메뉴 건너뛰기




Volumn 17, Issue 19-20, 2012, Pages 1127-1132

Gallium as a potential candidate for treatment of osteoporosis

Author keywords

[No Author keywords available]

Indexed keywords

GALLIUM;

EID: 84866743960     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.06.007     Document Type: Review
Times cited : (46)

References (61)
  • 1
    • 0032445152 scopus 로고    scopus 로고
    • Mechanisms of therapeutic activity for gallium
    • L.R. Bernstein Mechanisms of therapeutic activity for gallium Pharmacol. Rev. 50 1998 665 682
    • (1998) Pharmacol. Rev. , vol.50 , pp. 665-682
    • Bernstein, L.R.1
  • 2
    • 0013639688 scopus 로고
    • Deposition of radio gallium (Ga72) in skeletal tissues
    • H.C. Dudley, and G.E. Maddox Deposition of radio gallium (Ga72) in skeletal tissues J. Pharmacol. Exp. Ther. 96 1949 224 227
    • (1949) J. Pharmacol. Exp. Ther. , vol.96 , pp. 224-227
    • Dudley, H.C.1    Maddox, G.E.2
  • 3
  • 4
    • 0038147469 scopus 로고    scopus 로고
    • Gallium nitrate in the treatment of lymphoma
    • D.J. Straus Gallium nitrate in the treatment of lymphoma Semin. Oncol. 30 Suppl. 5 2003 25 33
    • (2003) Semin. Oncol. , vol.30 , Issue.SUPPL. 5 , pp. 25-33
    • Straus, D.J.1
  • 5
    • 0022006708 scopus 로고
    • Phase II trial of gallium nitrate in patients with advanced malignant melanoma
    • E.S. Casper Phase II trial of gallium nitrate in patients with advanced malignant melanoma Cancer Treat. Rep. 69 1985 1019 1020
    • (1985) Cancer Treat. Rep. , vol.69 , pp. 1019-1020
    • Casper, E.S.1
  • 6
    • 0025781712 scopus 로고
    • A phase II trial of gallium nitrate (NSC #15200) in previously treated ovarian carcinoma. A Gynecologic Oncology Group Study
    • J.H. Malfetano A phase II trial of gallium nitrate (NSC #15200) in previously treated ovarian carcinoma. A Gynecologic Oncology Group Study Am. J. Clin. Oncol. 14 1991 349 351
    • (1991) Am. J. Clin. Oncol. , vol.14 , pp. 349-351
    • Malfetano, J.H.1
  • 7
    • 0025767037 scopus 로고
    • Gallium prevents adjuvant arthritis in rats and interferes with macrophage/T-cell function in the immune response
    • V. Matkovic Gallium prevents adjuvant arthritis in rats and interferes with macrophage/T-cell function in the immune response Curr. Ther. Res. 50 1991 255 267
    • (1991) Curr. Ther. Res. , vol.50 , pp. 255-267
    • Matkovic, V.1
  • 8
    • 0024554859 scopus 로고
    • Gallium in the treatment of hypercalcemia and bone metastasis
    • R.P. Warrell Jr., and R. Bockman Gallium in the treatment of hypercalcemia and bone metastasis Important Adv. Oncol. 1989 205 220
    • (1989) Important Adv. Oncol. , pp. 205-220
    • Warrell, Jr.R.P.1    Bockman, R.2
  • 9
    • 0019186171 scopus 로고
    • Phase I-II clinical trial of gallium nitrate (NSC-15200)
    • M.K. Samson Phase I-II clinical trial of gallium nitrate (NSC-15200) Cancer Clin. Trials 3 1980 131 136
    • (1980) Cancer Clin. Trials , vol.3 , pp. 131-136
    • Samson, M.K.1
  • 10
    • 0028216884 scopus 로고
    • Treatment of patients with advanced Paget's disease of bone with two cycles of gallium nitrate
    • R.S. Bockman, and B. Bosco Treatment of patients with advanced Paget's disease of bone with two cycles of gallium nitrate Semin. Arthritis Rheum. 23 1994 268 269
    • (1994) Semin. Arthritis Rheum. , vol.23 , pp. 268-269
    • Bockman, R.S.1    Bosco, B.2
  • 11
    • 8344260657 scopus 로고    scopus 로고
