Toxicological properties of emission particles from heavy duty engines powered by conventional and bio-based diesel fuels and compressed natural gas

Particle and Fibre Toxicology

Volumn 9, Issue , 2012, Pages

  Jalava, Pasi I ^a   Aakko Saksa, Päivi ^b   Murtonen, Timo ^b   Happo, Mikko S ^a   Markkanen, Ari ^a   Yli Pirilä, Pasi ^a   Hakulinen, Pasi ^c   Hillamo, Risto ^d   Mäki Paakkanen, Jorma ^c   Salonen, Raimo O ^c   Jokiniemi, Jorma ^a,b   Hirvonen, Maija Riitta ^a,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d FINNISH METEOROLOGICAL INSTITUTE   (Finland)

Author keywords

Biodiesel; Compressed natural gas; Emissions; Hydrotreated vegetable oil; In vitro toxicology; Particulate matter

Indexed keywords

BIODIESEL; COMPRESSED NATURAL GAS; HYDROGENATED VEGETABLE OIL; MACROPHAGE INFLAMMATORY PROTEIN 2; NATURAL GAS; POLITEF; POLYCYCLIC AROMATIC HYDROCARBON; RAPESEED METHYL ESTER; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AIR POLLUTION; ANIMAL CELL; APOPTOSIS; ARTICLE; CATALYST; CELL CYCLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DIESEL ENGINE; DILUTION; DOSE RESPONSE; EXHAUST GAS; GENOTOXICITY; LIQUID; MOUSE; NONHUMAN; OXIDATIVE CATALYST; PRIORITY JOURNAL; TOXICOLOGY;

AIR POLLUTANTS; ANIMALS; APOPTOSIS; BIOFUELS; CELL CYCLE; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CYTOKINES; GAS, NATURAL; HYDROGENATION; MACROPHAGES; MICE; PARTICULATE MATTER; PLANT OILS; REACTIVE OXYGEN SPECIES; VEHICLE EMISSIONS;

BRASSICA NAPUS;

EID: 84866702100     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-9-37     Document Type: Article

References (61)

1. Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong YL, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, Whitsel L, Kaufman JD. Amer Heart Assoc Council Epidemiol,Council Kidney CardiovascDis,CouncilNutrPhys Activity Metab:Particulate Matter Air Pollutionand Cardiovascular Disease AnUpdate to the ScientificStatement From the AmericanHeart Association. Circulation 2010, 121:2331-2378. 10.1161/CIR.0b013e3181dbece1, 20458016.
2. Schwartz J, Laden F, Zanobetti A. The concentration-response relation between PM(2.5) and daily deaths. Environ Health Persp 2002, 110:1025-1102.
3. Hoek G, Brunekreef B, Goldbohm S, Fischer P, van den Brandt PA. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 2002, 360:1203-1209. 10.1016/S0140-6736(02)11280-3, 12401246.
4. Lanki T, de Hartog JJ, Heinrich J, Hoek G, Janssen NA, Peters A, Stölzel M, Timonen KL, Vallius M, Vanninen E, Pekkanen J. Can we identify sources of fine particles responsible for exercise-induced ischemia on days with elevated air pollution? The ULTRA study. Environ Health Persp 2006, 114:655-660.
5. Tonne C, Melly S, Mittlemann M, Coull B, Goldberg R, Schwartz J. A case-control analysis of exposure to traffic and acute myocardial infarction. Environ Health Persp 2007, 115:53-57.
6. Janssen NAH, Lanki T, de Hartog JJ, Hoek G, Timonen KL, Tiittanen P, Pekkanen J. Personal indoor and outdoor concentrations of fine particles in relation to daily variations of urinary concentrations of lung clara cell protein CC16. Epidemiology 2002, 13:S239.
7. Barnett AG, Williams GM, Schwartz J, Neller AH, Best TL, Petroechevsky AL, Simpson RW. Air pollution and child respiratory health: a case crossoverstudy in Australia and New Zealand. Am J RespCrit Care 2005, 171:1272-1278.
8. Attfield MD, Schleiff PL, Lubin JH, Blair A, Stewart PA, Vermeulen R, Coble JB, Silverman DT. The diesel exhaust in miners study: A cohort mortality study with emphasis on lung cancer. J Natl Cancer Inst 2012, 104:869-883. 10.1093/jnci/djs035, 3373218, 22393207.
9. Silverman DT, Samanic CM, Lubin JH, Blair AE, Stewart PA, Vermeulen R, Coble JB, Rothman N, Schleiff PL, Travis WD, Ziegler RG, Wacholder S, Attfield MD. The diesel exhaust in miners study: A nested case-control study of lung cancer and diesel exhaust. J Natl Cancer Inst 2012, 104:855-868. 10.1093/jnci/djs034, 3369553, 22393209.
10. Pope CA, Dockery DW. Health effects of fine particulate air pollution: Lines that connect. J Air Waste Manage 2006, 56:709-742.
11. Risom L, Moller P, Loft S. Oxidative stress-induced DNA damage by particulate air pollution. Mutat Res 2005, 592:119-137. 10.1016/j.mrfmmm.2005.06.012, 16085126.
12. Nemmar A, Al Maskari S, Ali BH, Al Amri IS. Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats. Am J Physiol Lung Cell MolPhysiol 2007, 292:L664-L670.
13. Salvi S, Blomberg A, Rudell B, Kelly F, Sandtröm T, Holgate S, Frew A. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J RespirCrit Care Med 1999, 159(3):702-709.
14. Peretz A, Peck EC, Bammler TK, Beyer RP, Sullivan JH, Trenga CA, Srinouprachnah S, Farin FM, Kaufman JD. Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: an exploratory study of healthy human volunteers. InhalToxicol 2007, 19(14):1107-1119.
15. Sehlsted M, Behndig AF, Boman C, Blomberg A, Sandstrom T, Pourazar J. Airway inflammatory response to diesel exhaust generated at urban cycle running conditions. InhalToxicol 2010, 22:1140-1150.
16. Tzamkiozis T, Stoeger T, Cheung K, Ntziachristos L, Sioutas C, Samaras Z. Monitoring the inflammatory potential of exhaust particles from passenger cars in mice. InhalToxicol 2010, 22(suppl 2):59-69.
17. Jalava PI, Tapanainen M, Kuuspalo K, Markkanen A, Hakulinen P, Happo MS, Pennanen AS, Ihalainen M, Yli-Pirilä P, Makkonen U, Teinilä K, Mäki-Paakkanen J, Salonen RO, Jokiniemi J, Hirvonen MR. Toxicologicaleffects of emission particles from fossil- and biodiesel-fueled diesel engine with and without DOC/POC catalyticconverter. InhalToxicol 2010, 22(suppl 2):48-58.
18. Phalen RF, Mendez LB, Oldham MJ. New developments in aerosol dosimetry. InhalToxicol 2010, 22(suppl 2):6-14.
19. Hesterberg TW, Long CM, Sax SN, Lapin CA, McLellan RO, Bunn WB, Valberg PA. Particulate matter in new technology diesel exhaust (NTDE) is Quantitatively and Qualitatively Very Different from that Found in Traditional Diesel Exhaust (TDE). J Air Waste Manage 2011, 61:894-913.
20. Swanson KJ, Madden MC, Ghio AJ. Biodiesel exhaust: the need for health effects research. Environ Health Persp 2007, 115:496-499.
