Dichloromethane fraction of laminaria japonica ethanolic extract inhibits lipopolysaccharide-induced nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 cells via NF-kB pathway

Inflammation

Volumn 35, Issue 5, 2012, Pages 1650-1658

  Lee, Ji Young ^a   Lee, Min Sup ^a   Choi, Ji Woong ^a   Shin, Tai Sun ^b   Woo, Hee Chul ^a   Kim, Hyeung Rak ^a  

^a Pukyong National University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Anti inflammation; Laminaria japonica; MAP kinases; NF kappaB; RAW 264.7 cells

Indexed keywords

ALCOHOL; CYCLOOXYGENASE 2; DICHLOROMETHANE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LAMINARIA JAPONICA EXTRACT; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN RAW 264.7; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVATION; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; LAMINARIA; LAMINARIA JAPONICA; MACROPHAGE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; DOWN-REGULATION; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LAMINARIA; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

LAMINARIA JAPONICA;

EID: 84866738239     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-012-9481-2     Document Type: Article

References (34)

1. Xie, Q.W., R.Whisnant, and C. Nathan. 1993. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. The Journal of Experimental Medicine 177: 1779-1784.
2. Guha, M., and N. Mackman. 2001. LPS induction of gene expression in human monocytes. Cellular Signalling 13: 85-94.
3. Dinarello, C.A. 1999. Cytokines as endogenous pyrogens. Journal of Infectious Diseases 179(Suppl 2): S294-S304.
4. Marks-Konczalik, J., S.C. Chu, and J. Moss. 1998. Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappa-binding sites. Journal of Biological Chemistry 273: 22201-22208.
5. Vane, J.R., J.A. Mitchell, I. Appleton, A. Tomlinson, D. Bishop-Bailey, J. Croxtall, and D.A. Willoughby. 1994. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proceedings of the National Academy of Sciences of the United States of America 91: 2046-2050.
6. Makarov, S.S. 2001. NF-kappa B in rheumatoid arthritis: A pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Research & Therapy 3: 200-206.
7. Li, Q., and I.M. Verma. 2002. NF-kappaB regulation in the immune system. Nature Reviews Immunology 2: 725-734.
8. D'Acquisto, F., T. Iuvone, L. Rombola, L. Sautebin, M. Di Rosa, and R. Carnuccio. 1997. Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Letters 418: 175-178.
9. Chen, Z., J. Hagler, V.J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes & Development 9: 1586-1597.
10. Sheu, M.L., K.F. Chao, Y.J. Sung, W.W. Lin, S.Y. Lin-Shiau, and S.H. Liu. 2005. Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the upregulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. Cellular Signalling 17: 975-984.
11. Bhat, N.R., P. Zhang, J.C. Lee, and E.L. Hogan. 1998. Extracellular signal-regulated kinase and p38 subgroups of mitogenactivated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxinstimulated primary glial cultures. Journal of Neuroscience 18: 1633-1641.
12. Kao, S.J., H.C. Lei, C.T. Kuo, M.S. Chang, B.C. Chen, Y.C. Chang, W.T. Chiu, and C.H. Lin. 2005. Lipoteichoic acid induces nuclear factor-kappaB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages. Immunology 115: 366-374.
13. Shin, J.S., Y.M. Park, J.H. Choi, H.J. Park, M.C. Shin, Y.S. Lee, and K.T. Lee. 2010. Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. International Immunopharmacology 10: 943-950.
14. Cremer, T.J., P. Shah, E. Cormet-Boyaka,M.A. Valvano, J.P. Butchar, and S. Tridandapani. 2011. Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanism. Journal of Immunology 187: 635-643.