    • Gallium compounds as antineoplastic agents
    • C.R. Chitambar Gallium compounds as antineoplastic agents Curr. Opin. Oncol. 16 2004 547 552
    • (2004) Curr. Opin. Oncol. , vol.16 , pp. 547-552
    • Chitambar, C.R.1
  • 12
    • 77954789725 scopus 로고    scopus 로고
    • Medical applications and toxicities of gallium compounds
    • C.R. Chitambar Medical applications and toxicities of gallium compounds Int. J. Environ. Res. Public Health 7 2010 2337 2361
    • (2010) Int. J. Environ. Res. Public Health , vol.7 , pp. 2337-2361
    • Chitambar, C.R.1
  • 13
    • 0000535655 scopus 로고
    • Parametric correlation of formation constants in aqueous solution: Ligands with large donor atoms
    • R.D. Hancock, and F. Marsicano Parametric correlation of formation constants in aqueous solution: ligands with large donor atoms Inorg. Chem. 19 1980 2709 2714
    • (1980) Inorg. Chem. , vol.19 , pp. 2709-2714
    • Hancock, R.D.1    Marsicano, F.2
  • 14
    • 0030860162 scopus 로고    scopus 로고
    • Gallium speciation in aqueous solution. Experimental study and modeling. Part 2. Solubility of alpha-GaOOH in acidic solutions from 150 to 250 degrees C and hydrolysis constants of gallium (III) to 300 degrees C
    • P. Benezeth Gallium speciation in aqueous solution. Experimental study and modeling. Part 2. Solubility of alpha-GaOOH in acidic solutions from 150 to 250 degrees C and hydrolysis constants of gallium (III) to 300 degrees C Geochim. Cosmochim. Acta 61 1997 1345 1357
    • (1997) Geochim. Cosmochim. Acta , vol.61 , pp. 1345-1357
    • Benezeth, P.1
  • 15
    • 0021107162 scopus 로고
    • Thermodynamic binding constants for gallium transferrin
    • W.R. Harris, and V.L. Pecoraro Thermodynamic binding constants for gallium transferrin Biochemistry 22 1983 292 299
    • (1983) Biochemistry , vol.22 , pp. 292-299
    • Harris, W.R.1    Pecoraro, V.L.2
  • 16
    • 0034101581 scopus 로고    scopus 로고
    • Chemistry and pharmacokinetics of gallium maltolate, a compound with high oral gallium bioavailability
    • L.R. Bernstein Chemistry and pharmacokinetics of gallium maltolate, a compound with high oral gallium bioavailability Met. Based Drugs 7 2000 33 47
    • (2000) Met. Based Drugs , vol.7 , pp. 33-47
    • Bernstein, L.R.1
  • 17
    • 0023004168 scopus 로고
    • Gallium increases bone calcium and crystallite perfection of hydroxyapatite
    • R.S. Bockman Gallium increases bone calcium and crystallite perfection of hydroxyapatite Calcif. Tissue Int. 39 1986 376 381
    • (1986) Calcif. Tissue Int. , vol.39 , pp. 376-381
    • Bockman, R.S.1
  • 18
    • 0025325372 scopus 로고
    • Distribution of trace levels of therapeutic gallium in bone as mapped by synchrotron X-ray microscopy
    • R.S. Bockman Distribution of trace levels of therapeutic gallium in bone as mapped by synchrotron X-ray microscopy Proc. Natl. Acad. Sci. U.S.A. 87 1990 4149 4153
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 4149-4153
    • Bockman, R.S.1
  • 19
    • 0038486159 scopus 로고    scopus 로고
    • The effects of gallium nitrate on bone resorption
    • R. Bockman The effects of gallium nitrate on bone resorption Semin. Oncol. 30 Suppl. 5 2003 5 12
    • (2003) Semin. Oncol. , vol.30 , Issue.SUPPL. 5 , pp. 5-12
    • Bockman, R.1
  • 20
    • 0842269107 scopus 로고    scopus 로고
    • Bone tissue incorporates in vitro gallium with a local structure similar to gallium-doped brushite
