Influence of geometry, porosity, and surface characteristics of silica nanoparticles on acute toxicity: Their vasculature effect and tolerance threshold

ACS Nano

Volumn 6, Issue 3, 2012, Pages 2289-2301

  Yu, Tian ^a   Greish, Khaled ^a,d   McGill, Lawrence D ^c   Ray, Abhijit ^a   Ghandehari, Hamidreza ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

^c ARUP LABORATORIES   (United States)

^d UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

acute toxicity; geometry; mesoporous; silica nanoparticles

Indexed keywords

ACUTE TOXICITY; BIOMEDICAL APPLICATIONS; CELL TRACKING; GENE TRANSFECTION; HYDRODYNAMIC SIZE; IN-VIVO; MAXIMUM TOLERATED DOSE; MESOPOROUS; ORGAN FAILURE; PHYSICOCHEMICAL PROPERTY; RATIONAL DESIGN; SERUM PROTEINS; SILICA NANOPARTICLES; SURFACE CHARACTERISTICS; TOXIC EFFECT; VASCULATURE;

ASPECT RATIO; DRUG DELIVERY; GENES; GEOMETRY; HYDRODYNAMICS; MEDICAL APPLICATIONS; MEDICAL NANOTECHNOLOGY; MESOPOROUS MATERIALS; MOLECULAR BIOLOGY; ORGANIC COMPOUNDS; POROSITY; TOXICITY;

SILICON COMPOUNDS;

NANOPARTICLE; SILICON DIOXIDE;

ANGIOGENESIS; ANIMAL; ARTICLE; BLOOD ANALYSIS; BLOOD EXAMINATION; BODY WEIGHT; CHEMISTRY; DRUG EFFECT; FEMALE; MAXIMUM TOLERATED DOSE; MOUSE; PHYSICAL CHEMISTRY; POROSITY; SURFACE PROPERTY; TOXICITY TESTING;

ANIMALS; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; FEMALE; HEMATOLOGIC TESTS; MAXIMUM TOLERATED DOSE; MICE; NANOPARTICLES; NEOVASCULARIZATION, PHYSIOLOGIC; PHYSICOCHEMICAL PROCESSES; POROSITY; SILICON DIOXIDE; SURFACE PROPERTIES; TOXICITY TESTS, ACUTE;

EID: 84859129491     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn2043803     Document Type: Article

References (35)

