Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism

Experimental Diabetes Research

Volumn 2012, Issue , 2012, Pages

  Mandelbaum, Amitai D ^a   Melkman Zehavi, Tal ^a   Oren, Roni ^a   Kredo Russo, Sharon ^a   Nir, Tomer ^b   Dor, Yuval ^b   Hornstein, Eran ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DICER; MICRORNA; PROTEIN DICER1; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; CRE RECOMBINASE; DEAD BOX PROTEIN; DICER1 PROTEIN, MOUSE; INSULIN; INTEGRASE; RIBONUCLEASE III;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOARCHITECTURE; EMBRYO; EMBRYO DEVELOPMENT; GENE DISRUPTION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; IMPAIRED GLUCOSE TOLERANCE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE; ANIMAL; BLOOD; CROSS BREEDING; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; GROWTH, DEVELOPMENT AND AGING; HETEROZYGOTE; METABOLISM; MOUSE MUTANT; MUTATION; ORGANOGENESIS; PATHOLOGY; SECRETION (PROCESS); TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CADHERINS; CROSSES, GENETIC; DEAD-BOX RNA HELICASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE INTOLERANCE; HETEROZYGOTE; INSULIN; INSULIN-SECRETING CELLS; INTEGRASES; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICRORNAS; MUTATION; ORGANOGENESIS; RIBONUCLEASE III;

EID: 84867028085     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/470302     Document Type: Article

References (30)

