Determination of cellular uptake and intracellular levels of Cenersen (Aezea®, EL625), a p53 antisense oligonucleotide in acute myeloid leukemia cells

Journal of Pharmaceutical and Biomedical Analysis

Volumn 71, Issue , 2012, Pages 228-232

  Alachkar, Houda ^a   Xie, Zhiliang ^b   Marcucci, Guido ^a,b   Chan, Kenneth K ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Acute myeloid leukemia (AML); Cenersen; Enzyme linked immunosorbent assay (ELISA); Intracellular uptake; P53 antisense

Indexed keywords

CENERSEN; MESSENGER RNA; OLIGONUCLEOTIDE; PROTEIN P53;

ACCURACY; ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER CELL CULTURE; CELL LYSATE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CROSS REACTION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; DRUG UPTAKE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; LIMIT OF QUANTITATION; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SYNTHESIS;

ANIMALS; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, ACUTE; MICE; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84866770298     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.08.011     Document Type: Article

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