A comparative study of Vitamin e TPGS/HPMC supersaturated system and other solubilizer/polymer combinations to enhance the permeability of a poorly soluble drug through the skin

Drug Development and Industrial Pharmacy

Volumn 38, Issue 11, 2012, Pages 1408-1416

  Ghosh, Indrajit ^a,b   Michniak Kohn, Bozena ^a  

^a RUTGERS UNIVERSITY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Crystal growth; Permeation rate; Porcine skin; Supersaturated systems; Synthetic membrane; Vitamin E TPGS

Indexed keywords

ALPHA TOCOPHEROL; HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; POLOXAMER; POLYMER; POVIDONE; PROPYLENE GLYCOL; SILICONE; SOLUBILIZER; TOCOFERSOLAN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTAL; CRYSTALLIZATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG SOLUTION; DRUG STABILITY; EXPERIMENTAL PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MICROSCOPY; NONHUMAN; PARTICLE SIZE; SKIN; SKIN PENETRATION; THERMODYNAMICS;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DRUG STABILITY; IBUPROFEN; MEMBRANES, ARTIFICIAL; METHYLCELLULOSE; PARTICLE SIZE; PERMEABILITY; POLOXAMER; POLYETHYLENE GLYCOLS; POVIDONE; PROPYLENE GLYCOL; SKIN; SKIN ABSORPTION; SOLUBILITY; SOLVENTS; SWINE; VITAMIN E;

EID: 84866892858     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.653363     Document Type: Article

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