1. Slowing, I. I.; Vivero-Escoto, J. L.; Wu, C. W.; Lin, V. S. Mesoporous Silica Nanoparticles as Controlled Release Drug Delivery and Gene Transfection Carriers Adv. Drug Delivery Rev. 2008, 60, 1278-1288
2. He, Q.; Shi, J. Mesoporous Silica Nanoparticle Based Nano Drug Delivery Systems: Synthesis, Controlled Drug Release and Delivery, Pharmacokinetics and Biocompatibility J. Mater. Chem. 2011, 21, 5845-5855
3. Vivero-Escoto, J. L.; Slowing, I. I.; Trewyn, B. G.; Lin, V. S. Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery Small 2010, 6, 1952-1967
4. Lu, J.; Liong, M.; Li, Z.; Zink, J. I.; Tamanoi, F. Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals Small 2010, 6, 1794-1805
5. Li, L.; Tang, F.; Liu, H.; Liu, T.; Hao, N.; Chen, D.; Teng, X.; He, J. In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy ACS Nano 2010, 4, 6874-6882
6. Nan, A.; Bai, X.; Son, S. J.; Lee, S. B.; Ghandehari, H. Cellular Uptake and Cytotoxicity of Silica Nanotubes Nano Lett. 2008, 8, 2150-2154
7. Tsai, C. P.; Hung, Y.; Chou, Y. H.; Huang, D. M.; Hsiao, J. K.; Chang, C.; Chen, Y. C.; Mou, C. Y. High-Contrast Paramagnetic Fluorescent Mesoporous Silica Nanorods as a Multifunctional Cell-Imaging Probe Small 2008, 4, 186-191
8. Chen, D.; Li, L.; Tang, F.; Qi, S. Facile and Scalable Synthesis of Tailored Silica Nanorattle Structures Adv. Mater. 2009, 21, 3804-3807
9. Malugin, A.; Ghandehari, H. Caspase 3 Independent Cell Death Induced by Amorphous Silica Nanoparticles Nanosci. Nanotechnol. Lett. 2011, 3, 309-313
10. Slowing, I.; Trewyn, B. G.; Lin, V. S. Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells J. Am. Chem. Soc. 2006, 128, 14792-14793
11. Yamashita, K.; Yoshioka, Y.; Higashisaka, K.; Mimura, K.; Morishita, Y.; Nozaki, M.; Yoshida, T.; Ogura, T.; Nabeshi, H.; Nagano, K. et al. Silica and Titanium Dioxide Nanoparticles Cause Pregnancy Complications in Mice Nat. Nanotechnol. 2011, 6, 321-328
12. Nishimori, H.; Kondoh, M.; Isoda, K.; Tsunoda, S.; Tsutsumi, Y.; Yagi, K. Silica Nanoparticles as Hepatotoxicants Eur. J. Pharm. Biopharm. 2009, 72, 496-501
13. Lu, X.; Tian, Y.; Zhao, Q.; Jin, T.; Xiao, S.; Fan, X. Integrated Metabonomics Analysis of the Size-Response Relationship of Silica Nanoparticles-Induced Toxicity in Mice Nanotechnology 2011, 22, 055101
14. Xie, G.; Sun, J.; Zhong, G.; Shi, L.; Zhang, D. Biodistribution and Toxicity of Intravenously Administered Silica Nanoparticles in Mice Arch. Toxicol. 2010, 84, 183-190
15. Isoda, K.; Hasezaki, T.; Kondoh, M.; Tsutsumi, Y.; Yagi, K. Effect of Surface Charge on Nano-Sized Silica Particles-Induced Liver Injury Pharmazie 2011, 66, 278-281
16. Hudson, S. P.; Padera, R. F.; Langer, R.; Kohane, D. S. The Biocompatibility of Mesoporous Silicates Biomaterials 2008, 29, 4045-4055
17. Yu, T.; Malugin, A.; Ghandehari, H. Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity ACS Nano 2011, 5, 5717-5728
18. Lin, Y. S.; Abadeer, N.; Haynes, C. L. Stability of Small Mesoporous Silica Nanoparticles in Biological Media Chem. Commun. (Cambridge, U. K.) 2011, 47, 532-534
19. Dobrovolskaia, M. A.; Patri, A. K.; Zheng, J.; Clogston, J. D.; Ayub, N.; Aggarwal, P.; Neun, B. W.; Hall, J. B.; McNeil, S. E. Interaction of Colloidal Gold Nanoparticles with Human Blood: Effects on Particle Size and Analysis of Plasma Protein Binding Profiles Nanomed.: Nanotechnol., Biol., Med. 2009, 5, 106-117
20. Bihari, P.; Vippola, M.; Schultes, S.; Praetner, M.; Khandoga, A. G.; Reichel, C. A.; Coester, C.; Tuomi, T.; Rehberg, M.; Krombach, F. Optimized Dispersion of Nanoparticles for Biological in Vitro and in Vivo Studies Part Fibre Toxicol. 2008, 5, 14
21. 2 Nanoparticles in Cell Culture Media Environ. Sci. Technol. 2010, 44, 7309-7314
22. Chen, Z.; Meng, H.; Xing, G.; Chen, C.; Zhao, Y.; Jia, G.; Wang, T.; Yuan, H.; Ye, C.; Zhao, F. et al. Acute Toxicological Effects of Copper Nanoparticles in Vivo Toxicol. Lett. 2006, 163, 109-120
23. Chen, J.; Dong, X.; Zhao, J.; Tang, G. In Vivo Acute Toxicity of Titanium Dioxide Nanoparticles to Mice after Intraperitoneal Injection J. Appl. Toxicol. 2009, 29, 330-337
24. Endemann, D. H.; Schiffrin, E. L. Endothelial Dysfunction J. Am. Soc. Nephrol. 2004, 15, 1983-1992
25. Muzykantov, V. R. Biomedical Aspects of Targeted Delivery of Drugs to Pulmonary Endothelium Expert Opin. Drug Delivery 2005, 2, 909-926
26. He, Q.; Zhang, Z.; Gao, F.; Li, Y.; Shi, J. In Vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and Pegylation Small 2011, 7, 271-280
27. Galagudza, M. M.; Korolev, D. V.; Sonin, D. L.; Postnov, V. N.; Papayan, G. V.; Uskov, I. S.; Belozertseva, A. V.; Shlyakhto, E. V. Targeted Drug Delivery into Reversibly Injured Myocardium with Silica Nanoparticles: Surface Functionalization, Natural Biodistribution, and Acute Toxicity Int. J. Nanomed. 2010, 5, 231-237
28. Zhao, Y.; Sun, X.; Zhang, G.; Trewyn, B. G.; Slowing, I. I.; Lin, V. S. Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects ACS Nano 2011, 5, 1366-1375
29. Liu, X.; Sun, J. Endothelial Cells Dysfunction Induced by Silica Nanoparticles through Oxidative Stress Via JNK/P53 and NF-κB Pathways Biomaterials 2010, 31, 8198-8209
30. Hainfeld, J. F.; Slatkin, D. N.; Focella, T. M.; Smilowitz, H. M. Gold Nanoparticles: A New X-Ray Contrast Agent Br. J. Radiol. 2006, 79, 248-253
31. Waters, K. M.; Masiello, L. M.; Zangar, R. C.; Tarasevich, B. J.; Karin, N. J.; Quesenberry, R. D.; Bandyopadhyay, S.; Teeguarden, J. G.; Pounds, J. G.; Thrall, B. D. Macrophage Responses to Silica Nanoparticles Are Highly Conserved across Particle Sizes Toxicol. Sci. 2009, 107, 553-569
32. Oberdorster, G.; Oberdorster, E.; Oberdorster, J. Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles Environ. Health Perspect. 2005, 113, 823-839
33. Krug, H. F.; Wick, P. Nanotoxicology: An Interdisciplinary Challenge Angew. Chem., Int. Ed. 2011, 50, 1260-1278
34. Liu, T.; Li, L.; Teng, X.; Huang, X.; Liu, H.; Chen, D.; Ren, J.; He, J.; Tang, F. Single and Repeated Dose Toxicity of Mesoporous Hollow Silica Nanoparticles in Intravenously Exposed Mice Biomaterials 2011, 32, 1657-1668
35. Yadav, S.; Shire, S. J.; Kalonia, D. S. Viscosity Analysis of High Concentration Bovine Serum Albumin Aqueous Solutions Pharm. Res. 2011, 28, 1973-1983