-
1
-
-
15644363454
-
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
-
Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y and Kitamura Y: Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279(5350): 577-580, 1998.
-
(1998)
Science
, vol.279
, Issue.5350
, pp. 577-580
-
-
Hirota, S.1
Isozaki, K.2
Moriyama, Y.3
Hashimoto, K.4
Nishida, T.5
Ishiguro, S.6
Kawano, K.7
Hanada, M.8
Kurata, A.9
Takeda, M.10
Muhammad Tunio, G.11
Matsuzawa, Y.12
Kanakura, Y.13
Shinomura, Y.14
Kitamura, Y.15
-
2
-
-
0041971080
-
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
-
Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y and Kitamura Y: Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. Gastroenterology 125(3): 660-667, 2003.
-
(2003)
Gastroenterology
, vol.125
, Issue.3
, pp. 660-667
-
-
Hirota, S.1
Ohashi, A.2
Nishida, T.3
Isozaki, K.4
Kinoshita, K.5
Shinomura, Y.6
Kitamura, Y.7
-
3
-
-
0242670019
-
PDGFRA activating mutations in gastrointestinal stromal tumors
-
Heinrich MC, Corless CL, Duensing A, Mcgreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD and Fletcher JA: PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299(5607): 708-710, 2003.
-
(2003)
Science
, vol.299
, Issue.5607
, pp. 708-710
-
-
Heinrich, M.C.1
Corless, C.L.2
Duensing, A.3
Mcgreevey, L.4
Chen, C.J.5
Joseph, N.6
Singer, S.7
Griffith, D.J.8
Haley, A.9
Town, A.10
Demetri, G.D.11
Fletcher, C.D.12
Fletcher, J.A.13
-
4
-
-
0033883060
-
KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
-
Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T, Demetri G, Xiao S, Singer S, Fletcher CD and Fletcher JA: KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 156(3): 791-795, 2000.
-
(2000)
Am J Pathol
, vol.156
, Issue.3
, pp. 791-795
-
-
Lux, M.L.1
Rubin, B.P.2
Biase, T.L.3
Chen, C.J.4
Maclure, T.5
Demetri, G.6
Xiao, S.7
Singer, S.8
Fletcher, C.D.9
Fletcher, J.A.10
-
5
-
-
0035890740
-
KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
-
Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD and Fletcher JA: KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 61(22): 8118-8121, 2001.
-
(2001)
Cancer Res
, vol.61
, Issue.22
, pp. 8118-8121
-
-
Rubin, B.P.1
Singer, S.2
Tsao, C.3
Duensing, A.4
Lux, M.L.5
Ruiz, R.6
Hibbard, M.K.7
Chen, C.J.8
Xiao, S.9
Tuveson, D.A.10
Demetri, G.D.11
Fletcher, C.D.12
Fletcher, J.A.13
-
6
-
-
0035066051
-
Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours
-
Hirota S, Nishida T, Isozaki K, Taniguchi M, Nakamura J, Okazaki T and Kitamura Y: Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours. J Pathol 193(4): 505-510, 2001.
-
(2001)
J Pathol
, vol.193
, Issue.4
, pp. 505-510
-
-
Hirota, S.1
Nishida, T.2
Isozaki, K.3
Taniguchi, M.4
Nakamura, J.5
Okazaki, T.6
Kitamura, Y.7
-
7
-
-
0033816156
-
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
-
Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ and Lydon NB: Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295(1): 139-145, 2000.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, Issue.1
, pp. 139-145
-
-
Buchdunger, E.1
Cioffi, C.L.2
Law, N.3
Stover, D.4
Ohno-Jones, S.5
Druker, B.J.6
Lydon, N.B.7
-
8
-
-
0035810148
-
Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
-
Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B and Demetri GD: Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 344(14): 1052-1056, 2001.
