The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: Implications for neurodegenerative diseases

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 11, 2012, Pages 2057-2068

  Seiberlich, Veronika ^a   Goldbaum, Olaf ^a   Zhukareva, Victoria ^b   Richter Landsberg, Christiane ^a  

^a UNIVERSITY OF OLDENBURG   (Germany)

^b LifeSensors Inc   (United States)

Author keywords

Deubiquitinating enzymes; Heat shock proteins; Microtubules; Oligodendroglia; P62; Tau protein

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; PR 619; SMALL MOLECULE TRANSPORT AGENT; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CELL SURVIVAL; DEGENERATIVE DISEASE; HOMEOSTASIS; HUMAN; HUMAN CELL; INCUBATION TIME; NERVE CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; UBIQUITIN PROTEASOME SYSTEM; UBIQUITINATION;

AMINOPYRIDINES; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICROTUBULE-ORGANIZING CENTER; MICROTUBULES; OLIGODENDROGLIA; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN MULTIMERIZATION; TAU PROTEINS; THIOCYANATES; UBIQUITIN; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

EID: 84867011262     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.04.011     Document Type: Article

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