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Volumn 20, Issue 10, 2012, Pages 1932-1943

Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GANCICLOVIR; RETROVIRUS VECTOR; THYMIDINE KINASE;

EID: 84866989041     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.166     Document Type: Article
Times cited : (22)

References (51)
  • 2
    • 33645734405 scopus 로고    scopus 로고
    • Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
    • Ott, MG, Schmidt, M, Schwarzwaelder, K, Stein, S, Siler, U, Koehl, U et al. (2006). Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med 12: 401-409.
    • (2006) Nat Med , vol.12 , pp. 401-409
    • Ott, M.G.1    Schmidt, M.2    Schwarzwaelder, K.3    Stein, S.4    Siler, U.5    Koehl, U.6
  • 4
    • 70449427834 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    • Cartier, N, Hacein-Bey-Abina, S, Bartholomae, CC, Veres, G, Schmidt, M, Kutschera, I et al. (2009). Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 326: 818-823.
    • (2009) Science , vol.326 , pp. 818-823
    • Cartier, N.1    Hacein-Bey-Abina, S.2    Bartholomae, C.C.3    Veres, G.4    Schmidt Kutschera M, I.5
  • 5
    • 77956928344 scopus 로고    scopus 로고
    • Transfusion independence and HMGA2 activation after gene therapy of human ß-thalassaemia
    • Cavazzana-Calvo, M, Payen, E, Negre, O, Wang, G, Hehir, K, Fusil, F et al. (2010). Transfusion independence and HMGA2 activation after gene therapy of human ß-thalassaemia. Nature 467: 318-322.
    • (2010) Nature , vol.467 , pp. 318-322
    • Cavazzana-Calvo, M.1    Payen, E.2    Negre, O.3    Wang, G.4    Hehir, K.5    Fusil, F.6
  • 6
    • 80052050274 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene therapy for adenosine deaminase-defcient severe combined immunodefciency leads to long-term immunological recovery and metabolic correction
    • Gaspar, HB, Cooray, S, Gilmour, KC, Parsley, KL, Zhang, F, Adams, S et al. (2011). Hematopoietic stem cell gene therapy for adenosine deaminase-defcient severe combined immunodefciency leads to long-term immunological recovery and metabolic correction. Sci Transl Med 3: 97ra80.
    • (2011) Sci Transl Med , vol.3
    • Gaspar, H.B.1    Cooray, S.2    Gilmour, K.C.3    Parsley, K.L.4    Zhang, F.5    Adams, S.6
  • 7
    • 80052050274 scopus 로고    scopus 로고
    • Longterm persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodefciency
    • Gaspar, HB, Cooray, S, Gilmour, KC, Parsley, KL, Adams, S, Howe, SJet al. (2011) Longterm persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodefciency. Sci Transl Med; 3: 97ra79.
    • (2011) Sci Transl Med , vol.3
    • Gaspar, H.B.1    Cooray, S.2    Gilmour, K.C.3    Parsley, K.L.4    Adams, S.5    Howe, S.J.6
  • 10
    • 21144437399 scopus 로고    scopus 로고
    • Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis
    • Modlich, U, Kustikova, OS, Schmidt, M, Rudolph, C, Meyer, J, Li, Z et al. (2005). Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis. Blood 105: 4235-4246.
    • (2005) Blood , vol.105 , pp. 4235-4246
    • Modlich, U.1    Kustikova, O.S.2    Schmidt, M.3    Rudolph, C.4    Meyer, J.5    Li, Z.6
  • 11
    • 21044448037 scopus 로고    scopus 로고
    • Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking
    • Kustikova, O, Fehse, B, Modlich, U, Yang, M, Düllmann, J, Kamino, K et al. (2005). Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science 308: 1171-1174.
    • (2005) Science , vol.308 , pp. 1171-1174
    • Kustikova, O.1    Fehse, B.2    Modlich, U.3    Yang, M.4    Düllmann, J.5    Kamino, K.6
  • 12
    • 51349090473 scopus 로고    scopus 로고
    • Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
    • Hacein-Bey-Abina, S, Garrigue, A, Wang, G P, Soulier, J, Lim, A, Morillon, E et al. (2008). Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 118: 3132-3142.
