Cerebrospinal fluid cathepsin B and S

Neurological Sciences

Volumn 34, Issue 4, 2013, Pages 445-448

  Nilsson, Elin ^a   Bodolea, Constantin ^b   Gordh, Torsten ^a   Larsson, Anders ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b BABE BOLYAI UNIVERSITY   (Romania)

Author keywords

Age; Cathepsin B; Cathepsin S; Cerebrospinal fluid

Indexed keywords

BOVINE SERUM ALBUMIN; CATHEPSIN B; CATHEPSIN S; COLLAGEN TYPE 4; CYSTATIN C; EXOPEPTIDASE; LAMININ; PROTEINASE;

ADULT; AGED; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CELL NUCLEUS; CEREBROSPINAL FLUID; CYTOSOL; ELECTIVE SURGERY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SPACE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; SURGICAL TECHNIQUE; TISSUE DISTRIBUTION;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CATHEPSIN B; CATHEPSINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVOUS SYSTEM DISEASES; SPINAL PUNCTURE; YOUNG ADULT;

EID: 84866738362     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-012-1022-0     Document Type: Article

References (20)

1. Barclay J, Clark AK, Ganju P, Gentry C, Patel S, Wotherspoon G, Buxton F, Song C, Ullah J, Winter J, Fox A, Bevan S, Malcangio M (2007) Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain 130:225-234
2. Clark AK, Yip PK, Grist J, Gentry C, Staniland AA, Marchand F, Dehvari M, Wotherspoon G, Winter J, Ullah J, Bevan S, Malcangio M (2007) Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci USA 104:10655-10660
3. Clark AK, Yip PK, Malcangio M (2009) The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. J Neurosci 29:6945-6954
4. Coulibaly S, Schwihla H, Abrahamson M, Albini A, Cerni C, Clark JL, Ng KM, Katunuma N, Schlappack O, Glossl J, Mach L (1999) Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C. Int J Cancer 83:526-531
5. Driessen C, Bryant RA, Lennon-Dumenil AM, Villadangos JA, Bryant PW, Shi GP, Chapman HA, Ploegh HL (1999) Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J Cell Biol 147:775-790
6. Flannery T, Gibson D, Mirakhur M, McQuaid S, Greenan C, Trimble A, Walker B, McCormick D, Johnston PG (2003) The clinical significance of cathepsin S expression in human astrocytomas. Am J Pathol 163:175-182
7. Frlan R, Gobec S (2006) Inhibitors of cathepsin B. Curr Med Chem 13:2309-2327
8. Gole B, Alonso MBD, Dolenc V, Lah T (2009) Post-translational regulation of cathepsin B, but not of other cysteine cathepsins, contributes to increased glioblastoma cell invasiveness in vitro. Pathol Oncol Res 15:711-723
9. Hao HP, Doh-Ura K, Nakanishi H (2007) Impairment of microglial responses to facial nerve axotomy in cathepsin S-deficient mice. J Neurosci Res 85:2196-2206
10. Hook G, Hook V, Kindy M (2011) The cysteine protease inhibitor, E64d, reduces brain amyloid-beta and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, beta-secretase activity. J Alzheimers Dis 26(2):387-408
11. Hook V, Hook G, Kindy M (2010) Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease. Biol Chem 391:861-872
12. Kuester D, Lippert H, Roessner A, Krueger S (2008) The cathepsin family and their role in colorectal cancer. Pathol Res Pract 204:491-500
13. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ (1995) The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain: an immunocytochemical study. Am J Pathol 146:848-860
14. Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA (1995) Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. Biochem J 311(Pt 1):299-305
15. Nakanishi H (2003) Microglial functions and proteases. Mol Neurobiol 27:163-176
16. Nakanishi H, Tominaga K, Amano T, Hirotsu I, Inoue T, Yamamoto K (1994) Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues. Exp Neurol 126:119-128
17. Ndjole AM, Bodolea C, Nilsen T, Gordh T, Flodin M, Larsson A (2010) Determination of cerebrospinal fluid cystatin C on Architect ci8200. J Immunol Methods 360:84-88
18. Sun L, Wu Z, Baba M, Peters C, Uchiyama Y, Nakanishi H (2010) Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse. Biochem Biophys Res Commun 399:391-395
19. Sundelof J, Sundstrom J, Hansson O, Eriksdotter-Jonhagen M, Giedraitis V, Larsson A, Degerman-Gunnarsson M, Ingelsson M, Minthon L, Blennow K, Kilander L, Basun H, Lannfelt L (2010) Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls. J Alzheimers Dis 22:1223-1230
20. Wendt W, Lubbert H, Stichel CC (2008) Upregulation of cathepsin S in the aging and pathological nervous system of mice. Brain Res 1232:7-20