Cytotoxic antibodies monitoring in kidney transplantation - their clinical relevance and challenges

Romanian Journal of Morphology and Embryology

Volumn 53, Issue 3, 2012, Pages 515-519

  Gîngu, Constantin ^a   Moise, Ana ^a   Constantinescu, Ileana ^a   Serbanescu B ^a   Surcel, C ^a   Sinescu, I ^a  

^a CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Acute rejection; Anti HLA sensitization; Renal transplant

Indexed keywords

EID: 84867003065     PISSN: 12200522     EISSN: 20668279     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Murphey CL, Forsthuber TG. Trends in HLA antibody screening and identification and their role in transplantation, Expert Rev Clin Immunol, 2008, 4(3):391-399.
2. Akalin E, Dinavahi R, Friedlander R, Ames S, de Boccardo G, Sehgal V, Schröppel B, Bhaskaran M, Lerner S, Fotino M, Murphy B, Bromberg JS. Addition of plasmapheresis decreases the incidence of acute antibody-mediated rejection in sensitized patients with strong donor-specific antibodies, Clin J Am Soc Nephrol, 2008, 3(4):1160-1167.
3. Stegall MD, Gloor J, Winters JL, Moore SB, Degoey S. A comparison of plasmapheresis vs. high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody, Am J Transplant, 2006, 6(2):346-351.
4. Hickstein H, Korten G, Bast R, Barz D, Nizze H, Schmidt R. Immunoadsorption of sensitized kidney transplant candidates immediately prior to surgery, Clin Transplant, 2002, 16(2):97-101.
5. Mai ML, Ahsan N, Wadei HM, Genco PV, Geiger XJ, Willingham DL, Taner CB, Hewitt WR, Grewal HP, Nguyen JH, Hughes CB, Gonwa TA. Excellent renal allograft survival in donor-specific antibody positive transplant patients-role of intravenous immunoglobulin and rabbit antithymocyte globulin, Transplantation, 2009, 87(2):227-232.
6. Süsal C, Döhler B, Opelz G. Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk of graft failure: a Collaborative Transplant Study report, Hum Immunol, 2009, 70(8):569-573.
7. Süsal C, Opelz G. Kidney graft failure and presensitization against HLA class I and class II antigens, Transplantation, 2002, 73(8):1269-1273.
8. Süsal C, Opelz G. Good kidney transplant outcome in recipients with presensitization against HLA class II but not HLA class I, Hum Immunol, 2004, 65(8):810-816.
9. Süsal C, Pelzl S, Simon T, Opelz G. Advances in pre-and posttransplant immunologic testing in kidney transplantation, Transplant Proc, 2004, 36(1):29-34.
10. Halloran PF, Schlaut J, Solez K, Srinivasa NS. The significance of the anti-class I response. II. Clinical and pathologic features of renal transplants with anti-class I-like antibody, Transplantation, 1992, 53(3):550-555.
11. Pollinger HS, Stegall MD, Gloor JM, Moore SB, Degoey SR, Ploeger NA, Park WD, Pollinger HS, Stegall MD, Gloor JM, Moore SB, Degoey SR, Ploeger NA, Park WD. Kidney transplantation in patients with antibodies against donor HLA class II, Am J Transplant, 2007, 7(4):857-863.
12. Ghasemian SR, Light JA, Sasaki TA, Barhyte DY. Hyperacute rejection from antibody against class II HLA antigens, Clin Transplant, 1998, 12(6):569-571.
13. Thaunat O, Hanf W, Dubois V, McGregor B, Perrat G, Chauvet C, Touraine JL, Morelon E. Chronic humoral rejection mediated by anti-HLA-DP alloantibodies: insights into the role of epitope sharing in donor-specific and nondonor specific alloantibodies generation, Transpl Immunol, 2009, 20(4):209-211.
14. Mytilineos J, Deufel A, Opelz G. Clinical relevance of HLADPB locus matching for cadaver kidney retransplants: a report of the Collaborative Transplant Study, Transplantation, 1997, 63(9):1351-1354.
