Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: Ameliorative effects of Withania somnifera and Withanolide A

Neurochemical Research

Volumn 37, Issue 9, 2012, Pages 1915-1927

  Soman, Smijin ^a   Korah, P K ^a   Jayanarayanan, S ^a   Mathew, Jobin ^b   Paulose, C S ^a  

^a Department of Physics   (India)

^b CMS COLLEGE   (India)

Author keywords

Antioxidant; Epilepsy; NMDA; Withania somnifera

Indexed keywords

CARBAMAZEPINE; CATALASE; EXCITATORY AMINO ACID TRANSPORTER; GLUTATHIONE PEROXIDASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; WITHANIA SOMNIFERA EXTRACT; WITHANOLIDE; WITHANOLIDE A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; MAZE TEST; MEMORY DISORDER; NONHUMAN; OXIDATIVE STRESS; PLANT ROOT; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DENSITY; SPATIAL MEMORY; TEMPORAL LOBE EPILEPSY; UPREGULATION;

ANIMALS; CATALASE; COGNITION DISORDERS; DIZOCILPINE MALEATE; EPILEPSY, TEMPORAL LOBE; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY AMINO ACID TRANSPORTER 1; HEMOSTASIS; IMMUNOHISTOCHEMISTRY; MALE; MAZE LEARNING; MEMORY DISORDERS; OXIDATIVE STRESS; PLANT ROOTS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, N-METHYL-D-ASPARTATE; SPACE PERCEPTION; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; WITHANIA; WITHANOLIDES;

RATTUS; WITHANIA SOMNIFERA;

EID: 84866687472     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0810-5     Document Type: Article

References (56)

