Hepatotoxic Potential of Nanomaterials

Nanotoxicity: From In Vivo and In Vitro Models to Health Risks

Volumn , Issue , 2009, Pages 183-189

  Sahu, Saura C ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Colloidal gold in rheumatoid arthritis treatment; Hepatotoxic potential of nanomaterials; Hepatotoxic potential of nanomaterials in consumer products and medical devices; Hepatotoxicity of nanomaterials in vitro and in vivo; Liver, potential target organ of nanomaterials; Multiple target organs of nanomaterials in human body; Nanomaterial hepatotoxicity mechanism; Nanoparticles in liver cells and cellular dysfunction and liver injury; Nanotechnology emerging new branch of modern technology; Superparamagnetic iron oxide nanoparticles (SPIONs) in cancer diagnostics and treatment

Indexed keywords

EID: 84866882734     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470747803.ch10     Document Type: Chapter

References (30)

1. Brownlie A, Uchegbu IF, Schatziein AG (2004) PEI-based vesicle-polymer hybrid gene delivery system with improved biocompatibility. International Journal of Pharmaceutics 274, 41-52.
2. Chan VSW (2006) Nanomedicine: An unresolved regulatory issue. Regulatory Toxicology and Pharmacology 46, 218-224.
3. Chen Z, Meng H, Xing G, Zhao Y, Jia G, Yuan H, Ye C, Chai Z, Zhu C, Fang X, Ma B,Wan L (2006) Acute toxicological effects of copper nanoparticles in vivo. Toxicology Letters 163, 1090-1120.
4. Fernandez-Urrusuno R, Fattal E, Feger J, Couvreur P, Therond P (1997) Evaluation of hepatic antioxidant systems after intravenous administration of polymeric nanoparticles. Biomaterials 18, 511-517.
5. Food and Drug Administration (1999) FDA issues final ruling on OTC products containing colloidal silver. Available at http://www.fda.gov/bbs/topics/ANSWERS/ANS00971.html
6. Geze A, Chau LT, Choisnard L, Mathieu JP, Marti-Batlle D, Riou L, Putaux JL, Wouessidjewe D (2007) Biodistribution of intravenously administered amphiphiilic ß-cyclodextrin nanospheres. International Journal of Pharmaceutics 344, 135-142.
7. Gopee NV, Roberts DW, Webb P, Cozart CR, Siitonen PH, Warbritton AR, Yu WW, Colvin VL, Walker NJ, Howard PC (2007) Migration of intradermally injected quantum dots to sentinel organs in mice. Toxicological Sciences 98, 249-257.
8. Hoet PHM, Brüske-Hohlfeld I, Salata OV (2004) Nanoparticles-known and unknown health risks. Journal of Nanobiotechnology 2, 12-23.
9. Hori K, Martin TG, Rainey P (2002) Believe it or not-silver still poison! Veterinary and Human Toxicology 44, 291-291.
10. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ (2005) In vitro toxicity of nanoparticles in BRL 3a rat liver cells. Toxicology In Vitro 19, 975-983.
11. Jain KK (2005) Nanotechnology in clinical laboratory diagnostics. Clinica Chimica Acta 358, 37-54.
12. Jain TK, Reddy MK,Morales MA, Leslie-Pelecky DL, Labhasetwar V (2008) Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. ASAP Mol. Pharmaceutics 10, 1021.
13. Kamruzzaman SKM, Ha YS, Kim SJ, Chang Y, Kim TJ, Ho Lee G, Kang IK (2007) Surface modification of magnetite nanoparticles using lactobionic acid and their interaction with hepatocytes. Biomaterials 28, 710-716.
14. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. (2003) Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111, 455-460.
15. Lu B, Xiong S, Yang H, Yin X, Chao R (2006) Solid nanoparticles of mitoxantrone for local injection against breast cancer and its lymph node metastases. European Journal of Pharmaceutical Sciences 28, 86-95.
16. McClean S, Prosser E, Meehan E, O'Malley D, Clarke N, Ramtoola A, Brayden D (1998) Binding and uptake of biodegradable poly-DL-lactide micro-and nanoparticles in intestinal epithelia. European Journal of Pharm Science 6, 153-163.
17. Mettier SR (1946) Classification and treatment of rheumatic diseases with special emphasis on infectious and rheumatoid arthritis. American Journal of Orthodontics and Oral Surgery 32, A440-A444.
18. Nel A, Xia T, Li N (2006) Toxic potential of materials at the nanolevel. Science 311, 622-627.
19. Oberdorster G, Sharp Z, Atudorei V, Elder A (2002) Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Hlth Part A 65, 1531-1543.
20. Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Nanotoxicology 113, 823-839.
21. Park JH, Kwon S, Lee M, Chung H, Kim J, Kim Y, Park R, Kim I, Seo S, Kwon I, Jeong S (2006) Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: In vivo biodistribution and anti-tumor activity. Biomaterials 27, 119-126.
22. Patel HM (1992) Serum opsonin and liposomes: their interaction and opsonophagocytosis. Crit Rev Ther Drug Carrier Syst 9, 39-90.
23. Peter HH, Irene BH, Oleg VS (2004) Nanoparticles-known and unknown health risks. Journal of Nanobiotechnology 2, 12.
24. Sadauskas E, Wallin H, Stoltenberg M, Vogel U, Doering P, Larsen A, Danscher G (2007) Kupffer cells are central in the removal of nanoparticles from the organism. Particle and Fibre Toxicology 4, 10.
25. Sayes CM, Gobin AM, Ausman KD, Mendez J, West JL, Colvin VL (2005) Nano-C60 cytotoxicity is due to lipid peroxidation. Biomaterials 26, 7587-7595.
26. Stolnik S, Illum L, Davis SS (1995) Long circulating microparticulate drug carriers. Adv Drug Del Rev 16, 195-214.
27. Wagner V, Dullaart A, Bock A, Zweck A (2006) The emerging nanomedicine landscape. Nature Biotechnology 24, 1211-1217.
28. Wang J, Zhou G, Chen C, Yu H, Ma Y, Jia G, Li B, Jiao F, Zhao Y, Chai Z (2007) Acute toxicity and distribution of different sized titanium dioxide in mice after oral administration. Toxicology Letters 168, 176-185.
29. White JM, PowellAM, BradyK(2003) Severe generalized argyria secondary to ingestion of colloidal silver protein. Clinical and Experimental Dermatology 28, 254-256.
30. Zhou J, Leuschner C, Kumar C, Hormes JF, Soboyejo WO (2006) Sub-cellular accumulation of magnetic nanoparticles in breast tumors and metastases. Biomaterials 27, 2001-2008.