Stevioside suppressed inflammatory cytokine secretion by downregulation of NF-kB and MAPK signaling pathways in LPS-Stimulated RAW264.7 cells

Inflammation

Volumn 35, Issue 5, 2012, Pages 1669-1675

  Fengyang, Li ^a   Yunhe, Fu ^a   Bo, Liu ^a   Zhicheng, Liu ^a   Depeng, Li ^a   Dejie, Liang ^a   Wen, Zhang ^a   Yongguo, Cao ^a   Naisheng, Zhang ^a   Xichen, Zhang ^a   Zhengtao, Yang ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Cytokines; Mitogen activated protein kinase (MAPK); Nuclear factor kappaB (NF kB); RAW264.7 cells; Stevioside

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; RNA; STEVIOSIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN RAW264.7; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CELL SURVIVAL; DITERPENES, KAURANE; DOWN-REGULATION; GLUCOSIDES; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TUMOR NECROSIS FACTOR-ALPHA;

STEVIA REBAUDIANA;

EID: 84866743570     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-012-9483-0     Document Type: Article

References (29)

1. Conese, M., and B.M. Assael. 2001. Bacterial infections and inflammation in the lungs of cystic fibrosis patients. Pediatric Infectious Disease Journal 20: 207-213.
2. Atabai, K., and M.A. Matthay. 2002. The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: Definitions and epidemiology. Thorax 57: 452-458.
3. Rubenfeld, G.D., E. Caldwell, E. Peabody, J. Weaver, D.P. Martin, M. Neff, E.J. Stern, and L.D. Hudson. 2005. Incidence and outcomes of acute lung injury. The New England Journal of Medicine 353: 1685-1693.
4. Boje, K.M. 2004. Nitric oxide neurotoxicity in neurodegenerative diseases. Frontiers in Bioscience 9: 763-776.
5. Takeuchi, H., S. Jin, J. Wang, G. Zhang, J. Kawanokuchi, R. Kuno, Y. Sonobe, T. Mizuno, and A. Suzumura. 2006. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. Journal of Biological Chemistry 281: 21362-21368.
6. Hartlage-Rubsamen, M., R. Lemke, and R. Schliebs. 1999. Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection. Journal of Neuroscience Research 57: 388-398.
7. Jeppesen, P.B., S. Gregersen, K.K. Alstrup, and K. Hermansen. 2002. Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: Studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine 9: 9-14.
8. Chan, P., B. Tomlinson, Y.J. Chen, J.C. Liu, M.H. Hsieh, and J.T. Cheng. 2000. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. British Journal of Clinical Pharmacology 50: 215-220.
9. Lee, C.N., K.L. Wong, J.C. Liu, Y.J. Chen, J.T. Cheng, and P. Chan. 2001. Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta Medica 67: 796-799.
10. Yasukawa, K., S. Kitanaka, and S. Seo. 2002. Inhibitory effect of stevioside on tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biological and Pharmaceutical Bulletin 25: 14881490.
11. Boonkaewwan, C., C. Toskulkao, and M. Vongsakul. 2006. Antiinflammatory and immunomodulatory activities of stevioside and its metabolite steviol on THP-1 cells. Journal of Agricultural and Food Chemistry 54: 785-789.
12. Boonkaewwan, C., M. Ao, C. Toskulkao, and M.C. Rao. 2008. Specific immunomodulatory and secretory activities of stevioside and steviol in intestinal cells. Journal of Agricultural and Food Chemistry 56: 3777-3784.
13. Liu, Y.Z., Y.G. Cao, J.Q. Ye, W.G. Wang, K.J. Song, X.L. Wang, C.H. Wang, R.T. Li, and X.M. Deng. 2010. Immunomodulatory effects of proanthocyanidin a-1 derived in vitro from Rhododendron spiciferum. Fitoterapia 81: 108-114.