21. Labeckas G, Slavinskas S. The effect of rapeseed oil methyl ester on direct injection Diesel engine performance and exhaust emissions. Energ Convers Manag 2006, 47:1954-1967.
22. Karavalakis G, Stournas S, Bakeas E. Light vehicle regulated andunregulated emissions from different biodiesels. Sci Total Environ 2009, 407:3338-3346. 10.1016/j.scitotenv.2008.12.063, 19269679.
23. Kooter IM, van Vught MATM, Jedynska AD, Tromp PC, Houtzager MMG, Verbeek RP, Kadijk G, Mulderij M, Krul CAM. Toxicological characterization of diesel engine emissions using biodiesel and a closed soot filter. Atmos Environ 2011, 45:1574-1580.
24. Canakci M. Combustion characteristics of a turbocharged DI compression ignition engine fueled with petroleum diesel fuels and biodiesel. BioresourTechnol 2007, 98:1167-1175.
25. Cheung KL, Polidori A, Ntziachristos L, Tzamkiozis T, Samaras Z, Cassee FR, Gerlofs M, Sioutas C. Chemical characteristics and oxidative potential of particulate matter emissions from gasoline, diesel, and biodiesel cars. EnvironSciTechnol 2009, 43:6334-6340.
26. Bünger J, Krahl J, Baum K, Schröder O, Müller M, Westphal G, Ruhnau P, Schulz TG, Hallier E. Cytotoxic and mutageniceffects, particlesize and concentrationanalysis of diesel engine emissions using biodiesel and petrol diesel as fuel. ArchToxicol 2000, 74:490-498.
27. Turio-Baldassarri L, Battistelli CL, Conti L, Crebelli R, De Berardis B, Iamiceli AL, Gambino M, Iannaccone S. Evaluation of emission toxicity of urban bus engines: Compressednatural gas and comparison with liquidfuels. Sci Total Environ 2006, 355:64-77. 10.1016/j.scitotenv.2005.02.037, 16442433.
28. Seagrave J, Gigliotti A, McDonald JD, Seilkop SK, Whitney KA, Zielinska B, Mauderly JL. Composition, toxicity, and mutagenicity of particulate and semivolatile emissions from heavy-duty compressed natural gas-powered vehicles. ToxicolSci 2005, 87:232-241.
29. Murtonen T, Aakko-Saksa P, Kuronen M, Mikkonen S, Lehtoranta K. Emissions with heavy-duty diesel engines and vehicles using FAME, HVO and GTL fuels with and without DOC+POC aftertreatment. SAE Int. J. Fuels and Lubricants 2010, 2(2):147-166.
30. Lehtoranta K, Matilainen P, Asenbrygg JM, Lievonen A, Kinnunen TJJ, Keskinen J, Solla A. Particle oxidation catalyst in light duty and heavy duty diesel applications. SAE technical paper 2007, :01-2017.
31. Tapanainen M, Jalava PI, Mäki-Paakkanen J, Hakulinen P, Happo MS, Lamberg H, Ruusunen J, Tissari J, Nuutinen K, Yli-Pirilä P, Hillamo R, Salonen RO, Jokiniemi J, Hirvonen M-R. In vitro immunotoxic activities of particles emitted from two different small-scale wood combustion appliances. Atmos Environ 2011, 45:7546-7554.
32. Jalava PI, Salonen RO, Hälinen AI, Sillanpää M, Sandell E, Hirvonen MR. Effects of sample preparation on chemistry, cytotoxicity, and inflammatory responses induced by air particulate matter. InhalToxicol 2005, 17:107-117.
33. Jalava PI, Salonen RO, Hälinen AI, Pennanen AS, Sillanpää M, Hillamo R, Hirvonen M-R. In-vitro inflammatory and cytotoxic effects of size segregated particulate samples collected during long-range transport of wildfire smoke to Helsinki. ToxicolApplPharmacol 2006, 215:341-353.
34. Teinilä K, Kerminen V-M, Hillamo R. A study of size segregated aerosol chemistry in the Antarctic atmosphere. J Geophys Res 2000, 105:3893-3904.
35. Pakkanen T, Loukkola K, Korhonen CH, Aurela M, Mäkelä T, Hillamo RE, Aarnio P, Koskentalo T, Kousa A, Maenhaut W. Sources and chemical composition of atmospheric fine and coarse particles in the Helsinki area. Atmos Environ 2001, 35:5381-5391.
36. Saarnio K, Sillanpää M, Hillamo R, Sandell E, Pennanen AS, Salonen RO. Polycyclic aromatic hydrocarbons in size-segregated particulate matter from six urban sites in Europe. Atmos Environ 2008, 40:9087-9097.
37. WHO Selected non-heterocyclic polycyclic aromatichydrocarbons.Environmentalhealth criteria 202 1998, Geneva Switzerland: WHO International Program of Chemical Safety, WHO.
38. Frey AK, Tissari J, Saarnio KM, Timonen HJ, Tolonen-Kivimäki O, Aurela MA, Saarikoski SK, Makkonen U, Hytönen K, Jokiniemi J, Salonen RO, Hillamo REJ. Chemical composition andmass size distribution of fine particulate matter emitted by a small masonry heater. Bor Environ Res 2009, 14:255-271.
39. Penttinen P, Pelkonen J, Huttunen K, Toivola M, Hirvonen MR. Interactions between Streptomyces californicusand Stachybotryschartarumcan induce apoptosis and cell cycle arrest in mouse RAW264.7 macrophages. ToxicolAppl Pharm 2005, 202:278-288.
40. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991, 139:271-279. 10.1016/0022-1759(91)90198-O, 1710634.
41. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry 1992, 13:795-808. 10.1002/cyto.990130802, 1333943.
42. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1998, 175:184-191.
43. Clark RH, Lampreia I, Stradling RJ Schmidt M. Emissions Performance of Shell GTL Fuel in the Context of Future Fuel Specifications. SAE Technical Paper 2006, :01-3325.
44. McCormick R, Graboski M, Alleman T, Herring A. Impact of biodiesel source material and chemical structure on emissions of criteria pollutants from a heavy duty engine. Environ SciTechnol 2001, 35:1742-1747.
45. Akasaka Y, Suzuki T, Sakurai Y. Exhaust emissions of a DI diesel engine fueled with blends of biodiesel and low sulfur diesel fuel. SAE technical paper 1997, :972998.
46. McGill R, Storey J, Wagner R, Irick D, Aakko P, Westerholm M, Nylund N-O, Lappi M. Emission performance of selected biodiesel fuels. SAE technical paper 2003, :01-1866.
47. Jalava PI, Hirvonen MR, Sillanpaa M, Pennanen AS, Happo MS, Hillamo R, Cassee FR, Gerlofs-Nijland M, Borm PJA, Schins RPF, Janssen NAH, Salonen RO. Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line. Inhal Toxicol 2009, 21:994-1006. 10.1080/08958370802695710, 19772479.
48. Happo MS, Hirvonen M-R, Hälinen AI, Jalava PI, Pennanen AS, Sillanpää M, Hillamo R, Salonen RO. Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples from contrasting air pollution in Europe. Inhal Toxicol 2008, 20:1-17. 10.1080/08958370701758593, 18236215.
49. Biswas S, Verma V, Schauer JJ, Cassee FR, Cho AK, Sioutas C. Oxidative Potential of Semi-Volatile and Non Volatile Particulate Matter (PM) from Heavy-Duty Vehicles Retrofitted with Emission Control Technologies. Environ Sci Technol 2009, 43:3905-3912. 10.1021/es9000592, 19544906.
50. Verma V, Schafer MM, Schauer JJ, Sioutas C. Contribution of transition metals in the reactive oxygen species activity of PM emissions from retrofitted heavy-duty vehicles. Atmos Environ 2010, 44:5165-5173.
51. Lucking AJ, Lundback M, Barath SL, Mills NL, Sidhu MK, Langrish JP, Boon NA, Pourazar J, Badimon JJ, Gerlofs-nijland ME, Cassee FR, Boman C, Donaldson K, Sandstrom T, Newby DE, Blomberg A. Particle Traps Prevent Adverse Vascular and Prothrombotic Effects of Diesel Engine Exhaust Inhalation in Men. Circulation 2011, 123:1721-1728. 10.1161/CIRCULATIONAHA.110.987263, 21482966.
52. Ghio AJ, Smith CB, Madden MC. Diesel exhaust particles and airway inflammation. Curropinpulm med 2012, 18:144-150.
53. McDonald JD, Campen MJ, Harrod KS, Seagrave J, Seilkop SK, Mauderly JL. Engine-Operating Load Influences Diesel Exhaust Composition and Cardiopulmonary and Immune Responses. Environ Health Persp 2011, 119:1136-1141.
54. Totlandsdal AI, Cassee FR, Schwarze P, Refsnes M, Lag M. Diesel exhaust particles induce CYP1A1 and pro-inflammatory responses via differential pathways in human bronchial epithelial cells. Part FibreToxicol 2010, 7:41.
55. Brito JM, Belotti L, Toledo AC, Antonangelo L, Silva FS, Alvim DS, Andre PA, Saldiva PHN, Rivero DHRF. Acute Cardiovascular and Inflammatory Toxicity Induced by Inhalation of Diesel and Biodiesel Exhaust Particles. Toxicol Sci 2010, 116:67-78. 10.1093/toxsci/kfq107, 20385657.
56. Hemmingsen JG, Moller P, Nojgaard JK, Rousgaard M, Loft S. Oxidative Stress, Genotoxicity, And Vascular Cell Adhesion Molecule Expression in Cells Exposed to Particulate Matter from Combustion of Conventional Diesel and Methyl Ester Biodiesel Blends. Environ SciTechnol 2011, 45:8535-8551.
57. Liu YY, Lin TC, Wang YJ, Ho WL. Carbonyl Compounds and Toxicity Assessments of Emissions from a Diesel Engine Running on Biodiesels. J Air Waste manage 2009, 59:163-171.
58. Januario DANF, Perin PM, Maluf M, Lichtenfels AJ, Saldiva PHN. Biological Effects and Dose-response Assessment of Diesel Exhaust Particles on In Vitro Early Embryo Development in Mice. ToxicolSci 2010, 117:200-208.
59. Yun YP, Lee JY, Ahn EK, Lee KH, Yoon HK, Lim Y. Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line. Toxicol in vitro 2009, 23:21-28. 10.1016/j.tiv.2008.09.018, 18940243.
60. Kennedy IM. The health effects of combustion-generated aerosols. ProcCombust Inst 2007, 28:2757-2770.
61. Bünger J, Krahl J, Munack A, Ruschel Y, Schroder O, Emmert B, West G, Muller M, Hallier E, Bruning T. Strong mutagenic effects of diesel engine emissions using vegetable oil as fuel. ArchToxicol 2007, 81:599-603.