Principles and applications of selective biophysical methods for characterization and comparability assessment of a monoclonal antibody

Current Pharmaceutical Biotechnology

Volumn 13, Issue 10, 2012, Pages 2078-2101

  Maity, Haripada ^a   Lai, Yin ^a   Srivastava, Arvind ^a   Goldstein, Joel ^a  

^a ImClone Systems   (United States)

Author keywords

Aggregation; Comparability; Degradation; Differential scanning calorimetry; Fluorescence; IgG; Light scattering; Stability

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY;

ABSORPTION SPECTROSCOPY; ANALYTIC METHOD; ARTICLE; BIOPHYSICS; CIRCULAR DICHROISM; COMPARATIVE STUDY; DEGRADATION KINETICS; DIFFERENTIAL SCANNING CALORIMETRY; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HYDRODYNAMICS; INFRARED SPECTROMETRY; LIGHT SCATTERING; MOLECULAR WEIGHT; MULTIANGLE LIGHT SCATTERING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; QUASI ELASTIC LIGHT SCATTERING; SENSITIVITY ANALYSIS; STATIC LIGHT SCATTERING; THERMOSTABILITY; ULTRAVIOLET RADIATION;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; DRUG STABILITY; HUMANS; IMMUNOGLOBULIN G; LIGHT; PROTEIN CONFORMATION; SCATTERING, RADIATION; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84866654927     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920112802273344     Document Type: Article

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