10′(Z),13′(E)-Heptadecadienylhydroquinone Inhibits Swarming and Virulence Factors and Increases Polymyxin B Susceptibility in Proteus mirabilis

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Liu, Ming Che ^a   Lin, Shwu Bin ^a   Chien, Hsiung Fei ^c   Wang, Won Bo ^b   Yuan, Yu Han ^a   Hsueh, Po Ren ^c   Liaw, Shwu Jen ^a,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

10',13' HEPTADECADIENYLHYDROQUINONE; AMPICILLIN; BACTERIAL PROTEIN; CIPROFLOXACIN; GENTAMICIN; HEMOLYSIN; HYDROQUINONE DERIVATIVE; KANAMYCIN; LIPOPOLYSACCHARIDE; POLYMYXIN B; PROTEIN RCSB; PROTEIN RPPA; STREPTOMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; 10'(Z),13'(E) HEPTADECADIENYLHYDROQUINONE; 10'(Z),13'(E)-HEPTADECADIENYLHYDROQUINONE; ACYLTRANSFERASE; ANTIINFECTIVE AGENT; CHALCONE SYNTHASE; RCSB PROTEIN, BACTERIA;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL GENE; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM MUTANT; BINDING AFFINITY; BIOFILM; CONTROLLED STUDY; FLHDC GENE; GENE EXPRESSION REGULATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PMRL GENE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEUS MIRABILIS; RPPA GENE; SIGNAL TRANSDUCTION; SWARMING MOTILITY; WILD TYPE; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MUTATION;

PROTEUS MIRABILIS;

ACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG SYNERGISM; GENE EXPRESSION REGULATION, BACTERIAL; HEMOLYSIN PROTEINS; HYDROQUINONES; MICROBIAL SENSITIVITY TESTS; MUTATION; POLYMYXIN B; PROMOTER REGIONS, GENETIC; PROTEUS MIRABILIS; SIGNAL TRANSDUCTION; VIRULENCE FACTORS;

EID: 84866672762     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045563     Document Type: Article

References (43)

