Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 9, 2012, Pages 899-908

  Oliveira, Irisdalva S ^a   Da Silva, Francilene V ^a   Viana, Ana Flávia S C ^a   Dos Santos, Márcio R V ^b   Quintans Júnior, Lucindo J ^b   Martins, Maria Do Carmo C ^a   Nunes, Paulo H M ^a   Oliveira, Francisco De A ^a   Oliveira, Rita De C M ^a  

^a FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^b FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

Author keywords

Carvacrol; Gastroprotective; KATP hchannel; Nitric oxide; Prostaglandin; Sulfhydryl groups

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ADENOSINE TRIPHOSPHATE; ALCOHOL; CARBENOXOLONE; CARVACROL; CATALASE; CIMETIDINE; FREE RADICAL; IBUPROFEN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNEL; PROSTAGLANDIN; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SAFETY; DRUG STRUCTURE; ENZYME ACTIVATION; FEMALE; GASTROPROTECTIVE ACTIVITY; ISCHEMIA; MOUSE; NONHUMAN; PH MEASUREMENT; PYLORUS; RAT; REPERFUSION INJURY; STOMACH JUICE; STOMACH LESION; STOMACH MUCUS; STOMACH SECRETION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; ETHANOL; FEMALE; KATP CHANNELS; MICE; MONOTERPENES; MUCUS; NITRIC OXIDE SYNTHASE; PROSTAGLANDINS; RATS; RATS, WISTAR; REPERFUSION INJURY; STOMACH ULCER;

EID: 84866740052     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0771-x     Document Type: Article

References (64)