14. Arms, L., B.M. Girard, and M.A. Vizzard. 2010. Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis. American Journal of Physiology. Renal Physiology 298: 589-600.
15. Choi, Y.H., G.Y. Jin, G.Z. Li, and G.H. Yan. 2011. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting nuclear factor-kappa B activation in RAW 264.7 macrophages. Biological and Pharmaceutical Bulletin 34: 959-966.
16. Choi, E.M., and J.K. Hwang. 2005. Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW 264.7 macrophages. Fitoterapia 76: 608-613.
17. Connolly, M.K., A.S. Bedrosian, J. Mallen-St Clair, A.P. Mitchell, J. Ibrahim, A. Stroud, H.L. Pachter, D. Bar-Sagi, A.B. Frey, and G. Miller. 2009. In liver fibrosis, dendritic cells govern hepaticinflammation in mice via TNF-alpha. Journal of Clinical Investigation 119: 3213-3225.
18. Maskrey, B.H., I.L. Megson, P.D. Whitfield, and A.G. Rossi. 2011. Mechanisms of resolution of inflammation. A focus on cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 31: 1001-1006.
19. Christman, J.W., R.T. Sadikot, and T.S. Blackwell. 2000. The role of nuclear factor-kappa B in pulmonary diseases. Chest 117: 1482-1487.
20. McCoy, M.K., K.A. Ruhn, A. Blesch, and M.G. Tansey. 2011. Tnf: A key neuroinflammatory mediator of neurotoxicity and neurodegeneration in models of Parkinson's disease. Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy 691: 539-540.
21. Kishimoto, T., T. Taga, K. Yamasaki, T. Matsuda, B. Tang, A. Muraguchi, Y. Horii, S. Suematsu, Y. Hirata, H. Yawata, et al. 1989. Normal and abnormal regulation of human B cell differentiation by a new cytokine, BSF2/IL-6. Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy 254: 135-143.
22. Romano, M., M. Sironi, C. Toniatti, N. Polentarutti, P. Fruscella, P. Ghezzi, R. Faggioni, W. Luini, V. van Hinsbergh, S. Sozzani, F. Bussolino, V. Poli, G. Ciliberto, and A. Mantovani. 1997. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6: 315-325.
23. Lee, S.M., E.J. Kim, K. Suk, and W.H. Lee. 2011. Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-kappaB in THP-1 cells. Cellular Immunology 271: 157-162.
24. Ha, Y.M., S.W. Chung, J.M. Kim, D.H. Kim, J.Y. Kim, E.K. Lee, J. Lee, Y.J. Kim, M.A. Yoo, K.S. Jeong, and H.Y. Chung. 2010. Molecular activation of NF-kappaB, pro-inflammatory mediators, and signal pathways in gamma-irradiated mice. Biotechnology Letters 32: 373-378.
25. Rao, K.M. 2001. Map kinase activation in macrophages. Journal of Leukocyte Biology 69: 3-10.
26. Jiang, J.X., Y. Zhang, S.H. Ji, P. Zhu, and Z.G. Wang. 2002. Kinetics of mitogen-activated protein kinase family in lipopolysaccharide-stimulated mouse Kupffer cells and their role in cytokine production. Shock 18: 336-341.
27. Choi, K., M. Kim, J. Ryu, and C. Choi. 2007. Ginsenosides compound K and Rh (2) inhibit tumor necrosis factor-alphainduced activation of the NF-kappaB and JNK pathways in human astroglial cells. Neuroscience Letters 421: 37-41.
28. Bode, J.G., C. Ehlting, and D. Haussinger. 2012. The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis. Cellular Signaling 24: 1185-1194.
29. Ruimi, N., H. Rwashdeh, S. Wasser, B. Konkimalla, T. Efferth, M. Borgatti, R. Gambari, and J. Mahajna. 2010. Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-kappaB and MAPK activities in RAW 264.7 macrophage cells. International Journal of Molecular Medicine 25: 421-432.