Large loop excision of the transformation zone and cervical intraepithelial neoplasia: A 22-year experience

Anticancer Research

Volumn 32, Issue 9, 2012, Pages 4141-4145

  Stasinou, Sofia M ^a   Valasoulis, George ^a   Kyrgiou, Maria ^b   Malamou Mitsi, Vasiliki ^a   Bilirakis, Evripidis ^c   Pappa, Lina ^a   Deligeoroglou, Emmanouil ^d   Nasioutziki, Maria ^e   Founta, Christina ^a   Daponte, Alexandros ^f   Koliopoulos, George ^a   Loufopoulos, Aristotelis ^e   Karakitsos, Petros ^g   Paraskevaidis, Evangelos ^a  

^a UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c KAT HOSPITAL   (Greece)

^d UNIVERSITY OF ATHENS   (Greece)

^e ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^f UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^g UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cervical intraepithelial neoplasia (CIN); Electrosurgical excision; HPV DNA; HPV related biomarkers; Human papillomavirus (HPV); Large loop excision of the transformation zone (LLETZ); Loop electrosurgical excision procedure (LEEP)

Indexed keywords

ADULT; ARTICLE; CANCER SURGERY; COLPOSCOPY; CYTOPATHOLOGY; FEMALE; GREECE; HISTOPATHOLOGY; HUMAN; LARGE LOOP EXCISION OF THE TRANSFORMATION ZONE; MAJOR CLINICAL STUDY; MALIGNANT TRANSFORMATION; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; POSTOPERATIVE CARE; PRIORITY JOURNAL; REOPERATION; RETROSPECTIVE STUDY; SURGICAL TECHNIQUE; TREATMENT FAILURE; UNIVERSITY HOSPITAL; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CONIZATION; UTERUS BIOPSY; WART VIRUS;

ADULT; CERVICAL INTRAEPITHELIAL NEOPLASIA; COLPOSCOPY; CONIZATION; FEMALE; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; RETROSPECTIVE STUDIES; UTERINE CERVICAL NEOPLASMS;

EID: 84867030015     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Martin-Hirsch PL, Paraskevaidis E, and Kitchener H: Surgery for cervical intraepithelial neoplasia. Cochrane Database Syst Rev: CD001318, 2000.
2. Martin-Hirsch PP, Paraskevaidis E, Bryant A, Dickinson HO, and Keep SL: Surgery for cervical intraepithelial neoplasia. Cochrane Database Syst Rev: CD001318, 2010.
3. Prendiville W: Large loop excision of the transformation zone. Clin Obstet Gynecol 38: 622-639, 1995.
4. Paraskevaidis E, Kitchener H, Adonakis G, Parkin D and Lolis D: Incomplete excision of CIN in conization: further excision or conservative management? Eur J Obstet Gynecol Reprod Biol 53: 45-47, 1994.
5. Soutter WP, de Barros Lopes A, Fletcher A, Monaghan JM, Duncan ID, Paraskevaidis E and Kitchener HC: Invasive cervical cancer after conservative therapy for cervical intraepithelial neoplasia. Lancet 349: 978-980, 1997.
6. Paraskevaidis E, Lolis ED, Koliopoulos G, Alamanos Y, Fotiou S and Kitchener HC: Cervical intraepithelial neoplasia outcomes after large loop excision with clear margins. Obstet Gynecol 95: 828-831, 2000.
7. Paraskevaidis E, Kalantaridou SN, Paschopoulos M, Zikopoulos K, Diakomanolis E, Dalkalitsis N, Makrydimas G, Pappa L, Malamou-Mitsi V and Agnantis NJ: Factors affecting outcome after incomplete excision of cervical intraepithelial neoplasia. Eur J Gynaecol Oncol 24: 541-543, 2003.
8. Paraskevaidis E, Koliopoulos G, Paschopoulos M, Stefanidis K, Navrozoglou I and Lolis D: Effects of ball cauterization following loop excision and follow-up colposcopy. Obstet Gynecol 97: 617-620, 2001.
9. Nuovo J, Melnikow J, Willan AR and Chan BK: Treatment outcomes for squamous intraepithelial lesions. Int J Gynaecol Obstet 68: 25-33, 2000.
10. Kyrgiou M, Tsoumpou I, Vrekoussis T, Martin-Hirsch P, Arbyn M, Prendiville W, Mitrou S, Koliopoulos G, Dalkalitsis N, Stamatopoulos P and Paraskevaidis E: The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: the Cochrane Colposcopy and Cervical Cytopathology Collaborative Group (C5 group) approach. Cancer Treat Rev 32: 516-523, 2006.
11. Paraskevaidis E, Kitchener HC, Malamou-Mitsi V, Agnanti N and Lolis D: Thermal tissue damage following laser and large loop conization of the cervix. Obstet Gynecol 84: 752-754, 1994.
12. Paraskevaidis E, Davidson EJ, Koliopoulos G, Alamanos Y, Lolis E and Martin-Hirsch P: Bleeding after loop electrosurgical excision procedure performed in either the follicular or luteal phase of the menstrual cycle: A randomized trial. Obstet Gynecol 99: 997-1000, 2002.
13. Kyrgiou M, Koliopoulos G, Martin-Hirsch P, Arbyn M, Prendiville W and Paraskevaidis E: Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: Systematic review and meta-analysis. Lancet 367: 489-498, 2006.
14. Arbyn M, Kyrgiou M, Simoens C, Raifu AO, Koliopoulos G, Martin-Hirsch P, Prendiville W and Paraskevaidis E: Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: Meta-analysis. BMJ 337: a1284, 2008.
15. Paraskevaidis E, Kyrgiou M and Martin-Hirsch P: Have we dismissed ablative treatment too soon in colposcopy practice? Br J Obstet Gynaecol 114: 3-4, 2007.
16. Paraskevaidis E, Bilirakis E, Koliopoulos G, Lolis ED, Kalantaridou S, Paschopoulos M, Plachouras N, Malamou-Mitsi V and Kitchener HC: Cervical regeneration after diathermy excision of cervical intraepithelial neoplasia as assessed by transvaginal sonography. Eur J Obstet Gynecol Reprod Biol 102: 88-91, 2002.
17. Paraskevaidis E, Koliopoulos G, Malamou-Mitsi V, Zikopoulos K, Paschopoulos M, Pappa L, Agnantis NJ and Loli DE: Large loop excision of the transformation zone for treating cervical intraepithelial neoplasia: A 12-year experience. Anticancer Res 21: 3097-3099, 2001.
18. Arbyn M, Primic-Zakelj M, Raifu AO, Grce M, Paraskevaidis E, Diakomanolis E, Kesic V, Nicula FA, Suteu O and von Karsa L: The burden of cervical cancer in south-east Europe at the beginning of the 21st century. Coll Anthropol 31(Suppl 2): 7-10, 2007.