1. Jacobsen SM, Stickler DJ, Mobley HL, Shirtliff ME, (2008) Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis. Clin Microbiol Rev 21: 26-59.
2. Mobley HL, Chippendale GR, Swihart KG, Welch RA, (1991) Cytotoxicity of the HpmA hemolysin and urease of Proteus mirabilis and Proteus vulgaris against cultured human renal proximal tubular epithelial cells. Infect Immun 59: 2036-2042.
3. Allison C, Coleman N, Jones PL, Hughes C, (1992) Ability of Proteus mirabilis to invade human urothelial cells is coupled to motility and swarming differentiation. Infect Immun 60: 4740-4746.
4. Liaw SJ, Lai HC, Ho SW, Luh KT, Wang WB, (2000) Inhibition of virulence factor expression and swarming differentiation in Proteus mirabilis by p-nitrophenylglycerol. J Med Microbiol 49: 725-731.
5. Liaw SJ, Lai HC, Ho SW, Luh KT, Wang WB, (2001) Characterisation of p-nitrophenylglycerol-resistant Proteus mirabilis super-swarming mutants. J Med Microbiol 50: 1039-1048.
6. Liaw SJ, Lai HC, Wang WB, (2004) Modulation of swarming and virulence by fatty acids through the RsbA protein in Proteus mirabilis. Infect Immun 72: 6836-6845.
7. Fraser GM, Hughes C, (1999) Swarming motility. Curr Opin Microbiol 2: 630-635.
8. Liaw SJ, Lai HC, Ho SW, Luh KT, Wang WB, (2003) Role of RsmA in the regulation of swarming motility and virulence factor expression in Proteus mirabilis. J Med Microbiol 52: 19-28.
9. Morgenstein RM, Szostek B, Rather PN, (2010) Regulation of gene expression during swarmer cell differentiation in Proteus mirabilis. FEMS Microbiol Rev 34: 753-763.
10. Belas R, Schneider R, Melch M, (1998) Characterization of Proteus mirabilis precocious swarming mutants: identification of rsbA, encoding a regulator of swarming behavior. J Bacteriol 180: 6126-6139.
11. Wang WB, Lai HC, Hsueh PR, Chiou RY, Lin SB, et al. (2006) Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol. J Med Microbiol 55: 1313-1321.
12. Majdalani N, Gottesman S, (2005) The Rcs phosphorelay: a complex signal transduction system. Annu Rev Microbiol 59: 379-405.
13. Takeda S, Fujisawa Y, Matsubara M, Aiba H, Mizuno T, (2001) A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC -> YojN -> RcsB signalling pathway implicated in capsular synthesis and swarming behaviour. Mol Microbiol 40: 440-450.
14. Clemmer KM, Rather PN, (2007) Regulation of flhDC expression in Proteus mirabilis. Res Microbiol 158: 295-302.
15. Francez-Charlot A, Laugel B, Van Gemert A, Dubarry N, Wiorowski F, et al. (2003) RcsCDB His-Asp phosphorelay system negatively regulates the flhDC operon in Escherichia coli. Mol Microbiol 49: 823-832.
16. Wang Q, Zhao Y, McClelland M, Harshey RM, (2007) The RcsCDB signaling system and swarming motility in Salmonella enterica serovar Typhimurium: dual regulation of flagellar and SPI-2 virulence genes. J Bacteriol 189: 8447-8457.
17. Fraser GM, Claret L, Furness R, Gupta S, Hughes C, (2002) Swarming-coupled expression of the Proteus mirabilis hpmBA haemolysin operon. Microbiology 148: 2191-2201.
18. Hancock RE, Scott MG, (2000) The role of antimicrobial peptides in animal defenses. Proc Natl Acad Sci U S A 97: 8856-8861.
19. Belas R, Manos J, Suvanasuthi R, (2004) Proteus mirabilis ZapA metalloprotease degrades a broad spectrum of substrates, including antimicrobial peptides. Infect Immun 72: 5159-5167.
20. Phan V, Belas R, Gilmore BF, Ceri H, (2008) ZapA, a virulence factor in a rat model of Proteus mirabilis-induced acute and chronic prostatitis. Infect Immun 76: 4859-4864.
21. Walker KE, Moghaddame-Jafari S, Lockatell CV, Johnson D, Belas R, (1999) ZapA, the IgA-degrading metalloprotease of Proteus mirabilis, is a virulence factor expressed specifically in swarmer cells. Mol Microbiol 32: 825-836.
22. Peschel A, (2002) How do bacteria resist human antimicrobial peptides? Trends Microbiol 10: 179-186.
23. Gunn JS, Lim KB, Krueger J, Kim K, Guo L, et al. (1998) PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance. Mol Microbiol 27: 1171-1182.
24. Gunn JS, Ryan SS, Van Velkinburgh JC, Ernst RK, Miller SI, (2000) Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar Typhimurium. Infect Immun 68: 6139-6146.
25. Wang WB, Chen IC, Jiang SS, Chen HR, Hsu CY, et al. (2008) Role of RppA in the regulation of polymyxin b susceptibility, swarming, and virulence factor expression in Proteus mirabilis. Infect Immun 76: 2051-2062.
26. Jiang SS, Liu MC, Teng LJ, Wang WB, Hsueh PR, et al. (2010) Proteus mirabilis pmrI, an RppA-regulated gene necessary for polymyxin B resistance, biofilm formation, and urothelial cell invasion. Antimicrob Agents Chemother 54: 1564-1571.
27. Nordlund JJ, Grimes PE, Ortonne JP, (2006) The safety of hydroquinone. J Eur Acad Dermatol Venereol 20: 781-787.
28. Wu PL, Lin SB, Huang CP, Chiou RY, (2002) Antioxidative and cytotoxic compounds extracted from the sap of Rhus succedanea. J Nat Prod 65: 1719-1721.
29. Chen YR, Y-Y R, Lin TY, Huang CP, Tang WC, et al. (2009) Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis. J Agric Food Chem 57: 2200-2205.
30. Huang CP, Fang WH, Lin LI, Chiou RY, Kan LS, et al. (2008) Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning. Toxicol Appl Pharmacol 227: 331-338.
31. Qiu J, Wang D, Xiang H, Feng H, Jiang Y, et al. (2010) Subinhibitory concentrations of thymol reduce enterotoxins A and B and alpha-hemolysin production in Staphylococcus aureus isolates. PLoS One 5: e9736.
32. Gotoh Y, Eguchi Y, Watanabe T, Okamoto S, Doi A, et al. (2010) Two-component signal transduction as potential drug targets in pathogenic bacteria. Curr Opin Microbiol 13: 232-239.
33. Belas R, Erskine D, Flaherty D, (1991) Transposon mutagenesis in Proteus mirabilis. J Bacteriol 173: 6289-6293.
34. Jiang SS, Lin TY, Wang WB, Liu MC, Hsueh PR, et al. (2010) Characterization of UDP-glucose dehydrogenase and UDP-glucose pyrophosphorylase mutants of Proteus mirabilis: defectiveness in polymyxin B resistance, swarming, and virulence. Antimicrob Agents Chemother 54: 2000-2009.
35. Clinical and Laboratory Standards Institute (2009) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard M07-A8 teC, Wayne, PA.
36. Lee S, Hinz A, Bauerle E, Angermeyer A, Juhaszova K, et al. (2009) Targeting a bacterial stress response to enhance antibiotic action. Proc Natl Acad Sci U S A 106: 14570-14575.
37. Pescaretti Mde L, Lopez FE, Morero RD, Delgado MA, (2010) Transcriptional autoregulation of the RcsCDB phosphorelay system in Salmonella enterica serovar Typhimurium. Microbiology 156: 3513-3521.
38. Kim W, Killam T, Sood V, Surette MG, (2003) Swarm-cell differentiation in Salmonella enterica serovar Typhimurium results in elevated resistance to multiple antibiotics. J Bacteriol 185: 3111-3117.
39. Parsek MR, Singh PK, (2003) Bacterial biofilms: an emerging link to disease pathogenesis. Annu Rev Microbiol 57: 677-701.
40. Morgenstein RM, Clemmer KM, Rather PN, (2010) Loss of the waaL O-antigen ligase prevents surface activation of the flagellar gene cascade in Proteus mirabilis. J Bacteriol 192: 3213-3221.
41. Pandey DK, Mishra N, Singh P, (2005) Relative phytotoxicity of hydroquinone on rice (Oryza sativa L.) and associated aquatic weed green musk chara (Chara zeylanica Willd.). Pestic Biochem Physiol 83: 82-96.
42. Zhang Y, Lucocq JM, Hayes JD, (2009) The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochem J 418: 293-310.
43. Maresh J, Zhang J, Tzeng YL, Goodman NA, Lynn DG, (2007) Rational design of inhibitors of VirA-VirG two-component signal transduction. Bioorg Med Chem Lett 17: 3281-3286.