    • (2008) J Clin Invest , vol.118 , pp. 3132-3142
    • Hacein-Bey-Abina, S.1    Garrigue, A.2    Wang, G.P.3    Soulier, J.4    Lim, A.5    Morillon, E.6
  • 13
    • 51349158298 scopus 로고    scopus 로고
    • Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
    • Howe, SJ, Mansour, MR, Schwarzwaelder, K, Bartholomae, C, Hubank, M, Kempski, H et al. (2008). Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest 118: 3143-3150.
    • (2008) J Clin Invest , vol.118 , pp. 3143-3150
    • Howe, S.J.1    Mansour, M.R.2    Schwarzwaelder, K.3    Bartholomae, C.4    Hubank, M.5    Kempski, H.6
  • 15
    • 70449127230 scopus 로고    scopus 로고
    • Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors
    • Modlich, U, Navarro, S, Zychlinski, D, Maetzig, T, Knoess, S, Brugman, MH et al. (2009). Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. Mol Ther 17: 1919-1928.
    • (2009) Mol Ther , vol.17 , pp. 1919-1928
    • Modlich, U.1    Navarro, S.2    Zychlinski, D.3    Maetzig, T.4    Knoess, S.5    Brugman, M.H.6
  • 16
    • 0036099418 scopus 로고    scopus 로고
    • Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors
    • Yannaki, E, Tubb, J, Aker, M, Stamatoyannopoulos, G and Emery, DW (2002). Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors. Mol Ther 5(5 Pt 1): 589-598.
    • (2002) Mol Ther , vol.5 , Issue.5 PART 1 , pp. 589-598
    • Yannaki, E.1    Tubb, J.2    Aker, M.3    Stamatoyannopoulos, G.4    Emery, D.W.5
  • 17
    • 58049220057 scopus 로고    scopus 로고
    • Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential
    • Ramezani, A, Hawley, TS and Hawley, RG (2008). Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential. Stem Cells 26: 3257-3266.
    • (2008) Stem Cells , vol.26 , pp. 3257-3266
    • Ramezani, A.1    Hawley, T.S.2    Hawley, R.G.3
  • 18
    • 79958288056 scopus 로고    scopus 로고
    • Treatment of canine leukocyte adhesion defciency by foamy virus vectors expressing CD18 from a PGK promoter
    • Bauer, TR Jr, Olson, EM, Huo, Y, Tuschong, LM, Allen, JM, Li, Y et al. (2011). Treatment of canine leukocyte adhesion defciency by foamy virus vectors expressing CD18 from a PGK promoter. Gene Ther 18: 553-559.
    • (2011) Gene Ther , vol.18 , pp. 553-559
    • Bauer Jr., T.R.1    Olson, E.M.2    Huo, Y.3    Tuschong, L.M.4    Allen, J.M.5    Li, Y.6
  • 19
    • 50549096864 scopus 로고    scopus 로고
    • Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors
    • Hu, J, Renaud, G, Gomes, TJ, Golmes, T, Ferris, A, Hendrie, PC et al. (2008). Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors. Mol Ther 16: 1617-1623.
    • (2008) Mol Ther , vol.16 , pp. 1617-1623
    • Hu, J.1    Renaud, G.2    Gomes, T.J.3    Golmes, T.4    Ferris, A.5    Hendrie, P.C.6
  • 20
    • 80053350622 scopus 로고    scopus 로고
    • Site-specifc integration and tailoring of cassette design for sustainable gene transfer
    • Lombardo, A, Cesana, D, Genovese, P, Di Stefano, B, Provasi, E, Colombo, DF et al. (2011). Site-specifc integration and tailoring of cassette design for sustainable gene transfer. Nat Methods 8: 861-869.
    • (2011) Nat Methods , vol.8 , pp. 861-869
    • Lombardo, A.1    Cesana, D.2    Genovese, P.3    Di Stefano, B.4    Provasi, E.5    Colombo, D.F.6
  • 21
    • 79953844921 scopus 로고    scopus 로고
    • Genotoxicity of retroviral hematopoietic stem cell gene therapy
    • Trobridge, GD (2011). Genotoxicity of retroviral hematopoietic stem cell gene therapy. Expert Opin Biol Ther 11: 581-593.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 581-593
    • Trobridge, G.D.1
  • 22
    • 34250718593 scopus 로고    scopus 로고
    • The suicide gene therapy challenge: How to improve a successful gene therapy approach
    • Bonini, C, Bondanza, A, Perna, SK, Kaneko, S, Traversari, C, Ciceri, F et al. (2007). The suicide gene therapy challenge: how to improve a successful gene therapy approach. Mol Ther 15: 1248-1252.
