In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics

Journal of Controlled Release

Volumn 163, Issue 1, 2012, Pages 46-54

  Yu, Tian ^a   Hubbard, Dallin ^a   Ray, Abhijit ^a   Ghandehari, Hamidreza ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Biodistribution; Geometry; Nanotoxicity; Porosity; Silica nanoparticles

Indexed keywords

BIODISTRIBUTIONS; HIGH ASPECT RATIO; HYDRODYNAMIC SIZE; IN-VIVO; INTRAVENOUS INJECTIONS; MESOPOROUS; MESOPOROUS NANOSPHERES; NANOTOXICITY; PHARMACOKINETIC ANALYSIS; PRIMARY AMINES; SILICA NANOPARTICLES; STEADY STATE; SURFACE CHARACTERISTICS; SYSTEMIC CIRCULATION;

ASPECT RATIO; BIOLOGICAL ORGANS; GEOMETRY; MESOPOROUS MATERIALS; MICROCIRCULATION; NANORODS; ORGANIC COMPOUNDS; PHARMACOKINETICS; POROSITY;

NANOPARTICLES;

AMINE; NANOPARTICLE; NANOROD; NANOSPHERE; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIOACCUMULATION; CHEMICAL BOND; CHEMICAL MODIFICATION; CHEMICAL REACTION; CIRCULATION; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GEOMETRY; HYDRODYNAMICS; IN VIVO STUDY; ISOTOPE LABELING; LIVER; LUNG CAPILLARY; MOUSE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; SPLEEN; STEADY STATE; SURFACE PROPERTY; THIN LAYER CHROMATOGRAPHY; TRANSMISSION ELECTRON MICROSCOPY; URINARY EXCRETION;

ANIMALS; FEMALE; MICE; NANOPARTICLES; POROSITY; SILICON DIOXIDE; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 84866729700     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.046     Document Type: Conference Paper

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