15. Madrid, L.V., M.W. Mayo, J.Y. Reuther, and A.S. Baldwin Jr. 2001. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. Journal of Biological Chemistry 276: 18934-18940.
16. Blunt, J.W., B.R. Copp, M.H. Munro, P.T. Northcote, andM.R. Prinsep. 2010. Marine natural products. Natural Product Reports 27: 165-237.
17. Abad, M.J., L.M. Bedoya, and P. Bermejo. 2008. Natural marine antiinflammatory products. Mini Reviews inMedicinal Chemistry 8: 740-754.
18. Jang, B.C., J.H. Paik, S.P. Kim, D.H. Shin, D.K. Song, J.G. Park, M.H. Suh, J.W. Park, and S.I. Suh. 2005. Catalase induced expression of inflammatory mediators via activation of NFkappaB, PI3K/AKT, p70S6K, and JNKs in BV2 microglia. Cellular Signalling 17: 625-633.
19. Woo,M.N., S.M. Jeon,Y.C.Shin,M.K. Lee,M.A.Kang, andM.S. Choi. 2009. Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice. Molecular Nutrition & Food Research 53: 1603-1611.
20. Kim, A.R., T.S. Shin, M.S. Lee, J.Y. Park, K.E. Park, N.Y. Yoon, J.S. Kim, J.S. Choi, B.C. Jang, D.S. Byun, and H.R. Kim. 2009. Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties. Journal of Agricultural and Food Chemistry 57: 3483-3489.
21. Tseng, C.K., and C.F. Chang. 1984. Chinese seaweeds in herbal medicine. Hydrobiologia 116/117: 152-154.
22. Huang, H.L., and B.G. Wang. 2004. Antioxidant capacity and lipophilic content of seaweeds collected from the Qingdao coastline. Journal of Agricultural and Food Chemistry 52: 4993-4997.
23. Yuan, Y.V., and N.A. Walsh. 2006. Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds. Food and Chemical Toxicology 44: 1144-1150.
24. Zhang, Z., P. Zhang,M. Hamada, S. Takahashi, G. Xing, J. Liu, and N. Sugiura. 2008. Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line. Oncology Reports 20: 1099-1103.
25. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. The FASEB Journal 6: 3051-3064.
26. Santangelo, C., R. Vari, B. Scazzocchio, R. Di Benedetto, C. Filesi, and R. Masella. 2007. Polyphenols, intracellular signalling and inflammation. Annali dell'Istituto Superiore di Sanità 43: 394-405.
27. Nickel, T., H. Hanssen, Z. Sisic, S. Pfeiler, C. Summo, D. Schmauss, E. Hoster, and M. Weis. 2011. Immunoregulatory effects of the flavonol quercetin in vitro and in vivo. European Journal of Nutrition 50: 163-172.
28. Seibel, J., A.F. Molzberger, T. Hertrampf, U. Laudenbach-Leschowski, and P. Diel. 2009. Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis. European Journal of Nutrition 48: 213-220.
29. Zapolska-Downar D., D. Bryk, M. Malecki, K. Hajdukiewicz, and D. Sitkiewicz. 2012. Aronia melanocarpa fruit extract exhibits antiinflammatory activity in human aortic endothelial cells. European Journal of Nutrition. doi:10.1007/s00394-011-0240-1.
30. Kim, A.R., M.S. Lee, T.S. Shin, H. Hua, B.C. Jang, J.S. Choi, D.S. Byun, T. Utsuki, D. Ingram, and H.R. Kim. 2011. Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-kappaB, Akt, and p38 MAPK. Toxicology In Vitro 25: 1789-1795.
31. Beutler, B., and A. Cerami. 1989. The biology of cachectin/TNF-a primary mediator of the host response. Annual Review of Immunology 7: 625-655.
32. Kim, E.Y., and K.D. Moudgil. 2008. Regulation of autoimmune inflammation by pro-inflammatory cytokines. Immunology Letters 120: 1-5.
33. Yoshimura, A. 2006. Signal transduction of inflammatory cytokines and tumor development. Cancer Science 97: 439-447.
34. Hou, D.X., S. Masuzaki, S. Tanigawa, F. Hashimoto, J. Chen, T. Sogo, and M. Fujii. 2010. Oolong tea theasinensins attenuate cyclooxygenase-2 expression in lipopolysaccharide (LPS)-activated mouse macrophages: Structure-activity relationship and molecular mechanisms. Journal of Agricultural and Food Chemistry 58: 12735-12743.