    • (2007) Mol Ther , vol.15 , pp. 1248-1252
    • Bonini, C.1    Bondanza, A.2    Perna, S.K.3    Kaneko, S.4    Traversari, C.5    Ciceri, F.6
  • 23
    • 0034041950 scopus 로고    scopus 로고
    • Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer
    • Shalev, M, Kadmon, D, Teh, BS, Butler, EB, Aguilar-Cordova, E, Thompson, TC et al. (2000). Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer. J Urol 163: 1747-1750.
    • (2000) J Urol , vol.163 , pp. 1747-1750
    • Shalev, M.1    Kadmon, D.2    Teh, B.S.3    Butler, E.B.4    Aguilar-Cordova, E.5    Thompson, T.C.6
  • 24
    • 7044235842 scopus 로고    scopus 로고
    • AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomised, controlled study
    • Immonen, A, Vapalahti, M, Tyynelä, K, Hurskainen, H, Sandmair, A, Vanninen, R et al. (2004). AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study. Mol Ther 10: 967-972.
    • (2004) Mol Ther , vol.10 , pp. 967-972
    • Immonen, A.1    Vapalahti, M.2    Tyynelä, K.3    Hurskainen, H.4    Sandmair, A.5    Vanninen, R.6
  • 25
    • 0030843493 scopus 로고    scopus 로고
    • HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
    • Bonini, C, Ferrari, G, Verzeletti, S, Servida, P, Zappone, E, Ruggieri, L et al. (1997). HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276: 1719-1724.
    • (1997) Science , vol.276 , pp. 1719-1724
    • Bonini, C.1    Ferrari, G.2    Verzeletti, S.3    Servida, P.4    Zappone, E.5    Ruggieri, L.6
  • 26
    • 65349157330 scopus 로고    scopus 로고
    • Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): A non-randomised phase I-II study
    • Ciceri, F, Bonini, C, Stanghellini, MT, Bondanza, A, Traversari, C, Salomoni, M et al. (2009). Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study. Lancet Oncol 10: 489-500.
    • (2009) Lancet Oncol , vol.10 , pp. 489-500
    • Ciceri, F.1    Bonini, C.2    Stanghellini, M.T.3    Bondanza, A.4    Traversari, C.5    Salomoni, M.6
  • 28
    • 0034694011 scopus 로고    scopus 로고
    • A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
    • Rainov, NG (2000). A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 11: 2389-2401.
    • (2000) Hum Gene Ther , vol.11 , pp. 2389-2401
    • Rainov, N.G.1
  • 29
    • 0036319775 scopus 로고    scopus 로고
    • Suicide gene transduction sensitizes murine embryonic and human mesenchymal stem cells to ablation on demand-a fail-safe protection against cellular misbehavior
    • Fareed, MU and Moolten, FL (2002). Suicide gene transduction sensitizes murine embryonic and human mesenchymal stem cells to ablation on demand-a fail-safe protection against cellular misbehavior. Gene Ther 9: 955-962.
    • (2002) Gene Ther , vol.9 , pp. 955-962
    • Fareed, M.U.1    Moolten, F.L.2
  • 30
    • 70349849524 scopus 로고    scopus 로고
    • Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates
    • Menzel, O, Birraux, J, Wildhaber, BE, Jond, C, Lasne, F, Habre, W et al. (2009). Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates. Mol Ther 17: 1754-1760.
    • (2009) Mol Ther , vol.17 , pp. 1754-1760
    • Menzel, O.1    Birraux, J.2    Wildhaber, B.E.3    Jond, C.4    Lasne, F.5    Habre, W.6
  • 31
    • 37149040112 scopus 로고    scopus 로고
    • Ablation of tumor-derived stem cells transplanted to the central nervous system by genetic modifcation of embryonic stem cells with a suicide gene
    • Jung, J, Hackett, NR, Pergolizzi, RG, Pierre-Destine, L, Krause, A and Crystal, RG (2007). Ablation of tumor-derived stem cells transplanted to the central nervous system by genetic modifcation of embryonic stem cells with a suicide gene. Hum Gene Ther 18: 1182-1192.
