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Volumn 37, Issue 9, 2012, Pages 2053-2063

Therapeutic efficacy of silibinin on human neuroblastoma cells: Akt and NF-κB expressions may play an important role in silibinin-induced response

Author keywords

Akt; MMP 2; Neuroblastoma; NF B; Silibinin

Indexed keywords

GELATINASE A; GELATINASE B; I KAPPA B KINASE; I KAPPA B KINASE 1; I KAPPA B KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN KINASE B; SILIBININ; UNCLASSIFIED DRUG; UROKINASE RECEPTOR;

EID: 84866736330     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0827-9     Document Type: Article
Times cited : (17)

References (46)
  • 1
    • 0037366067 scopus 로고    scopus 로고
    • Neurobastoma: Biological insights inro a clinical enigma
    • Brodeur GM (2003) Neurobastoma: biological insights inro a clinical enigma. Nature 3:203-216
    • (2003) Nature , vol.3 , pp. 203-216
    • Brodeur, G.M.1
  • 2
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
    • Yao R, Cooper G (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.2
  • 3
    • 0037112455 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapyinduced apoptosis via phosphatidylinositol 3-kinase pathway
    • Jaboin J et al (2002) Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapyinduced apoptosis via phosphatidylinositol 3-kinase pathway. Cancer Res 62:6756-6763
    • (2002) Cancer Res , vol.62 , pp. 6756-6763
    • Jaboin, J.1
  • 4
    • 23944494086 scopus 로고    scopus 로고
    • Biological effects of TrkA and TrkB receptor signaling in neuroblastoma
    • Schramm A et al (2005) Biological effects of TrkA and TrkB receptor signaling in neuroblastoma. Cancer Lett 228:143-153
    • (2005) Cancer Lett , vol.228 , pp. 143-153
    • Schramm, A.1
  • 5
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T (2001) Oncogenic kinase signalling. Nature 17(411):355-365
    • (2001) Nature , vol.17 , Issue.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 6
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers C (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.2
  • 7
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3 K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M et al (2006) Beyond PTEN mutations: the PI3 K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6:184-192
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1
  • 8
    • 3042823868 scopus 로고    scopus 로고
    • The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
    • Chakravarti A et al (2004) The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol 22:1926-1933
    • (2004) J Clin Oncol , vol.22 , pp. 1926-1933
    • Chakravarti, A.1
  • 9
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3-kinase signaling pathway in glioblastoma patients in vivo
    • Choe G et al (2003) Analysis of the phosphatidylinositol 3-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 63:2742-2746
    • (2003) Cancer Res , vol.63 , pp. 2742-2746
    • Choe, G.1
  • 10
    • 33846694864 scopus 로고    scopus 로고
    • Activation of Akt predicts poor outcome in neuroblastoma
    • Opel D et al (2007) Activation of Akt predicts poor outcome in neuroblastoma. Cancer Res 67(2):735-745
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 735-745
    • Opel, D.1
  • 11
    • 70349115668 scopus 로고    scopus 로고
    • The PI3 K/Akt/mTOR pathway as therapeutic target in neuroblastoma
    • Fulda S (2009) The PI3 K/Akt/mTOR pathway as therapeutic target in neuroblastoma. Curr Cancer Drug Targets 9(6):729-737
    • (2009) Curr Cancer Drug Targets , vol.9 , Issue.6 , pp. 729-737
    • Fulda, S.1
  • 12
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3 K signaling in cancer: Opportunities, challenges and limitations
    • Engelmann J (2009) Targeting PI3 K signaling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9:550-569
