메뉴 건너뛰기




Volumn 13, Issue 9, 2012, Pages 12000-12016

Anti-epidermal growth factor receptor (EGFR) antibodies overcome resistance of ovarian cancer cells to targeted therapy and natural cytotoxicity

Author keywords

Antibody dependent cellular cytotoxicity; Cetuximab; EGFR; NK cell; Ovarian cancer; PstS 1

Indexed keywords

BACTERIAL PROTEIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; PSTS 1 PROTEIN; UNCLASSIFIED DRUG; VANDETANIB;

EID: 84866910154     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms130912000     Document Type: Article
Times cited : (26)

References (42)
  • 3
    • 0031056372 scopus 로고    scopus 로고
    • EGFR and steroid receptors in ovarian carcinoma: Comparison with prognostic parameters and outcome of patients
    • Fischer-Colbrie, J.; Witt, A.; Heinzl, H.; Speiser, P.; Czerwenka, K.; Sevelda, P.; Zeillinger, R. EGFR and steroid receptors in ovarian carcinoma: Comparison with prognostic parameters and outcome of patients. Anticancer Res. 1997, 17, 613-619.
    • (1997) Anticancer Res , vol.17 , pp. 613-619
    • Fischer-Colbrie, J.1    Witt, A.2    Heinzl, H.3    Speiser, P.4    Czerwenka, K.5    Sevelda, P.6    Zeillinger, R.7
  • 4
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn, J.; Baselga, J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 2003, 21, 2787-2799.
    • (2003) J. Clin. Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 5
    • 67249098554 scopus 로고    scopus 로고
    • Inhibition of functional HER family members increases the sensitivity to docetaxel in human ovarian cancer cell lines
    • Bijman, M.N.; van Berkel, M.P.; Kok, M.; Janmaat, M.L.; Boven, E. Inhibition of functional HER family members increases the sensitivity to docetaxel in human ovarian cancer cell lines. AntiCancer Drugs 2009, 20, 450-460.
    • (2009) AntiCancer Drugs , vol.20 , pp. 450-460
    • Bijman, M.N.1    van Berkel, M.P.2    Kok, M.3    Janmaat, M.L.4    Boven, E.5
  • 6
    • 47249145102 scopus 로고    scopus 로고
    • A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer
    • Konner, J.; Schilder, R.J.; DeRosa, F.A.; Gerst, S.R.; Tew, W.P.; Sabbatini, P.J.; Hensley, M.L.; Spriggs, D.R.; Aghajanian, C.A. A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer. Gynecol. Oncol. 2008, 110, 140-145.
    • (2008) Gynecol. Oncol , vol.110 , pp. 140-145
    • Konner, J.1    Schilder, R.J.2    Derosa, F.A.3    Gerst, S.R.4    Tew, W.P.5    Sabbatini, P.J.6    Hensley, M.L.7    Spriggs, D.R.8    Aghajanian, C.A.9
  • 7
    • 39249085402 scopus 로고    scopus 로고
    • Phase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: A gynecologic oncology group study
    • Gynecologic Oncology Group
    • Secord, A.A.; Blessing, J.A.; Armstrong, D.K.; Rodgers, W.H.; Miner, Z.; Barnes, M.N.; Lewandowski, G.; Mannel, R.S. Gynecologic Oncology Group. Phase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: A gynecologic oncology group study. Gynecol. Oncol. 2008, 108, 493-499.
    • (2008) Gynecol. Oncol , vol.108 , pp. 493-499
    • Secord, A.A.1    Blessing, J.A.2    Armstrong, D.K.3    Rodgers, W.H.4    Miner, Z.5    Barnes, M.N.6    Lewandowski, G.7    Mannel, R.S.8
  • 8
    • 60749092998 scopus 로고    scopus 로고
    • Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash
    • Schilder, R.J.; Pathak, H.B.; Lokshin, A.E.; Holloway, R.W.; Alvarez, R.D.; Aghajanian, C.; Min, H.; Devarajan, K.; Ross, E.; Drescher, C.W. et al. Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash. Gynecol. Oncol. 2009, 113, 21-27.