    • M. Korbas Bone tissue incorporates in vitro gallium with a local structure similar to gallium-doped brushite J. Biol. Inorg. Chem. 9 2004 67 76
    • (2004) J. Biol. Inorg. Chem. , vol.9 , pp. 67-76
    • Korbas, M.1
  • 21
    • 0025062311 scopus 로고
    • Gallium inhibits bone resorption by a direct effect on osteoclasts
    • T.J. Hall, and T.J. Chambers Gallium inhibits bone resorption by a direct effect on osteoclasts Bone Miner. 8 1990 211 216
    • (1990) Bone Miner. , vol.8 , pp. 211-216
    • Hall, T.J.1    Chambers, T.J.2
  • 22
    • 0029248068 scopus 로고
    • Effect of bisphosphonates and gallium on dentin resorption in vitro
    • F.R. Liewehr Effect of bisphosphonates and gallium on dentin resorption in vitro Endod. Dent. Traumatol. 11 1995 20 26
    • (1995) Endod. Dent. Traumatol. , vol.11 , pp. 20-26
    • Liewehr, F.R.1
  • 23
    • 0025986070 scopus 로고
    • Gallium nitrate inhibits bone resorption and collagen synthesis in neonatal mouse calvariae
    • P. Lakatos Gallium nitrate inhibits bone resorption and collagen synthesis in neonatal mouse calvariae J. Bone Miner. Res. 6 1991 1121 1126
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 1121-1126
    • Lakatos, P.1
  • 24
    • 0026586733 scopus 로고
    • Reversible inhibition of osteoclastic activity by bone-bound gallium (III)
    • H.C. Blair Reversible inhibition of osteoclastic activity by bone-bound gallium (III) J. Cell Biochem. 48 1992 401 410
    • (1992) J. Cell Biochem. , vol.48 , pp. 401-410
    • Blair, H.C.1
  • 25
    • 0033990438 scopus 로고    scopus 로고
    • In vitro evaluation of the effect of freshly mixed amalgam and gallium-based alloy on the viability of primary periosteal and osteoblast cell cultures
    • F.J. Shaini In vitro evaluation of the effect of freshly mixed amalgam and gallium-based alloy on the viability of primary periosteal and osteoblast cell cultures Biomaterials 21 2000 113 119
    • (2000) Biomaterials , vol.21 , pp. 113-119
    • Shaini, F.J.1
  • 26
    • 0025976366 scopus 로고
    • Bone particles from gallium-treated rats are resistant to resorption in vivo
    • R. Donnelly Bone particles from gallium-treated rats are resistant to resorption in vivo Bone Miner. 12 1991 167 179
    • (1991) Bone Miner. , vol.12 , pp. 167-179
    • Donnelly, R.1
  • 27
    • 0022981596 scopus 로고
    • Gallium nitrate: The second metal with clinical activity
    • B.J. Foster Gallium nitrate: the second metal with clinical activity Cancer Treat. Rep. 70 1986 1311 1319
    • (1986) Cancer Treat. Rep. , vol.70 , pp. 1311-1319
    • Foster, B.J.1
  • 28
    • 77950235381 scopus 로고    scopus 로고
    • Gallium modulates osteoclastic bone resorption in vitro without affecting osteoblasts
    • E. Verron Gallium modulates osteoclastic bone resorption in vitro without affecting osteoblasts Br. J. Pharmacol. 159 2010 1681 1692
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 1681-1692
    • Verron, E.1
  • 29
    • 84856104178 scopus 로고    scopus 로고
    • Molecular effects of gallium on osteoclastic differentiation of mouse and human monocytes
    • E. Verron Molecular effects of gallium on osteoclastic differentiation of mouse and human monocytes Biochem. Pharmacol. 83 2011 671 679
    • (2011) Biochem. Pharmacol. , vol.83 , pp. 671-679
    • Verron, E.1
  • 30
    • 0027259282 scopus 로고
    • Effect of gallium nitrate in vitro and in normal rats
