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Volumn 527, Issue 2, 2012, Pages 100-104

Valproate causes reduction of the excitatory amino acid aspartate in nerve terminals

Author keywords

Aspartate; Epilepsy; Excitotoxicity; Nerve terminal; Neurotransmission; Valproate

Indexed keywords

4 AMINOBUTYRIC ACID; ASPARTIC ACID; GLUTAMIC ACID; VALPROIC ACID;

EID: 84866760778     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.08.042     Document Type: Article
Times cited : (17)

References (41)
  • 1
    • 0021273331 scopus 로고
    • Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities
    • Battistin L., Varotto M., Berlese G., Roman G. Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities. Neurochemical Research 1984, 9:225-231.
    • (1984) Neurochemical Research , vol.9 , pp. 225-231
    • Battistin, L.1    Varotto, M.2    Berlese, G.3    Roman, G.4
  • 2
    • 38149041804 scopus 로고    scopus 로고
    • Immunogold quantification of amino acids and proteins in complex subcellular compartments
    • Bergersen L.H., Storm-Mathisen J., Gundersen V. Immunogold quantification of amino acids and proteins in complex subcellular compartments. Nature Protocols 2008, 3:144-152.
    • (2008) Nature Protocols , vol.3 , pp. 144-152
    • Bergersen, L.H.1    Storm-Mathisen, J.2    Gundersen, V.3
  • 3
    • 0026451073 scopus 로고
    • The effect of sodium valproate on extracellular GABA and other amino acids in the rat ventral hippocampus: an in vivo microdialysis study
    • Biggs C.S., Pearce B.R., Fowler L.J., Whitton P.S. The effect of sodium valproate on extracellular GABA and other amino acids in the rat ventral hippocampus: an in vivo microdialysis study. Brain Research 1992, 594:138-142.
    • (1992) Brain Research , vol.594 , pp. 138-142
    • Biggs, C.S.1    Pearce, B.R.2    Fowler, L.J.3    Whitton, P.S.4
  • 4
    • 0027169611 scopus 로고
    • Enrichment of glutamate-like immunoreactivity in primary afferent terminals throughout the spinal cord dorsal horn
    • Broman J., Anderson S., Ottersen O.P. Enrichment of glutamate-like immunoreactivity in primary afferent terminals throughout the spinal cord dorsal horn. European Journal of Neuroscience 1993, 5:1050-1061.
    • (1993) European Journal of Neuroscience , vol.5 , pp. 1050-1061
    • Broman, J.1    Anderson, S.2    Ottersen, O.P.3
  • 6
    • 0023161315 scopus 로고
    • 2+ uptake and amino acid neurotransmitter release in vitro
    • 2+ uptake and amino acid neurotransmitter release in vitro. Epilepsia 1987, 28:378-382.
    • (1987) Epilepsia , vol.28 , pp. 378-382
    • Crowder, J.M.1    Bradford, H.F.2
  • 7
    • 0142059132 scopus 로고    scopus 로고
    • Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro
    • Cunningham M.O., Woodhall G.L., Jones R.S. Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro. Neuropharmacology 2003, 45:907-917.
    • (2003) Neuropharmacology , vol.45 , pp. 907-917
    • Cunningham, M.O.1    Woodhall, G.L.2    Jones, R.S.3
  • 8
    • 0026587128 scopus 로고
    • Selectivity of amino acid transmitters acting at N-methyl-d-aspartate and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors
    • Curras M.C., Dingledine R. Selectivity of amino acid transmitters acting at N-methyl-d-aspartate and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors. Molecular Pharmacology 1992, 41:520-526.
    • (1992) Molecular Pharmacology , vol.41 , pp. 520-526
    • Curras, M.C.1    Dingledine, R.2
  • 9
    • 33644847187 scopus 로고    scopus 로고
    • Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex
    • Gobbi G., Janiri L. Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex. Psychopharmacology 2006, 185:255-262.
    • (2006) Psychopharmacology , vol.185 , pp. 255-262
    • Gobbi, G.1    Janiri, L.2
  • 10
    • 0014532570 scopus 로고
    • Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism
    • Godin Y., Heiner L., Mark J., Mandel P. Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism. Journal of Neurochemistry 1969, 16:869-873.
    • (1969) Journal of Neurochemistry , vol.16 , pp. 869-873
    • Godin, Y.1    Heiner, L.2    Mark, J.3    Mandel, P.4
  • 11
    • 0032529722 scopus 로고    scopus 로고
    • Synaptic vesicular localization and exocytosis of l-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus
    • Gundersen V., Chaudhry F.A., Bjaalie J.G., Fonnum F., Ottersen O.P., Storm-Mathisen J. Synaptic vesicular localization and exocytosis of l-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus. Journal of Neuroscience 1998, 18:6059-6070.
    • (1998) Journal of Neuroscience , vol.18 , pp. 6059-6070
    • Gundersen, V.1    Chaudhry, F.A.2    Bjaalie, J.G.3    Fonnum, F.4    Ottersen, O.P.5    Storm-Mathisen, J.6
  • 12
    • 0035192655 scopus 로고    scopus 로고
    • Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study
    • Gundersen V., Fonnum F., Ottersen O.P., Storm-Mathisen J. Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study. Journal of Cerebral Blood Flow and Metabolism 2001, 21:41-51.
    • (2001) Journal of Cerebral Blood Flow and Metabolism , vol.21 , pp. 41-51
    • Gundersen, V.1    Fonnum, F.2    Ottersen, O.P.3    Storm-Mathisen, J.4
  • 13
    • 2342451337 scopus 로고    scopus 로고
    • GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission
    • Gundersen V., Holten A.T., Storm-Mathisen J. GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission. Molecular and Cellular Neurosciences 2004, 26:156-165.
    • (2004) Molecular and Cellular Neurosciences , vol.26 , pp. 156-165
    • Gundersen, V.1    Holten, A.T.2    Storm-Mathisen, J.3
  • 14
    • 0030612955 scopus 로고    scopus 로고
    • Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate
    • Hassel B., Bachelard H., Jones P., Fonnum F., Sonnewald U. Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate. Journal of Cerebral Blood Flow and Metabolism 1997, 17:1230-1238.
    • (1997) Journal of Cerebral Blood Flow and Metabolism , vol.17 , pp. 1230-1238
    • Hassel, B.1    Bachelard, H.2    Jones, P.3    Fonnum, F.4    Sonnewald, U.5
  • 15
    • 0035812867 scopus 로고    scopus 로고
    • Differential synaptic localization of GluR2 and EAAC1 in the macaque monkey entorhinal cortex: a postembedding immunogold study
    • He Y., Hof P.R., Janssen W.G., Rothstein J.D., Morrison J.H. Differential synaptic localization of GluR2 and EAAC1 in the macaque monkey entorhinal cortex: a postembedding immunogold study. Neuroscience Letters 2001, 311:161-164.
    • (2001) Neuroscience Letters , vol.311 , pp. 161-164
    • He, Y.1    Hof, P.R.2    Janssen, W.G.3    Rothstein, J.D.4    Morrison, J.H.5
  • 16
    • 0026755921 scopus 로고
    • Increased aspartate release from brain slices of epileptic experimental animals and effect of valproate on it
    • Hiramatsu M., Kinno I., Kanakura K., Sato K., Mori A. Increased aspartate release from brain slices of epileptic experimental animals and effect of valproate on it. Japanese Journal of Psychiatry and Neurology 1992, 46:541-543.
    • (1992) Japanese Journal of Psychiatry and Neurology , vol.46 , pp. 541-543
    • Hiramatsu, M.1    Kinno, I.2    Kanakura, K.3    Sato, K.4    Mori, A.5
  • 18
    • 38449091521 scopus 로고    scopus 로고
    • Glutamine as a precursor for transmitter glutamate, aspartate and GABA in the cerebellum: a role for phosphate-activated glutaminase
    • Holten A.T., Gundersen V. Glutamine as a precursor for transmitter glutamate, aspartate and GABA in the cerebellum: a role for phosphate-activated glutaminase. Journal of Neurochemistry 2008, 104:1032-1042.
    • (2008) Journal of Neurochemistry , vol.104 , pp. 1032-1042
    • Holten, A.T.1    Gundersen, V.2
  • 19
    • 0035652349 scopus 로고    scopus 로고
    • The acute effect of valproate on cerebral energy metabolism in mice