    • (2009) Gynecol. Oncol , vol.113 , pp. 21-27
    • Schilder, R.J.1    Pathak, H.B.2    Lokshin, A.E.3    Holloway, R.W.4    Alvarez, R.D.5    Aghajanian, C.6    Min, H.7    Devarajan, K.8    Ross, E.9    Drescher, C.W.10
  • 9
    • 28944439741 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER-1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: Results from a phase II multicenter study
    • Gordon, A.N.; Finkler, N.; Edwards, R.P.; Garcia, A.A.; Crozier, M.; Irwin, D.H.; Barrett, E. Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER-1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: Results from a phase II multicenter study. Int. J. Gynecol. Cancer 2005, 15, 785-792.
    • (2005) Int. J. Gynecol. Cancer , vol.15 , pp. 785-792
    • Gordon, A.N.1    Finkler, N.2    Edwards, R.P.3    Garcia, A.A.4    Crozier, M.5    Irwin, D.H.6    Barrett, E.7
  • 10
    • 78149360639 scopus 로고    scopus 로고
    • Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: A phase II study based on surgical reassessment
    • Blank, S.V.; Christos, P.; Curtin, J.P.; Goldman, N.; Runowicz, C.D.; Sparano, J.A.; Liebes, L.; Chen, H.X.; Muggia, F.M. Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: A phase II study based on surgical reassessment. Gynecol. Oncol. 2010, 119, 451-456.
    • (2010) Gynecol. Oncol , vol.119 , pp. 451-456
    • Blank, S.V.1    Christos, P.2    Curtin, J.P.3    Goldman, N.4    Runowicz, C.D.5    Sparano, J.A.6    Liebes, L.7    Chen, H.X.8    Muggia, F.M.9
  • 11
    • 44349178606 scopus 로고    scopus 로고
    • A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers
    • Scottish Gynecological Cancer Trials Group
    • Vasey, P.A.; Gore, M.; Wilson, R.; Rustin, G.; Gabra, H.; Guastalla, J.P.; Lauraine, E.P.; Paul, J.; Carty, K.; Kaye, S. Scottish Gynecological Cancer Trials Group. A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers. Br. J. Cancer 2008, 98, 1774-1780.
    • (2008) Br. J. Cancer , vol.98 , pp. 1774-1780
    • Vasey, P.A.1    Gore, M.2    Wilson, R.3    Rustin, G.4    Gabra, H.5    Guastalla, J.P.6    Lauraine, E.P.7    Paul, J.8    Carty, K.9    Kaye, S.10
  • 12
    • 78049477139 scopus 로고    scopus 로고
    • Overexpression of tumour vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer
    • Chambers, S.K.; Clouser, M.C.; Baker, A.F.; Roe, D.J.; Cui, H.; Brewer, M.A.; Hatch, K.D.; Gordon, M.S.; Janicek, M.F.; Isaacs, J.D. et al. Overexpression of tumour vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer. Clin. Cancer Res. 2010, 16, 5320-5328.
    • (2010) Clin. Cancer Res , vol.16 , pp. 5320-5328
    • Chambers, S.K.1    Clouser, M.C.2    Baker, A.F.3    Roe, D.J.4    Cui, H.5    Brewer, M.A.6    Hatch, K.D.7    Gordon, M.S.8    Janicek, M.F.9    Isaacs, J.D.10
  • 13
    • 23044511620 scopus 로고    scopus 로고
    • Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: A Gynecologic Oncology Group study
    • Schilder, R.J.; Sill, M.W.; Chen, X.; Darcy, K.M.; Decesare, S.L.; Lewandowski, G.; Lee, R.B.; Arciero, C.A.; Wu, H.; Godwin, A.K. Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: A Gynecologic Oncology Group study. Clin. Cancer Res. 2005, 11, 5539-5548.