-
(2001)
N Engl J Med
, vol.344
, Issue.14
, pp. 1052-1056
-
-
Joensuu, H.1
Roberts, P.J.2
Sarlomo-Rikala, M.3
Andersson, L.C.4
Tervahartiala, P.5
Tuveson, D.6
Silberman, S.7
Capdeville, R.8
Dimitrijevic, S.9
Druker, B.10
Demetri, G.D.11
-
9
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
-
Van Oosterom AT, Judson I, Verweij J, Stroobants S, Donato Di Paola E, Dimitrijevic S, Martens M, Webb A, Sciot R, Van Glabbeke M, Silberman S and Nielsen OS: Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 358(9291): 1421-1423, 2001.
-
(2001)
Lancet
, vol.358
, Issue.9291
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, I.2
Verweij, J.3
Stroobants, S.4
Di Donato Paola, E.5
Dimitrijevic, S.6
Martens, M.7
Webb, A.8
Sciot, R.9
Van Glabbeke, M.10
Silberman, S.11
Nielsen, O.S.12
-
10
-
-
20844448396
-
A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient
-
Tamborini E, Bonadiman L, Greco A, Albertini V, Negri T, Gronchi A, Bertulli R, Colecchia M, Casali PG, Pierotti MA and Pilotti S: A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient. Gastroenterology 127(1): 294-299, 2004.
-
(2004)
Gastroenterology
, vol.127
, Issue.1
, pp. 294-299
-
-
Tamborini, E.1
Bonadiman, L.2
Greco, A.3
Albertini, V.4
Negri, T.5
Gronchi, A.6
Bertulli, R.7
Colecchia, M.8
Casali, P.G.9
Pierotti, M.A.10
Pilotti, S.11
-
11
-
-
20844460619
-
A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
-
Chen LL, Trent JC, Wu EF, Fuller GN, Ramdas L, Zhang W, Raymond AK, Prieto VG, Oyedeji CO, Hunt KK, Pollock RE, Feig BW, Hayes KJ, Choi H, Macapinlac HA, Hittelman W, Velasco MA, Patel S, Burgess MA, Benjamin RS and Frazier ML: A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res 64(17): 5913-5919, 2004.
-
(2004)
Cancer Res
, vol.64
, Issue.17
, pp. 5913-5919
-
-
Chen, L.L.1
Trent, J.C.2
Wu, E.F.3
Fuller, G.N.4
Ramdas, L.5
Zhang, W.6
Raymond, A.K.7
Prieto, V.G.8
Oyedeji, C.O.9
Hunt, K.K.10
Pollock, R.E.11
Feig, B.W.12
Hayes, K.J.13
Choi, H.14
Macapinlac, H.A.15
Hittelman, W.16
Velasco, M.A.17
Patel, S.18
Burgess, M.A.19
Benjamin, R.S.20
Frazier, M.L.21
more..
-
12
-
-
20344393896
-
Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation
-
Antonescu CR, Besmer P, Guo T, Arkun K, Hom G, Koryotowski B, Leversha MA, Jeffrey PD, Desantis D, Singer S, Brennan MF, Maki RG and Dematteo RP: Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res 11(11): 4182-4190, 2005.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.11
, pp. 4182-4190
-
-
Antonescu, C.R.1
Besmer, P.2
Guo, T.3
Arkun, K.4
Hom, G.5
Koryotowski, B.6
Leversha, M.A.7
Jeffrey, P.D.8
Desantis, D.9
Singer, S.10
Brennan, M.F.11
Maki, R.G.12
Dematteo, R.P.13
-
13
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
-
Demetri GD, Van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, Mcarthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM and Casali PG: Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368(9544): 1329-1338, 2006.
