Oxidative stress, genotoxicity, and vascular cell adhesion molecule expression in cells exposed to particulate matter from combustion of conventional diesel and methyl ester biodiesel blends

Environmental Science and Technology

Volumn 45, Issue 19, 2011, Pages 8545-8551

  Hemmingsen, Jette Gjerke ^a   Møller, Peter ^a   Nøjgaard, Jakob Klenø ^b   Roursgaard, Martin ^a   Loft, Steffen ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

A549 CELLS; ANIMAL FAT; BIODIESEL BLENDS; CELL TYPES; CYTOKINES; DNA DAMAGES; EURO-4 ENGINES; EURO-4 STANDARDS; GENOTOXICITIES; HUMAN UMBILICAL CORD; LIGHT DUTY VEHICLES; MASS CONCENTRATION; METHYL ESTERS; MRNA EXPRESSION; MRNA LEVEL; PARTICLE EMISSIONS; PARTICULATE MATTER; RAPESEED OIL METHYL ESTER; REACTIVE OXYGEN SPECIES; VASCULAR CELL ADHESION;

BIODIESEL; CELL ADHESION; COMBUSTION; DIESEL ENGINES; DNA; ENDOTHELIAL CELLS; ENGINES; ESTERIFICATION; ESTERS; VEGETABLE OILS;

PARTICLES (PARTICULATE MATTER);

BIODIESEL; DIESEL FUEL; ESTER; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; MESSENGER RNA; METHYL GROUP; MONOCYTE CHEMOTACTIC PROTEIN 1; RAPESEED OIL; REACTIVE OXYGEN METABOLITE; VASCULAR CELL ADHESION MOLECULE 1;

BIOFUEL; COMBUSTION; DIESEL; ENGINE; ESTER; FAT; GENE EXPRESSION; GENOTOXICITY; OXIDATION; PARTICULATE MATTER; POLLUTION EXPOSURE; TOXIC SUBSTANCE; TOXICITY TEST; VIABILITY;

ARTICLE; CELL TYPE; CELL VIABILITY; COMBUSTION; CONTROLLED STUDY; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; MOTOR VEHICLE; NEOPLASM; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; PROTEIN EXPRESSION; STANDARD; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR DISEASE;

BIOFUELS; CELL LINE; CELL SURVIVAL; DNA DAMAGE; ESTERS; GASOLINE; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MOTOR VEHICLES; MUTAGENS; N-GLYCOSYL HYDROLASES; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; REACTIVE OXYGEN SPECIES; VASCULAR CELL ADHESION MOLECULE-1; VEHICLE EMISSIONS;

ANIMALIA; BRASSICA NAPUS;

EID: 80053423950     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es200956p     Document Type: Article

References (27)