    • (2007) Hum Gene Ther , vol.18 , pp. 1182-1192
    • Jung, J.1    Hackett, N.R.2    Pergolizzi, R.G.3    Pierre-Destine, L.4    Krause, A.5    Crystal, R.G.6
  • 32
  • 33
    • 70349333986 scopus 로고    scopus 로고
    • Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU
    • Dotti, G, Tian, M, Savoldo, B, Najjar, A, Cooper, LJ, Jackson, J et al. (2009). Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU. Mol Imaging 8: 230-237.
    • (2009) Mol Imaging , vol.8 , pp. 230-237
    • Dotti, G.1    Tian, M.2    Savoldo, B.3    Najjar, A.4    Cooper, L.J.5    Jackson, J.6
  • 35
    • 0032950813 scopus 로고    scopus 로고
    • Production and culture of HSVtk transduced suicidal lymphocytes induces variable changes in the lymphocyte subset composition
    • rd and Kornblau, SM (1999). Production and culture of HSVtk transduced suicidal lymphocytes induces variable changes in the lymphocyte subset composition. Bone Marrow Transplant 23: 907-915.
    • (1999) Bone Marrow Transplant , vol.23 , pp. 907-915
    • Marini III, F.C.1    Kornblau, S.M.2
  • 36
    • 0035174929 scopus 로고    scopus 로고
    • Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene
    • Garin, MI, Garrett, E, Tiberghien, P, Apperley, JF, Chalmers, D, Melo, JV et al. (2001). Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene. Blood 97: 122-129.
    • (2001) Blood , vol.97 , pp. 122-129
    • Garin, M.I.1    Garrett, E.2    Tiberghien, P.3    Apperley, J.F.4    Chalmers, D.5    Melo, J.V.6
  • 37
    • 0035300565 scopus 로고    scopus 로고
    • Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing
    • Black, ME, Kokoris, MS and Sabo, P (2001). Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing. Cancer Res 61: 3022-3026.
    • (2001) Cancer Res , vol.61 , pp. 3022-3026
    • Black, M.E.1    Kokoris, M.S.2    Sabo, P.3
  • 38
    • 0036708008 scopus 로고    scopus 로고
    • Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity
    • Kokoris, MS and Black, ME (2002). Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity. Protein Sci 11: 2267-2272.
    • (2002) Protein Sci , vol.11 , pp. 2267-2272
    • Kokoris, M.S.1    Black, M.E.2
  • 39
    • 0034192255 scopus 로고    scopus 로고
    • Importance of the CD3 marker for evaluating changes in rhesus macaque CD4/CD8 T-cell ratios
    • Dykhuizen, M, Ceman, J, Mitchen, J, Zayas, M, MacDougall, A, Helgeland, J et al. (2000). Importance of the CD3 marker for evaluating changes in rhesus macaque CD4/CD8 T-cell ratios. Cytometry 40: 69-75.
    • (2000) Cytometry , vol.40 , pp. 69-75
    • Dykhuizen, M.1    Ceman, J.2    Mitchen, J.3    Zayas, M.4    MacDougall, A.5    Helgeland, J.6
  • 40
    • 0034199170 scopus 로고    scopus 로고
    • Introduction of a xenogeneic gene via hematopoietic stem cells leads to specifc tolerance in a rhesus monkey model
    • Heim, DA, Hanazono, Y, Giri, N, Wu, T, Childs, R, Sellers, SE et al. (2000). Introduction of a xenogeneic gene via hematopoietic stem cells leads to specifc tolerance in a rhesus monkey model. Mol Ther 1: 533-544.
    • (2000) Mol Ther , vol.1 , pp. 533-544
    • Heim, D.A.1    Hanazono, Y.2    Giri, N.3    Wu, T.4    Childs, R.5    Sellers, S.E.6
  • 41
    • 0346656767 scopus 로고    scopus 로고
    • Induction of transgene-specifc immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells
    • Kung, SK, An, DS, Bonifacino, A, Metzger, ME, Ringpis, GE, Mao, SH et al. (2003). Induction of transgene-specifc immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells. Mol Ther 8: 981-991.