    • (2005) Clin. Cancer Res , vol.11 , pp. 5539-5548
    • Schilder, R.J.1    Sill, M.W.2    Chen, X.3    Darcy, K.M.4    Decesare, S.L.5    Lewandowski, G.6    Lee, R.B.7    Arciero, C.A.8    Wu, H.9    Godwin, A.K.10
  • 15
    • 0034068319 scopus 로고    scopus 로고
    • Antitumour effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello, F.; Caputo, R.; Bianco, R.; Damiano, V.; Pomatico, G.; de Placido, S.; Bianco, A.R.; Tortora, G. Antitumour effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin. Cancer Res. 2000, 6, 2053-2063.
    • (2000) Clin. Cancer Res , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3    Damiano, V.4    Pomatico, G.5    de Placido, S.6    Bianco, A.R.7    Tortora, G.8
  • 16
    • 74249089783 scopus 로고    scopus 로고
    • Phase II study of gefitinib in combination with paclitaxel (p) and carboplatin (c) as second-line therapy for ovarian, tubal or peritoneal adenocarcinoma (1839IL/0074)
    • Pautier, P.; Joly, F.; Kerbrat, P.; Bougnoux, P.; Fumoleau, P.; Petit, T.; Rixe, O.; Ringeisen, F.; Carrasco, A.T.; Lhomme, C. Phase II study of gefitinib in combination with paclitaxel (p) and carboplatin (c) as second-line therapy for ovarian, tubal or peritoneal adenocarcinoma (1839IL/0074). Gynecol. Oncol. 2010, 116, 157-162.
    • (2010) Gynecol. Oncol , vol.116 , pp. 157-162
    • Pautier, P.1    Joly, F.2    Kerbrat, P.3    Bougnoux, P.4    Fumoleau, P.5    Petit, T.6    Rixe, O.7    Ringeisen, F.8    Carrasco, A.T.9    Lhomme, C.10
  • 17
    • 74549205168 scopus 로고    scopus 로고
    • Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2
    • Annunziata, C.M.; Walker, A.J.; Minasian, L.; Yu, M.; Kotz, H.; Wood, B.J.; Calvo, K.; Choyke, P.; Kimm, D.; Steinberg, S.M. et al. Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. Clin. Cancer Res. 2010, 16, 664-672.
    • (2010) Clin. Cancer Res , vol.16 , pp. 664-672
    • Annunziata, C.M.1    Walker, A.J.2    Minasian, L.3    Yu, M.4    Kotz, H.5    Wood, B.J.6    Calvo, K.7    Choyke, P.8    Kimm, D.9    Steinberg, S.M.10
  • 18
    • 34548509226 scopus 로고    scopus 로고
    • FCGR2a and FCGR3a polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab
    • Zhang, W.; Gordon, M.; Schultheis, A.M.; Yang, D.Y.; Nagashima, F.; Azuma, M.; Chang, H.M.; Borucka, E.; Lurje, G.; Sherrod, A.E. et al. FCGR2a and FCGR3a polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J. Clin. Oncol. 2007, 25, 3712-3718.
    • (2007) J. Clin. Oncol , vol.25 , pp. 3712-3718
    • Zhang, W.1    Gordon, M.2    Schultheis, A.M.3    Yang, D.Y.4    Nagashima, F.5    Azuma, M.6    Chang, H.M.7    Borucka, E.8    Lurje, G.9    Sherrod, A.E.10
  • 19
    • 10644241833 scopus 로고    scopus 로고
    • Impact of FasL-induced apoptosis in the elimination of tumour cells by NK cells
    • Screpanti, V.; Wallin, R.P.; Grandien, A.; Ljunggren, H.G. Impact of FasL-induced apoptosis in the elimination of tumour cells by NK cells. Mol. Immunol. 2005, 42, 495-499.