    • Johannessen C.U., Petersen D., Fonnum F., Hassel B. The acute effect of valproate on cerebral energy metabolism in mice. Epilepsy Research 2001, 47:247-256.
    • (2001) Epilepsy Research , vol.47 , pp. 247-256
    • Johannessen, C.U.1    Petersen, D.2    Fonnum, F.3    Hassel, B.4
  • 21
    • 0017667355 scopus 로고
    • Effects of sodium dipropylacetate on gamma-aminobutyric acid and biogenic amines in rat brain
    • Kukino K., Deguchi T. Effects of sodium dipropylacetate on gamma-aminobutyric acid and biogenic amines in rat brain. Chemical and Pharmaceutical Bulletin 1977, 25:2257-2262.
    • (1977) Chemical and Pharmaceutical Bulletin , vol.25 , pp. 2257-2262
    • Kukino, K.1    Deguchi, T.2
  • 22
    • 0017344533 scopus 로고
    • Synaptic and non-synaptic mitochondria from rat brain: isolation and characterization
    • Lai J.C., Walsh J.M., Dennis S.C., Clark J.B. Synaptic and non-synaptic mitochondria from rat brain: isolation and characterization. Journal of Neurochemistry 1977, 28:625-631.
    • (1977) Journal of Neurochemistry , vol.28 , pp. 625-631
    • Lai, J.C.1    Walsh, J.M.2    Dennis, S.C.3    Clark, J.B.4
  • 23
    • 20444485368 scopus 로고    scopus 로고
    • Different basal levels of CaMKII phosphorylated at Thr286/287 at nociceptive and low-threshold primary afferent synapses
    • Larsson M., Broman J. Different basal levels of CaMKII phosphorylated at Thr286/287 at nociceptive and low-threshold primary afferent synapses. European Journal of Neuroscience 2005, 21:2445-2458.
    • (2005) European Journal of Neuroscience , vol.21 , pp. 2445-2458
    • Larsson, M.1    Broman, J.2
  • 24
    • 0242268073 scopus 로고    scopus 로고
    • Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus
    • Li Z.P., Zhang X.Y., Lu X., Zhong M.K., Ji Y.H. Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus. Neurochemistry International 2004, 44:263-270.
    • (2004) Neurochemistry International , vol.44 , pp. 263-270
    • Li, Z.P.1    Zhang, X.Y.2    Lu, X.3    Zhong, M.K.4    Ji, Y.H.5
  • 25
    • 0027437539 scopus 로고
    • In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats
    • Loscher W. In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats. Neuroscience Letters 1993, 160:177-180.
    • (1993) Neuroscience Letters , vol.160 , pp. 177-180
    • Loscher, W.1
  • 26
    • 0037742375 scopus 로고    scopus 로고
    • Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
    • Löscher W. Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action. Progress in Neurobiology 1999, 58:31-59.
    • (1999) Progress in Neurobiology , vol.58 , pp. 31-59
    • Löscher, W.1
  • 27
    • 0028351099 scopus 로고
    • Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma
    • Loscher W., Horstermann D. Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma. Naunyn-Schmiedebergs Archiv fur Pharmakologie 1994, 349:270-278.
    • (1994) Naunyn-Schmiedebergs Archiv fur Pharmakologie , vol.349 , pp. 270-278
    • Loscher, W.1    Horstermann, D.2
  • 28
    • 0021259522 scopus 로고
    • Drug-induced changes in GABA content of nerve endings in 11 rat brain regions. Correlation to pharmacological effects
    • Loscher W., Vetter M. Drug-induced changes in GABA content of nerve endings in 11 rat brain regions. Correlation to pharmacological effects. Neuroscience Letters 1984, 47:325-331.
    • (1984) Neuroscience Letters , vol.47 , pp. 325-331
    • Loscher, W.1    Vetter, M.2
  • 29
    • 0018384989 scopus 로고
    • Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons
    • Macdonald R.L., Bergey G.K. Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons. Brain Research 1979, 170:558-562.
    • (1979) Brain Research , vol.170 , pp. 558-562
    • Macdonald, R.L.1    Bergey, G.K.2
  • 30
    • 0022565563 scopus 로고
    • Anticonvulsant drugs: mechanisms of action
