Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: Quantification using UPLC-ES/MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 71, Issue , 2012, Pages 119-126

  Sepehr, Estatira ^a   Lebl Rinnova, Marketa ^b   Mann, Meagan K ^b   Pisani, Samantha L ^b   Churchwell, Mona I ^a   Korol, Donna L ^b   Katzenellenbogen, John A ^b   Doerge, Daniel R ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Estrogen receptor subtypes; Isotope dilution quantification; Mass spectrometry; Pharmacokinetics; Synthetic deuterium labeling

Indexed keywords

1,3,5 TRIS(4 HYDROXYPHENYL) 4 PROPYLPYRAZOLE; ARYLSULFATASE; BETA GLUCURONIDASE; DIARYLPROPIONITRILE; ESTROGEN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HYDROLYSIS; ISOTOPE DILUTION ASSAY; LIMIT OF DETECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY ANALYSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY;

ANIMALS; ARYLSULFATASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLUCURONIDASE; HYDROLYSIS; LIGANDS; METABOLIC DETOXICATION, PHASE II; NITRILES; PROPIONATES; PYRAZOLES; RATS; RATS, LONG-EVANS; RECEPTORS, ESTROGEN; TANDEM MASS SPECTROMETRY;

EID: 84866774346     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.08.022     Document Type: Article

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