15. Billen EVA, Christiaans MHL, Doxiadis IIN, Voorter CEM, van den Berg-Loonen EM. HLA-DP antibodies before and after renal transplantation, Tissue Antigens, 2010, 75(3):278-285.
16. Muczynski KA, Cotner T, Anderson SK. Unusual expression of human lymphocyte antigen class II in normal renal microvascular endothelium, Kidney Int, 2001, 59(2):488-497.
17. Muczynski KA, Ekle DM, Coder DM, Anderson SK. Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression, J Am Soc Nephrol, 2003, 14(5): 1336-1348.
18. Martin S, Dyer PA, Mallick NP, Gokal R, Harris R, Johnson RW. Posttransplant antidonor lymphocytotoxic antibody production in relation to graft outcome, Transplantation, 1987, 44(1):50-53.
19. Scornik JC, Salomon DR, Lim PB, Howard RJ, Pfaff WW. Posttransplant antidonor antibodies and graft rejection. Evaluation by two-color flow cytometry, Transplantation, 1989, 47(2):287-290.
20. Müller-Steinhardt M, Fricke L, Kirchner H, Hoyer J, Klüter H. Monitoring of anti-HLA class I and II antibodies by flow cytometry in patients after first cadaveric kidney transplantation, Clin Transplant, 2000, 14(1):85-89.
21. Supon P, Constantino D, Hao P, Cagle L, Hahn A, Conti DJ, Freed BM. Prevalence of donor-specific anti-HLA antibodies during episodes of renal allograft rejection, Transplantation, 2001, 71(4):577-580.
22. Piazza A, Poggi E, Borrelli L, Servetti S, Monaco PI, Buonomo O, Valeri M, Torlone N, Adorno D, Casciani CU. Impact of donor-specific antibodies on chronic rejection occurrence and graft loss in renal transplantation: posttransplant analysis using flow cytometric techniques, Transplantation, 2001, 71(8):1106-1112.
23. Hourmant M, Cesbron-Gautier A, Terasaki PI, Mizutani K, Moreau A, Meurette A, Dantal J, Giral M, Blancho G, Cantarovich D, Karam G, Follea G, Soulillou JP, Bignon JD. Frequency and clinical implications of development of donorspecific and non-donor-specific HLA antibodies after kidney transplantation, J Am Soc Nephrol, 2005, 16(9):2804-2812.
24. Mizutani K, Terasaki P, Rosen A, Esquenazi V, Miller J, Shih RN, Pei R, Ozawa M, Lee J. Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure, Am J Transplant, 2005, 5(9):2265-2272.
25. Gebel HM, Harris SB, Zibari G, Bray RA. Conundrums with FlowPRA beads, Clin Transplant, 2002, 16(Suppl 7):24-29.
26. Seveso M, Bosio E, Ancona E, Cozzi E. De novo anti-HLA antibody responses after renal transplantation: detection and clinical impact, Contrib Nephrol, 2009, 162:87-98.
27. Hwang SH, Oh HB, Shin ES, Yew M, Kim SC, Han DJ. Influence of mismatching of HLA cross-reactive groups on cadaveric kidney transplantation, Transplant Proc, 2005, 37(10):4194-4198.
28. Lazda VA, Mozes MF. An evaluation of HLA cross-reactive group matching on graft survival in deceased donor kidney recipients, Transplant Proc, 2005, 37(2):661-663.
29. Laux G, Opelz G. Immunological relevance of CREG matching in cadaver kidney transplantation, Transplantation, 2004, 78(3):442-446.
30. Meng HL, Jin XB, Li XT, Wang HW, Lü JJ. Impact of human leukocyte antigen matching and recipients' panel reactive antibodies on two-year outcome in presensitized renal allograft recipients, Chin Med J, 2009, 122(4):420-426.
31. Su X, Zenios SA, Chakkera H, Milford EL, Chertow GM. Diminishing significance of HLA matching in kidney transplantation, Am J Transplant, 2004, 4(9):1501-1508.
32. Martins L, Fonseca I, Sousa S, Matos C, Santos J, Dias L, Henriques AC, Sarmento AM, Cabrita A. The influence of HLA mismatches and immunosuppression on kidney graft survival: an analysis of more than 1300 patients, Transplant Proc, 2007, 39(8):2489-2493.