1. Waldbaum S, Patel M (2010) Mitochondria, oxidative stress, and temporal lobe epilepsy. Epilepsy Res 88(1):23-45
2. Costello DJ, Delanty N (2004) Oxidative injury in epilepsy: potential for antioxidant therapy? Expert Rev 4(3):541-553
3. Shin EJ, Jeong JH, Chung YH, Kim WK, Ko KH, Bach JH, Hong JS, Yoneda Y, Kim HC (2011) Role of oxidative stress in epileptic seizures. Neurochem Int 59(2):122-137
4. Govindarajan R, Vijayakumar M, Pushpangadan P (2005) Antioxidant approach to disease management and the role of 'Rasayana' herbs of Ayurveda. J Ethnopharmacol 99(2):165-178
5. Kulkarni SK, DhirA(2008) Withania somnifera: an Indian ginseng. Prog Neuropsychopharmacol Biol Psychiatr 32(5):1093-1105
6. Misra L, Sangwan NS, Tuli R (2008) Withanolides from Withania somnifera roots. Phytochemistry 69:1000-1004
7. Hort J, Brozek G, Komárek V, Langmeier M, Mares P (2000) Interstrain differences in cognitive functions in rats in relation to status epilepticus. Behav Brain Res 112(1-2):77-83
8. Pazdernik TL, Emerson MR, Cross R, Nelson SR, Samson FE (2001) Soman- induced seizures: limbic activity, oxidative stress and neuroprotective proteins. J Appl Toxicol 21:S87-S94
9. Lyne R, Freitas MD, Mo○nica Í et al (2010) Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. Control 81:505-509
10. Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine, 3rd edn. Clarendon Press, Oxford
11. Freitas RM, Bezerra Felipe CF, Nascimento VS, Oliveira AA, Viana GS, Fonteles MM (2003) Pilocarpine-induced seizures in adult rats: monoamine content and muscarinic and dopaminergic receptor changes in the striatum. Comp Biochem Physiol C Toxicol Pharmacol 136(2):103-108
12. Stadtman ER (2001) Protein oxidation in aging and age-related diseases. Ann NY Acad Sci 928:22-38
13. Wasterlain CG, Fujikawa DG, Penix L, Sankar R (1993) Pathophysiological mechanisms of brain damage from status epilepticus. Epilepsia 34(1):S37-S53
14. Hauser WA, Hesdorffer DC (1990) Epilepsy: frequency, cause and consequences, 1st edn. Epilepsy Foundation of America Press/Demos, New York
15. Do SH, Kamatchi GL, Washington JM, Zuo Z (2002) Effects of volatile anesthetics on glutamate transporter, excitatory amino acid transporter type 3. Anesthesiology 96:1492-1497
16. Rossi DJ, Oshima T, Attwell D (2000) Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature 403:316-321
17. Lucas DR, Newhouse JP (1957) The toxic effect of sodium L-glutamate on the inner layers of the retina. AMA Arch Ophthalmol 58(2):193-201
18. Sun DA, Sombati S, DeLorenzo RJ (2001) Glutamate injuryinduced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced ''epilepsy''. Stroke 32(10):2344-2350
19. Urbanska EM, Czuczwar SJ, Kleinrok Z, Turski WA (1998) Excitatory amino acids in epilepsy. Restor Neurol Neurosci 13(1-2):25-39
20. Z-zhong Guan (2008) Cross-talk between oxidative stress and modifications of cholinergic and glutaminergic receptors in the pathogenesis of Alzheimer's disease. Acta Pharmacol Sin 29(7):773-780
21. Scartezzini P, Speroni E (2000) Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol 71:23-43
22. Aamodt SM, Constantine-Paton M (1999) The role of neural activity in synaptic development and its implications for adult brain function. Adv Neurol 79:133-144
23. Gröticke I, Hoffmann K, Löscher W (2008) Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate. Exp Neurol 213(1):71-83
24. Kwan P, Brodie MJ (2000) Early identification of refractory epilepsy. N Engl J Med 342(5):314-319
25. Turski WA, Cavalheiro EA, Schwarz M et al (1983) Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 9:315-335
26. Kobayashi M, Wen X, Buckmaster PS (2003) Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy. J Neurosci 23:8471-8479
27. Racine RJ (1972) Modification of seizure activity by electrical stimu- lation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281-294
28. Jarrard LE (1995) What does the hippocampus really do? Behav Brain Res 71(1-2):1-10
29. Lopes da Silva FH, Gorter JA, Wadman WJ (1986) Kindling of the hippocampus induces spatial memory deficits in the rat. Neurosci Lett 63(2):115-120
30. Mathew J, Gangadharan G, Kuruvilla KP, Paulose CS (2011) Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochem Res 36(1):7-16
31. Hevner RF, Hodge RD, Daza RAM, Englund C (2006) Transcriptionfactors in glutamatergic neurogenesis : conserved programs in neocortex, cerebellum, and adult hippocampus. Neurosci Res 55:223-233
32. Heffner TG, Hartman JA, Seiden LS (1980) A rapid method for the regional dissection of the rat brain. Pharmacol Biochem Behav 13:453-456
33. Marklund S, Plum CM (1978) Superoxide dismutase in juvenile neuronal ceroid-lipofuscinosis (Spielmeyer-Vogt-Batten's disease). J Neurochem 31(2):521-523
34. Aebi HE (1984) Catalase in vitro. Methods Enzymol 105:121-125
35. Freitas RM, Vasconcelos SMM, Souza FCF, Viana GSB, Fonteles MMF (2005) Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats. FEBS J 272(6):1307-1312
36. Hoffman DJ, Zanelli SA, Kubin JM, Om P, Delivoria PM (1996) The in vivo effect of bilirubin on the N-methyl-D-aspartate receptor/ion channel complex in the brains of newborn piglets. Pediatr Res 40:804-808
37. Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann NY Acad Sci 51:660-672
38. Lowry OH, Roserbbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with Folin phenol reagent. J Biol Chem 193:265-275
39. Chen S, Kobayashi M, Honda Y, Kakuta S, Sato F, Kiyoshi K (2007) Preferential neuron loss in rat piriform cortex following pilocarpine induced status epilepticus. Epilepsy Res 74:1-18
40. Mathern GW, Leiphart JL, DeVera A, Adelson PD, Seki T, Neder L, Leite JP (2002) Seizures decrease postnatal neurogenesis and granule cell development in the human fascia dentata. Epilepsia 43:68-73
41. Motamedi G, Meador K (2003) Epilepsy and cognition. Epilepsy Behav 4(2):25-38
42. Eric JH, Philip AW, Edward FD (2002) Effect of Fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine induced epilepsy. Epilepsia 43:1337-1345
43. Sagar H, Oxbury J M (1987) Hippocampal neuron loss in temporal lobe epilepsy: Correlation with early childhood convulsions. Ann Neurol 22(3):334-340
44. Oliver CN, Starke-Reed PE, Stadtman ER, Liku GJ, Carney JM, Floyd RA (1990) Oxidative damage to proteins, loss of glutamine synthetase activity and produc- tion of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc Natl Acad Sci 87:5144-5147
45. Halliwell B, Gutteridge JMC (1999) Antioxidant defenses. In: Halliwell B, Gutteridge JMC (Eds) Free radicals in biology and medicine, 3rd ed. Oxford University Press, New York, pp 175
46. Mishra LC, Singh BB, Dagenais S (2000) Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Alternat Med Rev J Clin Ther 5(4):334-346
47. Devi PU, Manocha A, Vohora D (2008) Seizures, antiepileptics, antioxidants and oxidative stress: an insight for researchers. Expert Opin Pharmacother 9(18):3169-3177
48. Felipe Dal-pizzol, Vianna ÃMR, Schro N et al (2000) Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats. Neurosci Lett 291:179-182
49. Dhuley JN (1998) Effect of ashwagandha on lipid peroxidation in stress-induced animals. J Ethnopharmacol 60:173-178
50. Naffah-Mazzacoratti MG, Cavalheiro EA, Ferreira EC, Abdalla DSP, Amado D, Bellissimo MI (2001) Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats. Epilepsy Res 46:121-128
51. Mark RJ, Hensley K, Butterfield DA, Mattson MP (1995) Amyloid beta-peptide impairs ion-motiveATPase activities: evidence for a role in loss of neuronal Ca2? homeostasis and cell death. J Neurosci 15:6239-6249
52. Blanc EM, Kelly JF, Mark RJ, Waeg G, Mattson MP (1997) 4-Hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic acetylcholine and metabotropic glutamate receptors: possible action on G alpha(q/11). J Neurochem 69(2):570-580
53. Helms G, Ciumas C, Kyaga S, Savic I (2006) Increased thalamus levels of glutamate and glutamine (Glx) in patients with idiopathic generalised epilepsy. J Neurol Neurosurg Psychiatry 77(4):489-494
54. Van der Vliet A, Bast A (1990) Effect of oxidative stress on receptors and signal transmission. Chem Biol Interact 85(2-3):95-116
55. Wong-ekkabut J, Xu Z, Triampo W, Tang IM, Tieleman DP, Monticelli L (2007) Effect of lipid peroxidation of lipid bilayers: a molecular dynamic study. Biophys J 93:4225-4236
56. Kuboyama T, Tohda C, Komatsu K (2005) Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol 144(7):961-971