1. Almeida RN, Navarro DS, Barbosa-Filho JM (2001) Plants with central analgesic activity. Phytomedicine 8:310-322
2. Amaral JF, Silva MI, Neto MR, Neto PF, Moura BA, de Melo CT, de Araújo FL, de Sousa DP, de Vasconcelos PF, de Vasconcelos SM, de Sousa FC (2007) Antinociceptive effect of the monoterpene R- (+)-limonene in mice. Biol Pharm Bull 30:1217-1220
3. Amaral MPM, Braga FAV, Passos FFB, Almeida FRC, Oliveira RCM, Carvalho AA, Chaves MH, Oliveira F (2009) Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats. Lat Am Pharm 28:775-82
4. Argolo ACC, Sant'Ana AEG, Pletsch M, Coelho LCBB (2004) Antioxidant activity of leaf extracts from Bauhinia monandra. Biores Technol 95:229-233
5. Astudillo A, Hong E, Bye R, Navarrete A (2004) Antispasmodic activity of extracts and compounds of Acalypha phleoides cav. Phytother Res 18:102-106
6. Avila JR, de la Lastra CA, Martin MJ, Motilva V, Luque I, Delgado D, Esteban J, Herrerias J (1996) Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflamm Res 45:83-88
7. Bandyopadhyay U, Biswas K, Chatterjee R, Bandyopadhyay D, Chattopadhyay I, Ganguly CK, Chakraborty T, Bhattacharya K, Banerjee RK (2002) Gastroprotective effect of Neem (Azadirachta indica) bark extract: possible involvement of H(+)-K (+)-ATPase inhibition and scavenging of hydroxyl radical. Life Sci 71:2845-2865
8. Beers RF Jr, Sizer IW (1952) A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 95:133-140
9. Ben Arfa A, Combes S, Preziosi-Belloy L, Gontard N, Chalier P (2006) Antimicrobial activity of carvacrol related to its chemical structure. Lett Appl Microbiol 43:149-154
10. Berenguer B, Trabadela C, Sánchez-Fidalgo S, Quílez A, Miño P, de la Puerta R, Martín-Calero MJ (2007) The aerial parts of Guazuma ulmifolia Lam. protect against NSAID-induced gastric lesions. J Ethnopharmacol 114:153-160
11. Bhargava KP, Gupta MB, Tangri KK (1973) Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone. Eur J Pharmacol 22:191-195
12. Brand-Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. LWT - Food Sci Technol 28:25-30
13. Canbek M, Uyanoglu M, Bayramoglu G, Senturk H, Erkasap N, Koken T, Uslu S, Demirustu C, Aral E, Husnu Can Baser K (2008) Effects of carvacrol on defects of ischemia-reperfusion in the rat liver. Phytomedicine 15:447-452
14. Chan FK, Leung WK (2002) Peptic ulcer disease. The Lancet 360:933-941
15. Chi SC, Jun HW (1990) Anti-inflammatory activity of ketoprofen gel on carrageenan induced paw edema in rats. Int J Pharm 79:974-977
16. Corne SJ, Morrissey SM, Woods RJ (1974) A method for the quantitative estimation of gastric barrier mucous. J Physiol 242:116-117
17. Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH (1992) The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107:660-664
18. Cunha TM, Verri WA Jr, Silva JS, Poole S, Cunha FQ, Ferreira SH (2005) A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. PNAS 102:1755-1760
19. De Sousa DP, Gonçalves JC, Quintans-Júnior L, Cruz JS, Araújo DA, de Almeida RN (2006) Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents. Neurosci Lett 401:231-235
20. Enomoto S, Asano R, Iwahori Y, Narui T, Okada Y, Singab AN, Okuyama T (2001) Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol Pharm Bull 24:307-310
21. Fenaroli G (2002) Fenaroli's handbook of flavor ingredients, 4th edn. CRC, Boca Raton
22. Garcia ML, Hanner M, Hans-G K, Koch R, Schmalhofer W, Slaughter RS, Kaczorowski GJ (1997) Pharmacology of potassium channels. Adv Pharmacol 39:425-471
23. Guimarães AG, Oliveira GF, Melo MS, Cavalcanti SC, Antoniolli AR, Bonjardim LR, Silva FA, Santos JP, Rocha RF, Moreira JC, Araújo AA, Gelain DP, Quintans-Júnior LJ (2010) Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol. Bas Clin Pharmacol Toxicol 107:949-957
24. Guimarães AG, Xavier MA, De Santana MT, Camargo EA, Santos CA, Brito FA, Barreto EO, Cavalcanti SC, Antoniolli AR, Oliveira RC, Quintans-Júnior LJ (2012) Carvacrol attenuates mechanical hypernociception and inflammatory response. Naunyn-Schmied Arch Pharmacol. doi:10.1007/s00210-011-0715-x
25. Halliwell B (1990) How to characterize a biological antioxidant. Free Radical Res Commun 9:1-32
26. Hiruma-Lima CA, Gracioso JS, Bighetti EJ, Grassi-Kassisse DM, Nunes DS, Brito AR (2002) Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. Phytomedicine 9:523-529
27. Hotta M, Nakata R, Katsukawa M, Hori K, Takahashi S, Inoue H (2010) Carvacrol, a component of thyme oil, activates PPAR alpha and gamma, and suppresses COX-2 expression. J Lipid Res 51:132-139
28. Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG (1964) Food flavourings and compounds of related structure. I. Acute oral toxicity. Food Cosm Toxicol 2:327-343
29. Kawai T, Joh T, Iwata F, Itoh M (1994) Gastric epithelial damage induced by local ischemia-reperfusion with or without exogenous acid. Am J Physiol 266:263-270
30. Krimer N, Başer KHC, Tümen G (1995) Carvacrol rich plants in Turkey. Chem Nat Comp 31:37-42
31. Laine L, Takeuchi K, Tarnawski A (2008) Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 135:41-60
32. Landa P, Kokoska L, Pribylova M, Vanek T, Marsik P (2009) In vitro anti-inflammatory activity of carvacrol: inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesis. Arch Pharm Res 32:75-78
33. Lemos TL, Matos FJA, Alencar JW, Craveiro AA, Clark AM, McChesney JD (1990) Antimicrobial activity of essential oil of Brazilian plants. Phytother Res 4:82-84
