Tissue-selective regulation of androgen-responsive genes

Endocrine Research

Volumn 37, Issue 4, 2012, Pages 203-215

  Otto Duessel, Maya ^a   He, Miaoling ^a   Jones, Jeremy O ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Androgens; Gene ontology; Microarray; Prostate; QPCR; Selectivity

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FOREBRAIN; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; HORMONE ACTION; HORMONE SENSITIVITY; MALE; MICROARRAY ANALYSIS; MUSCLE; NONHUMAN; OVARY; PRIORITY JOURNAL; PROSTATE; RAT; SKIN; UTERUS;

ANDROGENS; ANIMALS; CASTRATION; DIHYDROTESTOSTERONE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; OVARY; PROSENCEPHALON; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; SKIN;

EID: 84866898978     PISSN: 07435800     EISSN: 15324206     Source Type: Journal    
DOI: 10.3109/07435800.2012.668254     Document Type: Article

References (41)

1. Brinkmann AO. Molecular basis of androgen insensitivity. Mol Cell Endocrinol 2001;179(1-2):105-109.
2. Zhou Q, Nie R, Prins GS, Saunders PT, Katzenellenbogen BS, Hess RA. Localization of androgen and estrogen receptors in adult male mouse reproductive tract. J Androl 2002;23(6):870-881.
3. Holzbeierlein JM, McLaughlin MD, Thrasher JB. Complications of androgen deprivation therapy for prostate cancer. Curr Opin Urol 2004;14(3):177-183.
4. Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S. Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. J Clin Endocrinol Metab 2004;89(10):5245-5255.
5. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C. Androgens and bone. Endocrine Rev 2004;25(3):389-425.
6. Singh R, Artaza JN, Taylor WE, et al. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 2006;147 (1):141-154.
7. Lieberburg I, MacLusky N, McEwen BS. Androgen receptors in the perinatal rat brain. Brain Res 1980;196(1):125-138.
8. Shah NM, Pisapia DJ, Maniatis S, Mendelsohn MM, Nemes A, Axel R. Visualizing sexual dimorphism in the brain. Neuron 2004;43(3):313-319.
9. Taylor LG, Canfield SE, Du XL. Review of major adverse effects of androgen-deprivation therapy in men with prostate cancer. Cancer 2009;115(11):2388-2399.
10. Alsantali A, Shapiro J. Androgens and hair loss. Curr Opin Endocrinol Diabetes Obes 2009;16 (3):246-253.
11. Park SY, Kwack MH, Chung EJ, et al. Establishment of SV40T-transformed human dermal papilla cells and identification of dihydrotestosterone-regulated genes by cDNA microarray. J Dermatol Sci 2007;47 (3):201-208.
12. Ehrmann DA, Liljenquist DR, Kasza K, Azziz R, Legro RS, Ghazzi MN. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2006;91 (1):48-53.
13. Al Kadri H, Hassan S, Al-Fozan HM, Hajeer A. Hormone therapy for endometriosis and surgical menopause. Cochrane Database Syst Rev 2009;(1):CD005997.
14. Gonzalez LO, Corte MD, Vazquez J, et al. Androgen receptor expression in breast cancer: relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors. BMC Cancer 2008;8:149.
15. Keller ET, Ershler WB, Chang C. The androgen receptor: a mediator of diverse responses. Front Biosci 1996:1:d59-d71.
16. Jones JO. Improving selective androgen receptor modulator discovery and preclinical evaluation (review). Expert Opin Drug Discov 2009;4(9):981-993.
17. Tostain JL, Blanc F. Testosterone deficiency: a common, unrecognized syndrome. Nat Clin Pract Urol 2008;5(7):388-396.
18. Sprenkle PC, Fisch H. Pathologic effects of testosterone deprivation. Curr Opin Urol 2007;17 (6):424-430.
19. Pucci E, Petraglia F. Treatment of androgen excess in females: yesterday, today and tomorrow. Gynecol Endocrinol 1997;11(6):411-433.
20. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics. CA Cancer J Clin 2010;60(5):277-300.
21. Mostaghel EA, Montgomery B, Nelson PS. Castration-resistant prostate cancer: targeting androgen metabolic pathways in recurrent disease. Urol Oncol 2009;27(3):251-257.
22. Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003;19(2):185-193.
23. Dennis G Jr., Sherman BT, Hosack DA, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003;4(5):P3.
24. Klipper-Aurbach Y, Wasserman M, Braunspiegel-Weintrob N, et al. Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus. Med Hypotheses 1995;45(5):486-490.
25. Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat 1979;6:65-70.
26. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004;3:Article3.
27. Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004;5(10):R80.
28. Wang XD, Wang BE, Soriano R, et al. Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis. Differentiation 2007;75 (3):219-234.
29. Ivanga M, Labrie Y, Calvo E, et al. Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus. Mol Reprod Dev 2009;76(3):278-288.
30. Zhang Y, Calvo E, Martel C, Luu-The V, Labrie F, Tchernof A. Response of the adipose tissue transcriptome to dihydrotestosterone in mice. Physiol Genomics 2008;35(3):254-261.
31. Xu C, Graf LF, Fazli L, et al. Regulation of global gene expression in the bone marrow microenvironment by androgen: androgen ablation increases insulin-like growth factor binding protein-5 expression. Prostate 2007;67(15):1621-1629.
32. Zhou Q, Shima JE, Nie R, Friel PJ, Griswold MD. Androgen-regulated transcripts in the neonatal mouse testis as determined through microarray analysis. Biol Reprod 2005;72(4):1010-1019.
33. Nantermet PV, Xu J, Yu Y, et al. Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland. J Biol Chem 2004;279(2):1310-1322.
34. Nantermet PV, Masarachia P, Gentile MA, et al. Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways. Endocrinology 2005;146(2):564-578.
35. Drummond ES, Harvey AR, Martins RN. Androgens and Alzheimer's disease. Curr Opin Endocrinol Diabetes Obes 2009;16(3):254-259.
36. van Helden YG, Godschalk RW, Heil SG, et al. Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/-mice. Carcinogenesis 2010;31(8):1329-1337.
37. Bayer-Garner IB, Givens V, Smoller B. Immunohistochemical staining for androgen receptors: a sensitive marker of sebaceous differentiation. Am J Dermatopathol 1999;21(5):426-431.
38. Trueb RM. Molecular mechanisms of androgenetic alopecia. Exp Gerontol 2002;37(8-9):981-990.
39. Gentile MA, Nantermet PV, Vogel RL, et al. Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and induction of {beta}-catenin. J Mol Endocrinol 2010;44(1):55-73.
40. Treister NS, Richards SM, Rowley P, Jensen RV, Sullivan DA. Influence of testosterone on gene expression in the ovariectomized mouse submandibular gland. Eur J Oral Sci 2006;114(4):328-336.
41. Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT. Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal 2008;6:e010.