Circulating Heat Shock Protein 60 Levels Are Elevated in HIV Patients and Are Reduced by Anti-Retroviral Therapy

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Anraku, Itaru ^a   Rajasuriar, Reena ^b,c   Dobbin, Caroline ^d   Brown, Richard ^d   Lewin, Sharon R ^b,e,f   Suhrbier, Andreas ^a,g  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b ALFRED HOSPITAL   (Australia)

^c UNIVERSITY OF MALAYA   (Malaysia)

^d CBio Ltd   (Australia)

^e MONASH UNIVERSITY   (Australia)

^f BURNET INSTITUTE   (Australia)

^g GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD14 ANTIGEN; CHAPERONIN 60; EARLY PREGNANCY FACTOR; LIPOPOLYSACCHARIDE;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; INFLAMMATION; MALE; PROTEIN BLOOD LEVEL; VIRUS LOAD;

ADULT; ANTI-RETROVIRAL AGENTS; ANTIGENS, CD14; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CHAPERONIN 10; CHAPERONIN 60; FEMALE; GENE EXPRESSION; HIV; HIV INFECTIONS; HUMANS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; VIRAL LOAD;

EID: 84867016549     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045291     Document Type: Article

References (27)

1. Johnson BJ, Le TT, Dobbin CA, Banovic T, Howard CB, et al. (2005) Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. J Biol Chem 280: 4037-4047.
2. Corrao S, Campanella C, Anzalone R, Farina F, Zummo G, et al. (2010) Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: current knowledge and perspectives. Life Sci 86: 145-152.
3. Lewthwaite J, Owen N, Coates A, Henderson B, Steptoe A, (2002) Circulating human heat shock protein 60 in the plasma of British civil servants: relationship to physiological and psychosocial stress. Circulation 106: 196-201.
4. Grundtman C, Kreutmayer SB, Almanzar G, Wick MC, Wick G, (2011) Heat shock protein 60 and immune inflammatory responses in atherosclerosis. Arterioscler Thromb Vasc Biol 31: 960-968.
5. Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M, (2007) Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide. J Biol Chem 282: 4669-4680.
6. Yuan J, Dunn P, Martinus RD, (2011) Detection of Hsp60 in saliva and serum from type 2 diabetic and non-diabetic control subjects. Cell Stress Chaperones 16: 689-693.
7. Kondo Y, Ueno Y, Kobayashi K, Kakazu E, Shiina M, et al. (2010) Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes. J Infect Dis 202: 202-213.
8. Rizzo M, Macario AJ, de Macario EC, Gouni-Berthold I, Berthold HK, et al. (2011) Heat shock protein-60 and risk for cardiovascular disease. Curr Pharm Des 17: 3662-3668.
9. Xu Q, Schett G, Perschinka H, Mayr M, Egger G, et al. (2000) Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation 102: 14-20.
10. Hamelin C, Cornut E, Poirier F, Pons S, Beaulieu C, et al. (2011) Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer. FEBS J 278: 4845-4859.
11. Rizzo M, Cappello F, Marfil R, Nibali L, Marino Gammazza A, et al. (2012) Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study. Cell Stress Chaperones 17: 399-407.
12. Wu CT, Ou LS, Yeh KW, Lee WI, Huang JL, (2011) Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis. Clin Rheumatol 30: 959-965.
13. Shamaei-Tousi A, Steptoe A, O'Donnell K, Palmen J, Stephens JW, et al. (2007) Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors. Cell Stress Chaperones 12: 384-392.
14. Rajasuriar R, Booth D, Solomon A, Chua K, Spelman T, et al. (2010) Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor alpha and microbial translocation. J Infect Dis 202: 1254-1264.
15. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, et al. (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12: 1365-1371.
16. Li Y, Si R, Feng Y, Chen HH, Zou L, et al. (2011) Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem 286: 31308-31319.
17. Gaardbo JC, Hartling HJ, Gerstoft J, Nielsen SD, (2012) Incomplete Immune Recovery in HIV Infection: Mechanisms, Relevance for Clinical Care, and Possible Solutions. Clin Dev Immunol 2012: 670957.
18. Goh YC, Yap CT, Huang BH, Cronshaw AD, Leung BP, et al. (2011) Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis. Cell Mol Life Sci 68: 1581-1592.
19. Kim SC, Stice JP, Chen L, Jung JS, Gupta S, et al. (2009) Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res 105: 1186-1195.
20. Kim YS, Koh JM, Lee YS, Kim BJ, Lee SH, et al. (2009) Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via up-regulation of toll-like receptors. Bone 45: 68-76.
21. Kulkarni OP, Ryu M, Kantner C, Sardy M, Naylor D, et al. (2012) Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice. Nephrol Dial Transplant 27: 1358-1367.
22. Rea IM, McNerlan S, Pockley AG, (2001) Serum heat shock protein and anti-heat shock protein antibody levels in aging. Exp Gerontol 36: 341-352.
23. Merendino AM, Bucchieri F, Campanella C, Marciano V, Ribbene A, et al. (2010) Hsp60 is actively secreted by human tumor cells. PLoS One 5: e9247.
24. Lichtfuss GF, Hoy J, Rajasuriar R, Kramski M, Crowe SM, et al. (2011) Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection. Biomark Med 5: 171-186.
25. Friis-Moller N, Reiss P, Sabin CA, Weber R, Monforte A, et al. (2007) Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 356: 1723-1735.
26. Koh JM, Lee YS, Kim YS, Park SH, Lee SH, et al. (2009) Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency. Bone 45: 650-660.
27. Ofotokun I, McIntosh E, Weitzmann MN, (2012) HIV: inflammation and bone. Curr HIV/AIDS Rep 9: 16-25.