GAGE Cancer-Germline Antigens Are Recruited to the Nuclear Envelope by Germ Cell-Less (GCL

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Gjerstorff, Morten F ^a   Rösner, Heike I ^b   Pedersen, Christina B ^a   Greve, Katrine B V ^a   Schmidt, Steffen ^a   Wilson, Katherine L ^c   Mollenhauer, Jan ^a   Besir, Hüseyin ^d   Poulsen, Flemming M ^b   Møllegaard, Niels Erik ^e   Ditzel, Henrik J ^a,f  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Protein Expression and Purification Core Facility   (Germany)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DOUBLE STRANDED DNA; EMERIN; LAP2BETA PROTEIN; MESSENGER RNA; PROTEIN GAGE; PROTEIN MAN1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GERM CELL LESS; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; MALIGNANT NEOPLASTIC DISEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; TESTIS; TWO HYBRID SYSTEM;

ANTIGENS, NEOPLASM; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN; CIRCULAR DICHROISM; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMANS; MALE; NEOPLASM PROTEINS; NUCLEAR ENVELOPE; ORGAN SPECIFICITY; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; TESTIS; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

METAZOA; PRIMATES;

EID: 84866706224     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045819     Document Type: Article

References (55)

1. Killen MW, Taylor TL, Stults DM, Jin W, Wang LL, et al. (2011) Configuration and rearrangement of the human GAGE gene clusters. Am J Transl Res 3: 234-242.
2. Gjerstorff MF, Besir H, Larsen MR, Ditzel HJ, (2010) Expression, purification and characterization of the cancer-germline antigen GAGE12I: a candidate for cancer immunotherapy. Protein Expr Purif 73: 217-222.
3. Liu Y, Zhu Q, Zhu N (2007) Recent duplication and positive selection of the GAGE gene family. Genetica.
4. Gjerstorff MF, Johansen LE, Nielsen O, Kock K, Ditzel HJ, (2006) Restriction of GAGE protein expression to subpopulations of cancer cells is independent of genotype and may limit the use of GAGE proteins as targets for cancer immunotherapy. Br J Cancer 94: 1864-1873.
5. Simpson AJ, Caballero OL, Jungbluth A, Chen YT, Old LJ, (2005) Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer 5: 615-625.
6. Gjerstorff MF, Ditzel HJ, (2008) An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. Tissue Antigens 71: 187-192.
7. Cilensek ZM, Yehiely F, Kular RK, Deiss LP, (2002) A member of the GAGE family of tumor antigens is an anti-apoptotic gene that confers resistance to Fas/CD95/APO-1, Interferon-gamma, taxol and gamma-irradiation. Cancer Biol Ther 1: 380-387.
8. Kular RK, Yehiely F, Kotlo KU, Cilensek ZM, Bedi R, et al. (2009) GAGE, an antiapoptotic protein binds and modulates the expression of nucleophosmin/B23 and interferon regulatory factor 1. J Interferon Cytokine Res 29: 645-655.
9. Jongens TA, Hay B, Jan LY, Jan YN, (1992) The germ cell-less gene product: a posteriorly localized component necessary for germ cell development in Drosophila. Cell 70: 569-584.
10. Kimura T, Ito C, Watanabe S, Takahashi T, Ikawa M, et al. (2003) Mouse germ cell-less as an essential component for nuclear integrity. Mol Cell Biol 23: 1304-1315.
11. Leatherman JL, Levin L, Boero J, Jongens TA, (2002) germ cell-less acts to repress transcription during the establishment of the Drosophila germ cell lineage. Curr Biol 12: 1681-1685.
12. Mansharamani M, Wilson KL, (2005) Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor. J Biol Chem 280: 13863-13870.
13. Nili E, Cojocaru GS, Kalma Y, Ginsberg D, Copeland NG, et al. (2001) Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci 114: 3297-3307.
14. Holaska JM, Lee KK, Kowalski AK, Wilson KL, (2003) Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. J Biol Chem 278: 6969-6975.
15. Holaska JM, Wilson KL, (2006) Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy. Anat Rec A Discov Mol Cell Evol Biol 288: 676-680.
16. Dittmer TA, Misteli T, (2011) The lamin protein family. Genome Biol 12: 222.
17. Montes de Oca R, Andreassen PR, Wilson KL (2011) Barrier-to-autointegration factor influences specific histone modifications. Nucleus 2.
18. Margalit A, Brachner A, Gotzmann J, Foisner R, Gruenbaum Y, (2007) Barrier-to-autointegration factor-a BAFfling little protein. Trends Cell Biol 17: 202-208.
19. Wilson KL, Berk JM, (2010) The nuclear envelope at a glance. J Cell Sci 123: 1973-1978.
20. Wagner N, Krohne G, (2007) LEM-Domain proteins: new insights into lamin-interacting proteins. Int Rev Cytol 261: 1-46.
21. Zastrow MS, Vlcek S, Wilson KL, (2004) Proteins that bind A-type lamins: integrating isolated clues. J Cell Sci 117: 979-987.
22. Kind J, van Steensel B, (2010) Genome-nuclear lamina interactions and gene regulation. Curr Opin Cell Biol 22: 320-325.