    • Macdonald R.L., McLean M.J. Anticonvulsant drugs: mechanisms of action. Advances in Neurology 1986, 44:713-736.
    • (1986) Advances in Neurology , vol.44 , pp. 713-736
    • Macdonald, R.L.1    McLean, M.J.2
  • 31
    • 70349096650 scopus 로고    scopus 로고
    • Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection
    • Monti B., Polazzi E., Contestabile A. Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection. Current Molecular Pharmacology 2009, 2:95-109.
    • (2009) Current Molecular Pharmacology , vol.2 , pp. 95-109
    • Monti, B.1    Polazzi, E.2    Contestabile, A.3
  • 32
    • 8344270103 scopus 로고    scopus 로고
    • Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake
    • Morland C., Boldingh K.A., Iversen E.G., Hassel B. Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake. Journal of Cerebral Blood Flow and Metabolism 2004, 24:1226-1234.
    • (2004) Journal of Cerebral Blood Flow and Metabolism , vol.24 , pp. 1226-1234
    • Morland, C.1    Boldingh, K.A.2    Iversen, E.G.3    Hassel, B.4
  • 33
    • 33947424365 scopus 로고    scopus 로고
    • Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain
    • Morland C., Henjum S., Iversen E.G., Skrede K.K., Hassel B. Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochemistry International 2007, 50:703-709.
    • (2007) Neurochemistry International , vol.50 , pp. 703-709
    • Morland, C.1    Henjum, S.2    Iversen, E.G.3    Skrede, K.K.4    Hassel, B.5
  • 34
    • 79954571300 scopus 로고    scopus 로고
    • Aspartate release and signalling in the hippocampus
    • Nadler J.V. Aspartate release and signalling in the hippocampus. Neurochemical Research 2011, 36:668-676.
    • (2011) Neurochemical Research , vol.36 , pp. 668-676
    • Nadler, J.V.1
  • 35
    • 0023545235 scopus 로고
    • Postembedding light- and electron microscopic immunocytochemistry of amino acids: description of a new model system allowing identical conditions for specificity testing and tissue processing
    • Ottersen O.P. Postembedding light- and electron microscopic immunocytochemistry of amino acids: description of a new model system allowing identical conditions for specificity testing and tissue processing. Experimental Brain Research 1987, 69:167-174.
    • (1987) Experimental Brain Research , vol.69 , pp. 167-174
    • Ottersen, O.P.1
  • 36
    • 0026544324 scopus 로고
    • Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum
    • Ottersen O.P., Zhang N., Walberg F. Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum. Neuroscience 1992, 46:519-534.
    • (1992) Neuroscience , vol.46 , pp. 519-534
    • Ottersen, O.P.1    Zhang, N.2    Walberg, F.3
  • 37
    • 35248894933 scopus 로고    scopus 로고
    • The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?
    • Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?. Cellular and Molecular Life Sciences 2007, 64:2090-2103.
    • (2007) Cellular and Molecular Life Sciences , vol.64 , pp. 2090-2103
    • Rosenberg, G.1
  • 38
    • 0018130714 scopus 로고
    • Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity
    • Schechter P.J., Tranier Y., Grove J. Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity. Journal of Neurochemistry 1978, 31:1325-1327.
    • (1978) Journal of Neurochemistry , vol.31 , pp. 1325-1327
    • Schechter, P.J.1    Tranier, Y.2    Grove, J.3
  • 39
    • 4344600690 scopus 로고    scopus 로고
    • Anticonvulsants as mood stabilizers and adjuncts to antipsychotics: valproate, lamotrigine, carbamazepine, and oxcarbazepine and actions at voltage-gated sodium channels
    • Stahl S.M. Anticonvulsants as mood stabilizers and adjuncts to antipsychotics: valproate, lamotrigine, carbamazepine, and oxcarbazepine and actions at voltage-gated sodium channels. Journal of Clinical Psychiatry 2004, 65:738-739.
    • (2004) Journal of Clinical Psychiatry , vol.65 , pp. 738-739
    • Stahl, S.M.1


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