    • L.G. Jenis Effect of gallium nitrate in vitro and in normal rats J. Cell Biochem. 52 1993 330 336
    • (1993) J. Cell Biochem. , vol.52 , pp. 330-336
    • Jenis, L.G.1
  • 31
    • 0027454638 scopus 로고
    • Gallium nitrate regulates rat osteoblast expression of osteocalcin protein and mRNA levels
    • P.T. Guidon Jr. Gallium nitrate regulates rat osteoblast expression of osteocalcin protein and mRNA levels J. Bone Miner. Res. 8 1993 103 112
    • (1993) J. Bone Miner. Res. , vol.8 , pp. 103-112
    • Guidon, Jr.P.T.1
  • 32
    • 0027165638 scopus 로고
    • Gallium nitrate increases type i collagen and fibronectin mRNA and collagen protein levels in bone and fibroblast cells
    • R.S. Bockman Gallium nitrate increases type I collagen and fibronectin mRNA and collagen protein levels in bone and fibroblast cells J. Cell Biochem. 52 1993 396 403
    • (1993) J. Cell Biochem. , vol.52 , pp. 396-403
    • Bockman, R.S.1
  • 33
    • 0026512657 scopus 로고
    • Effects of gallium on bone in the rat
    • G.K. Wakley Effects of gallium on bone in the rat J. Bone Miner. Res. 7 1992 11 19
    • (1992) J. Bone Miner. Res. , vol.7 , pp. 11-19
    • Wakley, G.K.1
  • 34
    • 0028269634 scopus 로고
    • The effects of gallium nitrate on osteopenia induced by ovariectomy and a low-calcium diet in rats
    • L.S. Stern The effects of gallium nitrate on osteopenia induced by ovariectomy and a low-calcium diet in rats Bone Miner. 25 1994 59 69
    • (1994) Bone Miner. , vol.25 , pp. 59-69
    • Stern, L.S.1
  • 35
    • 77951937795 scopus 로고    scopus 로고
    • Biochemical mechanism of gallium on prevention of fatal cage-layer osteoporosis
    • C. Li Biochemical mechanism of gallium on prevention of fatal cage-layer osteoporosis Biol. Trace Elem. Res. 134 2010 195 202
    • (2010) Biol. Trace Elem. Res. , vol.134 , pp. 195-202
    • Li, C.1
  • 36
    • 72349087968 scopus 로고    scopus 로고
    • Activity of gallium on prevention of fatal cage-layer osteoporosis
    • X. Chen, and C. Wang Activity of gallium on prevention of fatal cage-layer osteoporosis Biol. Trace Elem. Res. 132 2010 129 135
    • (2010) Biol. Trace Elem. Res. , vol.132 , pp. 129-135
    • Chen, X.1    Wang, C.2
  • 38
    • 77951648861 scopus 로고    scopus 로고
    • Therapeutic effect of organic gallium on ovariectomized osteopenic rats by decreased serum minerals and increased bone mineral content
    • Z. Ma, and Q. Fu Therapeutic effect of organic gallium on ovariectomized osteopenic rats by decreased serum minerals and increased bone mineral content Biol. Trace Elem. Res. 133 2010 342 349
    • (2010) Biol. Trace Elem. Res. , vol.133 , pp. 342-349
    • Ma, Z.1    Fu, Q.2
  • 39
    • 77951939239 scopus 로고    scopus 로고
    • Comparison of the therapeutic effects of yeast-incorporated gallium with those of inorganic gallium on ovariectomized osteopenic rats
    • Z. Ma, and F. Qin Comparison of the therapeutic effects of yeast-incorporated gallium with those of inorganic gallium on ovariectomized osteopenic rats Biol. Trace Elem. Res. 134 2010 280 287
    • (2010) Biol. Trace Elem. Res. , vol.134 , pp. 280-287
    • Ma, Z.1    Qin, F.2
  • 40
    • 0037173578 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells
    • R.R. Crichton Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells J. Inorg. Biochem. 91 2002 9 18
    • (2002) J. Inorg. Biochem. , vol.91 , pp. 9-18
    • Crichton, R.R.1
  • 41
