Antisense oligonucleotide targeting p53 increased apoptosis of MCF-7 cells induced by ionizing radiation

Acta Pharmacologica Sinica

Volumn 27, Issue 11, 2006, Pages 1453-1458

  Dai, Li Cheng ^a   Wang, Xiang ^a   Yao, Xing ^a   Min, Li Shan ^a   Qian, Fu Chu ^a   He, Jian Fang ^a  

^a HUZHOU CENTRAL HOSPITAL   (China)

Author keywords

Antisense oligodeoxyribonucleotides; Cell cycle; MCF 7; p53 genes; Radiation tolerance

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; PROTEIN BAX; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; PROTEIN TARGETING; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENES, P53; HUMANS; MALE; OLIGONUCLEOTIDES, ANTISENSE; PROSTATIC NEOPLASMS; RADIATION, IONIZING; RNA, MESSENGER; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33750353987     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00405.x     Document Type: Article

References (32)

1. Jung M, Dritschilo A. Signal transduction and cellular responses to ionizing radiation. Semin Radiat Oncol 1996; 6: 268-72.
2. Gudkov AV, Komarova EA. The role of p53 in determining sensitivity to radiotherapy. Nat Rev (cancer) 2003; 3: 117-28.
3. Fei P, Bernhard EJ, EI-Deiry WS. Tissue-specific induction of p53 targets in vivo. Cancer Res 2002; 62: 7316-27.
4. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited interleukin-6. Nature 1991; 352: 345-7.
5. Yonish-Rouach E, Grunwald D, Wilder S, Kimchi A, May E, Lawrence JJ. p53-mediated cell death: relationship to cell cycle control. Mol Cell Biol 1993; 13: 1415-23.
6. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM. WAF1, a potential mediator of p53 tumour suppression. Cell 1993; 75: 817-25.
7. Reimer CL, Borras AM, Kurdistani SK, Garreau JR, Chung M, Aaronson SA. Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. J Biol Chem 1999; 274: 11022-9.
8. Chin PL, Momand J, Pfeifer GP. In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation. Oncogene 1997; 15: 87-99.
9. Bow JJ, Howdgson B. Replication licesing-defining the proliferative state? Trends cell Biol 2002; 12: 72-8.
10. Short SC, Woodcock M, Marples B, Joiner MC. Effects of cell cycle phase on low-dose hyper-radiosensitivity. Int J Radiat Biol 2003; 79: 99-105.
11. Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 2004; 59: 928-42.
12. Ribeiro JCC, Barnetson AR, Fisher RJ, Mameghan H, Russell PJ. Relationship between radiation response and p53 status in human bladder cancer cells. Int J Radiat Biol 1997; 72: 11-20.
13. Kawashima K, Mihara K, Usuki H, Shimizu N, Namba M. Transfected mutant p53 gene increases X-ray-induced cell killing and mutation in human fibroblasts immortalized with 4-nitroquinoline 1-oxide but does not induce neoplastic transformation of the cells. Int J Cancer 1995; 61: 76-9.
14. Biard DSF, Martin M, Rhun YL, Duthu A, Lefaix JL, May E. Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development. Cancer Res 1994; 54: 3361-4.
15. McIlwrath AJ, Vasey PA, Ross GM, Brown R. Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Res 1994; 54: 3718-22.
16. Brachman DG, Beckett M, Graves D, Haraf D, Vokes E, Weichselbaum RR. p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines. Cancer Res 1993; 53: 3667-9.
17. Böhnke A, Westphal F, Schmidt A, El-Awady A, Dahm-Daphi J. Role of p53 mutations, protein function and DNA damage for the radiosensitivity of human tumour cells. Int J Radiat Biol 2004; 1: 53-63.
18. Dai JM, Zhang SQ, Zhang W, Lin RX, Ji ZZ, Wang SQ. Antisense oligodeoxynucleotides targeting the serine/threonine kinase Pim-2 inhibited proliferation of DU-145 cells. Acta Pharmacol Sin 2005; 26: 364-8.
19. Yang SP, Song ST, Tang ZM, Song HF. Optimization of antisense drug design against conservative local motif in stimulant secondary structures of HER-2 mRNA and QSAR analysis. Acta Pharmacol Sin 2003; 24: 897-902.
20. Chalk AM, Sonnhammer EL. Computational antisense oligo prediction with a neural network model. Bioinformatics 2002; 18: 1567-75.
21. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003; 31: 3406-15.
22. Shao RG, Cao CX, Shimizu T, O'Connor PM, Kohn KW, Pommier Y. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. Cancer Res 1997; 57: 4029-35.
23. Matsuzoe D, Hideshima T, Kimura A, Inada K, Watanabe K, Akita Y, et al. p53 mutations predict non-small cell lung carcinoma response to radiotherapy. Cancer Lett 1999; 135: 189-94.
24. Nicole C, Christa Z, Margit S, Ingrid S, Dan T, Uwe W, et al. p53-dependent radioresistance in ovarian carcinoma cell lines. Cancer Lett 2000; 150: 191-9.
25. 1 checkpoint does not decrease cell survival following DNA damage. Cancer Res 1993; 53: 4164-8.
26. Brachman DG, Beckett M, Graves D, Haraf D, Vokes E, Weichselbaum RR. p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines. Cancer Res 1993; 53: 3667-9.
27. Liu XF, Xia YF, Li MZ, Wang HM, He YX, Zheng ML, et al. The effect of p21 antisense oligodeoxynucleotides on the radiosensitivity of nasopharyngeal carcinoma cells with normal p53 function. Cell Biol Int 2006; 30: 283-7.
28. 1 checkpoint control. Cell 1995; 82: 675-84.
29. Kokunai T, Urui S, Tomita H, Tamaki N. Overcoming of radioresistance in human gliomas by p21WAF1/CIP1 antisense oligonucleotide. J Neurooncol 2001; 51: 111-9
30. WAF1/CIP1. Cancer Gene Ther 2003; 10: 926-34.
31. El-Deiry WS. The role of p53 in chemosensitivity and radiosensitivity. Oncogene 2003; 22: 7486-95.
32. Li G, Ho VC. p53-dependent DNA repair and apoptosis respond differently to high-and low-dose ultraviolet radiation. Br J Dermatol 1998; 139: 3-10.