Ultrasound-Enhanced Monoclonal Antibody Production

Ultrasound in Medicine and Biology

Volumn 38, Issue 11, 2012, Pages 1949-1957

  Xing, James Z ^a   Yang, Xiaoyan ^a   Xu, Peng ^a   Ang, Woon T ^b   Chen, Jie ^a,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b IntelligentNano Inc   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Hybridoma; Low intensity pulsed ultrasound; Monoclonal antibody production; Ultrasound enhanced drug production; Value added biotechnology

Indexed keywords

CELL PERMEABILITY; COST-EFFECTIVE SOLUTIONS; DRUG MANUFACTURING; DRUG PRODUCTION; DUTY CYCLES; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWING DEMAND; HYBRIDOMA; HYBRIDOMA CELLS; LACTATE DEHYDROGENASE; LOW-INTENSITY PULSED ULTRASOUND; MANUFACTURING COST; MONOCLONAL ANTIBODIES (MAB); MONOCLONAL ANTIBODY PRODUCTION; OUTER MEMBRANE; PHARMACEUTICAL COMPANY; PULSE REPETITION FREQUENCIES; SCANNING ELECTRON MICROSCOPY IMAGE; STRUCTURAL CHANGE; ULTRASOUND TECHNOLOGY;

AUTOMOBILE MANUFACTURE; HEALTH CARE; MONOCLONAL ANTIBODIES; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

ULTRASONICS;

CD4 ANTIBODY; LACTATE DEHYDROGENASE; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STIMULATION; DRUG MANUFACTURE; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; HYBRIDOMA CELL CULTURE; LOW INTENSITY PULSED ULTRASOUND; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; TECHNOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASOUND;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; DOSE-RESPONSE RELATIONSHIP, RADIATION; HIGH-ENERGY SHOCK WAVES; HYBRIDOMAS; MICE; PROTEIN ENGINEERING; RADIATION DOSAGE; SONICATION;

EID: 84867016413     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2012.06.008     Document Type: Article

References (26)

