A novel polyethyleneimine-coated adenoassociated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: Preparation and in vitro analysis

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 1575-1586

  Shao, Wei ^a   Paul, Arghya ^a   Abbasi, Sana ^a   Chahal, Parminder S ^b   Mena, Jimmy A ^b   Montes, Johnny ^b   Kamen, Amine ^b   Prakash, Satya ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Adeno associated virus type 2; Breast cancer therapy; Nanomedicine; Small interfering RNA delivery; Virus like particles

Indexed keywords

PARVOVIRUS VECTOR; POLYETHYLENEIMINE; SMALL INTERFERING RNA; CAPSID PROTEIN; DRUG CARRIER; NANOPARTICLE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG COATING; GEL ELECTROPHORESIS; GENETIC TRANSFECTION; IN VITRO STUDY; NONHUMAN; PARTICLE SIZE; VIRAL GENE DELIVERY SYSTEM; VIRUS LIKE AGENT; VIRUS PURIFICATION; WESTERN BLOTTING; ADENO ASSOCIATED VIRUS; ANIMAL; BREAST TUMOR; CELL LINE; CHEMISTRY; DRUG DELIVERY SYSTEM; FEMALE; GENE THERAPY; GENETICS; HUMAN; NANOMEDICINE; TUMOR CELL LINE;

ADENO-ASSOCIATED VIRUS - 2; HEXAPODA; MIRIDAE;

ANIMALS; BREAST NEOPLASMS; CAPSID PROTEINS; CELL LINE; CELL LINE, TUMOR; DEPENDOVIRUS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; GENE THERAPY; HUMANS; NANOMEDICINE; NANOPARTICLES; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84866766563     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S26891     Document Type: Article

References (31)

1. Shi Q, Zhang XL, Dai KR, Benderdour M, Fernandes JC. siRNA therapy for cancer and non-lethal diseases such as arthritis and osteoporosis. Expert Opin Biol Ther. 2011;11(1):5-16.
2. Tokatlian T, Segura T. siRNA applications in nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;2(3):305-315.
3. Song WJ, Du JZ, Sun TM, Zhang PZ, Wang J. Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery. Small. 2010;6(2):239-246.
4. Liu J, Sonshine DA, Shervani S, Hurt RH. Controlled release of biologically active silver from nanosilver surfaces. ACS Nano. 2010;4(11):6903-6913.
5. Nunes A, Amsharov N, Guo C, et al. Hybrid polymer-grafted multiwalled carbon nanotubes for in vitro gene delivery. Small. 2010;6(20):2281-2291.
6. Krajcik R, Jung A, Hirsch A, Neuhuber W, Zolk O. Functionalization of carbon nanotubes enables non-covalent binding and intracellular delivery of small interfering RNA for efficient knock-down of genes. Biochem Biophys Res Commun. 2008;369(2):595-602.
7. Yang R, Yang X, Zhang Z, et al. Single-walled carbon nanotubesmediated in vivo and in vitro delivery of siRNA into antigen-presenting cells. Gene Ther. 2006;13(24):1714-1723.
8. Ewert KK, Zidovska A, Ahmad A, et al. Cationic liposome-nucleic acid complexes for gene delivery and silencing: pathways and mechanisms for plasmid DNA and siRNA. Top Curr Chem. 2010;296: 191-226.
9. Hughes J, Yadava P, Mesaros R. Liposomal siRNA delivery. Methods Mol Biol. 2010;605:445-459.
10. Kim HK, Davaa E, Myung CS, Park JS. Enhanced siRNA delivery using cationic liposomes with new polyarginine-conjugated PEG-lipid. Int J Pharm. 2010;392(1-2):141-147.
11. Tanner P, Baumann P, Enea R, Onaca O, Palivan C, Meier W. Polymeric vesicles: from drug carriers to nanoreactors and artificial organelles. Acc Chem Res. 2011;44(10):1039-1049.
12. Sun X, Zhang N. Cationic polymer optimization for efficient gene delivery. Mini Rev Med Chem. 2010;10(2):108-125.
13. Roldao A, Mellado MC, Castilho LR, Carrondo MJ, Alves PM. Virus-like particles in vaccine development. Expert Rev Vaccines. 2010;9(10):1149-1176.
14. Garcea RL, Gissmann L. Virus-like particles as vaccines and vessels for the delivery of small molecules. Curr Opin Biotechnol. 2004;15(6):513-517.
15. Van Vliet KM, Blouin V, Brument N, Agbandje-McKenna M, Snyder RO. The role of the adeno-associated virus capsid in gene transfer. Methods Mol Biol. 2008;437:51-91.
16. Muralidhar S, Becerra SP, Rose JA. Site-directed mutagenesis of adeno-associated virus type 2 structural protein initiation codons: effects on regulation of synthesis and biological activity. J Virol. 1994;68(1):170-176.
17. Alam S, Sen E, Brashear H, Meyers C. Adeno-associated virus type 2 increases proteosome-dependent degradation of p21 WAF1 in a human papillomavirus type 31b-positive cervical carcinoma line. J Virol. 2006;80(10):4927-4939.
18. Aucoin MG, Perrier M, Kamen AA. Critical assessment of current adeno-associated viral vector production and quantification methods. Biotechnol Adv. 2008;26(1):73-88.
19. Aucoin MG, Perrier M, Kamen AA. Production of adeno-associated viral vectors in insect cells using triple infection: optimization of baculovirus concentration ratios. Biotechnol Bioeng. 2006;95(6):1081-1092.
20. Chahal PS, Aucoin MG, Kamen A. Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system. J Virol Methods. 2007;139(1):61-70.
21. Hsu PY, Yang YW. Effect of polyethylenimine on recombinant adeno-associated virus mediated insulin gene therapy. J Gene Med. 2005;7(10):1311-1321.
22. Chen C, Daniel MC, Quinkert ZT, et al. Nanoparticle-templated assembly of viral protein cages. Nano Lett. 2006;6(4):611-615.
23. Dixit SK, Goicochea NL, Daniel MC, et al. Quantum dot encapsulation in viral capsids. Nano Lett. 2006;6(9):1993-1999.
24. Ren Y, Wong SM, Lim LY. Folic acid-conjugated protein cages of a plant virus: a novel delivery platform for doxorubicin. Bioconjug Chem. 2007;18(3):836-843.
25. Bankiewicz KS, Eberling JL, Kohutnicka M, et al. Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using prodrug approach. Exp Neurol. 2000;164(1):2-14.
26. Meghrous J, Aucoin MG, Jacob D, Chahal PS, Arcand N, Kamen AA. Production of recombinant adeno-associated viral vectors using a baculovirus/insect cell suspension culture system: from shake flasks to a 20-L bioreactor. Biotechnol Prog. 2005;21(1):154-160.
27. Auricchio A, Hildinger M, O'Connor E, Gao GP, Wilson JM. Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column. Hum Gene Ther. 2001; 12(1):71-76.
28. Moulay G, Boutin S, Masurier C, Scherman D, Kichler A. Polymers for improving the in vivo transduction efficiency of AAV2 vectors. PLoS One. 2010;5(12):e15576.
29. Fein DE, Limberis MP, Maloney SF, Heath JM, Wilson JM, Diamond SL. Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung. Mol Ther. 2009;17(12):2078-2087.
30. Le HT, Yu QC, Wilson JM, Croyle MA. Utility of PEGylated recombinant adeno-associated viruses for gene transfer. J Control Release. 2005;108(1):161-177.
31. Nomura T, Koreeda N, Yamashita F, Takakura Y, Hashida M. Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors. Pharm Res. 1998;15(1):128-132.