    • 0027214995 scopus 로고
    • + binding
    • + binding Biochemistry 32 1993 3387 3395
    • (1993) Biochemistry , vol.32 , pp. 3387-3395
    • Kubal, G.1
  • 42
    • 0025641887 scopus 로고
    • Immunophenotypic differences between osteoclasts and macrophage polykaryons: Immunohistological distinction and implications for osteoclast ontogeny and function
    • N.A. Athanasou, and J. Quinn Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistological distinction and implications for osteoclast ontogeny and function J. Clin. Pathol. 43 1990 997 1003
    • (1990) J. Clin. Pathol. , vol.43 , pp. 997-1003
    • Athanasou, N.A.1    Quinn, J.2
  • 43
    • 0030797216 scopus 로고    scopus 로고
    • Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts
    • H. Palokangas Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts J. Cell Sci. 110 1997 1767 1780
    • (1997) J. Cell Sci. , vol.110 , pp. 1767-1780
    • Palokangas, H.1
  • 44
    • 0037648426 scopus 로고    scopus 로고
    • Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake
    • M.T. Mulari Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake Traffic 4 2003 113 125
    • (2003) Traffic , vol.4 , pp. 113-125
    • Mulari, M.T.1
  • 45
    • 62049085382 scopus 로고    scopus 로고
    • Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation
    • K.A. Ishii Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation Nat. Med. 15 2009 259 266
    • (2009) Nat. Med. , vol.15 , pp. 259-266
    • Ishii, K.A.1
  • 46
    • 60249083711 scopus 로고    scopus 로고
    • Severe iron deficiency decreases both bone formation and bone resorption in rats
    • S. Katsumata Severe iron deficiency decreases both bone formation and bone resorption in rats J. Nutr. 139 2009 238 243
    • (2009) J. Nutr. , vol.139 , pp. 238-243
    • Katsumata, S.1
  • 47
    • 0017132091 scopus 로고
    • Metabolism of vitamin D: Current status
    • H.F. DeLuca Metabolism of vitamin D: current status Am. J. Clin. Nutr. 29 1976 1258 1270
    • (1976) Am. J. Clin. Nutr. , vol.29 , pp. 1258-1270
    • Deluca, H.F.1
  • 48
    • 0017697003 scopus 로고
    • Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates
    • L. Tuderman Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates Eur. J. Biochem. 80 1977 341 348
    • (1977) Eur. J. Biochem. , vol.80 , pp. 341-348
    • Tuderman, L.1
  • 49
    • 0017622264 scopus 로고
    • Transferrin promotion of 67Ga and 59Fe uptake by cultured mouse myeloma cells
    • A.W. Harris, and R.G. Sephton Transferrin promotion of 67Ga and 59Fe uptake by cultured mouse myeloma cells Cancer Res. 37 1977 3634 3638
    • (1977) Cancer Res. , vol.37 , pp. 3634-3638
    • Harris, A.W.1    Sephton, R.G.2
  • 50
    • 0018406463 scopus 로고
    • A transferrin-mediated uptake of gallium-67 by EMT-6 sarcoma. I. Studies in tissue culture
    • S.M. Larson A transferrin-mediated uptake of gallium-67 by EMT-6 sarcoma. I. Studies in tissue culture J. Nucl. Med. 20 1979 837 842
    • (1979) J. Nucl. Med. , vol.20 , pp. 837-842
    • Larson, S.M.1
  • 51
    • 0019949142 scopus 로고
    • Tumor cell toxicity of stable gallium nitrate: Enhancement by transferrin and protection by iron
    • J.S. Rasey Tumor cell toxicity of stable gallium nitrate: enhancement by transferrin and protection by iron Eur. J. Cancer Clin. Oncol. 18 1982 661 668
    • (1982) Eur. J. Cancer Clin. Oncol. , vol.18 , pp. 661-668
    • Rasey, J.S.1
  • 52