1. Ang W., Scurtescu C., Hoy W., El-Bialy T., Tsui Y., Chen J. Design and Implementation of therapeutic ultrasound generating circuit for dental tissue formation and tooth-root healing. IEEE Trans Biomed Circuits Syst 2010, 4:49-61.
2. Birch J.R., Racher A.J. Antibody production. Adv Drug Del Rev 2006, 58:671-685.
3. Bordignon S. Stem-cell therapies for blood diseases. Nature 2006, 441:1100-1102.
4. Coussios C.C., Roy R.A. Applications of acoustics and cavitation to noninvasive therapy and drug delivery. Annu Rev Fluid Mech 2008, 40:395-420.
5. Doherty T.A., Soroosh P., Broide D.H., Croft M. CD4 cells are required for chronic eosinophilic lung inflammation but not airway remodelling. Am J Physiol Lung Cell Mol Physiol 2009, 296:L229-L235.
6. Gul H, Xu P, Ang WT, Huang M, Yang XY, Xing J, Chen J. Ultrasound treatment enhances proliferation of hematopoietic stem/progenitor cells: implication for clinical transplantation, gene and cellular therapies. Annual Conference of International Society for Cellular Therapy, 2010, Philadelphia, PA.
7. Iwashina T., Mochida J., Miyazaki T., Watanabe T., Iwabuchi S., Ando K., Hotta T., Sakai D. Low intensity pulsed ultrasound stimulates cell proliferation and proteoglycan production in rabbit intervertebral discs cells cultured in alginate. Biomaterials 2006, 27:354-361.
8. Kaufmann H., Fussenegger M. Metabolic engineering of mammalian cells for higher protein yield. Gene transfer and expression in mammalian cells 2003, 457-569. Elsevier Science, Amsterdam. S.C. Makrides (Ed.).
9. Kobayashi Y., Sakai D., Iwashina T., Iwabuchi S., Mochida J. Low-intensity pulsed ultrasound stimulates cell proliferation, proteoglycan synthesis and expression of growth factor-related genes in human nucleus pulposus cell line. J Eur Cell Mater 2009, 17:15-22.
10. Lionetti V., Fittipaldi A., Agostini S., Giacca M., Recchia F.A., Picano E. Enhanced caveolae-mediated endocytosis by diagnostic ultrasound in vitro. Ultrasound Med Biol 2009, 35:136-143.
11. Liu Y.B., Kon T., Li C.Y., Zhong P. High intensity focused ultrasound-induced gene activation in solid tumors. J Acoust Soc Am 2006, 120:492-501.
12. Mottram P.L., Murray-Segal L.J., Han W., Zhan Y., Brady J.L., Lew A.M. Transgenic anti-CD4 monoclonal antibody secretion by mouse segmental pancreas allografts promotes long term survival. Transpl Immunol 2000, 8:203-209.
13. Norman P. Monoclonal antibodies in the pipeline: A segment of major growth report 2011, Insight Pharma Reports (CHI), Needham, MA.
14. Pandey S. Hybridoma technology for production of monoclonal antibodies. Int J Pharmaceut Sci Rev Res 2010, 1:88-94.
15. Qiu Y., Luo Y., Zhang Y., Cui W., Zhang D., Wu J., Zhang J., Tu J. The correlation between acoustic cavitation and sonoporation involved in ultrasound-mediated DNA transfection with polyethylenimine (PEI) in vitro. J Control Rel 2010, 145:40-48.
16. Regueira T., Kildegaard K., Hansen B., Mortensen U., Hertweck C., Nielsen J. Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum. Appl Environ Microbiol 2011, 77:3035-3043.
17. Rodrigues M.E., Costa A.R., Henriques M., Azeredo J., Oliveria R. Technological progresses in monoclonal antibody production systems. Biotechnol Progr 2010, 26:332-351.
18. Shah A.J., Smogorzewska E.M., Hannum C., Crooks G.M. Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38- cells and maintains progenitor cells in vitro. Blood 1996, 87:3563-3570.
19. Shaheen M, Choi M, Zhao YP, Ang WT, Yang R, Xing J, Likes G, Zhang J, Chen J. Application of low-intensity pulsed ultrasound to increase bio-ethanol production in shake-flask fermentation. Ultrasound Med Biol [in press].
20. Sriram S., Carroll S., Fortin S., Cooper S., Ranges G. In-vivo immunomodulation by monoclonal anti-CD4 antibody II effect on T cell response to myelin basic protein and experimental allergic encephalomyelitis. J Immunol 1988, 141:464-468.
21. Sun J.S., Hong R.C., Chang W.H., Chen L.T., Lin F.H., Liu H.C. In vitro effects of low-intensity ultrasound stimulation on the bone cells. J Biomed Mater Res 2001, 57:449-456.
22. Wurm F.M. Production of recombinant protein therapeutics in cultivated mammalian cells. Nat Biotechnol 2004, 22:1393-1398.
23. Xu P., Gul-Uludag H., Ang W., Yang X., Huang M., Marquez-Curtis L., McGann L., Janowska-Wieczorek A., Xing J., Swanson E., Chen J. Low-intensity pulsed ultrasound-mediated stimulation of hematopoietic stem/progenitor cell viability, proliferation and differentiation in vitro. Biotechnol Lett 2012, [in press], Epub ahead of print July 5, 2012.
24. Yun J.H., Roh E.Y., Shin S., Jung N.H., Song E.Y., Lee D.S., Han K.S., Kim J.S., Kim B.J., Jeon H.W., Yoon K.S. Introducing pulsed low-intensity ultrasound to culturing human umbilical cord-derived mesenchymal stem cells. Biotechnol Lett 2009, 31:329-335.
25. Zhang Z.J., Huckle J., Francomano C.A., Spencer R.G. The effects of pulsed low-intensity ultrasound on chondrocyte viability, proliferation, gene expression and matrix production. Ultrasound Med Biol 2003, 29:1645-1651.
26. Zhao Y., Ang W., Xing J., Zhang J., Chen J. Application of ultrasound to enhance mycophenolic acid production. Ultrasound Med Biol 2012, [in press], Epub ahead of print June 30, 2012.