Polymorphisms in the myeloperoxidase gene locus are associated with acute kidney injuryrelated outcomes

Kidney International

Volumn 82, Issue 8, 2012, Pages 909-919

  Perianayagam, Mary C ^a   Tighiouart, Hocine ^b   Liangos, Orfeas ^c   Kouznetsov, Diana ^d   Wald, Ron ^e   Rao, Fangwen ^f   O'Connor, Daniel T ^f   Jaber, Bertrand L ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c KLINIKUM COBURG   (Germany)

^d UMASS MEMORIAL MEDICAL CENTER   (United States)

^e ST MICHAEL'S HOSPITAL   (Canada)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROSTANE DERIVATIVE; MYELOPEROXIDASE;

ACUTE KIDNEY FAILURE; ADVERSE OUTCOME; AGED; ARTICLE; ARTIFICIAL VENTILATION; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; COPY NUMBER VARIATION; DIALYSIS; ENZYME BLOOD LEVEL; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE PHENOTYPE CORRELATION; HEART SURGERY; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; MORTALITY; MYELOPEROXIDASE GENE; OXIDATIVE STRESS; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSTAGLANDIN URINE LEVEL; RISK ASSESSMENT;

EID: 84867058557     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.235     Document Type: Article

References (46)

1. Chertow GM, Burdick E, Honour M et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005; 16: 3365-3370.
2. Liangos O, Wald R, O'Bell JW et al. Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. Clin J Am Soc Nephrol 2006; 1: 43-51.
3. Bonventre JV, Weinberg JM. Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 2003; 14: 2199-2210.
4. Molitoris BA, Sutton TA. Endothelial injury and dysfunction: role in the extension phase of acute renal failure. Kidney Int 2004; 66: 496-499.
5. Kusaka J, Koga H, Hagiwara S et al. Age-Dependent Responses to Renal Ischemia-Reperfusion Injury. J Surg Res 2012; 172: 153-158.
6. Tanaka R, Fujita M, Tsuruta R et al. Urinary trypsin inhibitor suppresses excessive generation of superoxide anion radical, systemic inflammation, oxidative stress, and endothelial injury in endotoxemic rats. Inflamm Res 2010; 59: 597-606.
7. Kfouri F, de Castro I, Testagrossa L et al. Role of p21 and oxidative stress on renal tubular resistance after acute ischaemic injury. Nephrol Dial Transplant 2010; 25: 1795-1803.
8. Billings IV FT, Ball SK, Roberts II LJ et al. Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. Free Radic Biol Med 2011; 11: 1480-1487.
9. Homsi E, Mota da Silva Jr S, Machado de Brito S et al. p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury. Am J Nephrol 2011; 33: 49-59.
10. Jaber BL, Rao M, Guo D et al. Cytokine gene promoter polymorphisms and mortality in acute renal failure. Cytokine 2004; 25: 212-219.
11. Lu JC, Coca SG, Patel UD et al. Searching for genes that matter in acute kidney injury: a systematic review. Clin J Am Soc Nephrol 2009; 4: 1020-1031.
12. Stafford-Smith M, Podgoreanu M, Swaminathan M et al. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. Am J Kidney Dis 2005; 45: 519-530.
13. Perianayagam MC, Liangos O, Kolyada AY et al. NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure. J Am Soc Nephrol 2007; 18: 255-263.
14. du Cheyron D, Fradin S, Ramakers M et al. Angiotensin converting enzyme insertion/deletion genetic polymorphism: its impact on renal function in critically ill patients. Crit Care Med 2008; 36: 3178-3183.
15. Haase-Fielitz A, Haase M, Bellomo R et al. Decreased catecholamine degradation associates with shock and kidney injury after cardiac surgery. J Am Soc Nephrol 2009; 20: 1393-1403.
16. Popov AF, Hinz J, Schulz EG et al. The eNOS 786C/T polymorphism in cardiac surgical patients with cardiopulmonary bypass is associated with renal dysfunction. Eur J Cardiothorac Surg 2009; 36: 651-656.
17. Alam A, O'Connor DT, Perianayagam MC et al. Phenylethanolamine Nmethyltransferase gene polymorphisms and adverse outcomes in acute kidney injury. Nephron Clin Pract 2010; 114: c253-c259.
18. Popov AF, Schulz EG, Schmitto JD et al. Relation between renal dysfunction requiring renal replacement therapy and promoter polymorphism of the erythropoietin gene in cardiac surgery. Artif Organs 2010; 34: 961-968.