    • 0031857384 scopus 로고    scopus 로고
    • Uptake of gallium-67 in transfected cells and tumors absent or enriched in the transferrin receptor
    • C.A. Luttropp Uptake of gallium-67 in transfected cells and tumors absent or enriched in the transferrin receptor J. Nucl. Med. 39 1998 1405 1411
    • (1998) J. Nucl. Med. , vol.39 , pp. 1405-1411
    • Luttropp, C.A.1
  • 53
    • 0027134856 scopus 로고
    • Distribution of gallium-67 in normal and hypotransferrinemic tumor-bearing mice
    • M.H. Sohn Distribution of gallium-67 in normal and hypotransferrinemic tumor-bearing mice J. Nucl. Med. 34 1993 2135 2143
    • (1993) J. Nucl. Med. , vol.34 , pp. 2135-2143
    • Sohn, M.H.1
  • 54
    • 0030846547 scopus 로고    scopus 로고
    • Uptake of 26-Al and 67-Ga into brain and other tissues of normal and hypotransferrinaemic mice
    • A. Radunovic Uptake of 26-Al and 67-Ga into brain and other tissues of normal and hypotransferrinaemic mice Biometals 10 1997 185 191
    • (1997) Biometals , vol.10 , pp. 185-191
    • Radunovic, A.1
  • 55
    • 33846965225 scopus 로고    scopus 로고
    • The uptake mechanism of gallium-67 into hepatocytes treated with carbon tetrachloride
    • S. Abe The uptake mechanism of gallium-67 into hepatocytes treated with carbon tetrachloride Biol. Pharm. Bull. 30 2007 224 229
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 224-229
    • Abe, S.1
  • 56
    • 12144289279 scopus 로고    scopus 로고
    • Ten years' experience with alendronate for osteoporosis in postmenopausal women
    • H.G. Bone Ten years' experience with alendronate for osteoporosis in postmenopausal women N. Engl. J. Med. 350 2004 1189 1199
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1189-1199
    • Bone, H.G.1
  • 57
    • 52949152832 scopus 로고    scopus 로고
    • Fracture outcomes related to persistence and compliance with oral bisphosphonates
    • A.M. Gallagher Fracture outcomes related to persistence and compliance with oral bisphosphonates J. Bone Miner. Res. 23 2008 1569 1575
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 1569-1575
    • Gallagher, A.M.1
  • 58
    • 43249095727 scopus 로고    scopus 로고
    • Adherence to bisphosphonates therapy and hip fracture risk in osteoporotic women
    • V. Rabenda Adherence to bisphosphonates therapy and hip fracture risk in osteoporotic women Osteoporos. Int. 19 2008 811 818
    • (2008) Osteoporos. Int. , vol.19 , pp. 811-818
    • Rabenda, V.1
  • 59
    • 77954313439 scopus 로고    scopus 로고
    • Calcium phosphate biomaterials as bone drug delivery systems: A review
    • E. Verron Calcium phosphate biomaterials as bone drug delivery systems: a review Drug Discov. Today 15 2010 547 552
    • (2010) Drug Discov. Today , vol.15 , pp. 547-552
    • Verron, E.1
  • 60
    • 77955773606 scopus 로고    scopus 로고
    • In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite
    • E. Verron In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite Biomaterials 31 2010 7776 7784
    • (2010) Biomaterials , vol.31 , pp. 7776-7784
    • Verron, E.1
  • 61
    • 80052203833 scopus 로고    scopus 로고
    • Characterization and properties of novel gallium-doped calcium phosphate ceramics
    • C. Mellier Characterization and properties of novel gallium-doped calcium phosphate ceramics Inorg. Chem. 50 2011 8252 8260
    • (2011) Inorg. Chem. , vol.50 , pp. 8252-8260
    • Mellier, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.