    • (2003) Mol Ther , vol.8 , pp. 981-991
    • Kung, S.K.1    An, D.S.2    Bonifacino, A.3    Metzger, M.E.4    Ringpis, G.E.5    Mao, S.H.6
  • 42
    • 0032505705 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: Clinical follow-up and improved new vectors
    • Verzeletti, S, Bonini, C, Marktel, S, Nobili, N, Ciceri, F, Traversari, C et al. (1998). Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors. Hum Gene Ther 9: 2243-2251.
    • (1998) Hum Gene Ther , vol.9 , pp. 2243-2251
    • Verzeletti, S.1    Bonini, C.2    Marktel, S.3    Nobili, N.4    Ciceri, F.5    Traversari, C.6
  • 43
    • 0037457060 scopus 로고    scopus 로고
    • Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion
    • Herraiz, M, Beraza, N, Solano, A, Sangro, B, Montoya, J, Qian, C et al. (2003). Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion. Hum Gene Ther 14: 463-472.
    • (2003) Hum Gene Ther , vol.14 , pp. 463-472
    • Herraiz, M.1    Beraza, N.2    Solano, A.3    Sangro, B.4    Montoya, J.5    Qian, C.6
  • 44
    • 0037108189 scopus 로고    scopus 로고
    • Polyclonal long-term repopulating stem cell clones in a primate model
    • Schmidt, M, Zickler, P, Hoffmann, G, Haas, S, Wissler, M, Muessig, A et al. (2002). Polyclonal long-term repopulating stem cell clones in a primate model. Blood 100: 2737-2743.
    • (2002) Blood , vol.100 , pp. 2737-2743
    • Schmidt, M.1    Zickler, P.2    Hoffmann, G.3    Haas, S.4    Wissler, M.5    Muessig, A.6
  • 45
    • 0345144017 scopus 로고    scopus 로고
    • Clonality analysis after retroviral-mediated gene transfer to CD34 cells from the cord blood of ADA-defcient SCID neonates
    • Schmidt, M, Carbonaro, DA, Speckmann, C, Wissler, M, Bohnsack, J, Elder, M et al. (2003). Clonality analysis after retroviral-mediated gene transfer to CD34 cells from the cord blood of ADA-defcient SCID neonates. Nat Med 9: 463-468.
    • (2003) Nat Med , vol.9 , pp. 463-468
    • Schmidt, M.1    Carbonaro, D.A.2    Speckmann, C.3    Wissler, M.4    Bohnsack, J.5    Elder, M.6
  • 46
    • 39849110286 scopus 로고    scopus 로고
    • Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodefciency
    • Thornhill, SI, Schambach, A, Howe, SJ, Ulaganathan, M, Grassman, E, Williams, D et al. (2008). Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodefciency. Mol Ther 16: 590-598.
    • (2008) Mol Ther , vol.16 , pp. 590-598
    • Thornhill, S.I.1    Schambach, A.2    Howe, S.J.3    Ulaganathan, M.4    Grassman, E.5    Williams, D.6
  • 47
    • 77956502744 scopus 로고    scopus 로고
    • A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells
    • Zhou, S, Mody, D, DeRavin, SS, Hauer, J, Lu, T, Ma, Z et al. (2010). A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. Blood 116: 900-908.
    • (2010) Blood , vol.116 , pp. 900-908
    • Zhou, S.1    Mody, D.2    Deravin, S.S.3    Hauer, J.4    Lu, T.5    Ma, Z.6
  • 48
    • 9444260942 scopus 로고    scopus 로고
    • Tumor cells escape suicide gene therapy by genetic and epigenetic instability
    • Frank, O, Rudolph, C, Heberlein, C, von Neuhoff, N, Schröck, E, Schambach, A et al. (2004). Tumor cells escape suicide gene therapy by genetic and epigenetic instability. Blood 104: 3543-3549.
    • (2004) Blood , vol.104 , pp. 3543-3549
    • Frank, O.1    Rudolph, C.2    Heberlein, C.3    Von Neuhoff, N.4    Schröck, E.5    Schambach, A.6
  • 50
    • 44449118404 scopus 로고    scopus 로고
    • Large animal models for stem and progenitor cell analysis
    • Chapter 22: Unit 22A.1
    • Donahue, RE, Kuramoto, K and Dunbar, CE (2005). Large animal models for stem and progenitor cell analysis. Curr Protoc Immunol Chapter 22: Unit 22A.1.
    • (2005) Curr Protoc Immunol
    • Donahue, R.E.1    Kuramoto, K.2    Dunbar, C.E.3


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