19. Kyrgiou M, Koliopoulos G, Martin-Hirsch P, Kehoe S, Flannelly G, Mitrou S, Arbyn M, Prendiville W and Paraskevaidis E: Management of minor cervical cytological abnormalities: A systematic review and a meta-analysis of the literature. Cancer Treat Rev 33: 514-520, 2007.
20. Arbyn M, Dillner J, Van Ranst M, Buntinx F, Martin-Hirsch P and Paraskevaidis E: Re: Have we resolved how to triage equivocal cervical cytology? J Natl Cancer Inst 96: 1401-1402; author reply 1402, 2004.
21. Paraskevaidis E, Kalantaridou SN, Kaponis A, Chouliara S, Agnantis NJ, Dousias V, Zikopoulos K, Paschopoulos M, Stamatopoulos P and Lolis DE: Surgical management of early-stage cervical cancer: Ten years experience from one Greek health region. Eur J Gynaecol Oncol 23: 341-344, 2002.
22. Paraskevaidis E, Koliopoulos G, Kalantaridou S, Pappa L, Navrozoglou I, Zikopoulos K and Lolis DE: Management and evolution of cervical intraepithelial neoplasia during pregnancy and postpartum. Eur J Obstet Gynecol Reprod Biol 104: 67-69, 2002.
23. Ang C, Mukhopadhyay A, Burnley C, Faulkner K, Cross P, Martin-Hirsch P and Naik R: Histological recurrence and depth of loop treatment of the cervix in women of reproductive age: Incomplete excision versus adverse pregnancy outcome. Br J Obstet Gynaecol 118: 685-692, 2011.
24. Paraskevaidis E, Arbyn M, Sotiriadis A, Diakomanolis E, Martin-Hirsch P, Koliopoulos G, Makrydimas G, Tofoski J and Roukos DH: The role of HPV DNA testing in the follow-up period after treatment for CIN: a systematic review of the literature. Cancer Treat Rev 30: 205-211, 2004.
25. Arbyn M, Paraskevaidis E, Martin-Hirsch P, Prendiville W and Dillner J: Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidence. Gynecol Oncol 99: S7-11, 2005.
26. Koliopoulos G, Sotiriadis A, Kyrgiou M, Martin-Hirsch P, Makrydimas G and Paraskevaidis E: Conservative surgical methods for FIGO stage IA2 squamous cervical carcinoma and their role in preserving women's fertility. Gynecol Oncol 93: 469-473, 2004.
27. Paraskevaidis E, Koliopoulos G, Lolis E, Papanikou E, Malamou-Mitsi V and Agnantis NJ: Delivery outcomes following loop electrosurgical excision procedure for microinvasive (FIGO stage IA1) cervical cancer. Gynecol Oncol 86: 10-13, 2002.
28. Khalid S, Dimitriou E, Conroy R, Paraskevaidis E, Kyrgiou M, Harrity C, Arbyn M and Prendiville W: The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy-related morbidity. Br J Obstet Gynaecol 119: 685-691, 2012.
29. Koliopoulos G, Arbyn M, Martin-Hirsch P, Kyrgiou M, Prendiville W and Paraskevaidis E: Diagnostic accuracy of human papillomavirus testing in primary cervical screening: a systematic review and meta-analysis of non-randomized studies. Gynecol Oncol 104: 232-246, 2007.
30. Gok M, Coupe VM, Berkhof J, Verheijen RH, Helmerhorst TJ, Hogewoning CJ, Snijders PJ and Meijer CJ: HPV16 and increased risk of recurrence after treatment for CIN. Gynecol Oncol 104: 273-275, 2007.
31. Coupe VM, Berkhof J, Verheijen RH, and Meijer CJ: Cost-effectiveness of human papillomavirus testing after treatment for cervical intraepithelial neoplasia. Br J Obstet Gynaecol 114: 416-424, 2007.
32. Arbyn M, Buntinx F, Van Ranst M, Paraskevaidis E, Martin-Hirsch P and Dillner J: Virologic versus cytologic triage of women with equivocal Pap smears: A meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia. J Natl Cancer Inst 96: 280-293, 2004.
33. Nasioutziki M, Daniilidis A, Dinas K, Kyrgiou M, Valasoulis G, Loufopoulos PD, Paraskevaidis E, Loufopoulos A and Karakitsos P: The evaluation of p16 (INK4a) immunoexpression/immunostaining and human papillomavirus DNA test in cervical liquid-based cytological samples. Int J Gynecol Cancer 21: 79-85, 2011.