1. McCormick, R. L. The impact of biodiesel on pollutant emissions and public health Inhalation Toxicol. 2007, 19, 1033-1039 (Pubitemid 47537214)
2. Brook, R. D.; Rajagopalan, S.; Pope, C. A., III; Brook, J. R.; Bhatnagar, A.; Diez-Roux, A. V.; Holguin, F.; Hong, Y.; Luepker, R. V.; Mittleman, M. A.; Peters, A.; Siscovick, D.; Smith, S. C., Jr.; Whitsel, L.; Kaufman, J. D. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association Circulation 2010, 121, 2331-2378
3. Eisner, M. D.; Anthonisen, N.; Coultas, D.; Kuenzli, N.; Perez-Padilla, R.; Postma, D.; Romieu, I.; Silverman, E. K.; Balmes, J. R. Committee on Nonsmoking COPD, Environmental and Occupational Health Assembly An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 2010, 182, 693-718
4. Araujo, J. A.; Nel, A. E. Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress Part. Fibre Toxicol. 2009, 6, 24
5. Møller, P.; Mikkelsen, L.; Vesterdal, L. K.; Folkmann, J. K.; Forchhammer, L.; Roursgaard, M.; Danielsen, P. H.; Loft, S. Hazard identification of particulate matter on vasomotor dysfunction and progression of atherosclerosis Crit Rev. Toxicol. 2011, 41, 339-368
6. Risom, L.; Møller, P.; Loft, S. Oxidative stress-induced DNA damage by particulate air pollution Mutat. Res. 2005, 592, 119-137 (Pubitemid 41714049)
7. Loft, S.; Møller, P. Oxidative DNA damage and human cancer: need for cohort studies Antioxid. Redox Signaling 2006, 8, 1021-1031 (Pubitemid 44036519)
8. Cheung, K. L.; Polidori, A.; Ntziachristos, L.; Tzamkiozis, T.; Samaras, Z.; Cassee, F. R.; Gerlofs, M.; Sioutas, C. Chemical characteristics and oxidative potential of particulate matter emissions from gasoline, diesel, and biodiesel cars Environ. Sci. Technol. 2009, 43, 6334-6340
9. Brito, J. M.; Belotti, L.; Toledo, A. C.; Antonangelo, L.; Silva, F. S.; Alvim, D. S.; Andre, P. A.; Saldiva, P. H.; Rivero, D. H. Acute cardiovascular and inflammatory toxicity induced by inhalation of diesel and biodiesel exhaust particles Toxicol. Sci. 2010, 116, 67-78
10. Tzamkiozis, T.; Stoeger, T.; Cheung, K.; Ntziachristos, L.; Sioutas, C.; Samaras, Z. Monitoring the inflammatory potential of exhaust particles from passenger cars in mice Inhal. Toxicol. 2010, 22 (Suppl 2) 59-69
11. Danielsen, P. H.; Loft, S.; Kocbach, A.; Schwarze, P. E.; Møller, P. Oxidative damage to DNA and repair induced by Norwegian wood smoke particles in human A549 and THP-1 cell lines Mutat. Res. 2009, 674, 116-122
12. Forchhammer, L.; Johansson, C.; Loft, S.; Möller, L.; Godschalk, R. W.; Langie, S. A.; Jones, G. D.; Kwok, R. W.; Collins, A. R.; Azqueta, A.; Phillips, D. H.; Sozeri, O.; Stepnik, M.; Palus, J.; Vogel, U.; Wallin, H.; Routledge, M. N.; Handforth, C.; Allione, A.; Matullo, G.; Teixeira, J. P.; Costa, S.; Riso, P.; Porrini, M.; Møller, P. Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial Mutagenesis 2010, 25, 113-123
13. Frikke-Schmidt, H.; Roursgaard, M.; Lykkesfeldt, J.; Loft, S.; Nøjgaard, J. K.; Møller, P. Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells Toxicol. Lett. 2011, 203, 181-189
14. Danielsen, P. H.; Møller, P.; Jensen, K. A; Sharma, A. K.; Wallin, H.; Bossi, R.; Autrup, H.; Mølhave, L.; Ravanat, J.-L.; Briedé, J. J.; de Kok, T. M.; Loft, S. Oxidative stress, DNA damage and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines Chem. Res. Toxicol. 2010, 24, 168-184
15. TMMouse lung epithelial cells Environ. Mol. Mutagen. 2008, 49, 476-487
16. Karlsson, H. L.; Ljungman, A. G.; Lindbom, J.; Möller, L. Comparison of genotoxic and inflammatory effects of particles generated by wood combustion, a road simulator and collected from street and subway Toxicol. Lett. 2006, 165, 203-211 (Pubitemid 43994357)
17. Stone, V.; Shaw, J.; Brown, D. M.; Macnee, W.; Faux, S. P.; Donaldson, K. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function Toxicol. In Vitro 1998, 12, 649-659 (Pubitemid 28555771)
18. Folkmann, J. K.; Risom, L.; Jacobsen, N. R.; Wallin, H.; Loft, S.; Møller, P. Comparison of genotoxic and inflammatory effects of particles generated by wood combustion, a road simulator and collected from street and subway Environ. Health Perspect. 2009, 117, 703-708
19. Wardman, P. Fluorescent and luminescent probes for measurements of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects Free Radical Biol. Med. 2007, 43, 995-1022 (Pubitemid 47302656)
20. Møller, P.; Jacobsen, N. R.; Folkmann, J. K.; Danielsen, P. H.; Mikkelsen, L.; Hemmingsen, J. G.; Vesterdal, L. K.; Forchhammer, L.; Wallin, H.; Loft, S. Role of oxidative damage in toxicity of particulates Free Radical Res. 2010, 44, 1-46
21. Møller, P.; Loft, S. Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution Environ. Health Perspect. 2010, 118, 1126-1136
22. Danielsen, P. H.; Loft, S.; Møller, P. DNA damage and cytotoxicity in type II lung epithelial (A549) cell cultures after exposure to diesel exhaust and urban street particles Part. Fibre Toxicol. 2008, 5, 6
23. Vesterdal, L. k.; Folkmann, J. K.; Jacobsen, N. R.; Sheykhzade, M.; Wallin, H.; Loft, S.; Møller, P. Pulmonary exposure to carbon black nanoparticles and vascular effects Part. Fibre Toxicol. 2010, 7, 33
24. Li, N.; Xia, T.; Nel, A. E. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles Free Radical Biol. Med. 2008, 44, 1689-1699
25. Dybdahl, M.; Risom, L.; Bornholdt, J.; Autrup, H.; Loft, S.; Wallin, H. Inflammatory and genotoxic effects of diesel particles in vitro and in vivo Mutat. Res. 2004, 562, 119-131 (Pubitemid 38981786)
26. Kocbach, A.; Totlandsdal, A. I.; Lag, M.; Refsnes, M.; Schwarze, P. E. Differential binding of cytokines to environmentally relevant particles: a possible source for misinterpretation of in vitro results? Toxicol. Lett. 2008, 176, 131-137
27. Cheung, K. L.; Ntziachristos, L.; Tzamkiozis, T.; Schauer, J. J.; Samaras, Z.; Moore, K. F.; Sioutas, C. Emissions of particulate trace elements, metals and organic species from gasoline, diesel, and biodiesel passenger vehicles and their relation to oxidative potential Aerosol. Sci. Technol. 2010, 44, 500-513