang, Hyeun ^a  

^a Yeungnam University   (South Korea)

^b Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Leukotriene C4; Mast cell; Mitogen activated protein kinase; Prostaglandin D2; Saucerneol D; Syk kinase

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 2; ICOSANOID; LEUKOTRIENE C4; LIGNAN DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE C GAMMA1; PLANT EXTRACT; PROSTAGLANDIN D2; PROTEIN KINASE SYK; SAUCERNEOL D; SAURURUS CHINESIS EXTRACT; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MALE; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PLANT ROOT; SIGNAL TRANSDUCTION;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BONE MARROW CELLS; CELL DEGRANULATION; CYCLOOXYGENASE 2; EICOSANOIDS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOTRIENE C4; LIGNANS; MALE; MAP KINASE SIGNALING SYSTEM; MAST CELLS; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PLANT EXTRACTS; PROTEIN-TYROSINE KINASES; SAURURACEAE;

SAURURUS CHINENSIS;

EID: 84867094993     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.08.053     Document Type: Article

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