    • (2005) Mol. Immunol , vol.42 , pp. 495-499
    • Screpanti, V.1    Wallin, R.P.2    Grandien, A.3    Ljunggren, H.G.4
  • 20
    • 77956634317 scopus 로고    scopus 로고
    • The Bcr/abl-inhibitors imatinib, nilotinib and dasatinib differentially affect NK cell reactivity
    • Salih, J.; Hilpert, J.; Placke, T.; Grunebach, F.; Steinle, A.; Salih, H.R.; Krusch, M. The Bcr/abl-inhibitors imatinib, nilotinib and dasatinib differentially affect NK cell reactivity. Int. J. Cancer 2010, 127, 2119-2128.
    • (2010) Int. J. Cancer , vol.127 , pp. 2119-2128
    • Salih, J.1    Hilpert, J.2    Placke, T.3    Grunebach, F.4    Steinle, A.5    Salih, H.R.6    Krusch, M.7
  • 23
    • 4544226709 scopus 로고    scopus 로고
    • Mechanisms of bacillus calmette-guerin mediated natural killer cell activation
    • Suttmann, H.; Jacobsen, M.; Reiss, K.; Jocham, D.; Bohle, A.; Brandau, S. Mechanisms of bacillus calmette-guerin mediated natural killer cell activation. J. Urol. 2004, 172, 1490-1495.
    • (2004) J. Urol , vol.172 , pp. 1490-1495
    • Suttmann, H.1    Jacobsen, M.2    Reiss, K.3    Jocham, D.4    Bohle, A.5    Brandau, S.6
  • 24
    • 0026667184 scopus 로고
    • The mycobacterium tuberculosis 38-kDa antigen: Overproduction in escherichia coli, purification and characterization
    • Singh, M.; Andersen, A.B.; McCarthy, J.E.; Rohde, M.; Schutte, H.; Sanders, E.; Timmis, K.N. The mycobacterium tuberculosis 38-kDa antigen: Overproduction in escherichia coli, purification and characterization. Gene 1992, 117, 53-60.
    • (1992) Gene , vol.117 , pp. 53-60
    • Singh, M.1    Andersen, A.B.2    McCarthy, J.E.3    Rohde, M.4    Schutte, H.5    Sanders, E.6    Timmis, K.N.7
  • 25
    • 0037449496 scopus 로고    scopus 로고
    • B- and T-cell responses to the mycobacterium surface antigen PstS-1 in the respiratory tract and adjacent tissues. Role of adjuvants and routes of immunization
    • Rodriguez, A.; Troye-Blomberg, M.; Lindroth, K.; Ivanyi, J.; Singh, M.; Fernandez, C. B- and T-cell responses to the mycobacterium surface antigen PstS-1 in the respiratory tract and adjacent tissues. Role of adjuvants and routes of immunization. Vaccine 2003, 21, 458-467.
    • (2003) Vaccine , vol.21 , pp. 458-467
    • Rodriguez, A.1    Troye-Blomberg, M.2    Lindroth, K.3    Ivanyi, J.4    Singh, M.5    Fernandez, C.6
  • 26
    • 13144264115 scopus 로고    scopus 로고
    • Immunodominant PstS-1 antigen of mycobacterium tuberculosis is a potent biological response modifier for the treatment of bladder cancer
    • Sanger, C.; Busche, A.; Bentien, G.; Spallek, R.; Jonas, F.; Bohle, A.; Singh, M.; Brandau, S. Immunodominant PstS-1 antigen of mycobacterium tuberculosis is a potent biological response modifier for the treatment of bladder cancer. BMC Cancer 2004, 4, 86.
    • (2004) BMC Cancer , vol.4 , pp. 86
    • Sanger, C.1    Busche, A.2    Bentien, G.3    Spallek, R.4    Jonas, F.5    Bohle, A.6    Singh, M.7    Brandau, S.8
  • 27
    • 33646357881 scopus 로고    scopus 로고
    • The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes
    • Jung, S.B.; Yang, C.S.; Lee, J.S.; Shin, A.R.; Jung, S.S.; Son, J.W.; Harding, C.V.; Kim, H.J.; Park, J.K.; Paik, T.H. et al. The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes. Infect. Immun. 2006, 74, 2686-2696.