34. Tsoumpou I, Valasoulis G, Founta C, Kyrgiou M, Nasioutziki M, Daponte A, Koliopoulos G, Malamou-Mitsi V, Karakitsos P and Paraskevaidis E: High-risk human papillomavirus DNA test and p16(INK4a) in the triage of LSIL: a prospective diagnostic study. Gynecol Oncol 121: 49-53, 2011.
35. Koliopoulos G, Valasoulis G and Zilakou E: An update review on HPV testing methods for cervical neoplasia. Expert Opin Med Diagn 3: 123-131, 2009.
36. Valasoulis G, Tsoumpou I, Founta C, Kyrgiou M, Dalkalitsis N, Nasioutziki M, Kassanos D, Paraskevaidis E and Karakitsos P: The role of p16(INK4a) immunostaining in the risk assessment of women with LSIL cytology: A prospective pragmatic study. Eur J Gynaecol Oncol 32: 150-152, 2011.
37. Phadnis SV, Atilade A, Bowring J, Kyrgiou M, Young MPA, Evans H, Paraskevaidis E and Walker P: Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: A study of collagen distribution. Br J Obstet Gynaecol 118: 1585-1591, 2011.
38. Noehr B, Jensen A, Frederiksen K, Tabor A and Kjaer SK: Loop electrosurgical excision of the cervix and subsequent risk for spontaneous preterm delivery: a population-based study of singleton deliveries during a 9-year period. Am J Obstet Gynecol 201: 33 e31-36, 2009.
39. Founta C, Arbyn M, Valasoulis G, Kyrgiou M, Tsili A, Martin-Hirsch P, Dalkalitsis N, Karakitsos P, Kassanos D, Prendiville W, Loufopoulos A and Paraskevaidis E: Proportion of excision and cervical healing after large loop excision of the transformation zone for cervical intraepithelial neoplasia. Br J Obstet Gynaecol 117: 1468-1474, 2010.
40. Noehr B, Jensen A, Frederiksen K, Tabor A and Kjaer SK: Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery. Obstet Gynecol 114: 1232-1238, 2009.
41. Ortoft G, Henriksen T, Hansen E and Petersen L: After conisation of the cervix, the perinatal mortality as a result of preterm delivery increases in subsequent pregnancy. Br J Obstet Gynaecol 117: 258-267, 2010.
42. Jakobsson M, Gissler M, Paavonen J and Tapper AM: Loop electrosurgical excision procedure and the risk for preterm birth. Obstet and Gynecol 114: 504-510, 2009.
43. Prendiville W: The treatment of CIN: What are the risks? Cytopathology 20: 145-153, 2009.
44. Phadnis SV, Atilade A, Young MP, Evans H and Walker PG: The volume perspective: a comparison of two excisional treatments for cervical intraepithelial neoplasia (laser versus LLETZ). Br J Obstet Gynaecol 117: 615-619.
45. Kyrgiou M, Valasoulis G, Founta C, Koliopoulos G, Karakitsos P, Nasioutziki M, Navrozoglou I, Dalkalitsis N and Paraskevaidis E: Clinical management of HPV-related disease of the lower genital tract. Ann NY Acad Sci 1205: 57-68, 2010.
46. Kyrgiou M and Shafi MI: HPV vaccine. Obstet Gynaecol Reprod Med 19: 26-28, 2009.
47. Tsakiroglou M, Bakalis M, Valasoulis G, Paschopoulos M, Koliopoulos G, and Paraskevaidis E: Women's knowledge and utilization of gynecological cancer prevention services in the Northwest of Greece. Eur J Gynaecol Oncol 32: 178-181, 2011.
48. Kitchener HC and Paraskevaidis E: Patient's preference: A sound basis for policy? Br J Obstet Gynaecol 119: 5-6, 2012.
49. Valasoulis G, Koliopoulos G, Founta C, Kyrgiou M, Tsoumpou I, Valari O, Martin-Hirsch P, Daponte A, Karakitsos P and Paraskevaidis E: Alterations in human papillomavirus-related biomarkers after treatment of cervical intraepithelial neoplasia. Gynecol Oncol 121: 43-48, 2011.
50. Karakitsos P, Pouliakis A, Meristoudis C, Margari N, Kassanos D, Kyrgiou M, Panayiotides JG and Paraskevaidis E: A preliminary study of the potential of tree classifiers in triage of high-grade squamous intraepithelial lesions. Anal Quant Cytol Histol 33: 132-140, 2011.
51. Karakitsos P, Chrelias C, Pouliakis A, Koliopoulos G, Spathis A, Kyrgiou M, Meristoudis C, Chranioti A, Kottaridi C, Valasoulis G, Panayiotides I and Paraskevaidis E: Identification of Women for Referral to Colposcopy by Neural Networks: A Preliminary Study Based on Liquid Based Cytology and Molecular Biomarkers. J Biomed Biotechnol (in Press) 2012.