-
(2006)
Lancet
, vol.368
, Issue.9544
, pp. 1329-1338
-
-
Demetri, G.D.1
Van Oosterom, A.T.2
Garrett, C.R.3
Blackstein, M.E.4
Shah, M.H.5
Verweij, J.6
Mcarthur, G.7
Judson, I.R.8
Heinrich, M.C.9
Morgan, J.A.10
Desai, J.11
Fletcher, C.D.12
George, S.13
Bello, C.L.14
Huang, X.15
Baum, C.M.16
Casali, P.G.17
-
14
-
-
33646432734
-
Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate
-
Prenen H, Cools J, Mentens N, Folens C, Sciot R, Schoffski P, Van Oosterom A, Marynen P and Debiec-Rychter M: Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate. Clin Cancer Res 12(8): 2622-2627, 2006.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.8
, pp. 2622-2627
-
-
Prenen, H.1
Cools, J.2
Mentens, N.3
Folens, C.4
Sciot, R.5
Schoffski, P.6
Van Oosterom, A.7
Marynen, P.8
Debiec-Rychter, M.9
-
15
-
-
56749098278
-
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor
-
Heinrich MC, Maki RG, Corless CL, Antonescu CR, Harlow A, Griffith D, Town A, Mckinley A, Ou WB, Fletcher JA, Fletcher CD, Huang X, Cohen DP, Baum CM and Demetri GD: Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor. J Clin Oncol 26(33): 5352-5359, 2008.
-
(2008)
J Clin Oncol
, vol.26
, Issue.33
, pp. 5352-5359
-
-
Heinrich, M.C.1
Maki, R.G.2
Corless, C.L.3
Antonescu, C.R.4
Harlow, A.5
Griffith, D.6
Town, A.7
Mckinley, A.8
Ou, W.B.9
Fletcher, J.A.10
Fletcher, C.D.11
Huang, X.12
Cohen, D.P.13
Baum, C.M.14
Demetri, G.D.15
-
16
-
-
34249085905
-
Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: Proposal of new computed tomography response criteria
-
Choi H, Charnsangavej C, Faria SC, Macapinlac HA, Burgess MA, Patel SR, Chen LL, Podoloff DA and Benjamin RS: Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol 25(13): 1753-1759, 2007.
-
(2007)
J Clin Oncol
, vol.25
, Issue.13
, pp. 1753-1759
-
-
Choi, H.1
Charnsangavej, C.2
Faria, S.C.3
Macapinlac, H.A.4
Burgess, M.A.5
Patel, S.R.6
Chen, L.L.7
Podoloff, D.A.8
Benjamin, R.S.9
-
17
-
-
33644922956
-
Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors: Sequential analyses
-
Kikuchi H, Yamashita K, Kawabata T, Yamamoto M, Hiramatsu Y, Kondo K, Baba M, Ohta M, Kamiya K, Tanaka T, Suzuki S, Kitagawa K, Kitagawa M, Sugimura H and Konno H: Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors: sequential analyses. Cancer Sci 97(2): 127-132, 2006.
-
(2006)
Cancer Sci
, vol.97
, Issue.2
, pp. 127-132
-
-
Kikuchi, H.1
Yamashita, K.2
Kawabata, T.3
Yamamoto, M.4
Hiramatsu, Y.5
Kondo, K.6
Baba, M.7
Ohta, M.8
Kamiya, K.9
Tanaka, T.10
Suzuki, S.11
Kitagawa, K.12
Kitagawa, M.13
Sugimura, H.14
Konno, H.15
-
18
-
-
0033984319
-
Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
-
Dematteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM and Brennan MF: Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg 231(1): 51-58, 2000.
-
(2000)
Ann Surg
, vol.231
, Issue.1
, pp. 51-58
-
-
Dematteo, R.P.1
Lewis, J.J.2
Leung, D.3
Mudan, S.S.4
Woodruff, J.M.5
Brennan, M.F.6
-
19
-
-
0036769928
-
Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease
-
Roberts PJ and Eisenberg B: Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease. Eur J Cancer 38(Suppl 5): S37-38, 2002.
-
(2002)
Eur J Cancer
, vol.38
, Issue.SUPPL. 5
-
-
Roberts, P.J.1
Eisenberg, B.2
-
20
-
-
70450197345
-
Sunitinib: A multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies
-
Papaetis GS and Syrigos KN: Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies. BioDrugs 23(6): 377-389, 2009.