19. Perianayagam MC, Tighiouart H, Nievergelt CM et al. CYBA gene polymorphisms and adverse outcomes in acute kidney injury: a prospective cohort study. Nephron Extra 2011; 1: 112-123.
20. Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol 2005; 77: 598-625.
21. Cramer E, Pryzwansky KB, Villeval JL et al. Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold. Blood 1985; 65: 423-432.
22. Nauseef WM. Contributions of myeloperoxidase to proinflammatory events: more than an antimicrobial system. Int J Hematol 2001; 74: 125-133.
23. Piedrafita FJ, Molander RB, Vansant G et al. An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormoneretinoic acid response element. J Biol Chem 1996; 271: 14412-14420.
24. Babior BM. Phagocytes and oxidative stress. Am J Med 2000; 109: 33-44.
25. Chooklin S, Pereyaslov A, Bihalskyy I. Pathogenic role of myeloperoxidase in acute pancreatitis. Hepatobiliary Pancreat Dis Int 2009; 8: 627-631.
26. Morishita K, Tsuchiya M, Asano S et al. Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor. J Biol Chem 1987; 262: 15208-15213.
27. Pecoits-Filho R, Stenvinkel P, Marchlewska A et al. A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients. Kidney Int Suppl 2003; 63: S172-S176.
28. Doi K, Noiri E, Maeda R et al. Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients. Hypertens Res 2007; 30: 1193-1198.
29. Jaber BL, Pereira BJ, Bonventre JV et al. Polymorphism of host response genes: implications in the pathogenesis and treatment of acute renal failure. Kidney Int 2005; 67: 14-33.
30. Malle E, Buch T, Grone HJ. Myeloperoxidase in kidney disease. Kidney Int 2003; 64: 1956-1967.
31. Chatterjee PK, Brown PA, Cuzzocrea S et al. Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int 2001; 59: 2073-2083.
32. Burne-Taney MJ, Kofler J, Yokota N et al. Acute renal failure after whole body ischemia is characterized by inflammation and T cell-mediated injury. Am J Physiol Ren Physiol 2003; 285: F87-F94.
33. Molinas SM, Cortes-Gonzalez C, Gonzalez-Bobadilla Y et al. Effects of losartan pretreatment in an experimental model of ischemic acute kidney injury. Nephron Exp Nephrol 2009; 112: e10-e19.
34. Kim T, Harman PK, Lyons R et al. Brain natriuretic peptide is not renoprotective during renal ischemia-reperfusion injury in the rat. J Surg Res 2010; 164: e13-e19.
35. Kong HY, Zhu SM, Wang LQ et al. Sevoflurane protects against acute kidney injury in a small-size liver transplantation model. Am J Nephrol 2010; 32: 347-355.
36. Gulec M, Iraz M, Yilmaz HR et al. The effects of ginkgo biloba extract on tissue adenosine deaminase, xanthine oxidase, myeloperoxidase, malondialdehyde, and nitric oxide in cisplatin-induced nephrotoxicity. Toxicol Ind Health 2006; 22: 125-130.
37. Zhao ZG, Niu CY, Zhang YP et al. The mechanism of myocardium and pancreas injury in rabbits with acute renal failure might be related to myeloperoxidase and membrane pump activities. Ren Fail 2010; 32: 1216-1222.
38. Chevrier I, Tregouet DA, Massonnet-Castel S et al. Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: genetic determinants for atherosclerosis? Atherosclerosis 2006; 188: 150-154.
39. Hou SH, Bushinsky DA, Wish JB et al. Hospital-acquired renal insufficiency: a prospective study. Am J Med 1983; 74: 243-248.
40. Mehta RL, Kellum JA, Shah SV et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11: R31.
41. Levy MM, Fink MP, Marshall JC et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31: 1250-1256.
42. Knaus WA, Draper EA, Wagner DP et al. APACHE II: a severity of disease classification system. Crit Care Med 1985; 13: 818-829.
43. Knaus WA, Wagner DP. Multiple systems organ failure: epidemiology and prognosis. Crit Care Clin 1989; 5: 221-232.
44. Levey AS, Bosch JP, Lewis JB et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med 1999; 130: 461-470.
45. Purcell S, Neale B, Todd-Brown K et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
46. Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004; 74: 765-769.