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-569
    • Engelmann, J.1
  • 13
    • 0033519453 scopus 로고    scopus 로고
    • Induction of NF-kB by the Akt/PKB kinase
    • Kane LP et al (1999) Induction of NF-kB by the Akt/PKB kinase. Curr Biol 9:601-604
    • (1999) Curr Biol , vol.9 , pp. 601-604
    • Kane, L.P.1
  • 14
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kB a good target for cancer therapy? Hopes and pitfalls
    • Baud V, Karin M (2009) Is NF-kB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8:33-40
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 15
    • 0036826891 scopus 로고    scopus 로고
    • Constitutively active NFjB is required for the survival of S-type neuroblastoma
    • Bian X et al (2002) Constitutively active NFjB is required for the survival of S-type neuroblastoma. JBiol Chem 277(44):42144-42150
    • (2002) JBiol Chem , vol.277 , Issue.44 , pp. 42144-42150
    • Bian, X.1
  • 16
    • 36949000268 scopus 로고    scopus 로고
    • NF-kB controls growth of glioblastomas/ astrocytomas
    • Smith D et al (2008) NF-kB controls growth of glioblastomas/ astrocytomas. Mol Cell Biochem 307:141-147
    • (2008) Mol Cell Biochem , vol.307 , pp. 141-147
    • Smith, D.1
  • 17
    • 0036235624 scopus 로고    scopus 로고
    • Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma
    • Nagai S et al (2002) Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma. J Neurosurg 96:909-917
    • (2002) J Neurosurg , vol.96 , pp. 909-917
    • Nagai, S.1
  • 18
    • 0031880611 scopus 로고    scopus 로고
    • Immunohistochemical expression of MMP-2, MMP-9, and TIMP-2 in neuroblastoma: Association with tumor progression and clinical outcome
    • Ara T et al (1998) Immunohistochemical expression of MMP-2, MMP-9, and TIMP-2 in neuroblastoma: association with tumor progression and clinical outcome. J Pediatr Surg 33(8):1272-1278
    • (1998) J Pediatr Surg , vol.33 , Issue.8 , pp. 1272-1278
    • Ara, T.1
  • 19
    • 0029067536 scopus 로고
    • Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in paediatric tumour cells. Effects of tumour cell proliferation modulators on gelatinolytic activity
    • Veas Rd, Schweigerer L, Medina M (1995) Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in paediatric tumour cells. Effects of tumour cell proliferation modulators on gelatinolytic activity. J Cancer Res Clin Oncol 121(5):275-278
    • (1995) J Cancer Res Clin Oncol , vol.121 , Issue.5 , pp. 275-278
    • Rd, V.1    Schweigerer, L.2    Medina, M.3
  • 20
    • 0035170157 scopus 로고    scopus 로고
    • Late relapse and prognosis for neuroblastoma patients surviving 5 years or more: A report from the European Neuroblastoma Study Group ''Survey''
    • Cotterill S et al (2001) Late relapse and prognosis for neuroblastoma patients surviving 5 years or more: a report from the European Neuroblastoma Study Group ''Survey''. Med Pediatr Oncol 36(1):235-238
    • (2001) Med Pediatr Oncol , vol.36 , Issue.1 , pp. 235-238
    • Cotterill, S.1
  • 21
    • 0035398020 scopus 로고    scopus 로고
    • Late mortality experience in five-year survivors of childhood and adolescent cancer: The Childhood Cancer Survivor Study
    • Mertens A et al (2001) Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol 19(13):3163-3172
    • (2001) J Clin Oncol , vol.19 , Issue.13 , pp. 3163-3172
    • Mertens, A.1
  • 22
    • 0037109597 scopus 로고    scopus 로고
    • Milk thistle for the treatment of liver disease. A systematic review and meta-analysis
    • Jacobs BP et al (2002) Milk thistle for the treatment of liver disease. A systematic review and meta-analysis. Am J Med 113:506-515
    • (2002) Am J Med , vol.113 , pp. 506-515
    • Jacobs, B.P.1
  • 23
    • 77957598340 scopus 로고    scopus 로고
    • Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer
    • Deep G, Agarwal R (2010) Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev 49:447-463
    • (2010) Cancer Metastasis Rev , vol.49 , pp. 447-463
    • Deep, G.1    Agarwal, R.2
  • 25
    • 76649085810 scopus 로고    scopus 로고
    • Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9
    • Momeny M et al (2010) Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9. Anticancer Drugs 21(3):252-260
    • (2010) Anticancer Drugs , vol.21 , Issue.3 , pp. 252-260
    • Momeny, M.1
  • 26
    • 84872208392 scopus 로고    scopus 로고
    • Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human Glioblastoma U87MG cell line
    • Dizaji MZ, et al (2011) Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human Glioblastoma U87MG cell line. Neurochem Res
    • (2011) Neurochem Res
    • Dizaji, M.Z.1
  • 27
    • 34548313955 scopus 로고    scopus 로고
    • Clonogenic assay of cells in vivo
    • Franken NAP et al (2006) Clonogenic assay of cells in vivo. Nat Protoc 1(5):2315-2319
    • (2006) Nat Protoc , vol.1 , Issue.5 , pp. 2315-2319
    • Franken, N.A.P.1
  • 28
    • 77950353781 scopus 로고    scopus 로고
    • Zymography and reverse zymography for detecting MMPs and TIMPs
    • Hawkes S, Li H, Taniguchi G (2010) Zymography and reverse zymography for detecting MMPs and TIMPs. Methods Mol Biol 622:257-269
    • (2010) Methods Mol Biol , vol.622 , pp. 257-269
    • Hawkes, S.1    Li, H.2    Taniguchi, G.3
  • 29
    • 30344442477 scopus 로고    scopus 로고
    • Differential sensitivity of chemoresistant neuroblastoma subtypes to MAPK-targeted treatment correlates with ERK, p53 expression, and signaling response to U0126
    • Eppstein A et al (2006) Differential sensitivity of chemoresistant neuroblastoma subtypes to MAPK-targeted treatment correlates with ERK, p53 expression, and signaling response to U0126. J Pediatr Surg 41(1):252-259
    • (2006) J Pediatr Surg , vol.41 , Issue.1 , pp. 252-259
    • Eppstein, A.1
  • 30
    • 0031846685 scopus 로고    scopus 로고
    • Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines
    • Isaacs JS et al (1998) Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines. Cell Growth Differ 9:545-555
    • (1998) Cell Growth Differ , vol.9 , pp. 545-555
    • Isaacs, J.S.1
  • 31
    • 77951030589 scopus 로고    scopus 로고
    • MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
    • doi:10.1186/1476-4598-9-83
    • Foley NH et al (2010) MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2. Mol Cancer. doi:10.1186/1476-4598-9-83
    • (2010) Mol Cancer
    • Foley, N.H.1
  • 32
    • 73849152723 scopus 로고    scopus 로고
    • Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein Dysregulation of FLIP ubiquitination by Akt in chemoresistant ovarian cancer
    • Abedini MR et al (2010) Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein Dysregulation of FLIP ubiquitination by Akt in chemoresistant ovarian cancer. Oncogene 29:11-25
    • (2010) Oncogene , vol.29 , pp. 11-25
    • Abedini, M.R.1
  • 33
    • 4444346646 scopus 로고    scopus 로고
    • AKT involvement in cisplatin chemoresistance of human uterine cancer cells
    • Gagnon V, Mathieu I, Sexton E, Leblanc K, Asselin E (2004) AKT involvement in cisplatin chemoresistance of human uterine cancer cells. Gynecol Oncol 3:785-795
    • (2004) Gynecol Oncol , vol.3 , pp. 785-795
    • Gagnon, V.1    Mathieu, I.2    Sexton, E.3    Leblanc, K.4    Asselin, E.5
  • 34
    • 0037945211 scopus 로고    scopus 로고
    • HER2/PI-3 K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells
    • Knuefermann C et al (2003) HER2/PI-3 K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. Oncogene 22:3205-3212
    • (2003) Oncogene , vol.22 , pp. 3205-3212
    • Knuefermann, C.1
  • 35
    • 81555218920 scopus 로고    scopus 로고
    • Insulin caused drug resistance to oxaliplatin in colon cancer cell line HT29