34. Lewis DA, Hanson PJ (1991) Anti-ulcer drugs of plant origin. In: Ellis GP, West GB (eds) Progress in medicinal chemistry, vol 28. Elsevier Science Publishers, Amsterdam, pp 201-231
35. Li Y, Wang WP, Wang HY, Cho CH (2000) Intragastric administration of heparin enhances gastric ulcer healing through a nitric oxide dependent mechanism in rats. Eur J Pharmacol 399:205-214
36. Maity P, Biswas K, Roy S, Banerjee RK, Bandyopadhyay U (2003) Smoking and the pathogenesis of gastroduodenal ulcer-recent mechanism update. Mol Cell Biochem 253:329-338
37. Matsuda H, Li Y, Yoshikawa M (1999) Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulphydryls, and prostaglandins in gastroprotection by mormodin Ic, an oleanolic acid oligoglycoside, on ethanol induced gastric mucosal lesion in rats. Life Sci 65:27-32
38. Matsunaga T, Hasegawa C, Kawasuji T, Suzuki H, Akiyama T, Sagioka T, Takahashi R, Tsukamoto H, Morikawa T (2000) Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica. Biol Pharm Bull 23:595-598
39. Mincis M, Chebli JMF, Khouri ST, Mincis R (1995) Etanol e o trato gastrointestinal. Arch Gastroenterol 32:131-139
40. Olinda TM, Lemos TLG, Machado LL, Rao VS, Santos FA (2008) Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ATP channels. Phytomedicine 15:327-333
41. Paula AC, Toma W, Gracioso JS, Hiruma-Lima CA, Carneiro EM, Souza Brito AR (2006) The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats. B J Nutr 96:310-315
42. Peixoto-Neves D, Silva-Alves KS, Gomes MD, Lima FC, Lahlou S, Magalhães PJ, Ceccatto VM, Coelho-de-Souza AN, Leal-Cardoso JH (2010) Vasorelaxant effects of the monoterpenic phenol isomers, carvacrol and thymol, on rat isolated aorta. Fundam Clin Pharmacol 24:341-350
43. Pongpiriyadacha Y, Matsuda H, Morikawa T, Asao Y, Yoshikawa M (2003) Protective effects of polygodial on gastric mucosal lesions induced by necrotizing agents in rats and the possible mechanisms of action. Biol Pharm Bull 26:651-657
44. Rainsford KD (1998) An analysis from clinical-epidemiological data of the principal adverse events from the COX-2 selectives NSAID, nimesulide, with particular reference to hepatic injury. Inflammopharmacology 6:203-221
45. Rao ChV, Ojha SK, Radhakrishnan K, Govindarajan R, Rastogi S, Mehrotra S, Pushpangadan P (2004) Antiulcer activity of Utleria salicifolia rhizome extract. J Ethnopharmacol 91:243-249
46. Repetto MG, Llesuy SF (2002) Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res 35:523-534
47. Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:433-443
48. Rodríguez JA, Theoduloz C, Sánchez M, Yáñez T, Razmilic I, Schmeda-Hirschmann G (2005) Gastroprotective activity of a new semisynthetic solidagenone derivative in mice. J Pharm Pharmacol 57:265-271
49. Samonina GE, Kopylova GN, Lukjanzeva GV, Zhuykova SE, Smirnova EA, German SV, Guseva AA (2004) Antiulcer effects of amylin: a review. Pathophysiology 11:1-6
50. Sánchez M, Theoduloz C, Schmeda-Hirschmann G, Razmilic I, Yáñez T, Rodríguez JA (2006) Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: in vitro-in vivo relationships. Life Sci 79:1349-1356
51. Scholl I, Untersmayr E, Bakos N, Roth-Walter F, Gleiss A, Boltz- Nitulescu G, Scheiner O, Jensen-Jarolim E (2005) Antiulcer drugs promote oral sensitization and hypersensitivity to hazelnut allergens in BALB/c mice and humans. Amer J Clin Nut 81:154-160
52. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein H, Siplet H (1945) A simple method for the uniform production of gastric ulceration in rat. Gastroenterology 5:43
53. Silva MI, Moura BA, Neto MR, Tomé Ada R, Rocha NF, De Carvalho AM, Macêdo DS, Vasconcelos SM, De Sousa DP, Viana GS, De Sousa FC (2009) Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action. Naunyn-Schmied Arch Pharmacol 380:233-245
54. Soler-Rivas C, Espín JC, Wichers HJ (2000) An easy and fast test to compare total free radical scavenger capacity of foodstuffs. Phytochem Anal 11:1-9
55. Sun XB, Matsumoto T, Yamada H (1991) Effects of a polysaccharide fraction from the roots of Bupleurum folcatum L. on experimental gastric ulcer in rats and mice. J Pharm Pharmacol 43:699-704
56. Szabo S, Trier JS, Frankel PW (1981) Sulfhydryl compounds may mediate gastric cytoprotection. Science 214:201-202
57. Szabo S, Kusstatscher S, Sakoulas G, Sandor Z, Vincze A, Jadus M (1995) Growth factors: new endogenous drugs for ulcer healing. Scand J Gastroenterol Suppl 210:15-18
58. Szelenyi I, Thiemer K (1978) Distention ulcer as a model for testing of drugs for ulcerogenic side effects. Arch Toxicol 41:99-105
59. Ueda S, Okada Y (1989) Acid secretagogues induce Ca++ mobilization coupled to K+ conductance activation in rat parietal cells in tissue culture. Biochem Biophys Acta 1012:254-260
60. Van Den Broucke CO, Lemli JA (1982) Antispasmodic activity of Origanum compactum. Plant Med 45:188-190
61. Vonkeman HE, Klok RM, Postma MJ, Brouwers JR, Van de Laar MA (2007) Direct medical costs of serious gastrointestinal ulcers among users of NSAIDs. Drugs Aging 24:681-691
62. Wallace JL (2001) Mechanisms of protection and healing: current nowledge and future research. Amer J Med 11:19S-23S
63. Wolfe MM, Sanche G (2000) Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology 118:9-31
64. Zayachkivska OS, Konturek SJ, Drozdowicz D, Konturek PC, Brzozowski T, Ghegotsky MR (2005) Gastroprotective effects of flavonoids in plant extract. J Physiol Pharmacol 56:219-231