Unusual expression of human lymphocyte antigen class II in normal renal microvascular endothelium

Kidney International

Volumn 59, Issue 2, 2001, Pages 488-497

  Muczynski, Kimberly A ^a   Cotner, Tom ^a   Anderson, Susan K ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; CD4+ T cells; CIITA transcription factor; DR expression; Gene expression; Immune system; Major histocompatibility

Indexed keywords

ANTIBODY; CD4 ANTIGEN; HLA ANTIGEN CLASS 2; HLA DM ANTIGEN; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; MESSENGER RNA;

ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; KIDNEY CORTEX; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

EID: 0035134842     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.059002488.x     Document Type: Article

References (59)

1. Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon
2. Intracellular transport of class II MHC molecules directed by invariant chain
3. Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus
4. Chemistry and functional role of the invariant chain
5. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides
6. Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment
7. Intracellular assembly and transport of endogenous peptide-MHC class II complexes
8. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments
9. Mediation by HLA-DM of dissociation of peptides from HLA-DR
10. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
11. HLA-DM: An in vivo facilitator of MHC class II peptide loading
12. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
13. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA
14. Class II transactivator regulates the expression of multiple genes involved in antigen presentation
15. A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)
16. A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
17. RFXAP a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency
18. Expression of Ia-like antigens on the vasculature of human kidney
19. Localization of HLA-ABC and DR antigens in human kidney
20. Vascular and renal distribution of HLA-DR-like antigens
21. The immunohistochemical demonstration of major histocompatibility antigens in the human kidney using monoclonal antibodies
22. Expression of HLA-DQ-DR, and -DP antigens in normal kidney and glomerulonephritis
23. Expression of major histocompatibility complex (MHC) class II antigens and HLA-DR incompatibility
24. Vascular endothelial cell expression of adhesion molecules and HLA antigens in renal allografts
25. Immunopathology of renal allograft rejection analyzed with monoclonal antibodies to mononuclear cell markers
26. Increased expression of HLA-DR antigens on renal tubular cells in renal transplants: Relevance to the rejection response
27. Antigen presentation by renal tubular epithelial cells
28. Mononuclear leukocytes, expression of HLA class II antigens and intercellular adhesion molecule I in focal segmental glomerulosclerosis
29. Characterization of mononuclear cell subsets in renal cellular interstitial infiltrates
30. Regulation of the costimulater B7, not class II major histocompatibility complex, restricts the ability of murine kidney tubule cells to stimulate CD4+ T cells
31. Interferon-gammatreated renal tubular epithelial cells induce allospecific tolerance
32. Stimulated renal tubular epithelial cells induce anergy in CD4+ T cells
33. Processing and presentation of self and foreign antigens by the renal proximal tubule
34. Two populations of Ia-like molecules on a human B cell line
35. HLA-DC antigens can serve as recognition elements for human cytotoxic T lymphocytes
36. Detection of a novel human class II HLA antigen
37. Discoordinate surface expression of IFN-gamma-induced HLA class II proteins in nonprofessional antigen-presenting cells with absence of DM and class II colocalization
38. Cell adhesion molecules on vessels during inflammation in the mouse central nervous system
39. Ribonucleic acid isolated by cesium chloride centrifugation
40. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
41. Molecular and functional aspects of PECAM-1/CD 31
42. Class II transactivator-independent endothelial cell MHC class II gone activation induced by lymphocyte adhesion
43. Expression of Ia antigens by murine kidney epithelium after exposure to streptozotocin
44. IFN-gamma mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis
45. Major histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis
46. Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD 4 but not CD8 cells
47. Active suppression of the class II transactivator-encoding AIR- 1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells
48. CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant
49. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
50. Perspectives: Immunology: Regulating the regulator
51. Isolation of a B-cell-specific promoter for the human class II transactivator
52. Identification of distinct regions of 5′ flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II trans-activator gene
53. Discoordinate expression of invariant chain and MHC class II genes in class II transactivator-transfected fibroblasts defective for RFX 5
54. Contact-dependent endothelial class II HLA gone activation induced by NK cells is mediated by IFN-gamma-dependent and -independent mechanisms
55. Phenotypic characterization of alveolar capillary endothelial cells, alveolar epithelial cells and alveolar macrophages in patients with pulmonary fibrosis, with special reference to MHC class II antigens
56. The detailed distribution of MHC Class II antigens in normal human organs
57. Antigenic heterogeneity of vascular endothelium
58. MHC class II expression on human heart microvascular endothelial cells: Exquisite sensitivity to interferon-gamma and natural killer cells
59. Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants