The role of p16INK4a immunostaining in the risk assessment of women with LSIL cytology: A prospective pragmatic study

European Journal of Gynaecological Oncology

Volumn 32, Issue 2, 2011, Pages 150-152

  Valasoulis, G ^a   Tsoumpou, I ^b   Founta, C ^a   Kyrgiou, M ^c   Dalkalitsis, N ^a   Nasioutziki, M ^d   Kassanos, D ^e   Paraskevaidis, E ^a   Karakitsos, P ^e  

^a UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^b LANCASHIRE TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c WATFORD GENERAL HOSPITAL   (United Kingdom)

^d ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^e UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cervix; Immunostaining; Liquid based cytology; LSIL, CIN; p16INK4a

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ADULT; ARTICLE; CANCER DIAGNOSIS; CLINICAL TRIAL; COLPOSCOPY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; EMERGENCY HEALTH SERVICE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LOW GRADE INTRAEPITHELIAL LESION CYTOLOGY; MAJOR CLINICAL STUDY; PREDICTION; PROSPECTIVE STUDY; PUNCH BIOPSY; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SINGLE BLIND PROCEDURE; SMEAR; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY;

ADOLESCENT; ADULT; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOLOGICAL TECHNIQUES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS;

EID: 79955692435     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Sherman M.E., Lorincz A.T., Scott D.R., Wacholder S., Castle P.E., Glass A.G. et al.: "Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis". J. Natl. Cancer Inst., 2003, 95, 46.
2. Kyrgiou M., Koliopoulos G., Martin-Hirsch P., Arbyn M., Prendiville W., Paraskevaidis E.: "Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis". Lancet, 2006; 367, 489.
3. Arbyn M., Kyrgiou M., Simoens C., Raifu A.O., Koliopoulos G., Martin-Hirsch P. et al.: "Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis". Br. Med. J., 2008, 337, a1284.
4. Arbyn M., Buntinx F., Van Ranst M., Paraskevaidis E., Martin-Hirsch P., Dillner J.: "Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia". J. Natl. Cancer Inst., 2004, 96, 280.
5. Arbyn M., Paraskevaidis E., Martin-Hirsch P., Prendiville W., Dillner J.: "Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidence". Gynecol. Oncol., 2005, 99 (3 suppl. 1), S7.
6. Koliopoulos G., Valasoulis G., Zilakou E.: "An update review on HPV testing methods for cervical neoplasia". Expert. Opin. Med. Diagn., 2009, 3, 123.
7. Walboomers J.M., Jacobs M.V., Manos M.M., Bosch F.X., Kummer J.A., Shah K.V. et al.: "Human papillomavirus is a necessary cause of invasive cervical cancer worldwide". J. Pathol., 1999, 189, 12.
8. Muñoz N.: "Human papillomavirus and cancer: the epidemiological evidence". J. Clin. Virol., 2000, 19, 1.
9. Wentzensen N., von Knebel Doeberitz M.: "Biomarkers in cervical cancer screening". Dis. Markers, 2007, 23, 315.
10. Wentzensen N., Bergeron C., Cas F., Eschenbach D., Vinokurova S., von Knebel Doeberitz M.: "Evaluation of nuclear score for p16INK4a-stained cervical squamous cells in liquid-based cytology samples". Cancer, 2005, 105, 461.
11. Klaes R., Friedrich T., Spitkovsky D., Ridder R., Rudy W., Petry U. et al.: "Overexpression of p16INK4a as a specific marker for dysplactic and neoplastic epithelial cells of the cervix". Int. J. Cancer, 2001, 92, 276.
12. Trunk M.J., Dallenbach-Hellweg G., Ridder R., Petry K.U., Ikenberg H., Schneider V. et al.: "Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples". Acta Cytol., 2004, 48, 771.
13. Wentzensen N., Bergeron C., Cas F., Vinokurova S., von Knebel Doeberitz: "Triage of women with ASCUS and LSIL cytology". Cancer, 2007, 111, 58.
14. INK4a immunostaining in cytological and histological specimens from the uterine cervix: A systematic review and meta-analysis". Cancer Treat. Rev., 2009, 35, 210.