    • (2006) Infect. Immun , vol.74 , pp. 2686-2696
    • Jung, S.B.1    Yang, C.S.2    Lee, J.S.3    Shin, A.R.4    Jung, S.S.5    Son, J.W.6    Harding, C.V.7    Kim, H.J.8    Park, J.K.9    Paik, T.H.10
  • 28
    • 58149098805 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis 38-kda lipoprotein is apoptogenic for human monocyte-derived macrophages
    • Sanchez, A.; Espinosa, P.; Esparza, M.A.; Colon, M.; Bernal, G.; Mancilla, R. Mycobacterium tuberculosis 38-kda lipoprotein is apoptogenic for human monocyte-derived macrophages. Scand. J. Immunol. 2009, 69, 20-28.
    • (2009) Scand. J. Immunol , vol.69 , pp. 20-28
    • Sanchez, A.1    Espinosa, P.2    Esparza, M.A.3    Colon, M.4    Bernal, G.5    Mancilla, R.6
  • 29
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 30
    • 34347215518 scopus 로고    scopus 로고
    • Analysis of apoptosis by propidium iodide staining and flow cytometry
    • Riccardi, C.; Nicoletti, I. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nature Protoc. 2006, 1, 1458-1461.
    • (2006) Nature Protoc , vol.1 , pp. 1458-1461
    • Riccardi, C.1    Nicoletti, I.2
  • 31
    • 0030054907 scopus 로고    scopus 로고
    • Anti-tumour and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin
    • Prewett, M.; Rockwell, P.; Rose, C.; Goldstein, N. Anti-tumour and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin. Int. J. Oncol. 1996, 9, 217-224.
    • (1996) Int. J. Oncol , vol.9 , pp. 217-224
    • Prewett, M.1    Rockwell, P.2    Rose, C.3    Goldstein, N.4
  • 38
    • 27544497021 scopus 로고    scopus 로고
    • EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer
    • Huether, A.; Hopfner, M.; Baradari, V.; Schuppan, D.; Scherubl, H. EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. Biochem. Pharmacol. 2005, 70, 1568-1578.
    • (2005) Biochem. Pharmacol , vol.70 , pp. 1568-1578
    • Huether, A.1    Hopfner, M.2    Baradari, V.3    Schuppan, D.4    Scherubl, H.5
  • 39
    • 3442891161 scopus 로고    scopus 로고
    • Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
    • Huang, S.; Armstrong, E.A.; Benavente, S.; Chinnaiyan, P.; Harari, P.M. Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res. 2004, 64, 5355-5362.
    • (2004) Cancer Res , vol.64 , pp. 5355-5362
    • Huang, S.1    Armstrong, E.A.2    Benavente, S.3    Chinnaiyan, P.4    Harari, P.M.5
  • 41
    • 84862987061 scopus 로고    scopus 로고
    • Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: Preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer
    • Weickhardt, A.J.; Price, T.J.; Chong, G.; Gebski, V.; Pavlakis, N.; Johns, T.G.; Azad, A.; Skrinos, E.; Fluck, K.; Dobrovic, A. et al. Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: Preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer. J. Clin. Oncol. 2012, 30, 1505-1512.
    • (2012) J. Clin. Oncol , vol.30 , pp. 1505-1512
    • Weickhardt, A.J.1    Price, T.J.2    Chong, G.3    Gebski, V.4    Pavlakis, N.5    Johns, T.G.6    Azad, A.7    Skrinos, E.8    Fluck, K.9    Dobrovic, A.10
  • 42
    • 10344255635 scopus 로고    scopus 로고
    • CD107a as a functional marker for the identification of natural killer cell activity
    • Alter, G.; Malenfant, J.M.; Altfeld, M. CD107a as a functional marker for the identification of natural killer cell activity. J. Immunol. Methods 2004, 294, 15-22.
    • (2004) J. Immunol. Methods , vol.294 , pp. 15-22
    • Alter, G.1    Malenfant, J.M.2    Altfeld, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.