-
(2009)
BioDrugs
, vol.23
, Issue.6
, pp. 377-389
-
-
Papaetis, G.S.1
Syrigos, K.N.2
-
21
-
-
60849113175
-
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients
-
Gajiwala KS, Wu JC, Christensen J, Deshmukh GD, Diehl W, Dinitto JP, English JM, Greig MJ, He YA, Jacques SL, Lunney EA, Mctigue M, Molina D, Quenzer T, Wells PA, Yu X, Zhang Y, Zou A, Emmett MR, Marshall AG, Zhang HM and Demetri GD: KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc Natl Acad Sci USA 106(5): 1542-1547, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.5
, pp. 1542-1547
-
-
Gajiwala, K.S.1
Wu, J.C.2
Christensen, J.3
Deshmukh, G.D.4
Diehl, W.5
Dinitto, J.P.6
English, J.M.7
Greig, M.J.8
He, Y.A.9
Jacques, S.L.10
Lunney, E.A.11
Mctigue, M.12
Molina, D.13
Quenzer, T.14
Wells, P.A.15
Yu, X.16
Zhang, Y.17
Zou, A.18
Emmett, M.R.19
Marshall, A.G.20
Zhang, H.M.21
Demetri, G.D.22
more..
-
22
-
-
65349155963
-
Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene
-
Nishida T, Takahashi T, Nishitani A, Doi T, Shirao K, Komatsu Y, Nakajima K and Hirota S: Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene. Int J Clin Oncol 14(2): 143-149, 2009.
-
(2009)
Int J Clin Oncol
, vol.14
, Issue.2
, pp. 143-149
-
-
Nishida, T.1
Takahashi, T.2
Nishitani, A.3
Doi, T.4
Shirao, K.5
Komatsu, Y.6
Nakajima, K.7
Hirota, S.8
-
23
-
-
34247610583
-
Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor
-
Dematteo RP, Maki RG, Singer S, Gonen M, Brennan MF and Antonescu CR: Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor. Ann Surg 245(3): 347-352, 2007.
-
(2007)
Ann Surg
, vol.245
, Issue.3
, pp. 347-352
-
-
Dematteo, R.P.1
Maki, R.G.2
Singer, S.3
Gonen, M.4
Brennan, M.F.5
Antonescu, C.R.6
-
24
-
-
33744795769
-
Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors
-
Raut CP, Posner M, Desai J, Morgan JA, George S, Zahrieh D, Fletcher CD, Demetri GD and Bertagnolli MM: Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors. J Clin Oncol 24(15): 2325-2331, 2006.
-
(2006)
J Clin Oncol
, vol.24
, Issue.15
, pp. 2325-2331
-
-
Raut, C.P.1
Posner, M.2
Desai, J.3
Morgan, J.A.4
George, S.5
Zahrieh, D.6
Fletcher, C.D.7
Demetri, G.D.8
Bertagnolli, M.M.9
-
25
-
-
34247615184
-
Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/metastatic GIST
-
Gronchi A, Fiore M, Miselli F, Lagonigro MS, Coco P, Messina A, Pilotti S and Casali PG: Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/metastatic GIST. Ann Surg 245(3): 341-346, 2007.
-
(2007)
Ann Surg
, vol.245
, Issue.3
, pp. 341-346
-
-
Gronchi, A.1
Fiore, M.2
Miselli, F.3
Lagonigro, M.S.4
Coco, P.5
Messina, A.6
Pilotti, S.7
Casali, P.G.8
-
26
-
-
77149155973
-
Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate
-
Raut CP, Wang Q, Manola J, Morgan JA, George S, Wagner AJ, Butrynski JE, Fletcher CD, Demetri GD and Bertagnolli MM: Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate. Ann Surg Oncol 17(2): 407-415, 2010.
-
(2010)
Ann Surg Oncol
, vol.17
, Issue.2
, pp. 407-415
-
-
Raut, C.P.1
Wang, Q.2
Manola, J.3
Morgan, J.A.4
George, S.5
Wagner, A.J.6
Butrynski, J.E.7
Fletcher, C.D.8
Demetri, G.D.9
Bertagnolli, M.M.10
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