1. Bartel D. P., MicroRNAs: target recognition and regulatory functions. Cell 2009 136 2 215 233 2-s2.0-58249088751 10.1016/j.cell.2009.01.002
2. Baroukh N., Ravier M. A., Loder M. K., Hill E. V., Bounacer A., Scharfmann R., Rutter G. A., Van Obberghen E., MicroRNA-124a regulates foxa2 expression and intracellular signaling in pancreatic β -cell lines. Journal of Biological Chemistry 2007 282 27 19575 19588 2-s2.0-34547126004 10.1074/jbc.M611841200
3. El Ouaamari A., Baroukh N., Martens G. A., Lebrun P., Pipeleers D., Van Obberghen E., MiR-375 targets 3′l-phosphoinositide-dependent protein Kinase-1 and regulates glucose-induced biological responses in pancreatic β -cells. Diabetes 2008 57 10 2708 2717 2-s2.0-58149350343 10.2337/db07-1614
4. Hennessy E., O'Driscoll L., Molecular medicine of microRNAs: structure, function and implications for diabetes. Expert Reviews in Molecular Medicine 2008 10 e24 2-s2.0-53449087811 10.1017/S1462399408000781
5. Joglekar M. V., Parekh V. S., Hardikar A. A., New pancreas from old: microregulators of pancreas regeneration. Trends in Endocrinology and Metabolism 2007 18 10 393 400 2-s2.0-36249029999 10.1016/j.tem.2007.10.001
6. Poy M. N., Hausser J., Trajkovskia M., miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proceedings of the National Academy of Sciences of the United States of America 2009 106 14 5813 5818 10.1073/pnas.0810550106
7. Poy M. N., Spranger M., Stoffel M., microRNAs and the regulation of glucose and lipid metabolism. Diabetes, Obesity and Metabolism 2007 9 supplement 2 67 73 2-s2.0-35148819250 10.1111/j.1463-1326.2007.00775.x
8. Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., Lee J., Provost P., Rådmark O., Kim S., Kim V. N., The nuclear RNase III Drosha initiates microRNA processing. Nature 2003 425 6956 415 419 2-s2.0-0141843656 10.1038/nature01957
9. Hammond S. M., Dicing and slicing: the core machinery of the RNA interference pathway. FEBS Letters 2005 579 26 5822 5829 2-s2.0-26944441255 10.1016/j.febslet.2005.08.079
10. Lynn F. C., Skewes-Cox P., Kosaka Y., McManus M. T., Harfe B. D., German M. S., MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes 2007 56 12 2938 2945 2-s2.0-36248978699 10.2337/db07-0175
11. Morita S., Hara A., Kojima I., Horii T., Kimura M., Kitamura T., Ochiya T., Nakanishi K., Matoba R., Matsubara K., Hatada I., Dicer is required for maintaining adult pancreas. PLoS ONE 2009 4 1 2-s2.0-62649123872 10.1371/journal.pone.0004212 e4212
12. Melkman-Zehavi T., Oren R., Kredo-Russo S., Shapira T., Mandelbaum A. D., Rivkin N., Nir T., Lennox K. A., Behlke M. A., Dor Y., Hornstein E., miRNAs control insulin content in pancreatic β -cells via downregulation of transcriptional repressors. The EMBO Journal 2011 30 5 835 845 2-s2.0-79952259862 10.1038/emboj.2010.361
13. Angst B. D., Marcozzi C., Magee A. I., The cadherin superfamily: diversity in form and function. Journal of Cell Science 2001 114, part 4 629 641 2-s2.0-0035077317
14. Rouiller D. G., Cirulli V., Halban P. A., Uvomorulin mediates calcium-dependent aggregation of islet cells, whereas calcium-independent cell adhesion molecules distinguish between islet cell types. Developmental Biology 1991 148 1 233 242 2-s2.0-0025988037 10.1016/0012-1606(91)90332-W
15. Hauge-Evans A. C., Squires P. E., Persaud S. J., Jones P. M., Pancreatic β -cell-to- β -cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 1999 48 7 1402 1408 2-s2.0-0032992378 10.2337/diabetes.48.7.1402
16. Yamagata K., Nammo T., Moriwaki M., Ihara A., Iizuka K., Yang Q., Satoh T., Li M., Uenaka R., Okita K., Iwahashi H., Zhu Q., Cao Y., Imagawa A., Tochino Y., Hanafusa T., Miyagawa J. I., Matsuzawa Y., Overexpression of dominant-negative mutant hepatocyte nuclear factor-1 α in pancreatic β -cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced β -cell proliferation, and diabetes. Diabetes 2002 51 1 114 123 2-s2.0-0036091921
17. Dahl U., Sjodin A., Semb H., Cadherins regulate aggregation of pancreatic β -cells in vivo. Development 1996 122 9 2895 2902 2-s2.0-0029793745
18. Esni F., Täljedal I. B., Perl A. K., Cremer H., Christofori G., Semb H., Neural cell adhesion molecule (N-CAM) is required for cell: type segregation and normal ultrastructure in pancreatic islets. Journal of Cell Biology 1999 144 2 325 337 2-s2.0-0345435966 10.1083/jcb.144.2.325
19. Harfe B. D., McManus M. T., Mansfield J. H., Hornstein E., Tabin C. J., The RNaseIII enzyme dicer is required for morphogenesis but not patterning of the vertebrate limb. Proceedings of the National Academy of Sciences of the United States of America 2005 102 31 10898 10903 2-s2.0-23344439006 10.1073/pnas.0504834102
20. Gannon M., Shiota C., Postic C., Wright C. V. E., Magnuson M., Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 2000 26 2 139 142
21. Srinivas S., Watanabe T., Lin C. S., William C. M., Tanabe Y., Jessell T. M., Costantini F., Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Developmental Biology 2001 1 1 4 2-s2.0-0001803381
22. Cuellar T. L., Davis T. H., Nelson P. T., Loeb G. B., Harfe B. D., Ullian E., McManus M. T., Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America 2008 105 14 5614 5619 2-s2.0-44449132518 10.1073/pnas.0801689105
23. Kanellopoulou C., Muljo S. A., Kung A. L., Ganesan S., Drapkin R., Jenuwein T., Livingston D. M., Rajewsky K., Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes and Development 2005 19 4 489 501 2-s2.0-13844294261 10.1101/gad.1248505
24. Gradus B., Alon I., Hornstein E., miRNAs control tracheal chondrocyte differentiation. Developmental Biology 2011 360 1 58 65
25. Kalis M., Bolmeson C., Esguerra J. L. S., Beta-cell specific deletion of dicer1 leads to defective insulin secretion and diabetes mellitus. PLoS ONE 2011 6 12 e29166
26. Boussadia O., Kutsch S., Hierholzer A., Delmas V., Kemler R., E-cadherin is a survival factor for the lactating mouse mammary gland. Mechanisms of Development 2002 115 1-2 53 62 2-s2.0-0036269067 10.1016/S0925-4773(02)00090-4
27. Rogers G. J., Hodgkin M. N., Squires P. E., E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet. Cellular Physiology and Biochemistry 2007 20 6 987 994 2-s2.0-35848955929 10.1159/000110459
28. Lin X., Taguchi A., Park S., Kushner J. A., Li F., Li Y., White M. F., Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes. Journal of Clinical Investigation 2004 114 7 908 916 2-s2.0-9644260563 10.1172/JCI200422217
29. Stanger B. Z., Tanaka A. J., Melton D. A., Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 2007 445 7130 886 891 2-s2.0-33847210675 10.1038/nature05537
30. Nir T., Melton D. A., Dor Y., Recovery from diabetes in mice by β cell regeneration. Journal of Clinical Investigation 2007 117 9 2553 2561 2-s2.0-34848887156 10.1172/JCI32959