    • Chen J et al (2011) Insulin caused drug resistance to oxaliplatin in colon cancer cell line HT29. J Gastrointest Oncol 2(1):27-33
    • (2011) J Gastrointest Oncol , vol.2 , Issue.1 , pp. 27-33
    • Chen, J.1
  • 36
    • 26444503696 scopus 로고    scopus 로고
    • Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer
    • Oki E et al (2005) Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. Int J Cancer 117:376-380
    • (2005) Int J Cancer , vol.117 , pp. 376-380
    • Oki, E.1
  • 37
    • 0037043603 scopus 로고    scopus 로고
    • Doxorubicin resistant neuroblastoma cells secrete factors that activate AKT and attenuate cytotoxicity in drug-sensitive cells
    • Emran M, Rebbaa A, Mirkin B (2002) Doxorubicin resistant neuroblastoma cells secrete factors that activate AKT and attenuate cytotoxicity in drug-sensitive cells. Cancer Lett 182(1):53-59
    • (2002) Cancer Lett , vol.182 , Issue.1 , pp. 53-59
    • Emran, M.1    Rebbaa, A.2    Mirkin, B.3
  • 38
    • 67650617274 scopus 로고    scopus 로고
    • Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition
    • Li W et al (2009) Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition. Br J Cancer 10(2):342-349
    • (2009) Br J Cancer , vol.10 , Issue.2 , pp. 342-349
    • Li, W.1
  • 39
    • 14644410403 scopus 로고    scopus 로고
    • Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-jB: Implications for angioprevention and antiangiogenic therapy
    • Singh RP et al (2005) Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-jB: implications for angioprevention and antiangiogenic therapy. Oncogene 24:1188-1202
    • (2005) Oncogene , vol.24 , pp. 1188-1202
    • Singh, R.P.1
  • 40
    • 79959610127 scopus 로고    scopus 로고
    • Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB
    • Eberle K et al (2011) Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB. PLoS One 6(6): e21469
    • (2011) PLoS One , vol.6 , Issue.6
    • Eberle, K.1
  • 41
    • 0038621384 scopus 로고    scopus 로고
    • Role of NF-kappaB and Akt/PI3 K in the resistance of pancreatic carcinoma cell lines against gemcitabineinduced cell death
    • Arlt A et al (2003) Role of NF-kappaB and Akt/PI3 K in the resistance of pancreatic carcinoma cell lines against gemcitabineinduced cell death. Oncogene 22:3243-3251
    • (2003) Oncogene , vol.22 , pp. 3243-3251
    • Arlt, A.1
  • 42
    • 83955165140 scopus 로고    scopus 로고
    • Response and resistance to NF-jB inhibitors in mouse models of lung adenocarcinoma
    • Xue Wen et al (2011) Response and resistance to NF-jB inhibitors in mouse models of lung adenocarcinoma. Cancer Discov 1: 236-247
    • (2011) Cancer Discov , vol.1 , pp. 236-247
    • Wen, X.1
  • 43
    • 0036771765 scopus 로고    scopus 로고
    • Two pathways to NF-kappaB
    • Pomerantz J, Baltimore D (2002) Two pathways to NF-kappaB. Mol Cell 10:693-695
    • (2002) Mol Cell , vol.10 , pp. 693-695
    • Pomerantz, J.1    Baltimore, D.2
  • 44
    • 0037931474 scopus 로고    scopus 로고
    • RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation
    • Derudder E et al (2003) RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation. J Biol Chem 278:23278-23284
    • (2003) J Biol Chem , vol.278 , pp. 23278-23284
    • Derudder, E.1
  • 45
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases structure, function, and biochemistry
    • Visse R, Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases structure, function, and biochemistry. Circ Res 92:827-839
    • (2003) Circ Res , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 46
    • 0036512208 scopus 로고    scopus 로고
    • New functions for matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z (2002) New functions for matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161-173
    • (2002) Nat Rev Cancer , vol.2 , pp. 161-173
    • Egeblad, M.1    Werb, Z.2


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