Regulation of flhDC expression in Proteus mirabilis

Research in Microbiology

Volumn 158, Issue 3, 2007, Pages 295-302

  Clemmer, Katy M ^a   Rather, Philip N ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

flhDC; Proteus mirabilis; Swarming motility

Indexed keywords

MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; FLHDC GENE; GENE; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEUS MIRABILIS; TRANSPOSON;

BACTERIAL PROTEINS; BASE SEQUENCE; BLOTTING, NORTHERN; DNA TRANSPOSABLE ELEMENTS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; LAC OPERON; MUTAGENESIS, INSERTIONAL; MUTATION; OPERON; PROTEUS MIRABILIS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TRANS-ACTIVATORS;

PROTEUS MIRABILIS;

EID: 33947602619     PISSN: 09232508     EISSN: 17697123     Source Type: Journal    
DOI: 10.1016/j.resmic.2006.11.010     Document Type: Article

References (37)

1. Alavi M., and Belas R. Surface sensing, swarmer cell differentiation and biofilm development. Methods Enzymol. 336 (2001) 29-40
2. Barker C.S., Pruss B.M., and Matsumura P. Increased motility of Escherichia coli by insertion sequence element integration into the regulatory region of the flhD operon. J. Bacteriol. 186 (2004) 7529-7537
3. Belas R. Expression of multiple flagellin-encoding genes of Proteus mirabilis. J. Bacteriol. 176 (1994) 7169-7181
4. Belas R., Goldman M., and Ashliman K. Genetic analysis of Proteus mirabilis mutants defective in swarmer cell elongation. J. Bacteriol. 177 (1995) 823-828
5. Belas R., Schneider R., and Melch M. Characterization of Proteus mirabilis precocious swarming mutants: identification of rsbA, encoding a regulator of swarming behavior. J. Bacteriol. 180 (1998) 6126-6139
6. Belas R., and Suvanasuthi R. The ability of Proteus mirabilis to sense surfaces and regulate virulence gene expression involves FliL, a flagellar basal body protein. J. Bacteriol. 187 (2005) 6789-6803
7. Claret L., and Hughes C. Rapid turnover of FlhD and FlhC, the flagellar regulon transcriptional activator proteins, during Proteus swarming. J. Bacteriol. 182 (2000) 833-836
8. Chang A.C., and Cohen S.N. Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the p15A cryptic miniplasmid. J. Bacteriol. 134 (1978) 1141-1156
9. de Lorenzo V., Herrero M., Jakubzik U., and Timmis K.N. Mini-Tn5 transposon derivatives for insertion mutagenesis, promoter probing, and chromosomal insertion of cloned DNA in gram-negative eubacteria. J. Bacteriol. 172 (1990) 6568-6572
10. Dufour A., Furness R.B., and Hughes C. Novel genes that upregulate the Proteus mirabilis flhDC master operon controlling flagellar biogenesis and swarming. Mol. Microbiol. 29 (1998) 741-751
11. Eberl L., Christiansen G., Molin S., and Givskov M. Differentiation of Serratia liquefaciens into swarm cells is controlled by the expression of the flhD master operon. J. Bacteriol. 178 (1996) 554-559
12. Francez-Charlot A., Laugel B., Van Gemert A., Dubarry N., Wiorowski F., Castanie-Cornet M.P., Gutierrez C., and Cam K. RcsCDB His-Asp phosphorelay system negatively regulates the flhDC operon in Escherichia coli. Mol. Microbiol. 49 (2003) 823-832
13. Fraser G.M., and Hughes C. Swarming motility. Curr. Opin. Microbiol. 2 (1999) 630-635
14. Furness R.B., Fraser G.M., Hay N.A., and Hughes C. Negative feedback from a Proteus class II flagellum export defect to the flhDC master operon controlling cell division and flagellum assembly. J. Bacteriol. 179 (1997) 5585-5588
15. Givaudan A., and Lanois A. flhDC, the flagellar master operon of Xenorhabdus nematophilus: requirement for motility, lipolysis, extracellular hemolysis, and full virulence in insects. J. Bacteriol. 182 (2000) 107-115
16. Givskov M., Ostling J., Eberl L., Lindum P.W., Christensen A.B., Christiansen G., Molin S., and Kjelleberg S. Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1. J. Bacteriol. 180 (1998) 742-745
