Hypocholesterolemic effects of lactic acid-fermented soymilk on rats fed a high cholesterol diet

Nutrients

Volumn 4, Issue 9, 2012, Pages 1304-1316

  Kobayashi, Maki ^a   Hirahata, Rie ^a   Egusa, Shintaro ^b   Fukuda, Mitsuru ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b Marusan ai Co Ltd   (Japan)

Author keywords

Cholesterol; Fermented soymilk; Lipid metabolism

Indexed keywords

CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; LACTIC ACID; SOYBEAN PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CYTOCHROME P450 FAMILY 7 SUBFAMILY A POLYPEPTIDE 1 GENE; DOWN REGULATION; FERMENTATION INHIBITION; FERMENTED PRODUCT; GENE; GENE EXPRESSION REGULATION; HYPOCHOLESTEROLEMIA; INTRAABDOMINAL FAT; LIVER WEIGHT; MALE; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; SOYBEAN MILK; STEROL REGULATORY ELEMENT BINDING PROTEIN 2 GENE; SUBCUTANEOUS FAT; UPREGULATION;

RATTUS;

EID: 84866910880     PISSN: 20726643     EISSN: None     Source Type: Journal    
DOI: 10.3390/nu4091304     Document Type: Article

References (35)

1. Napoli, C.; Crudele, V.; Soricelli, A.; Al-Omran, M.; Vitale, N.; Infante, T.; Mancini, F.P. Primary prevention of atherosclerosis: A clinical challenge for the reversal of epigenetic mechanisms? Circulation 2012, 125, 2363-2373.
2. Kannel, W.B.; Castelli, W.P.; Gordon, T.; McNamara, P.M. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. Ann. Intern. Med. 1971, 74, 1-12.
3. Ross, R.; Harker, L. Hyperlipidemia and atherosclerosis. Science 1976, 193, 1094-1100.
4. Golbitz, P. Traditional soyfoods: Processing and products. J. Nutr. 1995, 125, 570S-572S.
5. Carroll, K.K. Review of clinical studies on cholesterol-lowering response to soy protein. J. Am. Diet. Assoc. 1991, 91, 820-827.
6. Kritchevsky, D. Dietary protein and experimental atherosclerosis. Ann. N. Y. Acad. Sci. 1993, 676, 180-187.
7. Sirtori, C.R.; Lovati, M.R.; Manzoni, C.; Monetti, M.; Pazzucconi, F.; Gatti, E. Soy and cholesterol reduction: Clinical experience. J. Nutr. 1995, 125, 598S-605S.
8. Sugano, M.; Koba, K. Dietary protein and lipid metabolism: A multifunctional effect. Ann. N. Y. Acad. Sci. 1993, 676, 215-222.
9. Lin, Y.; Meijer, G.W.; Vermeer, M.A.; Trautwein, E.A. Soy protein enhances the cholesterol-owering effect of plant sterol esters in cholesterol-fed hamsters. J. Nutr. 2004, 134, 143-148.
10. Moriyama, T.; Kishimoto, K.; Nagai, K.; Urade, R.; Ogawa, T.; Utsumi, S.; Maruyama, N.; Maebuchi, M. Soybean beta-conglycinin diet suppresses serum triglyceride levels in normal and genetically obese mice by induction of beta-oxidation, downregulation of fatty acid synthase, and inhibition of triglyceride absorption. Biosci. Biotechnol. Biochem. 2004, 68, 352-359.
11. Ascencio, C.; Torres, N.; Isoard-Acosta, F.; Gómez-Pérez, F.J.; Hernández-Pando, R.; Tovar, A.R. Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J. Nutr. 2004, 134, 522-529.
12. Wang, Y.; Jones, P.J.; Ausman, L.M.; Lichtenstein, A.H. Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects. Atherosclerosis 2004, 173, 69-75.
13. Taku, K.; Umegaki, K.; Sato, Y.; Taki, Y.; Endoh, K.; Watanabe, S. Soy isoflavones lower serum total and LDL cholesterol in humans: A meta-analysis of 11 randomized controlled trials. Am. J. Clin. Nutr. 2007, 85, 1148-1156.
14. Demonty, I.; Lamarch, B.; Jones, P.J. Role of isoflavones in the hypocholesterolemic effect of soy. Nutr. Rev. 2003, 61, 189-203.
15. Chen, J.R.; Liu, S.M.; Yang, S.C.; Suetsuna, K. Soymilk intake is associated with plasma and liver lipid profiles in rats fed a high-cholesterol diet. Nutrition 2004, 20, 929-933.
16. Choi, J.Y.; Jeon, J.E.; Jang, S.Y.; Jeong, Y.J.; Jeon, S.M.; Park, H.J.; Choi, M.S. Differential effects of powdered whole soy milk and its hydrolysate on antiobesity and antihyperlipidemic response to high-fat treatment in C57BL/6N mice. J. Agric. Food. Chem. 2011, 59, 2584-2591.
