Synthesis and biological evaluation of a novel 99mTc cyclopentadienyl tricarbonyl complex ([(Cp-R)99mTc(CO)3]) for sigma-2 receptor tumor imaging

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6352-6357

  Chen, Xin ^a   Cui, Meng Chao ^a   Deuther Conrad, Winnie ^b   Tu, Ying Feng ^c   Ma, Teng ^c   Xie, Ying ^c   Jia, Bing ^c   Li, Yan ^a   Xie, Fang ^a   Wang, Xia ^a   Steinbach, Jörg ^b   Brust, Peter ^b   Liu, Bo Li ^a   Jia, Hong Mei ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

^b INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

99mTc; Cyclopentadienyl tricarbonyl complex; Imaging agent; Sigma 2 receptor

Indexed keywords

1 CYCLOHEXYL 4 [3 (5 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)PROPYL]PIPERAZINE; 4 (4 CYCLOHEXYLPIPERAZIN 1 YL) 1 FERROCENYLBUTAN 1 ONE; 4 (4 CYCLOHEXYLPIPERAZIN 1 YL)BUTAN 1 ONE 1 CYCLOPENTADIENYLTRICARBONYL TC 99M; FERROCENE DERIVATIVE; HALOPERIDOL; OPIATE RECEPTOR AFFECTING AGENT; PB 28; RHENIUM COMPLEX; SIGMA 2 OPIATE RECEPTOR; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TUMOR LEVEL; GLIOMA CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; QUANTUM YIELD; RADIOCHEMISTRY; RECEPTOR AFFINITY;

ANIMALS; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; GLIOMA; MALE; MICE; ORGANOTECHNETIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; TECHNETIUM;

MUS; RATTUS;

EID: 84866740416     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.083     Document Type: Article

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