Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: Synthesis, biological evaluation and structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6338-6342

  Miyazaki, Masaki ^a   Kawato, Haruko ^a   Naito, Hiroyuki ^a   Ikeda, Masahiro ^a   Miyazaki, Masaya ^a   Kitagawa, Mayumi ^a   Seki, Takahiko ^a   Fukutake, Setsuko ^a   Aonuma, Masashi ^a   Soga, Tsunehiko ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Dihydroimidazothiazole; MDM2; p53; Protein protein interaction inhibitor

Indexed keywords

2 OXOPIPERAZINE; AM 8553; ANTINEOPLASTIC AGENT; DIHYDROIMIDAZOTHIAZOLE DERIVATIVE; LUPETAZINE; MI 219; NUTLIN 3; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

DRUG DESIGN; HUMANS; IMIDAZOLES; NEOPLASMS; PROTEIN INTERACTION MAPS; PROTO-ONCOGENE PROTEINS C-MDM2; THIAZOLES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84866739593     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.086     Document Type: Article

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