23. Prokocimer M, Davidovich M, Nissim-Rafinia M, Wiesel-Motiuk N, Bar DZ, et al. (2009) Nuclear lamins: key regulators of nuclear structure and activities. J Cell Mol Med 13: 1059-1085.
24. Prokocimer M, Margalit A, Gruenbaum Y, (2006) The nuclear lamina and its proposed roles in tumorigenesis: projection on the hematologic malignancies and future targeted therapy. J Struct Biol 155: 351-360.
25. Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T, (2008) SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature 452: 187-193.
26. Simon DN, Wilson KL, (2011) The nucleoskeleton as a genome-associated dynamic 'network of networks'. Nat Rev Mol Cell Biol 12: 695-708.
27. Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, et al. (2005) High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307: 1621-1625.
28. Artemenko KA, Bergstrom Lind S, Elfineh L, Mayrhofer C, Zubarev RA, et al. (2011) Optimization of immunoaffinity enrichment and detection: toward a comprehensive characterization of the phosphotyrosine proteome of K562 cells by liquid chromatography-mass spectrometry. Analyst 136: 1971-1978.
29. de la Luna S, Allen KE, Mason SL, La Thangue NB, (1999) Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J 18: 212-228.
30. Albagli O, Dhordain P, Deweindt C, Lecocq G, Leprince D, (1995) The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins. Cell Growth Differ 6: 1193-1198.
31. Stogios PJ, Prive GG, (2004) The BACK domain in BTB-kelch proteins. Trends Biochem Sci 29: 634-637.
32. Magae J, Wu CL, Illenye S, Harlow E, Heintz NH, (1996) Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J Cell Sci 109 (Pt 7): 1717-1726.
33. Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA, (1995) In vivo association of E2F and DP family proteins. Mol Cell Biol 15: 2536-2546.
34. Verona R, Moberg K, Estes S, Starz M, Vernon JP, et al. (1997) E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol Cell Biol 17: 7268-7282.
35. Gjerstorff MF, Harkness L, Kassem M, Frandsen U, Nielsen O, et al. (2008) Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation. Hum Reprod 23: 2194-2201.
36. Robertson SE, Dockendorff TC, Leatherman JL, Faulkner DL, Jongens TA, (1999) germ cell-less is required only during the establishment of the germ cell lineage of Drosophila and has activities which are dependent and independent of its localization to the nuclear envelope. Dev Biol 215: 288-297.
37. Kimura T, Yomogida K, Iwai N, Kato Y, Nakano T, (1999) Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells. Biochem Biophys Res Commun 262: 223-230.
38. Jongens TA, Ackerman LD, Swedlow JR, Jan LY, Jan YN, (1994) Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila. Genes Dev 8: 2123-2136.
39. Moore J, Han H, Lasko P, (2009) Bruno negatively regulates germ cell-less expression in a BRE-independent manner. Mech Dev 126: 503-516.
40. Romero P, Obradovic Z, Li X, Garner EC, Brown CJ, et al. (2001) Sequence complexity of disordered protein. Proteins 42: 38-48.
41. Uversky VN, Gillespie JR, Fink AL, (2000) Why are "natively unfolded" proteins unstructured under physiologic conditions? Proteins 41: 415-427.
42. Wang L, Brown SJ, (2006) BindN: a web-based tool for efficient prediction of DNA and RNA binding sites in amino acid sequences. Nucleic Acids Res 34: W243-248.
43. Heessen S, Fornerod M, (2007) The inner nuclear envelope as a transcription factor resting place. EMBO Rep 8: 914-919.
44. Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN, (2005) Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J 272: 5129-5148.
45. Adams VH, McBryant SJ, Wade PA, Woodcock CL, Hansen JC, (2007) Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2. J Biol Chem 282: 15057-15064.
46. Zeng Y, He Y, Yang F, Mooney SM, Getzenberg RH, et al. (2011) The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein. J Biol Chem 286: 13985-13994.
47. Dyson HJ, Wright PE, (2005) Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol 6: 197-208.
48. Shaklai S, Amariglio N, Rechavi G, Simon AJ, (2007) Gene silencing at the nuclear periphery. FEBS J 274: 1383-1392.
49. Gjerstorff MF, Kock K, Nielsen O, Ditzel HJ, (2007) MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development. Hum Reprod 22: 953-960.
50. Burger H, de Kretser DM (1981) The Testis, 2nd ed. New York: Raven Press.
51. Sasaki H, Matsui Y, (2008) Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet 9: 129-140.
52. Kota SK, Feil R, (2010) Epigenetic transitions in germ cell development and meiosis. Dev Cell 19: 675-686.
53. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, et al. (1991) A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254: 1643-1647.
54. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, et al. (1995) NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6: 277-293.
55. Demidov V, Frank-Kamenetskii MD, Egholm M, Buchardt O, Nielsen PE, (1993) Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1. Nucleic Acids Res 21: 2103-2107.