Human parathyroid hormone increases the mRNA expression of the IGF system and hematopoietic growth factors in osteoblasts, but does not influence expression in mesenchymal stem cells

Journal of Pediatric Hematology/Oncology

Volumn 34, Issue 7, 2012, Pages 491-496

  Lee, Jong Hwa ^a   Hwang, Kyou Jung ^b   Kim, Mi Yeon ^b   Lim, Yeon Jung ^c   Seol, In Joon ^d   Jin, Hye Jin ^e   Jang, Yun Kyung ^e   Choi, Soo Jin ^e   Oh, Wonil ^e   Cho, Youl Hee ^f   Lee, Young Ho ^d  

^a Wonkwang University   (South Korea)

^b Hanyang University   (South Korea)

^c Chungnam National University College of Medicine   (South Korea)

^d Hanyang University Medical Center   (South Korea)

^e MEDIPOST Co Ltd   (South Korea)

^f Hanyang University College of Medicine   (South Korea)

Author keywords

cord blood; human parathyroid hormone; insulin like growth factor; mesenchymal stem cell; osteoblast

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; INTERLEUKIN 6; MESSENGER RNA; PARATHYROID HORMONE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CELL DIFFERENTIATION; HEMATOPOIESIS; HUMAN; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MESENCHYMAL STEM CELL; OSTEOBLAST; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALKALINE PHOSPHATASE; CELLS, CULTURED; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; HUMANS; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; PARATHYROID HORMONE; RNA, MESSENGER; SOMATOMEDINS;

EID: 84866873587     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e318266c0ef     Document Type: Article

References (23)

1. Dexter TM, Spooncer E. Growth and differentiation in the hemopoietic system. Ann Rev Cell Biol. 1987;3:432-441.
2. Moore KA, Pytowski B, Witte L, et al. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA. 1997;94:4011-4016.
3. Lemischka IR. Microenvironmental regulation of hemato-poietic stem cells. Stem Cells. 1997;15(suppl 1):63-68.
4. Taichman RS. Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood. 2005;105:2631-2639.
5. Swarthout JT, D'Alonzo RC, Selvamurugan N, et al. Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene. 2002;282:1-17.
6. Tovey SC, Dedos SG, Taylor CW. Signaling from parathyroid hormone. Biochem Soc Trans. 2006;34:515-517.
7. McCarthy TL, Centrella M, Canalis E. Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor 1 in osteoblast-enriched cultures from fetal rat bone. Endocrinology. 1989;124:1247-1253.
8. McCarthy TL, Centrella M, Canalis E. Cyclic AMP induces insulin-like growth factor 1 synthesis in osteoblast-enriched cultures. J Biol Chem. 1990;265:15353-15356.
9. Torring O, Firek AF, Heath H, et al. Parathyroid hormone and parathyroid hormone-related peptide stimulate insulin-like growth hormone binding protein secretion by rat osteoblast-like cells through a adenosine 3,5-monophosphate- dependent mechanism. Endocrinology. 1991;128:1006-1014.
10. Linkhart TA, Mohan S. Parathyroid hormone stimulates release of insulin-like growth factor-1 (IGF-1) and IGF-2 from neonatal mouse calvaria in organ culture. Endocrinology. 1989;125:1484-1491.
11. Taichman RS, Emerson SG. The role of osteoblasts in the hematopoietic microenvironment. Stem Cells. 1998;16:7-15.
12. Greenfield E, Horowitz M, Lavish S. Stimulation by parathyroid hormone of interleukin-6 and leukemia inhibitory factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction. J Biol Chem. 1996;271:10984-10989.
13. Ponomaryov T, Peled A, Petit I, et al. Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function. J Clin Invest. 2000;106: 1331-1339.
14. Hofbauer LC, Khosla S, Dunstan CR, et al. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res. 2000;15:2-12.
15. Whitfield JF. Parathyroid hormone (PTH) and hematopoiesis: new support for some old observations. J Cell Biochem. 2005;96:278-284.
16. Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nature Immunol. 2006;7:333-337.
17. LeRoith D, McGuinness M, Shemer J, et al. Insulin-like growth factors. Biol Signals. 1992;1:173-181.
18. Zumkeller W, Burdach S. The insulin-like growth factor system in normal and malignant hematopoietic cells. Blood. 1999;94:3653-3657.
19. Zhang CC, Lodish HF. Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood. 2004;103:2513-2521.
20. Ballen K. Targeting the stem cell niche: squeezing blood from bones. Bone Marrow Transplant. 2007;39:655-660.
21. Owen TA, Aronow M, Shalhoub V, et al. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol. 1990;143: 420-430.
22. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425:836-841.
23. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418:41-49.