Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1,following VEGF stimulation of vascular endothelial cells

BMC Biochemistry

Volumn 3, Issue , 2002, Pages 1-11

  Chou, Mary T ^a   Wang, Jing ^a,b   Fujita, Donald J ^a  

^a Health Sciences Centre Calgary   (Canada)

^b Sangstat   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ARTICLE; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FAR WESTERN BLOTTING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; TIME; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

EID: 34248397608     PISSN: 14712091     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2091-3-32     Document Type: Article

References (51)

1. Ruegg C, Yilmaz A, Bieler G, Bamat J, Chaubert P and Lejeune FJ Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma. Nat Med 1998, 4:408-414
2. Bergers G, Javaherian K, Lo KM, Folkman J and Hanahan D Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 1999, 284:808-812
3. Folkman J Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995, 1:27-31
4. Isner JM and Asahara T Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J Clin Invest 1999, 103:1231-1236
5. Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T and Jain RK Tumor induction of VEGF promoter activity in stromal cells. Cell 1998, 94:715-725
6. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W and Ullrich A High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993, 72:835-846
7. Peters KG, De Vries C and Williams LT Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci U S A 1993, 90:8915-8919
8. Boshoff C and Weiss R AIDS-related malignancies. Nat Rev Cancer 2002, 2:373-382
9. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS and Dvorak HF Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983, 219:983-985
10. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J and Connolly DT Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989, 246:1309-1312
11. Dvorak HF, Dvorak AM, Manseau EJ, Wiberg L and Churchill WH Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs. Role of cellular immunity, myofibroblasts, microvascular damage, and infarction in line 1 tumor regression. J Natl Cancer Inst 1979, 62:1459-1472
12. Nagy JA, Brown LF, Senger DR, Lanir N, Van de WL, Dvorak AM and Dvorak HF Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta 1989, 948:305-326
13. Nagy JA, Brown LF, Senger DR, Lanir N, Van de WL, Dvorak AM and Dvorak HF Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta 1989, 948:305-326
14. Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM and Feder J Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 1989, 84:1470-1478
15. Ferrara N and Henzel WJ Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989, 161:851-858
16. Leung DW, Cachianes G, Kuang WJ, Goeddel DV and Ferrara N Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989, 246:1306-1309
17. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML and Schuh AC Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995, 376:62-66
18. Fong GH, Rossant J, Gertsenstein M and Breitman ML Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995, 376:66-70
19. Inoue T, Kibata K, Suzuki M, Nakamura S, Motoda R and Orita K Identification of a vascular endothelial growth factor (VEGF) antagonist, sFlt-1, from a human hematopoietic cell line NALM-16. FEBS Lett 2000, 469:14-18
20. Verbeek BS, Vroom TM, Adriaansen-Slot SS, Ottenhoff-Kalff AE, Geertzema JG, Hennipman A and Rijksen G c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis. J Pathol 1996, 180:383-388
21. Egan C, Pang A, Durda D, Cheng HC, Wang JH and Fujita DJ Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530. Oncogene 1999, 18:1227-1237
22. Bolen JB, Veillette A, Schwartz AM, DeSeau V and Rosen N Activation of pp60c-src protein kinase activity in human colon carcinoma. Proc Natl Acad Sci U S A 1987, 84:2251-2255
23. Cartwright CA, Meisler AI and Eckhart W Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis. Proc Natl Acad Sci U S A 1990, 87:558-562
24. Irby RB, Mao W, Coppola D, Kang J, Loubeau JM, Trudeau W, Karl R, Fujita DJ, Jove R and Yeatman TJ Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet 1999, 21:187-190
25. Lutz MP, Esser IB, Flossmann-Kast BB, Vogelmann R, Luhrs H, Friess H, Buchler MW and Adler G Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma. Biochem Biophys Res Commun 1998, 243:503-508
26. Visser CJ, Rijksen G, Woutersen RA and de Weger RA Increased immunoreactivity and protein tyrosine kinase activity of the protooncogene pp60c-src in preneoplastic lesions in rat pancreas. Lab Invest 1996, 74:2-11
27. Alonso G, Koegl M, Mazurenko N and Courtneidge SA Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors. J Biol Chem 1995, 270:9840-9848
28. Belsches-Jablonski AP, Biscardi JS, Peavy DR, Tice DA, Romney DA and Parsons SJ Src family kinases and HER2 interactions in human breast cancer cell growth and survival. Oncogene 2001, 20:1465-1475
29. Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, Cary LA, Moolenaar WH and Schlessinger J Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 2001, 276:20130-20135
30. Simeonova PP, Wang S, Hulderman T and Luster MI c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic: Role in carcinogenesis. J Biol Chem 2001,
31. Eliceiri BP, Paul R, Schwartzberg PL, Hood JD, Leng J and Cheresh DA Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999, 4:915-924
32. Suarez S and Ballmer-Hofer K VEGF transiently disrupts gap junctional communication in endothelial cells. J Cell Sci 2001, 114:1229-1235
33. Schlessinger J New roles for Src kinases in control of cell survival and angiogenesis. Cell 2000, 100:293-296
34. Zhou S, Carraway KL III, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP and Eng C Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature 1995, 373:536-539
35. Xu W, Harrison SC and Eck MJ Three-dimensional structure of the tyrosine kinase c-Src. Nature 1997, 385:595-602
36. Nada S, Okada M, MacAuley A, Cooper JA and Nakagawa H Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 1991, 351:69-72
37. Matsuda M, Mayer BJ, Fukui Y and Hanafusa H Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science 1990, 248:1537-1539
38. Williams JC, Weijland A, Gonfloni S, Thompson A, Courtneidge SA, Superti-Furga G and Wierenga RK The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions. J Mol Biol 1997, 274:757-775
39. Hunter T A tail of two src's: mutatis mutandis. Cell 1987, 49:1-4
40. Alexandropoulos K, Cheng G and Baltimore D Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc Natl Acad Sci U S A 1995, 92:3110-3114
41. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S and Lechleider RJ SH2 domains recognize specific phosphopeptide sequences. Cell 1993, 72:767-778
42. Cunningham SA, Arrate MP, Brock TA and Waxham MN Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites. Biochem Biophys Res Commun 1997, 240:635-639
43. Dougher-Vermazen M, Hulmes JD, Bohlen P and Terman BI Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor. Biochem Biophys Res Commun 1994, 205:728-738
44. Takahashi T, Yamaguchi S, Chida K and Shibuya M A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J 2001, 20:2768-2778
45. Meyer RD, Dayanir V, Majnoun F and Rahimi N The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules. J Biol Chem 2002, 277:27081-27087
46. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M and Heldin CH Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 1994, 269:26988-26995
47. Resh MD Myristylation and palmitylation of Src family members: the fats of the matter. Cell 1994, 76:411-413
48. Robbins SM, Quintrell NA and Bishop JM Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae. Mol Cell Biol 1995, 15:3507-3515
49. Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J and De Klerck B Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 2002, 8:831-840
50. Jaffe EA, Nachman RL, Becker CG and Minick CR Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973, 52:2745-2756
51. Cooper JA and Hunter T Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells. Mol Cell Biol 1981, 1:165-178