17. Gygi D., Bailey M.J., Allison C., and Hughes C. Requirement for FlhA in flagella assembly and swarm-cell differentiation by Proteus mirabilis. Mol. Microbiol. 15 (1995) 761-769
18. Harshey R.M. Bacterial motility on a surface: Many ways to a common goal. Annu. Rev. Microbiol. 57 (2003) 249-273
19. Hay N.A., Tipper D.J., Gygi D., and Hughes C. A nonswarming mutant of Proteus mirabilis lacks the Lrp global transcriptional regulator. J. Bacteriol. 179 (1997) 4741-4746
20. Kaniga K., Delor I., and Cornelis G.R. A wide host range suicide vector for improving reverse genetics in gram-negative bacteria: inactivation of the blaA gene of Yersinia enterocolitica. Gene 109 (1991) 137-141
21. Kapatral V., Campbell J.W., Minnich S.A., Thomson N.R., Matsumura P., and Pruss B.M. Gene array analysis of Yersinia entercolitica FlhD and FlhC: regulation of enzymes affecting synthesis and degradation of carbamoylphosphate. Microbiology 150 (2004) 2289-2300
22. Ko M., and Park C. H-NS-dependent regulation of flagellar synthesis is mediated by a LysR family protein. J. Bacteriol. 182 (2000) 4670-4672
23. Lehnen D., Blumer C., Polen T., Wackwitz B., Wendisch V.F., and Unden G. LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli. Mol. Microbiol. 45 (2002) 521-532
24. Li X., Rasko D.A., Lockatell C.V., Johnson D.E., and Mobley H.L. Repression of bacterial motility by a novel fimbrial gene product. EMBO J. 20 (2001) 4854-4862
25. Liaw S.J., Lai H.C., Ho S.W., Luh K.T., and Wang W.B. Characterisation of p-nitrophenylglycerol-resistant Proteus mirabilis super-swarming mutants. J. Med. Microbiol. 50 (2001) 1039-1048
26. Liaw S.J., Lai H.C., Ho S.W., Luh K.T., and Wang W.B. Role of RsmA in the regulation of swarming motility and virulence factor expression in Proteus mirabilis. J. Med. Microbiol. 52 (2003) 19-28
27. Liu J.H., Lai M.J., Ang S., Shu J.C., Soo P.C., Horng Y.T., Yi W.C., Lai H.C., Luk K.T., Ho S.W., and Swift S. Role of flhDC in the expression of the nuclease gene nucA, cell division and flagellar synthesis in Serratia marcescens. J. Biomed. Sci. 7 (2000) 475-483
28. Mobley H.L., and Belas R. Swarming and pathogenicity of Proteus mirabilis in the urinary tract. Trends Microbiol. 3 (1995) 280-284
29. Pruss B.M., Campbell J.W., Van Dyk T.K., Zhu C., Kogan Y., and Matsumura P. FlhD/FlhC is a regulator of anaerobic respiration and the Entner-Doudoroff pathway through induction of the methyl-accepting chemotaxis protein Aer. J. Bacteriol. 185 (2003) 534-543
30. Pruss B.M., Liu X., Hendrickson W., and Matsumura P. FlhD/FlhC-regulated promoters analyzed by gene array and lacZ gene fusions. FEMS Microbiol. Lett. 197 (2001) 91-97
31. Rauprich O., Matsushita M., Weijer C.J., Siegert F., Esipov S.E., and Shapiro J.A. Periodic phenomena in Proteus mirabilis swarm colony development. J. Bacteriol. 178 (1996) 6525-6538
32. Rozalski A., Sidorczyk Z., and Kotelko K. Potential virulence factors of Proteus bacilli. Microbiol. Mol. Biol. Rev. 61 (1997) 65-89
33. Shin S., and Park C. Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR. J. Bacteriol. 177 (1995) 4696-4702
34. Sturgill G.M., Siddiqui S., Ding X., Pecora N.D., and Rather P.N. Isolation of lacZ fusions to Proteus mirabilis genes regulated by intercellular signaling: potential role for the sugar phosphotransferase (Pts) system in regulation. FEMS Microbiol. Lett. 217 (2002) 43-50
35. Sturgill G., and Rather P.N. Evidence that putrescine acts as an extracellular signal required for swarming in Proteus mirabilis. Mol. Microbiol. 51 (2004) 437-446
36. Takeda S., Fujisawa Y., Matsubara M., Aiba H., and Mizuno T. A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC→YojN→RcsB signalling pathway implicated in capsular synthesis and swarming behaviour. Mol. Microbiol. 40 (2001) 440-450
37. Young G.M., Smith M.J., Minnich S.A., and Miller V.L. The Yersinia enterocolitica motility master regulatory operon, flhDC, is required for flagellin production, swimming motility, and swarming motility. J. Bacteriol. 181 (1999) 2823-2833