Pathogenic role of myeloperoxidase in acute pancreatitis

Hepatobiliary and Pancreatic Diseases International

Volumn 8, Issue 6, 2009, Pages 627-631

  Chooklin, Serge ^a   Pereyaslov, Andriy ^a   Bihalskyy, Ihor ^a  

^a DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

Author keywords

Acute pancreatitis; Cytokines; Myeloperoxidase; Pentoxifylline

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MYELOPEROXIDASE; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEMORRHAGIC PANCREATITIS; ACUTE PANCREATITIS; ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; RANDOMIZED CONTROLLED TRIAL;

ACUTE DISEASE; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG INJURY; MALE; MIDDLE AGED; NEUTROPHILS; PANCREATITIS; PANCREATITIS, ACUTE NECROTIZING; PENTOXIFYLLINE; PEROXIDASE; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 73849107564     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Felderbauer P, Müller C, Bulut K, Belyaev O, Schmitz F, Uhl W, et al. Pathophysiology and treatment of acute pancreatitis: new therapeutic targets - a ray of hope? Basic Clin Pharmacol Toxicol 2005;97:342-350.
2. Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, et al. Pathophysiology of acute pancreatitis. Pancreatology 2005;5:132-144.
3. Liu XM, Xu J, Wang ZF. Pathogenesis of acute lung injury in rats with severe acute pancreatitis. Hepatobiliary Pancreat Dis Int 2005;4:614-617. (Pubitemid 41723824)
4. Nauseef WM. Contributions of myeloperoxidase to proinflammatory events: more than an antimicrobial system. Int J Hematol 2001;74:125-133.
5. Breckwoldt MO, Chen JW, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, et al. Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proc Natl Acad Sci U S A 2008;105:18584-18589.
6. El Kebir D, József L, Pan W, Filep JG. Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation. Circ Res 2008;103:352-359.
7. Ng SW, Zhang H, Hegde A, Bhatia M. Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia. J Leukoc Biol 2008;83:288-295. (Pubitemid 351225609)
8. Basher F, Fan H, Zingarelli B, Borg KT, Luttrell LM, Tempel GE, et al. beta-Arrestin 2: a Negative Regulator of Inflammatory Responses in Polymorphonuclear Leukocytes. Int J Clin Exp Med 2008;1:32-41.
9. Levälampi T, Honkanen V, Lahdenne P, Nieminen R, Hakala M, Moilanen E. Effects of infliximab on cytokines, myeloperoxidase, and soluble adhesion molecules in patients with juvenile idiopathic arthritis. Scand J Rheumatol 2007;36:189-193. (Pubitemid 47174546)
10. Pattison DI, Davies MJ. Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases. Curr Med Chem 2006;13:3271-3290.
11. Kettritz R. Autoimmunity in kidney diseases. Scand J Clin Lab Invest Suppl 2008;241:99-103.
12. Nahm CH, Choi JW, Lee J. Delta neutrophil index in automated immature granulocyte counts for assessing disease severity of patients with sepsis. Ann Clin Lab Sci 2008;38:241-246.
13. Guo RF, Ward PA. Role of oxidants in lung injury during sepsis. Antioxid Redox Signal 2007;9:1991-2002. (Pubitemid 47622351)
14. Hartwig W, Klafs M, Kirschfink M, Hackert T, Schneider L, Gebhard MM, et al. Interaction of complement and leukocytes in severe acute pancreatitis: potential for therapeutic intervention. Am J Physiol Gastrointest Liver Physiol 2006;291:G844-850. (Pubitemid 44772010)
15. Pastor CM, Vonlaufen A, Georgi F, Hadengue A, Morel P, Frossard JL. Neutrophil depletion - but not prevention of Kupffer cell activation - decreases the severity of cerulein-induced acute pancreatitis. World J Gastroenterol 2006;12:1219-1224.
16. Gómez-Cambronero L, Camps B, de La Asunción JG, Cerdá M, Pellín A, Pallardó FV, et al. Pentoxifylline ameliorates cerulein-induced pancreatitis in rats: role of glutathione and nitric oxide. J Pharmacol Exp Ther 2000;293:670-676.
17. Pereda J, Sabater L, Cassinello N, Gómez-Cambronero L, Closa D, Folch-Puy E, Aparisi L, et al. Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases. Ann Surg 2004;240:108-116.
18. Gül M, Eşrefoǧlu M, Oztürk F, Ateş B, Otlu A. The beneficial effects of pentoxifylline on caerulein-induced acute pancreatitis in rats. Dig Dis Sci 2009;54:555-563.
19. Coimbra R, Melbostad H, Loomis W, Porcides RD, Wolf P, Tobar M, et al. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression. J Trauma 2006;60:115-125.
20. Borregaard N, Cowland JB. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 1997;89:3503-3521.
21. Kettle AJ, Winterbourn CC. A kinetic analysis of the catalase activity of myeloperoxidase. Biochemistry 2001;40:10204-10212.
22. Anderson MM, Requena JR, Crowley JR, Thorpe SR, Heinecke JW. The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl) lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation. J Clin Invest 1999;104:103-113.
23. Yao V, McCauley R, Cooper D, Platell C, Hall JC. Myeloperoxidase response to peritonitis in an experimental model. ANZ J Surg 2003;73:1052-1056. (Pubitemid 38030747)
24. Coimbra R, Porcides RD, Melbostad H, Loomis W, Tobar M, Hoyt DB, Wolf P. Nonspecific phosphodiesterase inhibition attenuates liver injury in acute endotoxemia. Surg Infect (Larchmt) 2005;6:73-85. (Pubitemid 40711367)
25. de Campos T, Deree J, Martins JO, Loomis WH, Shenvi E, Putnam JG, Coimbra R. Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. Pancreas 2008;37:42-49.
26. Zhu DJ, Xia B, Bi Q, Zhang SJ, Qiu BS, Zhao C. Functional protection of pentoxifylline against spinal cord ischemia/reperfusion injury in rabbits: necrosis and apoptosis effects. Chin Med J (Engl) 2008;121:2444-2449.