17. Kikuchi-Hayakawa, H.; Onodera, N.; Matsubara, S.; Yasuda, E.; Chonan, O.; Takahashi, R.; Ishikawa, F. Effects of soy milk and bifidobacterium fermented soy milk on lipid metabolism in aged ovariectomized rats. Biosci. Biotechnol. Biochem. 1998, 62, 1688-1692.
18. Kikuchi-Hayakawa, H.; Onodera, N.; Matsubara, S.; Yasuda, E.; Shimakawa, Y.; Ishikawa, F. Effects of soya milk and Bifidobacterium-fermented soya milk on plasma and liver lipids, and faecal steroids in hamsters fed on a cholesterol-free or cholesterol-enriched diet. Br. J. Nutr. 1998, 79, 97-105.
19. Kitawaki, R.; Nishimura, Y.; Takagi, N.; Iwasaki, M.; Tsuzuki, K.; Fukuda, M. Effects of Lactobacillus fermented soymilk and soy yogurt on hepatic lipid accumulation in rats fed a cholesterol-free diet. Biosci. Biotechnol. Biochem. 2009, 73, 1484-1488.
20. Kobayashi, M.; Harada, T.; Takagi, N.; Tsuzuki, K.; Sugawara, M.; Fukuda, M. Effects of lactic acid-fermented soymilk on lipid metabolism-related gene expression in rat liver. Biosci. Biotechnol. Biochem. 2012, 76, 19-24.
21. Reeves, P.G.; Nielsen, F.H.; Fahey, G.C., Jr. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 1993, 123, 1939-1951.
22. Folch, J.; Lees, M.; Sloane Stanley, G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957, 226, 497-509.
23. Harada, T.; Tanaka, M.; Tsuzuki, K.; Sugawara, M.; Takagi, N.; Fukuda, M. Effective Dosage of Lactic Fermented Soymilk for Improving Lipid Metabolism in Rats (in Japanese). Nippon Shokuhin Kagaku Kogaku Kaishi 2010, 57, 175-179.
24. Tovar, A.R.; Murguia, F.; Cruz, C.; Hernandez-Pando, R.; Aguilar, S.C.A.; Pedraza-Chaverri, J.; Correa-Rotter, R.; Torres, N. A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephrotic syndrome. J. Nutr. 2002, 132, 2562-2569.
25. Torres, N.; Torre-Villalvazo, I.; Tovar, A.R. Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders. J. Nutr. Biochem. 2006, 17, 365-373.
26. Simmen, F.A.; Mercado, C.P.; Zavacki, A.M.; Huang, S.A.; Greenway, A.D.; Kang, P.; Bowman, M.T.; Prior, R.L. Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat. J. Nutr. Biochem. 2010, 21, 1106-1113.
27. Nagata, Y.; Tanaka, K.; Sugano, M. Further studies on the hypocholesterolaemic effect ofsoya-bean protein in rats. Br. J. Nutr. 1981, 45, 233-241.
28. Nagaoka, S.; Awano, T.; Nagata, N.; Masaoka, M.; Hori, G.; Hashimoto, K. Serum cholesterol reduction and cholesterol absorption inhibition in Caco-2 cells by a soy protein peptic hydrolyze. Biosci. Biotechnol. Biochem. 1997, 61, 354-356.
29. Nagaoka, S.; Miwa, K.; Eto, M.; Kuzuya, Y.; Hori, G. Soy protein peptic hydrolysate with bound phospholipids decreases micellar solubility and cholesterol absorption in rats and Caco-2 cells. J. Nutr. 1999, 129, 1725-1730.
30. Lucas, E.A.; Khalil, D.A.; Daggy, B.P.; Arjmandi, B.H. Ethanol-extracted soy protein isolate does not modulate serum cholesterol in Golden Syrian hamsters: A model of postmenopausal hypercholesterolemia. J. Nutr. 2001, 131, 211-214.
31. Han, L.K.; Zheng, Y.N.; Xu, B.J.; Okuda, H.; Kimura, Y. Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. J. Nutr. 2002, 132, 2241-2245.
32. Joseph, S.B.; Laffitte, B.A.; Patel, P.H.; Watson, M.A.; Matsukuma, K.E.; Walczak, R.; Collins, J.L.; Osborne, T.F.; Tontonoz, P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J. Biol. Chem. 2002, 277, 11019-11025.
33. Myant, N.B.; Mitropoulos, K.A. Cholesterol 7 alpha-hydroxylase. J. Lipid Res. 1977, 18, 135-153.
34. Chen, J.; Raymond, K. Nuclear receptors, bile-acid detoxification, and cholestasis. Lancet 2006, 367, 454-456.
35. Horton, J.D.; Shimomura, I.; Brown, M.S.; Hammer, R.E.; Goldstein, J.L.; Shimano, H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J. Clin. Invest. 1998, 101, 2331-2339.